JP2015520612A5 - - Google Patents
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- Publication number
- JP2015520612A5 JP2015520612A5 JP2015514061A JP2015514061A JP2015520612A5 JP 2015520612 A5 JP2015520612 A5 JP 2015520612A5 JP 2015514061 A JP2015514061 A JP 2015514061A JP 2015514061 A JP2015514061 A JP 2015514061A JP 2015520612 A5 JP2015520612 A5 JP 2015520612A5
- Authority
- JP
- Japan
- Prior art keywords
- clostridium
- per gram
- produced cells
- fermentation medium
- potassium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 24
- 238000000855 fermentation Methods 0.000 claims 19
- 230000004151 fermentation Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 241000193403 Clostridium Species 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 8
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 7
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 6
- 239000010941 cobalt Substances 0.000 claims 5
- 229910017052 cobalt Inorganic materials 0.000 claims 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 4
- 239000011777 magnesium Substances 0.000 claims 4
- 229910052749 magnesium Inorganic materials 0.000 claims 4
- 229910052759 nickel Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 3
- 241001656809 Clostridium autoethanogenum Species 0.000 claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 3
- 235000019270 ammonium chloride Nutrition 0.000 claims 3
- 239000000908 ammonium hydroxide Substances 0.000 claims 3
- 239000011574 phosphorus Substances 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 239000011591 potassium Substances 0.000 claims 3
- 229910052700 potassium Inorganic materials 0.000 claims 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 3
- 229910052721 tungsten Inorganic materials 0.000 claims 3
- 239000010937 tungsten Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000193401 Clostridium acetobutylicum Species 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 244000061457 Solanum nigrum Species 0.000 claims 2
- 241000186339 Thermoanaerobacter Species 0.000 claims 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 2
- 235000011009 potassium phosphates Nutrition 0.000 claims 2
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 2
- 229960003495 thiamine Drugs 0.000 claims 2
- 235000019157 thiamine Nutrition 0.000 claims 2
- 239000011721 thiamine Substances 0.000 claims 2
- 241001468161 Acetobacterium Species 0.000 claims 1
- 239000004254 Ammonium phosphate Substances 0.000 claims 1
- 241000880298 Baculum Species 0.000 claims 1
- 241001464894 Blautia producta Species 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 241001656810 Clostridium aceticum Species 0.000 claims 1
- 241001468167 Clostridium magnum Species 0.000 claims 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 claims 1
- 102100030787 ERI1 exoribonuclease 2 Human genes 0.000 claims 1
- 241000186398 Eubacterium limosum Species 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 241001135750 Geobacter Species 0.000 claims 1
- 101000941690 Homo sapiens Cytochrome P450 1A1 Proteins 0.000 claims 1
- 101000938751 Homo sapiens ERI1 exoribonuclease 2 Proteins 0.000 claims 1
- 241000205276 Methanosarcina Species 0.000 claims 1
- 241000205275 Methanosarcina barkeri Species 0.000 claims 1
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 claims 1
- 241000178986 Oxobacter Species 0.000 claims 1
- 241000191992 Peptostreptococcus Species 0.000 claims 1
- 230000000789 acetogenic effect Effects 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims 1
- 235000019289 ammonium phosphates Nutrition 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229940041514 candida albicans extract Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical group [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 claims 1
- AVWLPUQJODERGA-UHFFFAOYSA-L cobalt(2+);diiodide Chemical compound [Co+2].[I-].[I-] AVWLPUQJODERGA-UHFFFAOYSA-L 0.000 claims 1
- BZRRQSJJPUGBAA-UHFFFAOYSA-L cobalt(ii) bromide Chemical compound Br[Co]Br BZRRQSJJPUGBAA-UHFFFAOYSA-L 0.000 claims 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims 1
- AAQNGTNRWPXMPB-UHFFFAOYSA-N dipotassium;dioxido(dioxo)tungsten Chemical compound [K+].[K+].[O-][W]([O-])(=O)=O AAQNGTNRWPXMPB-UHFFFAOYSA-N 0.000 claims 1
- 229960002089 ferrous chloride Drugs 0.000 claims 1
- 239000011790 ferrous sulphate Substances 0.000 claims 1
- 235000003891 ferrous sulphate Nutrition 0.000 claims 1
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 claims 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- 235000011147 magnesium chloride Nutrition 0.000 claims 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 1
- 239000004137 magnesium phosphate Substances 0.000 claims 1
- 229960002261 magnesium phosphate Drugs 0.000 claims 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims 1
- 235000010994 magnesium phosphates Nutrition 0.000 claims 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 1
- 235000019341 magnesium sulphate Nutrition 0.000 claims 1
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 claims 1
- LGQLOGILCSXPEA-UHFFFAOYSA-L nickel sulfate Chemical compound [Ni+2].[O-]S([O-])(=O)=O LGQLOGILCSXPEA-UHFFFAOYSA-L 0.000 claims 1
- 229910000363 nickel(II) sulfate Inorganic materials 0.000 claims 1
- KBJMLQFLOWQJNF-UHFFFAOYSA-N nickel(ii) nitrate Chemical compound [Ni+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O KBJMLQFLOWQJNF-UHFFFAOYSA-N 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000004323 potassium nitrate Substances 0.000 claims 1
- 235000010333 potassium nitrate Nutrition 0.000 claims 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 1
- 229910052939 potassium sulfate Inorganic materials 0.000 claims 1
- 235000011151 potassium sulphates Nutrition 0.000 claims 1
- 229910052979 sodium sulfide Inorganic materials 0.000 claims 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims 1
- XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 claims 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 claims 1
- 239000012138 yeast extract Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650093P | 2012-05-22 | 2012-05-22 | |
| US201261650098P | 2012-05-22 | 2012-05-22 | |
| US61/650,093 | 2012-05-22 | ||
| US61/650,098 | 2012-05-22 | ||
| US201261726225P | 2012-11-14 | 2012-11-14 | |
| US61/726,225 | 2012-11-14 | ||
| US13/890,777 US10100338B2 (en) | 2012-05-22 | 2013-05-09 | Method of operation of a syngas fermentation process |
| US13/890,777 | 2013-05-09 | ||
| PCT/US2013/041250 WO2013176948A2 (en) | 2012-05-22 | 2013-05-15 | Method of operation of a syngas fermentation process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520612A JP2015520612A (ja) | 2015-07-23 |
| JP2015520612A5 true JP2015520612A5 (enExample) | 2016-07-07 |
| JP6228596B2 JP6228596B2 (ja) | 2017-11-08 |
Family
ID=49621897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514061A Active JP6228596B2 (ja) | 2012-05-22 | 2013-05-15 | シンガス発酵プロセスの操作方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10100338B2 (enExample) |
| EP (1) | EP2852675B1 (enExample) |
| JP (1) | JP6228596B2 (enExample) |
| KR (2) | KR102046677B1 (enExample) |
| CN (2) | CN108841874B (enExample) |
| AR (1) | AR091109A1 (enExample) |
| AU (2) | AU2013266676B2 (enExample) |
| BR (2) | BR112014028956B1 (enExample) |
| CA (1) | CA2874086C (enExample) |
| RU (1) | RU2623170C2 (enExample) |
| TW (1) | TWI650422B (enExample) |
| WO (1) | WO2013176948A2 (enExample) |
| ZA (1) | ZA201409445B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9885063B2 (en) * | 2013-06-10 | 2018-02-06 | Ineos Bio Sa | Process for fermenting co-containing gaseous substrates in a low phosphate medium effective for reducing water usage |
| US9850503B2 (en) * | 2013-06-10 | 2017-12-26 | Ineos Bio Sa | Control of conductivity in anaerobic fermentation |
| US9617566B2 (en) * | 2014-07-11 | 2017-04-11 | Lanzatech New Zealand Limited | Control of bioreactor processes |
| US9765408B2 (en) * | 2014-08-12 | 2017-09-19 | Ineos Bio Sa | Process for controlling fermentation of co-containing substrates |
| EP3050967A1 (en) * | 2015-01-28 | 2016-08-03 | Evonik Degussa GmbH | A method of producing higher alcohols |
| CN107779477B (zh) * | 2016-08-25 | 2021-10-12 | 中国科学院天津工业生物技术研究所 | 一种食气厌氧菌利用合成气发酵产醇的培养体系和培养方法 |
| CN106399387A (zh) * | 2016-09-20 | 2017-02-15 | 江南大学 | 一种混合菌发酵合成气产乙醇的氮缺陷调控方法 |
| US11333607B2 (en) | 2018-10-02 | 2022-05-17 | Electronics And Telecommunications Research Institute | Fluorescent signal detection apparatus using diagnostic kit |
| KR102722662B1 (ko) | 2021-09-17 | 2024-10-29 | 한국과학기술연구원 | 합성 가스로부터 알코올을 제조하기 위한 에탄올 포함하는 배지 조성물 및 이를 이용한 알코올 생산 방법 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| JPH11341947A (ja) * | 1998-06-02 | 1999-12-14 | Yakult Honsha Co Ltd | 発酵管理方法 |
| US5972661A (en) | 1998-09-28 | 1999-10-26 | Penn State Research Foundation | Mixing systems |
| MXPA01011301A (es) | 1999-05-07 | 2003-07-14 | Bioengineering Resources Inc | Cepas clostridium que produce etanol a partir de gases que contienen substrato. |
| CN100360678C (zh) * | 1999-09-30 | 2008-01-09 | 科金斯公司 | 改进的发酵方法 |
| CN101519679B (zh) * | 2000-01-28 | 2013-11-13 | Dsmip资产公司 | 通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生 |
| NZ523484A (en) * | 2000-07-25 | 2005-01-28 | Emmaus Foundation Inc | Methods for increasing the production of ethanol from microbial fermentation |
| EP1584680A1 (en) * | 2004-04-08 | 2005-10-12 | Boehringer Ingelheim Austria GmbH | Fed-batch fermentation process for the production of plasmid DNA |
| NZ546496A (en) | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
| US20070275447A1 (en) | 2006-05-25 | 2007-11-29 | Lewis Randy S | Indirect or direct fermentation of biomass to fuel alcohol |
| MX2009007114A (es) * | 2007-01-11 | 2009-07-09 | Danisco Us Inc Genencor Div | Produccion de enzima en un medio de cultivo que comprende glicerol crudo. |
| WO2009022925A1 (en) | 2007-08-15 | 2009-02-19 | Lanzatech New Zealand Limited | Processes of producing alcohols |
| EP2217696B1 (en) | 2007-11-13 | 2015-09-16 | Lanzatech New Zealand Limited | Novel bacteria and methods of use thereof |
| US8852918B2 (en) * | 2007-11-13 | 2014-10-07 | Lanzatech New Zealand Limited | Bacteria and methods of use thereof |
| US9034618B2 (en) | 2009-03-09 | 2015-05-19 | Ineos Bio Sa | Method for sustaining microorganism culture in syngas fermentation process in decreased concentration or absence of various substrates |
| KR20110002029A (ko) | 2008-03-10 | 2011-01-06 | 이네오스 유에스에이 엘엘씨 | 다양한 기질의 감소된 농도 또는 부존재 하에서 합성가스 발효 프로세스에서 미생물 배양물을 유지하는 방법 |
| KR20130084704A (ko) | 2008-03-12 | 2013-07-25 | 란자테크 뉴질랜드 리미티드 | 미생물 알콜 생산 방법 |
| RU2418070C2 (ru) * | 2009-07-06 | 2011-05-10 | Общество с ограниченной ответственностью "Фирма Атлас" | Способ преобразования газообразного углеводородного сырья в жидкое топливо |
| WO2012074545A1 (en) | 2010-12-03 | 2012-06-07 | Ineos Bio Sa | Method of operation of fermentation of gaseous substrate comprising hydrogen |
| EP2646561B1 (en) | 2010-12-03 | 2019-07-24 | Jupeng Bio (HK) Limited | Method of operation of fermentation of carbon monoxide and hydrogen containing gaseous substrate |
| US9157058B2 (en) * | 2011-12-14 | 2015-10-13 | Kiverdi, Inc. | Method and apparatus for growing microbial cultures that require gaseous electron donors, electron acceptors, carbon sources, or other nutrients |
-
2013
- 2013-05-09 US US13/890,777 patent/US10100338B2/en active Active
- 2013-05-15 KR KR1020147035891A patent/KR102046677B1/ko active Active
- 2013-05-15 KR KR1020197033343A patent/KR102142234B1/ko active Active
- 2013-05-15 RU RU2014151620A patent/RU2623170C2/ru not_active IP Right Cessation
- 2013-05-15 WO PCT/US2013/041250 patent/WO2013176948A2/en not_active Ceased
- 2013-05-15 CN CN201810500522.6A patent/CN108841874B/zh active Active
- 2013-05-15 JP JP2015514061A patent/JP6228596B2/ja active Active
- 2013-05-15 AU AU2013266676A patent/AU2013266676B2/en active Active
- 2013-05-15 EP EP13728863.5A patent/EP2852675B1/en active Active
- 2013-05-15 BR BR112014028956-5A patent/BR112014028956B1/pt active IP Right Grant
- 2013-05-15 BR BR122021020217-6A patent/BR122021020217B1/pt active IP Right Grant
- 2013-05-15 CN CN201380026747.8A patent/CN104822836B/zh active Active
- 2013-05-15 CA CA2874086A patent/CA2874086C/en active Active
- 2013-05-21 AR ARP130101753 patent/AR091109A1/es unknown
- 2013-05-21 TW TW102117885A patent/TWI650422B/zh active
-
2014
- 2014-12-19 ZA ZA2014/09445A patent/ZA201409445B/en unknown
-
2016
- 2016-05-12 AU AU2016203101A patent/AU2016203101B2/en active Active
-
2018
- 2018-10-12 US US16/158,508 patent/US10858672B2/en active Active
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