JP2015518869A5 - - Google Patents
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- Publication number
- JP2015518869A5 JP2015518869A5 JP2015515488A JP2015515488A JP2015518869A5 JP 2015518869 A5 JP2015518869 A5 JP 2015518869A5 JP 2015515488 A JP2015515488 A JP 2015515488A JP 2015515488 A JP2015515488 A JP 2015515488A JP 2015518869 A5 JP2015518869 A5 JP 2015518869A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- acid
- lactide
- glycolide
- hydroxybutyric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 4
- 229920001432 poly(L-lactide) Polymers 0.000 claims 3
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 2
- JRHWHSJDIILJAT-UHFFFAOYSA-N 2-hydroxypentanoic acid Chemical compound CCCC(O)C(O)=O JRHWHSJDIILJAT-UHFFFAOYSA-N 0.000 claims 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 2
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims 2
- 229940005605 valeric acid Drugs 0.000 claims 2
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657049P | 2012-06-08 | 2012-06-08 | |
| US61/657,049 | 2012-06-08 | ||
| PCT/EP2013/061343 WO2013182503A1 (en) | 2012-06-08 | 2013-06-03 | Rapamycin 40-o-cyclic hydrocarbon esters, compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518869A JP2015518869A (ja) | 2015-07-06 |
| JP2015518869A5 true JP2015518869A5 (OSRAM) | 2017-03-09 |
| JP6101346B2 JP6101346B2 (ja) | 2017-03-22 |
Family
ID=48577737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015515488A Active JP6101346B2 (ja) | 2012-06-08 | 2013-06-03 | ラパマイシン−４０−ｏ−環状炭化水素エステル、組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9408884B2 (OSRAM) |
| EP (1) | EP2859001B1 (OSRAM) |
| JP (1) | JP6101346B2 (OSRAM) |
| CN (1) | CN104203959B (OSRAM) |
| AU (1) | AU2013270798B2 (OSRAM) |
| CA (1) | CA2869102C (OSRAM) |
| DK (1) | DK2859001T3 (OSRAM) |
| ES (1) | ES2574522T3 (OSRAM) |
| PL (1) | PL2859001T3 (OSRAM) |
| SG (1) | SG11201405777YA (OSRAM) |
| WO (1) | WO2013182503A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104203959B (zh) * | 2012-06-08 | 2017-09-15 | 百多力股份公司 | 雷帕霉素40‑o‑环状烃酯、组合物和方法 |
| US10751450B2 (en) * | 2012-06-08 | 2020-08-25 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
| US11395853B2 (en) * | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
| CN107759616B (zh) * | 2016-08-23 | 2020-11-17 | 上海微创医疗器械（集团）有限公司 | 一种化合物及其制备方法和用途 |
| SG11201900602XA (en) * | 2016-09-19 | 2019-02-27 | Biotronik Ag | Polymer-free drug eluting vascular stents |
| EP3558408B1 (en) * | 2016-12-22 | 2024-04-17 | Biotronik AG | Intratumoral drug delivery materials and methods for treating breast cancer |
| EP3720517A1 (en) * | 2017-12-06 | 2020-10-14 | Biotronik AG | Intracranial drug delivery materials and methods |
| CN111712231A (zh) * | 2018-02-23 | 2020-09-25 | 百多力股份公司 | 用于40-o-环状烃酯和相关结构的肠胃外制剂材料和方法 |
| EP3613449A1 (de) * | 2018-08-23 | 2020-02-26 | Biotronik Ag | Verbesserung der polymerschicht bei degradierbaren vorrichtungen |
| US20220088278A1 (en) * | 2019-01-30 | 2022-03-24 | Biotronik Ag | Covered Stent For Local Drug Delivery |
| EP3708176A1 (en) | 2019-03-15 | 2020-09-16 | Centre National De La Recherche Scientifique -Cnrs- | Mutant vsv ectodomain polypeptide and uses thereof |
| WO2022023414A2 (en) * | 2020-07-29 | 2022-02-03 | Biotronik Ag | Pharmaceutical microsphere compositions and methods |
| WO2022128810A1 (en) * | 2020-12-14 | 2022-06-23 | Biotronik Ag | Materials and methods for treating viral and other medicinal conditions |
| EP4593830A1 (en) * | 2022-09-30 | 2025-08-06 | Biotronik Ag | Macrocyclic triene immunosuppressive compounds for perivascular medical treatment of vascular access fistulas, grafts and other vascular conditions |
| WO2024068159A1 (en) * | 2022-09-30 | 2024-04-04 | Biotronik Ag | Synthesis and characterization of cyclic hydrocarbon esters of everolimus |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| ZA892859B (en) | 1988-04-22 | 1989-12-27 | Advanced Polymer Systems Inc | Porous particles in preparations involving immiscible phases |
| US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5138051A (en) | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
| US5102876A (en) | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5120727A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Rapamycin dimers |
| US5120725A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Bicyclic rapamycins |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5310903A (en) | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
| CA2175215C (en) * | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US5385910A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
| DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
| CN101467921B (zh) * | 2001-11-05 | 2012-08-15 | 生物传感器国际集团有限公司 | 药物洗脱支架的生产方法 |
| US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
| EP1663343B8 (en) | 2003-09-15 | 2019-12-04 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
| CA2544731A1 (en) | 2003-11-03 | 2005-05-12 | Altachem Pharma Ltd. | Rapamycin peptides conjugates: synthesis and uses thereof |
| SG152234A1 (en) * | 2004-04-14 | 2009-05-29 | Wyeth Corp | Regiospecific synthesis of rapamycin 42-ester derivatives |
| US7214759B2 (en) | 2004-11-24 | 2007-05-08 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same |
| US8021678B2 (en) * | 2006-02-10 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics |
| US7678901B2 (en) * | 2006-02-28 | 2010-03-16 | Wyeth | Rapamycin analogs containing an antioxidant moiety |
| CN101394867A (zh) * | 2006-03-07 | 2009-03-25 | 惠氏公司 | 大环内酯类免疫抑制剂的水溶性聚乙二醇结合物的制备方法 |
| CN104906087A (zh) * | 2006-09-13 | 2015-09-16 | 万能医药公司 | 大环内酯化合物及它们的使用方法 |
| US20110098241A1 (en) * | 2008-04-14 | 2011-04-28 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| US9321782B2 (en) | 2010-08-04 | 2016-04-26 | Meril Life Sciences Pvt. Ltd. | Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties |
| CN102018996B (zh) * | 2010-12-14 | 2013-03-06 | 中国医学科学院生物医学工程研究所 | 一种表面固定有抗体的药物血管支架的制备方法 |
| DE102011010539A1 (de) | 2011-02-07 | 2012-08-09 | Airbus Operations Gmbh | Aufrüstvorrichtung und Verfahren zur Herstellung einer aus einem Faserverbundwerkstoff bestehenden Rumpftonne für ein Luftfahrzeug |
| CN104203959B (zh) * | 2012-06-08 | 2017-09-15 | 百多力股份公司 | 雷帕霉素40‑o‑环状烃酯、组合物和方法 |
-
2013
- 2013-06-03 CN CN201380010936.6A patent/CN104203959B/zh active Active
- 2013-06-03 EP EP13727586.3A patent/EP2859001B1/en active Active
- 2013-06-03 DK DK13727586.3T patent/DK2859001T3/da active
- 2013-06-03 WO PCT/EP2013/061343 patent/WO2013182503A1/en not_active Ceased
- 2013-06-03 JP JP2015515488A patent/JP6101346B2/ja active Active
- 2013-06-03 PL PL13727586T patent/PL2859001T3/pl unknown
- 2013-06-03 SG SG11201405777YA patent/SG11201405777YA/en unknown
- 2013-06-03 ES ES13727586.3T patent/ES2574522T3/es active Active
- 2013-06-03 AU AU2013270798A patent/AU2013270798B2/en active Active
- 2013-06-03 US US14/406,198 patent/US9408884B2/en active Active
- 2013-06-03 CA CA2869102A patent/CA2869102C/en active Active
-
2016
- 2016-07-18 US US15/212,987 patent/US9867911B2/en active Active
-
2017
- 2017-12-01 US US15/829,012 patent/US20180078683A1/en not_active Abandoned
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