JP2015517572A5 - - Google Patents
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- Publication number
- JP2015517572A5 JP2015517572A5 JP2015513993A JP2015513993A JP2015517572A5 JP 2015517572 A5 JP2015517572 A5 JP 2015517572A5 JP 2015513993 A JP2015513993 A JP 2015513993A JP 2015513993 A JP2015513993 A JP 2015513993A JP 2015517572 A5 JP2015517572 A5 JP 2015517572A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- indole
- compound
- ethoxy
- fluoroethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- HNEGJTWNOOWEMH-UHFFFAOYSA-N 1-fluoropropane Chemical group [CH2]CCF HNEGJTWNOOWEMH-UHFFFAOYSA-N 0.000 claims 1
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 1
- -1 3-fluoro-propoxy Chemical group 0.000 claims 1
- WYTGDRQOERRVOD-UHFFFAOYSA-N 7-(2-nitroethyl)-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(CC[N+](=O)[O-])C=C3NC2=C1 WYTGDRQOERRVOD-UHFFFAOYSA-N 0.000 claims 1
- LTQKXJQXVGFYEJ-UHFFFAOYSA-N 7-(3-fluoropropyl)-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(CCCF)C=C3NC2=C1 LTQKXJQXVGFYEJ-UHFFFAOYSA-N 0.000 claims 1
- SLACXXPWBNDWSW-UHFFFAOYSA-N 7-(3-nitropropyl)-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(CCC[N+](=O)[O-])C=C3NC2=C1 SLACXXPWBNDWSW-UHFFFAOYSA-N 0.000 claims 1
- HCOLWFHEOAJVJC-UHFFFAOYSA-N 7-[2-(2-fluoroethoxy)ethoxy]-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(OCCOCCF)C=C3NC2=C1 HCOLWFHEOAJVJC-UHFFFAOYSA-N 0.000 claims 1
- PGQPLORRJVHERS-UHFFFAOYSA-N 7-[2-(2-fluoroethoxy)ethoxymethyl]-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(COCCOCCF)C=C3NC2=C1 PGQPLORRJVHERS-UHFFFAOYSA-N 0.000 claims 1
- NEKSMXSTDNEBFB-UHFFFAOYSA-N 7-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(OCCOCCOCCF)C=C3NC2=C1 NEKSMXSTDNEBFB-UHFFFAOYSA-N 0.000 claims 1
- BTZWEODKMIMOLZ-UHFFFAOYSA-N 7-[2-[2-(2-fluoroethoxy)ethoxy]ethyl]-5h-pyrido[4,3-b]indole Chemical compound C1=NC=C2C3=CC=C(CCOCCOCCF)C=C3NC2=C1 BTZWEODKMIMOLZ-UHFFFAOYSA-N 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/477,095 | 2012-05-22 | ||
| US13/477,095 US8932557B2 (en) | 2008-02-14 | 2012-05-22 | Imaging agents for detecting neurological dysfunction |
| PCT/US2012/061912 WO2013176698A1 (en) | 2012-05-22 | 2012-10-25 | Carboline and carbazole based imaging agents for detecting neurological dysfunction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517572A JP2015517572A (ja) | 2015-06-22 |
| JP2015517572A5 true JP2015517572A5 (https=) | 2015-10-15 |
| JP5976206B2 JP5976206B2 (ja) | 2016-08-23 |
Family
ID=47146722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513993A Active JP5976206B2 (ja) | 2012-05-22 | 2012-10-25 | 神経機能障害を検出するための造影剤 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2852572B1 (https=) |
| JP (1) | JP5976206B2 (https=) |
| KR (1) | KR101609504B1 (https=) |
| CN (2) | CN104781234A (https=) |
| AU (1) | AU2012381042B2 (https=) |
| CA (1) | CA2873963C (https=) |
| CO (1) | CO7131359A2 (https=) |
| ES (1) | ES2792830T3 (https=) |
| WO (1) | WO2013176698A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015110263A1 (en) * | 2014-01-21 | 2015-07-30 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins |
| JP6762233B2 (ja) * | 2014-04-22 | 2020-09-30 | ウニヴェルシテ ド モントリオールＵｎｉｖｅｒｓｉｔｅ Ｄｅ Ｍｏｎｔｒｅａｌ | 化合物および造血幹細胞および／または造血前駆細胞の増大におけるその使用 |
| HUE053939T2 (hu) | 2014-05-13 | 2021-08-30 | Hoffmann La Roche | Deuterált heterociklikus vegyületek és képalkotó kontrasztanyagként való használatuk |
| EA036518B1 (ru) * | 2015-02-02 | 2020-11-18 | Юсб Байофарма Спрл | Производные 9h-пирролодипиридина |
| JP6609866B2 (ja) * | 2015-03-04 | 2019-11-27 | 国立大学法人京都大学 | 放射性ヨウ素標識ピリド［１，２−ａ］ベンゾイミダゾール誘導体化合物 |
| TW201707726A (zh) * | 2015-08-19 | 2017-03-01 | 國立大學法人京都大學 | 放射性鹵素標誌吡啶并［１，２－ａ］苯并咪唑衍生物化合物 |
| CA3003884C (en) | 2015-11-13 | 2020-04-21 | Eli Lilly And Company | Azetidine derivatives for tau imaging |
| KR102472003B1 (ko) | 2016-07-22 | 2022-11-29 | 에이씨 이뮨 에스에이 | 타우 단백질 응집체를 이미징하기 위한 화합물 |
| WO2018015546A1 (en) | 2016-07-22 | 2018-01-25 | Ac Immune S.A. | Compounds for imaging tau protein aggregates |
| WO2018024642A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
| WO2018024643A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
| MX2019005007A (es) * | 2016-11-01 | 2019-07-18 | Arvinas Inc | Protac dirigidos a la proteína tau y métodos asociados de uso. |
| CN109884194A (zh) * | 2017-12-06 | 2019-06-14 | 新疆维吾尔药业有限责任公司 | 一种药用植物的分离方法及其产品和应用 |
| US20210041447A1 (en) | 2018-01-24 | 2021-02-11 | Ac Immune Sa | Azacarboline compounds for the detection of tau aggregates |
| EP3743423A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Gamma-carboline compounds for the detection of tau aggregates |
| CN108409634B (zh) * | 2018-05-10 | 2021-04-27 | 曲阜师范大学 | 咔唑类荧光胺类化合物标记试剂、合成和应用 |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| KR102215255B1 (ko) * | 2019-06-12 | 2021-02-15 | 한국과학기술연구원 | 타우 응집체에 선택적으로 결합하는 형광 탐침자로서 유효한 신규 화합물 및 이의 제조 방법 |
| EP3999182A1 (en) | 2019-07-17 | 2022-05-25 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| CN116003402B (zh) * | 2021-11-02 | 2025-08-29 | 上海如絮生物科技有限公司 | 一种三环类化合物、其中间体、制备方法和应用 |
| CN114539250B (zh) * | 2022-03-04 | 2023-08-29 | 上海裕兰生物科技有限公司 | 一种阿尔兹海默症PET-tau示踪剂的制备方法 |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| KR20250137711A (ko) | 2023-02-02 | 2025-09-18 | 일라이 릴리 앤드 캄파니 | 타우 영상화를 위한 신규 화합물 |
| CN117050070B (zh) * | 2023-07-05 | 2025-10-14 | 湘潭大学 | 一种荧光探针及其制备方法和在Aβ检测中的应用 |
| WO2025155625A1 (en) | 2024-01-16 | 2025-07-24 | Eli Lilly And Company | Novel compounds for tau imaging |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090170882A1 (en) * | 2004-06-30 | 2009-07-02 | Dashyant Dhanak | Methods and compositions |
| FR2885905A1 (fr) * | 2005-05-23 | 2006-11-24 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament |
| DE102006062203A1 (de) * | 2006-12-22 | 2008-06-26 | Curacyte Discovery Gmbh | Substituierte 5H-Pyrimido[5,4-b]indole als Induktoren der Apoptose bei B-CLL Zellen |
| WO2008132454A1 (en) * | 2007-04-26 | 2008-11-06 | Ge Healthcare Limited | Carbolines and their use as imaging agents |
| EP2247558B2 (en) * | 2008-02-14 | 2024-07-03 | Eli Lilly and Company | Novel imaging agents for detecting neurological dysfunction |
| JP2011529086A (ja) * | 2008-07-24 | 2011-12-01 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | Ａｄ病変を同定するために有用な造影剤 |
| JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Ｅｇ５阻害剤 |
| JP2012521988A (ja) * | 2009-03-23 | 2012-09-20 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | 神経学的障害を検知するためのイメージング剤 |
| US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| US10639608B2 (en) * | 2010-04-08 | 2020-05-05 | Siemens Medical Solutions Usa, Inc. | System, device and method for preparing tracers and transferring materials during radiosynthesis |
| JP5585382B2 (ja) * | 2010-10-22 | 2014-09-10 | コニカミノルタ株式会社 | 有機エレクトロルミネッセンス素子、照明装置及び表示装置 |
-
2012
- 2012-10-25 CN CN201280073373.0A patent/CN104781234A/zh active Pending
- 2012-10-25 CA CA2873963A patent/CA2873963C/en active Active
- 2012-10-25 ES ES12783780T patent/ES2792830T3/es active Active
- 2012-10-25 EP EP12783780.5A patent/EP2852572B1/en active Active
- 2012-10-25 CN CN201611136351.0A patent/CN107011342A/zh active Pending
- 2012-10-25 KR KR1020147032388A patent/KR101609504B1/ko active Active
- 2012-10-25 JP JP2015513993A patent/JP5976206B2/ja active Active
- 2012-10-25 WO PCT/US2012/061912 patent/WO2013176698A1/en not_active Ceased
- 2012-10-25 AU AU2012381042A patent/AU2012381042B2/en active Active
-
2014
- 2014-11-20 CO CO14255692A patent/CO7131359A2/es unknown
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