JP2015517534A5 - - Google Patents
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- Publication number
- JP2015517534A5 JP2015517534A5 JP2015512968A JP2015512968A JP2015517534A5 JP 2015517534 A5 JP2015517534 A5 JP 2015517534A5 JP 2015512968 A JP2015512968 A JP 2015512968A JP 2015512968 A JP2015512968 A JP 2015512968A JP 2015517534 A5 JP2015517534 A5 JP 2015517534A5
- Authority
- JP
- Japan
- Prior art keywords
- metformin
- metazolamide
- composition
- amount
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 claims description 29
- 229960004083 methazolamide Drugs 0.000 claims description 29
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 25
- 229960003105 metformin Drugs 0.000 claims description 23
- 229940125708 antidiabetic agent Drugs 0.000 claims description 10
- 239000003472 antidiabetic agent Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 7
- 210000004185 liver Anatomy 0.000 claims description 7
- 208000019423 liver disease Diseases 0.000 claims description 7
- 230000005976 liver dysfunction Effects 0.000 claims description 7
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 229960004329 metformin hydrochloride Drugs 0.000 claims 2
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 description 12
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261651335P | 2012-05-24 | 2012-05-24 | |
| US61/651,335 | 2012-05-24 | ||
| US201261666574P | 2012-06-29 | 2012-06-29 | |
| US61/666,574 | 2012-06-29 | ||
| PCT/AU2013/000265 WO2013173859A1 (en) | 2012-05-24 | 2013-03-15 | A method of improving liver function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246443A Division JP6412241B2 (ja) | 2012-05-24 | 2017-12-22 | 肝機能改善法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517534A JP2015517534A (ja) | 2015-06-22 |
| JP2015517534A5 true JP2015517534A5 (enExample) | 2016-05-12 |
| JP6360826B2 JP6360826B2 (ja) | 2018-07-18 |
Family
ID=49622927
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512968A Expired - Fee Related JP6360826B2 (ja) | 2012-05-24 | 2013-03-15 | 肝機能改善法 |
| JP2017246443A Expired - Fee Related JP6412241B2 (ja) | 2012-05-24 | 2017-12-22 | 肝機能改善法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017246443A Expired - Fee Related JP6412241B2 (ja) | 2012-05-24 | 2017-12-22 | 肝機能改善法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150150855A1 (enExample) |
| EP (1) | EP2854807A4 (enExample) |
| JP (2) | JP6360826B2 (enExample) |
| KR (1) | KR20150023405A (enExample) |
| CN (2) | CN104487073A (enExample) |
| BR (1) | BR112014029308A2 (enExample) |
| CA (1) | CA2874513A1 (enExample) |
| CO (1) | CO7160082A2 (enExample) |
| HK (1) | HK1209051A1 (enExample) |
| MX (1) | MX362111B (enExample) |
| NZ (2) | NZ702645A (enExample) |
| RU (1) | RU2653478C2 (enExample) |
| SG (2) | SG10201705388XA (enExample) |
| WO (1) | WO2013173859A1 (enExample) |
| ZA (1) | ZA201408704B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2106260B8 (en) | 2007-01-25 | 2018-04-04 | Naia Metabolic, Inc. | Insulin sensitisers and methods of treatment |
| MX2014014316A (es) * | 2012-05-24 | 2015-07-06 | Verva Pharmaceuticals Ltd | Método de reducción de peso. |
| US10039752B2 (en) * | 2016-07-21 | 2018-08-07 | Cipla Limited | Methazolamide for the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2783241A (en) * | 1957-02-26 | S-acylimino-x-substituted-az-i | ||
| DE10035227A1 (de) * | 2000-07-20 | 2002-01-31 | Solvay Pharm Gmbh | Verfahren zum Auffinden von Verbindungen, welche zur Behandlung und/oder Prophylaxe von Fettleibigkeit geeignet sind |
| TW200526678A (en) | 2003-08-01 | 2005-08-16 | Janssen Pharmaceutica Nv | Substituted indole-O-glucosides |
| EP2106260B8 (en) * | 2007-01-25 | 2018-04-04 | Naia Metabolic, Inc. | Insulin sensitisers and methods of treatment |
| MX2014014316A (es) * | 2012-05-24 | 2015-07-06 | Verva Pharmaceuticals Ltd | Método de reducción de peso. |
-
2013
- 2013-03-15 SG SG10201705388XA patent/SG10201705388XA/en unknown
- 2013-03-15 EP EP13794766.9A patent/EP2854807A4/en not_active Withdrawn
- 2013-03-15 CA CA2874513A patent/CA2874513A1/en not_active Abandoned
- 2013-03-15 CN CN201380033568.7A patent/CN104487073A/zh active Pending
- 2013-03-15 KR KR20147035500A patent/KR20150023405A/ko not_active Withdrawn
- 2013-03-15 WO PCT/AU2013/000265 patent/WO2013173859A1/en not_active Ceased
- 2013-03-15 BR BR112014029308A patent/BR112014029308A2/pt not_active Application Discontinuation
- 2013-03-15 SG SG11201407787VA patent/SG11201407787VA/en unknown
- 2013-03-15 RU RU2014152196A patent/RU2653478C2/ru not_active IP Right Cessation
- 2013-03-15 CN CN201811294792.2A patent/CN109498623A/zh active Pending
- 2013-03-15 MX MX2014014317A patent/MX362111B/es active IP Right Grant
- 2013-03-15 NZ NZ702645A patent/NZ702645A/en not_active IP Right Cessation
- 2013-03-15 HK HK15109811.1A patent/HK1209051A1/xx unknown
- 2013-03-15 US US14/403,507 patent/US20150150855A1/en not_active Abandoned
- 2013-03-15 NZ NZ723206A patent/NZ723206A/en not_active IP Right Cessation
- 2013-03-15 JP JP2015512968A patent/JP6360826B2/ja not_active Expired - Fee Related
-
2014
- 2014-11-26 ZA ZA2014/08704A patent/ZA201408704B/en unknown
- 2014-12-19 CO CO14279764A patent/CO7160082A2/es unknown
-
2017
- 2017-12-22 JP JP2017246443A patent/JP6412241B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-12 US US15/952,058 patent/US20180333399A1/en not_active Abandoned
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