JP2015515985A - 多発性硬化症を治療するための高投与量ラキニモドの使用 - Google Patents

多発性硬化症を治療するための高投与量ラキニモドの使用 Download PDF

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Publication number
JP2015515985A
JP2015515985A JP2015510436A JP2015510436A JP2015515985A JP 2015515985 A JP2015515985 A JP 2015515985A JP 2015510436 A JP2015510436 A JP 2015510436A JP 2015510436 A JP2015510436 A JP 2015510436A JP 2015515985 A JP2015515985 A JP 2015515985A
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Prior art keywords
laquinimod
patient
administration
human patient
score
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JP2015510436A
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English (en)
Japanese (ja)
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JP2015515985A5 (OSRAM
Inventor
バール−ゾハール,ダン
Original Assignee
テバ ファーマシューティカル インダストリーズ リミティド
テバ ファーマシューティカル インダストリーズ リミティド
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Publication of JP2015515985A publication Critical patent/JP2015515985A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2015510436A 2012-05-02 2013-05-01 多発性硬化症を治療するための高投与量ラキニモドの使用 Withdrawn JP2015515985A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261641389P 2012-05-02 2012-05-02
US61/641,389 2012-05-02
PCT/US2013/039090 WO2013166166A1 (en) 2012-05-02 2013-05-01 Use of high dose laquinimod for treating multiple sclerosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017141409A Division JP2017222691A (ja) 2012-05-02 2017-07-21 多発性硬化症を治療するための高投与量ラキニモドの使用

Publications (2)

Publication Number Publication Date
JP2015515985A true JP2015515985A (ja) 2015-06-04
JP2015515985A5 JP2015515985A5 (OSRAM) 2016-06-23

Family

ID=49514859

Family Applications (2)

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JP2015510436A Withdrawn JP2015515985A (ja) 2012-05-02 2013-05-01 多発性硬化症を治療するための高投与量ラキニモドの使用
JP2017141409A Withdrawn JP2017222691A (ja) 2012-05-02 2017-07-21 多発性硬化症を治療するための高投与量ラキニモドの使用

Family Applications After (1)

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JP2017141409A Withdrawn JP2017222691A (ja) 2012-05-02 2017-07-21 多発性硬化症を治療するための高投与量ラキニモドの使用

Country Status (21)

Country Link
US (3) US20130303569A1 (OSRAM)
EP (1) EP2844255A4 (OSRAM)
JP (2) JP2015515985A (OSRAM)
KR (1) KR20150013658A (OSRAM)
CN (2) CN104284663A (OSRAM)
AR (1) AR090885A1 (OSRAM)
AU (1) AU2013256352A1 (OSRAM)
BR (1) BR112014027010A2 (OSRAM)
CA (1) CA2870684A1 (OSRAM)
CL (1) CL2014002935A1 (OSRAM)
EA (1) EA201492010A1 (OSRAM)
HK (1) HK1206246A1 (OSRAM)
IL (1) IL235337A0 (OSRAM)
MX (1) MX2014013039A (OSRAM)
PE (1) PE20150161A1 (OSRAM)
PH (1) PH12014502447A1 (OSRAM)
SG (1) SG11201406594UA (OSRAM)
TW (2) TW201804997A (OSRAM)
UY (1) UY34775A (OSRAM)
WO (1) WO2013166166A1 (OSRAM)
ZA (1) ZA201408820B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2766020A4 (en) 2011-10-12 2015-04-01 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD
JP2015505564A (ja) 2012-02-03 2015-02-23 テバ ファーマシューティカル インダストリーズ リミティド 第一選択の抗TNEα療法に失敗したクローン病患者を治療するためのラキニモドの使用
JP6215238B2 (ja) 2012-02-16 2017-10-18 テバ ファーマシューティカル インダストリーズ リミティド N−エチル−n−フェニル−1,2−ジヒドロ−4,5−ジ−ヒドロキシ−1−メチル−2−オキソ−3−キノリンカルボキサミド、その製剤、および使用
US20130259856A1 (en) * 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
US20140107154A1 (en) * 2012-10-12 2014-04-17 Teva Pharmaceutical Industries, Ltd. Laquinimod for reducing thalamic damage in multiple sclerosis
HK1215210A1 (zh) 2012-11-07 2016-08-19 Teva Pharmaceutical Industries Ltd. 拉喹莫德胺盐
MX2015010296A (es) * 2013-02-15 2016-05-05 Teva Pharma Tratamiento de formas progresivas de esclerosis multiple con laquinimod.
US9233927B2 (en) 2013-03-14 2016-01-12 Teva Pharmaceutical Industries, Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
AR098924A1 (es) * 2013-12-23 2016-06-22 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y teriflunomida
AU2015253330A1 (en) 2014-04-29 2016-12-01 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status
WO2017027512A1 (en) * 2015-08-13 2017-02-16 Teva Pharmaceutical Industries Ltd. Use of laquinimod to treat traumatic brain injury
US20190108912A1 (en) * 2017-10-05 2019-04-11 Iquity, Inc. Methods for predicting or detecting disease
CN112437665A (zh) * 2018-07-20 2021-03-02 默克专利有限公司 用于治疗及预防多发性硬化症的方法中的经取代氨基-嘧啶化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011086470A1 (en) * 2010-01-13 2011-07-21 Ramot At Tel-Aviv University Ltd Treatment of multiple sclerosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
WO2006029411A2 (en) * 2004-09-09 2006-03-16 Yeda Research And Development Co. Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
WO2007146331A1 (en) * 2006-06-12 2007-12-21 Teva Pharmaceutical Industries, Ltd. Tannate salt form of polypeptide mixtures, their preparation and use
DK2442651T3 (en) * 2009-06-19 2015-09-21 Teva Pharma Treatment of multiple sclerosis with laquinimod
EP2766020A4 (en) * 2011-10-12 2015-04-01 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD
MX2015010296A (es) * 2013-02-15 2016-05-05 Teva Pharma Tratamiento de formas progresivas de esclerosis multiple con laquinimod.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011086470A1 (en) * 2010-01-13 2011-07-21 Ramot At Tel-Aviv University Ltd Treatment of multiple sclerosis

Also Published As

Publication number Publication date
CN105832733A (zh) 2016-08-10
CA2870684A1 (en) 2013-11-07
JP2017222691A (ja) 2017-12-21
HK1206246A1 (en) 2016-01-08
PE20150161A1 (es) 2015-02-22
SG11201406594UA (en) 2014-11-27
US20150265592A1 (en) 2015-09-24
EP2844255A4 (en) 2015-10-14
US20160000775A1 (en) 2016-01-07
AR090885A1 (es) 2014-12-10
CL2014002935A1 (es) 2015-03-06
MX2014013039A (es) 2015-02-04
KR20150013658A (ko) 2015-02-05
ZA201408820B (en) 2016-06-29
IL235337A0 (en) 2014-12-31
CN104284663A (zh) 2015-01-14
US20130303569A1 (en) 2013-11-14
PH12014502447A1 (en) 2015-01-12
AU2013256352A1 (en) 2014-11-27
UY34775A (es) 2013-11-29
TW201347762A (zh) 2013-12-01
BR112014027010A2 (pt) 2017-06-27
WO2013166166A1 (en) 2013-11-07
EA201492010A1 (ru) 2015-06-30
TW201804997A (zh) 2018-02-16
EP2844255A1 (en) 2015-03-11

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