JP2015514689A5 - - Google Patents
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- JP2015514689A5 JP2015514689A5 JP2014560435A JP2014560435A JP2015514689A5 JP 2015514689 A5 JP2015514689 A5 JP 2015514689A5 JP 2014560435 A JP2014560435 A JP 2014560435A JP 2014560435 A JP2014560435 A JP 2014560435A JP 2015514689 A5 JP2015514689 A5 JP 2015514689A5
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- 239000002245 particle Substances 0.000 claims description 22
- 230000005298 paramagnetic effect Effects 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims 6
- 150000002500 ions Chemical class 0.000 claims 6
- 229910052720 vanadium Inorganic materials 0.000 claims 6
- 239000002105 nanoparticle Substances 0.000 claims 5
- 229910052698 phosphorus Inorganic materials 0.000 claims 5
- 150000001450 anions Chemical class 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 229910021644 lanthanide ion Inorganic materials 0.000 claims 4
- 238000002595 magnetic resonance imaging Methods 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 238000012634 optical imaging Methods 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 238000002600 positron emission tomography Methods 0.000 claims 4
- 238000012285 ultrasound imaging Methods 0.000 claims 4
- 229910052688 Gadolinium Inorganic materials 0.000 claims 3
- 238000002059 diagnostic imaging Methods 0.000 claims 3
- 238000004020 luminiscence type Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000001590 oxidative effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229910052684 Cerium Inorganic materials 0.000 claims 2
- 229910052691 Erbium Inorganic materials 0.000 claims 2
- 229910052693 Europium Inorganic materials 0.000 claims 2
- 229910052689 Holmium Inorganic materials 0.000 claims 2
- 229910052779 Neodymium Inorganic materials 0.000 claims 2
- 229910052777 Praseodymium Inorganic materials 0.000 claims 2
- 229910052771 Terbium Inorganic materials 0.000 claims 2
- 229910052775 Thulium Inorganic materials 0.000 claims 2
- 229910052769 Ytterbium Inorganic materials 0.000 claims 2
- 230000000975 bioactive effect Effects 0.000 claims 2
- 229910052797 bismuth Inorganic materials 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000005284 excitation Effects 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims 2
- 150000002602 lanthanoids Chemical group 0.000 claims 2
- 229910052746 lanthanum Inorganic materials 0.000 claims 2
- 229910052727 yttrium Inorganic materials 0.000 claims 2
- 229910052692 Dysprosium Inorganic materials 0.000 claims 1
- 229910052772 Samarium Inorganic materials 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 229910052785 arsenic Inorganic materials 0.000 claims 1
- 229910052750 molybdenum Inorganic materials 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000005408 paramagnetism Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000003325 tomography Methods 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002535 acidifier Substances 0.000 description 1
- 230000003113 alkalizing effect Effects 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000005291 magnetic effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1252167A FR2987831A1 (fr) | 2012-03-09 | 2012-03-09 | Particules d'oxyde a base de terres rares et utilisation notamment en imagerie |
| FR1252167 | 2012-03-09 | ||
| PCT/FR2013/050500 WO2013132197A1 (fr) | 2012-03-09 | 2013-03-08 | Particules d'oxyde à base de terres rares et utilisation notamment en imagerie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514689A JP2015514689A (ja) | 2015-05-21 |
| JP2015514689A5 true JP2015514689A5 (cg-RX-API-DMAC7.html) | 2016-04-21 |
| JP6318096B2 JP6318096B2 (ja) | 2018-04-25 |
Family
ID=48083471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560435A Active JP6318096B2 (ja) | 2012-03-09 | 2013-03-08 | 希土類酸化物粒子及び特に画像化におけるその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20150010476A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2823016A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6318096B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104302731B (cg-RX-API-DMAC7.html) |
| FR (1) | FR2987831A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013132197A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2531336B (en) * | 2014-10-17 | 2019-04-10 | Thermo Fisher Scient Bremen Gmbh | Method and apparatus for the analysis of molecules using mass spectrometry and optical spectroscopy |
| FR3069927B1 (fr) * | 2017-08-04 | 2021-06-04 | Ecole Polytech | Procede de detection ultra-sensible a l'aide de particules photoluminescentes |
| US11357085B2 (en) * | 2017-09-25 | 2022-06-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Adaptive solid-state luminescent phosphors |
| US11279656B2 (en) | 2017-10-27 | 2022-03-22 | Applied Materials, Inc. | Nanopowders, nanoceramic materials and methods of making and use thereof |
| CN114381255B (zh) * | 2021-10-25 | 2022-10-11 | 中国科学院福建物质结构研究所 | 一种放射性医用同位素标记的稀土掺杂纳米材料和pet显像诊疗剂及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60312648T2 (de) * | 2003-04-30 | 2007-11-22 | Centrum Für Angewandte Nanotechnologie (Can) Gmbh | Lumineszente Kern-Mantel-Nanoteilchen |
| DE60310032T2 (de) * | 2003-04-30 | 2007-07-05 | Centrum Für Angewandte Nanotechnologie (Can) Gmbh | Kern-Mantel Nanoteilchen für (F) RET-Testverfahren |
| CN101368098B (zh) * | 2008-07-29 | 2011-07-13 | 浙江理工大学 | YVO4:Eu3+/YPO4核壳结构纳米荧光粉及其制备方法 |
| DE102009012698A1 (de) * | 2009-03-11 | 2010-09-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Partikel mit einer lumineszierenden anorganischen Schale, Verfahren zur Beschichtung von Partikeln sowie deren Verwendung |
-
2012
- 2012-03-09 FR FR1252167A patent/FR2987831A1/fr not_active Withdrawn
-
2013
- 2013-03-08 EP EP13715291.4A patent/EP2823016A1/fr not_active Withdrawn
- 2013-03-08 WO PCT/FR2013/050500 patent/WO2013132197A1/fr not_active Ceased
- 2013-03-08 JP JP2014560435A patent/JP6318096B2/ja active Active
- 2013-03-08 CN CN201380023918.1A patent/CN104302731B/zh not_active Expired - Fee Related
- 2013-03-08 US US14/383,859 patent/US20150010476A1/en not_active Abandoned
-
2018
- 2018-01-22 US US15/877,042 patent/US20180161461A1/en not_active Abandoned
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