JP2015511226A - 低酸素活性化プロドラッグ療法のための予測バイオマーカー - Google Patents

低酸素活性化プロドラッグ療法のための予測バイオマーカー Download PDF

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JP2015511226A
JP2015511226A JP2014554975A JP2014554975A JP2015511226A JP 2015511226 A JP2015511226 A JP 2015511226A JP 2014554975 A JP2014554975 A JP 2014554975A JP 2014554975 A JP2014554975 A JP 2014554975A JP 2015511226 A JP2015511226 A JP 2015511226A
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cancer
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JP2015511226A5 (enExample
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ハート，チャールズ
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スレッショルド ファーマシューティカルズ，インコーポレイテッド
スレッショルド ファーマシューティカルズ，インコーポレイテッド
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014554975A 2012-01-31 2013-01-30 低酸素活性化プロドラッグ療法のための予測バイオマーカー Pending JP2015511226A (ja)

Applications Claiming Priority (3)

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US201261593249P 2012-01-31 2012-01-31
US61/593,249 2012-01-31
PCT/US2013/023921 WO2013116385A1 (en) 2012-01-31 2013-01-30 Predictive biomarker for hypoxia-activated prodrug therapy

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Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
ZA200800314B (en) 2005-06-29 2009-09-30 Threshold Pharmaceuticals Inc Phosphoramidate alkylator prodrugs
EP2793882A4 (en) 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
WO2015025283A2 (en) * 2013-08-20 2015-02-26 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Dual action carbonic anhydrase inhibitors
US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
WO2016081547A1 (en) * 2014-11-19 2016-05-26 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
US20210369746A1 (en) * 2016-08-01 2021-12-02 Molecular Templates, Inc. Administration of hypoxia activated prodrugs in combination with immune modulatory agents for treating cancer
JP7762796B2 (ja) 2021-08-27 2025-10-30 アセンタウィッツ ファーマシューティカルズ リミテッド Ｐａｒｐ阻害剤に耐性のある患者のｔｈ－３０２による治療
WO2023025291A1 (zh) 2021-08-27 2023-03-02 深圳艾欣达伟医药科技有限公司 冻干制剂溶液及冻干制剂、方法和用途
US20250186468A1 (en) 2022-03-15 2025-06-12 Ascentawits Pharmaceuticals, Ltd. Method for treating patient with brca-mutated cancer
EP4509127A4 (en) 2022-04-15 2026-07-15 Ascentawits Pharmaceuticals Ltd CANCER TREATMENT METHOD USING TH-302 ALONE OR IN COMBINATION WITH A PARP INHIBITOR
EP4529926A4 (en) 2022-05-23 2026-07-01 Ascentawits Pharmaceuticals Ltd CANCER TREATMENT METHOD BY COMBINATION OF AN ALKYLATING AGENT PRODRUGATION AND A CELL CYCLE INHIBITOR
CN119894521A (zh) 2022-09-22 2025-04-25 深圳艾欣达伟医药科技有限公司 乏氧激活的化合物在制备治疗癌症患者的药物中的用途
EP4674418A1 (en) 2023-02-27 2026-01-07 Ascentawits Pharmaceuticals, Ltd. Solution, freeze-dried formulation, freeze-dried formulation unit package, injection, and injection preparation method
EP4755396A1 (en) 2023-07-28 2026-06-10 Ascentawits Pharmaceuticals, Ltd. Treatment of p53 gene mutation or defect negative cancer and tumor patients
CN121985960A (zh) 2023-10-18 2026-05-05 深圳艾欣达伟医药科技有限公司 治疗p53基因突变阴性、kras基因突变阳性、brca突变阳性患者

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012009288A2 (en) * 2010-07-12 2012-01-19 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer

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AU2003217606C1 (en) * 2002-02-21 2008-07-17 Institute Of Virology Soluble Form of Carbonic Anhydrase IX (s-CA IX), Assays to Detect s-CA IX, CA IXs Coexpression with HER-2/neu/c-erbB-2 and CA IX-Specific Monoclonal Antibodies to Non-Immunodominant Epitopes
AU2005241093B2 (en) * 2004-05-04 2008-06-05 Institute Of Virology Of Slovak Academy Of Sciences MN/CA IX/ CA9 and renal cancer prognosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012009288A2 (en) * 2010-07-12 2012-01-19 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, vol. 83, no. 12, JPN6016040005, 2000, pages 1589 - 1593, ISSN: 0003423196 *
ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, vol. 61, no. 13, JPN6016040006, 2001, pages 5262 - 5267, ISSN: 0003423197 *
ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, vol. [online], JPN6016039998, 19 December 2011 (2011-12-19), pages 10 - 1158, ISSN: 0003423192 *
ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, vol. 14, no. 21, JPN6016040003, 2008, pages 7110 - 7115, ISSN: 0003423195 *
ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＲＡＤＩＡＴＩＯＮ ＯＮＣＯＬＯＧＹ，ＢＩＯＬＯＧ, vol. 73, no. 4, JPN6016039999, 2009, pages 1177 - 1186, ISSN: 0003423193 *
ＪＯＵＲＮＡＬ ＯＦ ＵＲＯＬＯＧＹ, vol. 180, no. 2, JPN6016040001, 2008, pages 510 - 514, ISSN: 0003423194 *

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EP2810076A1 (en) 2014-12-10
WO2013116385A1 (en) 2013-08-08
JP2018052956A (ja) 2018-04-05
US20150005264A1 (en) 2015-01-01

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