JP2015510758A5 - - Google Patents
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- Publication number
- JP2015510758A5 JP2015510758A5 JP2014560516A JP2014560516A JP2015510758A5 JP 2015510758 A5 JP2015510758 A5 JP 2015510758A5 JP 2014560516 A JP2014560516 A JP 2014560516A JP 2014560516 A JP2014560516 A JP 2014560516A JP 2015510758 A5 JP2015510758 A5 JP 2015510758A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- apoptosis
- cell population
- inducing ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 24
- 238000000034 method Methods 0.000 claims 12
- 210000000130 stem cell Anatomy 0.000 claims 9
- 230000006907 apoptotic process Effects 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 6
- 230000005756 apoptotic signaling Effects 0.000 claims 5
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 3
- 102000015212 Fas Ligand Protein Human genes 0.000 claims 3
- 108010039471 Fas Ligand Protein Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000006786 activation induced cell death Effects 0.000 claims 2
- 239000000560 biocompatible material Substances 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- -1 polypropylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607033P | 2012-03-06 | 2012-03-06 | |
| PCT/IL2013/000026 WO2013132477A1 (en) | 2012-03-06 | 2013-03-05 | Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510758A JP2015510758A (ja) | 2015-04-13 |
| JP2015510758A5 true JP2015510758A5 (cg-RX-API-DMAC7.html) | 2016-04-21 |
| JP6429191B2 JP6429191B2 (ja) | 2018-11-28 |
Family
ID=49116028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560516A Expired - Fee Related JP6429191B2 (ja) | 2012-03-06 | 2013-03-05 | アポトーシスシグナル伝達抵抗性細胞を選択する装置および方法ならびにその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9783778B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3486315A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6429191B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101912982B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104245924B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013229008B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2866358C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2823040T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL234459B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2630301C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013132477A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016538253A (ja) * | 2013-10-09 | 2016-12-08 | セレクト バイオセラピューティクス リミテッド | デスリガンドへの移植前曝露による造血前駆細胞の活性化 |
| EP3303563B1 (en) | 2015-06-05 | 2020-05-27 | Cellect Biotherapeutics Ltd. | Selective surfaces for, and methods of, selecting a population of stem and progenitor cells, and uses thereof |
| WO2020039446A1 (en) * | 2018-08-22 | 2020-02-27 | Cellect Biotherapeutics Ltd. | Modulation of apoptosis susceptible cells |
| US20220002363A1 (en) * | 2020-07-03 | 2022-01-06 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods for treating pulmonary disease |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| JPS61235752A (ja) | 1985-04-11 | 1986-10-21 | Asahi Optical Co Ltd | 細胞分離材、分離器および分離方法 |
| IT8523298V0 (it) * | 1985-10-02 | 1985-10-02 | Pierrel Hospital Spa | Catetere venoso centrale. |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
| US4885234A (en) | 1988-09-29 | 1989-12-05 | Eastman Kodak Company | Photographic materials containing stable cyan coupler formulations |
| US5998024A (en) | 1995-02-02 | 1999-12-07 | Rainer H. Frey | Biocompatible material and method of manufacture and use thereof |
| HUP0003349A3 (en) | 1997-05-14 | 2001-12-28 | Aventis Pharmaceuticals Inc Co | Peptide parathyroid hormone analogs, pharmaceutical compositions comprising thereof and their use |
| US6040182A (en) | 1997-11-12 | 2000-03-21 | Becton Dickinson And Company | Method and materials for efficiency protein immobilization on tissue culture treated assay plates |
| GB9724270D0 (en) | 1997-11-17 | 1998-01-14 | Babraham The Inst | Methods and means for mutagenesis of dna |
| WO1999054266A1 (en) | 1998-04-22 | 1999-10-28 | St. Jude Medical Ab | Biocompatible material for implants |
| US20010049115A1 (en) * | 2000-01-17 | 2001-12-06 | Collins John Kevin | Vitro model for gastrointestinal inflammation |
| US20090130718A1 (en) | 1999-02-04 | 2009-05-21 | Diversa Corporation | Gene site saturation mutagenesis |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| WO2003002761A1 (en) | 2001-06-29 | 2003-01-09 | Novozymes A/S | Method of multimerization and site-directed mutagenesis |
| AU2002365177A1 (en) | 2001-07-02 | 2003-07-24 | The Board Of Trustees Of The Leland Stanford Junior University | Microarrays for cell phenotyping and manipulation |
| EP1281767A3 (en) | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Light emitting microorganisms and cells for diagnosis and therapy of tumors |
| DE10144252A1 (de) * | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| ATE438857T1 (de) * | 2002-06-13 | 2009-08-15 | Merck Patent Gmbh | Verfahren für die identifizierung von allo- antigenen und ihren verwendung für krebs therapie und transplantation |
| EP1551449B1 (en) * | 2002-07-12 | 2010-10-06 | The Johns Hopkins University | Reagents and methods for engaging unique clonotypic lymphocyte receptors |
| US20060009623A1 (en) | 2004-07-06 | 2006-01-12 | National University Of Singapore | C-terminal attachment of ligands to proteins for immobilization onto a support |
| ATE482268T1 (de) * | 2004-10-01 | 2010-10-15 | Topotarget Switzerland Sa | Ex-vivo-spülverfahren für autologe transplantationen mittels löslicher fasl-moleküle |
| EP1812555B1 (en) * | 2004-10-25 | 2015-04-22 | Cellerant Therapeutics, Inc. | Methods of expanding myeloid cell populations and uses thereof |
| EP1800613B1 (en) * | 2005-12-23 | 2008-07-16 | BIEDERMANN MOTECH GmbH | Flexible stabilization device for dynamic stabilization of bones or vertebrae |
| CN101517070A (zh) * | 2006-05-31 | 2009-08-26 | Styx有限责任公司 | 选择干细胞的方法及其用途 |
| CA2653881C (en) | 2006-05-31 | 2016-08-23 | Styx Llc | Methods of selecting stem cells and uses thereof |
| ES2558543T3 (es) * | 2007-03-16 | 2016-02-05 | Cellestis Limited | Un ensayo de respuesta inmunitaria mediada por células y kits para el mismo |
| KR100920729B1 (ko) | 2007-10-01 | 2009-10-07 | 한국생명공학연구원 | 펩타이드 혼성체를 사용한 배향성이 조절된 항체단분자막의 제조방법 |
| WO2009154840A2 (en) | 2008-03-27 | 2009-12-23 | Neostem, Inc. | Compositions and methods using stem cells in cutaneous wound healing |
| JP2011522515A (ja) * | 2008-04-10 | 2011-08-04 | マサチューセッツ インスティテュート オブ テクノロジー | 癌幹細胞を標的とする薬剤を同定する方法およびその使用 |
| CN102123746B (zh) * | 2008-06-13 | 2016-01-06 | 史密夫和内修有限公司 | 用于组织修复的固定装置 |
| CA2741426C (en) * | 2008-10-31 | 2020-04-21 | Meredith Hans | Method and device for activating stem cells |
| GB0823553D0 (en) | 2008-12-24 | 2009-01-28 | Immunosolv Ltd | Cell separation technique |
| JP2010227313A (ja) | 2009-03-27 | 2010-10-14 | Seiko Epson Corp | がん細胞除去システムおよびがん細胞除去装置 |
| JP5327457B2 (ja) | 2009-03-27 | 2013-10-30 | セイコーエプソン株式会社 | がん細胞分離装置およびその製造方法 |
| CA2804914A1 (en) * | 2010-07-22 | 2012-01-26 | Nadir Askenasy | Regulatory immune cells with enhanced targeted cell death effect |
-
2013
- 2013-03-05 CN CN201380021092.5A patent/CN104245924B/zh not_active Expired - Fee Related
- 2013-03-05 CA CA2866358A patent/CA2866358C/en active Active
- 2013-03-05 WO PCT/IL2013/000026 patent/WO2013132477A1/en not_active Ceased
- 2013-03-05 RU RU2014138001A patent/RU2630301C2/ru active
- 2013-03-05 US US14/383,288 patent/US9783778B2/en not_active Expired - Fee Related
- 2013-03-05 EP EP18181773.5A patent/EP3486315A1/en not_active Withdrawn
- 2013-03-05 CN CN201810972287.2A patent/CN109116033A/zh active Pending
- 2013-03-05 KR KR1020147027817A patent/KR101912982B1/ko not_active Expired - Fee Related
- 2013-03-05 EP EP13758162.5A patent/EP2823040B1/en active Active
- 2013-03-05 AU AU2013229008A patent/AU2013229008B2/en not_active Ceased
- 2013-03-05 JP JP2014560516A patent/JP6429191B2/ja not_active Expired - Fee Related
- 2013-03-05 DK DK13758162.5T patent/DK2823040T3/en active
-
2014
- 2014-09-04 IL IL234459A patent/IL234459B/en active IP Right Grant
-
2017
- 2017-09-07 US US15/697,928 patent/US20180208888A1/en not_active Abandoned
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