JP2015506698A5 - - Google Patents
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- Publication number
- JP2015506698A5 JP2015506698A5 JP2014555705A JP2014555705A JP2015506698A5 JP 2015506698 A5 JP2015506698 A5 JP 2015506698A5 JP 2014555705 A JP2014555705 A JP 2014555705A JP 2014555705 A JP2014555705 A JP 2014555705A JP 2015506698 A5 JP2015506698 A5 JP 2015506698A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cell
- cells
- inf
- melanoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010074328 Interferon-gamma Proteins 0.000 claims description 9
- 102000008070 Interferon-gamma Human genes 0.000 claims description 5
- 229960003130 interferon gamma Drugs 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims 53
- 201000011510 cancer Diseases 0.000 claims 53
- 210000004027 cell Anatomy 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 201000001441 melanoma Diseases 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- 210000004443 dendritic cell Anatomy 0.000 claims 11
- 238000000338 in vitro Methods 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 9
- 230000004987 nonapoptotic effect Effects 0.000 claims 7
- 230000002886 autophagic effect Effects 0.000 claims 6
- 102100037850 Interferon gamma Human genes 0.000 claims 4
- 230000005867 T cell response Effects 0.000 claims 4
- 210000003981 ectoderm Anatomy 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 210000003716 mesoderm Anatomy 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 210000001900 endoderm Anatomy 0.000 claims 3
- 230000003278 mimic effect Effects 0.000 claims 3
- 210000000933 neural crest Anatomy 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 108700012813 7-aminoactinomycin D Proteins 0.000 claims 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 2
- 230000030741 antigen processing and presentation Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 229940030156 cell vaccine Drugs 0.000 claims 2
- 230000036755 cellular response Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 229940115256 melanoma vaccine Drugs 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 claims 1
- 102000000412 Annexin Human genes 0.000 claims 1
- 108050008874 Annexin Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 239000004971 Cross linker Substances 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 1
- 108010010995 MART-1 Antigen Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- -1 Mel-2 Proteins 0.000 claims 1
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 claims 1
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 230000004900 autophagic degradation Effects 0.000 claims 1
- 230000032823 cell division Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229940029030 dendritic cell vaccine Drugs 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
- 239000000556 agonist Substances 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594304P | 2012-02-02 | 2012-02-02 | |
| US61/594,304 | 2012-02-02 | ||
| PCT/US2013/024123 WO2013116505A1 (en) | 2012-02-02 | 2013-01-31 | Pluripotent germ layer origin antigen presenting cancer vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015506698A JP2015506698A (ja) | 2015-03-05 |
| JP2015506698A5 true JP2015506698A5 (enExample) | 2017-08-24 |
Family
ID=48905824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555705A Pending JP2015506698A (ja) | 2012-02-02 | 2013-01-31 | 多能性胚葉起源抗原を提示する癌ワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150064217A1 (enExample) |
| EP (1) | EP2809775B1 (enExample) |
| JP (1) | JP2015506698A (enExample) |
| KR (1) | KR20140143361A (enExample) |
| CN (1) | CN104540937A (enExample) |
| AU (1) | AU2013215116A1 (enExample) |
| CA (1) | CA2863653A1 (enExample) |
| GB (1) | GB2512558A (enExample) |
| HK (2) | HK1209455A1 (enExample) |
| IL (1) | IL233928A0 (enExample) |
| NZ (1) | NZ628292A (enExample) |
| SG (1) | SG11201404543UA (enExample) |
| WO (2) | WO2013116541A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599528B (zh) * | 2013-12-04 | 2015-08-05 | 深圳市合一康生物科技股份有限公司 | 人树突状细胞疫苗的制备方法 |
| JP6423889B2 (ja) | 2014-10-07 | 2018-11-14 | サイトリミック株式会社 | Ｈｓｐ７０由来のペプチド、これを用いた癌の治療又は予防のための医薬組成物、免疫誘導剤、及び抗原提示細胞の製造方法 |
| EP3527216B1 (en) | 2016-10-11 | 2024-02-14 | NEC Corporation | A medicine comprising a toll-like receptor agonist, lag-3 protein, a hsp70-derived peptide and a gpc3-derived peptide |
| CN110198717A (zh) * | 2017-01-11 | 2019-09-03 | 国立研究开发法人国立癌症研究中心 | 免疫治疗药 |
| EP3582793A4 (en) * | 2017-02-17 | 2020-12-16 | Aivita Biomedical, Inc. | METHODS TO IMPROVE TUMOR IMMUNOGENICITY AND COMPOSITIONS FOR AUTOLOGOUS ANTI-CANCER IMMUNOTHERAPEUTICS USING MODIFIED TUMOR CELLS AND MODIFIED DENDRITIC CELLS |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL140796A0 (en) * | 2001-01-08 | 2002-02-10 | Hadasit Med Res Service | An autologous anti-cancer vaccine |
| EP2322603B1 (en) * | 2001-09-06 | 2019-10-16 | NorthWest Biotherapeutics, Inc. | Compositions and methods for priming monocytic dendritic cells and T cells for Th1 response |
| WO2006047515A2 (en) * | 2004-10-25 | 2006-05-04 | Baylor Research Institute | Dendritic cells loaded with heat shocked melanoma cell bodies |
| JP5281399B2 (ja) * | 2005-07-29 | 2013-09-04 | プロビデンス ヘルス システム | 小胞（ｄｒｉｂｂｌｅ）中の不完全なリボソーム産物、および免疫応答を刺激するための使用方法 |
| WO2008039974A2 (en) * | 2006-09-28 | 2008-04-03 | Cedars-Sinai Medical Center | Cancer vaccines and vaccination methods |
| US20090041792A1 (en) * | 2007-07-19 | 2009-02-12 | Istituto Superiore Di Sanita | Dendritic cells, uses therefor, and vaccines and methods comprising the same |
-
2013
- 2013-01-31 CN CN201380017689.2A patent/CN104540937A/zh active Pending
- 2013-01-31 HK HK15110097.4A patent/HK1209455A1/xx unknown
- 2013-01-31 NZ NZ628292A patent/NZ628292A/en not_active IP Right Cessation
- 2013-01-31 GB GB1414403.4A patent/GB2512558A/en not_active Withdrawn
- 2013-01-31 CA CA2863653A patent/CA2863653A1/en not_active Abandoned
- 2013-01-31 EP EP13743673.9A patent/EP2809775B1/en not_active Not-in-force
- 2013-01-31 KR KR1020147024678A patent/KR20140143361A/ko not_active Ceased
- 2013-01-31 US US14/375,966 patent/US20150064217A1/en not_active Abandoned
- 2013-01-31 HK HK15103009.6A patent/HK1202432A1/xx unknown
- 2013-01-31 SG SG11201404543UA patent/SG11201404543UA/en unknown
- 2013-01-31 WO PCT/US2013/024181 patent/WO2013116541A1/en not_active Ceased
- 2013-01-31 WO PCT/US2013/024123 patent/WO2013116505A1/en not_active Ceased
- 2013-01-31 AU AU2013215116A patent/AU2013215116A1/en not_active Abandoned
- 2013-01-31 JP JP2014555705A patent/JP2015506698A/ja active Pending
-
2014
- 2014-08-03 IL IL233928A patent/IL233928A0/en unknown
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