JP2015503929A5 - - Google Patents
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- Publication number
- JP2015503929A5 JP2015503929A5 JP2014553341A JP2014553341A JP2015503929A5 JP 2015503929 A5 JP2015503929 A5 JP 2015503929A5 JP 2014553341 A JP2014553341 A JP 2014553341A JP 2014553341 A JP2014553341 A JP 2014553341A JP 2015503929 A5 JP2015503929 A5 JP 2015503929A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- trap
- tissue culture
- cell
- culture fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004062 sedimentation Methods 0.000 claims description 46
- 210000001519 tissues Anatomy 0.000 claims description 39
- 239000012531 culture fluid Substances 0.000 claims description 32
- 238000000926 separation method Methods 0.000 claims description 8
- 230000014759 maintenance of location Effects 0.000 claims description 7
- 239000003104 tissue culture media Substances 0.000 claims description 7
- 239000002699 waste material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 238000003306 harvesting Methods 0.000 claims description 2
- 210000004027 cells Anatomy 0.000 claims 79
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 102100009906 F7 Human genes 0.000 claims 1
- 102100006624 F9 Human genes 0.000 claims 1
- 108010076282 Factor IX Proteins 0.000 claims 1
- 108010023321 Factor VII Proteins 0.000 claims 1
- 108010054218 Factor VIII Proteins 0.000 claims 1
- 229960000301 Factor VIII Drugs 0.000 claims 1
- 102000001690 Factor VIII Human genes 0.000 claims 1
- 239000003114 blood coagulation factor Substances 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 229960004222 factor IX Drugs 0.000 claims 1
- 229940012413 factor VII Drugs 0.000 claims 1
- 210000004962 mammalian cells Anatomy 0.000 claims 1
- 230000003134 recirculating Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 1
- 238000011072 cell harvest Methods 0.000 description 1
- 230000001627 detrimental Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587940P | 2012-01-18 | 2012-01-18 | |
| US61/587,940 | 2012-01-18 | ||
| PCT/US2013/021533 WO2013109520A1 (fr) | 2012-01-18 | 2013-01-15 | Systèmes de bioréacteur de perfusion et procédés d'exploitation de ces systèmes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015503929A JP2015503929A (ja) | 2015-02-05 |
| JP2015503929A5 true JP2015503929A5 (fr) | 2017-03-02 |
| JP6227562B2 JP6227562B2 (ja) | 2017-11-08 |
Family
ID=47605793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014553341A Active JP6227562B2 (ja) | 2012-01-18 | 2013-01-15 | 灌流バイオリアクターシステムおよびその操作方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2804943A1 (fr) |
| JP (1) | JP6227562B2 (fr) |
| CN (1) | CN104160013B (fr) |
| CA (1) | CA2861270C (fr) |
| HK (1) | HK1199056A1 (fr) |
| WO (1) | WO2013109520A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201803601SA (en) * | 2013-09-16 | 2018-06-28 | Genzyme Corp | Methods and systems for processing a cell culture |
| WO2015102528A1 (fr) * | 2013-12-30 | 2015-07-09 | Ge Healthcare Bio-Sciences Corp. | Dispositif de culture cellulaire |
| CN107250341A (zh) * | 2014-09-17 | 2017-10-13 | 麻省理工学院 | 用于灌注生物反应器细胞保留的方法及微流体系统 |
| US9944894B2 (en) | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| WO2017162467A1 (fr) * | 2016-03-21 | 2017-09-28 | General Electric Company | Expansion et repiquage de cellules souches pluripotentes au moyen d'un bioréacteur à plateforme basculante |
| CN107541464B (zh) * | 2017-10-31 | 2021-04-30 | 山东亦度生物技术有限公司 | 增强型的细胞微载体灌流培养的截留方法 |
| EP3797149A1 (fr) * | 2018-05-22 | 2021-03-31 | Nantkwest, Inc. | Procédés et systèmes de formation de lit de cellules pendant un biotraitement |
| JP7087704B2 (ja) * | 2018-06-13 | 2022-06-21 | 株式会社Ihi | 細胞培養システム及び細胞培養方法 |
| US11028359B2 (en) | 2018-09-11 | 2021-06-08 | Global Life Sciences Solutions Usa Llc | Separation devices, associated methods, and systems |
| GB201904083D0 (en) * | 2019-03-25 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | A bioreactor system |
| EP3835403A1 (fr) | 2019-12-11 | 2021-06-16 | Sartorius Stedim Biotech GmbH | Stratégie d'échange automatique de support pour cellules de suspension |
| JP7406205B2 (ja) * | 2020-03-24 | 2023-12-27 | 横河電機株式会社 | メタン生成装置 |
| WO2024092004A1 (fr) * | 2022-10-26 | 2024-05-02 | National Resilience, Inc. | Systèmes de bioréacteur et leurs procédés de fonctionnement |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05153973A (ja) * | 1991-12-03 | 1993-06-22 | Hitachi Ltd | 細胞培養方法及び装置 |
| US6338964B1 (en) | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
| CN1112442C (zh) * | 2000-06-14 | 2003-06-25 | 华东理工大学 | 细胞灌注培养过程中的细胞截留分离方法及其装置 |
| EP1451290B1 (fr) * | 2001-08-31 | 2011-01-05 | Bayer Schering Pharma Aktiengesellschaft | Unite et procede de fermentation a haute densite cellulaire |
| WO2006039588A2 (fr) | 2004-09-30 | 2006-04-13 | Bayer Healthcare Llc | Dispositifs et procedes de fabrication continue integree de molecules biologiques |
| WO2007071072A1 (fr) * | 2005-12-22 | 2007-06-28 | Corporation De L'ecole Polytechnique De Montreal | Bioréacteur de perfusion à haut rendement |
| US8512566B2 (en) * | 2009-12-11 | 2013-08-20 | General Electric Company | Disposable fluid path systems and methods for processing complex biological materials |
-
2013
- 2013-01-15 WO PCT/US2013/021533 patent/WO2013109520A1/fr active Application Filing
- 2013-01-15 JP JP2014553341A patent/JP6227562B2/ja active Active
- 2013-01-15 CA CA2861270A patent/CA2861270C/fr active Active
- 2013-01-15 EP EP13701545.9A patent/EP2804943A1/fr active Pending
- 2013-01-15 CN CN201380006057.6A patent/CN104160013B/zh active Active
-
2014
- 2014-12-18 HK HK14112683.1A patent/HK1199056A1/xx not_active IP Right Cessation
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