JP2015502926A5 - - Google Patents
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- Publication number
- JP2015502926A5 JP2015502926A5 JP2014541555A JP2014541555A JP2015502926A5 JP 2015502926 A5 JP2015502926 A5 JP 2015502926A5 JP 2014541555 A JP2014541555 A JP 2014541555A JP 2014541555 A JP2014541555 A JP 2014541555A JP 2015502926 A5 JP2015502926 A5 JP 2015502926A5
- Authority
- JP
- Japan
- Prior art keywords
- tautomer
- stereoisomer
- proportions
- mixture
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011118830.8 | 2011-11-18 | ||
| DE102011118830A DE102011118830A1 (de) | 2011-11-18 | 2011-11-18 | Morpholinylbenzotriazine |
| PCT/EP2012/004542 WO2013072015A1 (de) | 2011-11-18 | 2012-10-30 | Morpholinylbenzotriazine zur anwendung in der krebstherapie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502926A JP2015502926A (ja) | 2015-01-29 |
| JP2015502926A5 true JP2015502926A5 (cg-RX-API-DMAC10.html) | 2015-12-24 |
| JP6096792B2 JP6096792B2 (ja) | 2017-03-15 |
Family
ID=47143824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541555A Expired - Fee Related JP6096792B2 (ja) | 2011-11-18 | 2012-10-30 | 癌治療における使用のためのモルホリニルベンゾトリアジン |
Country Status (24)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9296701B2 (en) | 2012-04-24 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
| CA2904641C (en) | 2013-03-12 | 2021-07-20 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| DE102013008118A1 (de) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | Arylchinazoline |
| WO2015058067A1 (en) | 2013-10-17 | 2015-04-23 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
| EP3518931A4 (en) | 2016-09-27 | 2020-05-13 | Vertex Pharmaceuticals Incorporated | METHOD FOR TREATING CANCER WITH A COMBINATION OF DNA-DAMAGING SUBSTANCES AND DNA-PK INHIBITORS |
| CN107793373B (zh) * | 2017-10-31 | 2019-09-17 | 广西师范大学 | 2-取代苯并三嗪酮衍生物及其制备方法 |
| AU2019209290B2 (en) | 2018-01-17 | 2024-03-07 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
| KR20200110687A (ko) | 2018-01-17 | 2020-09-24 | 버텍스 파마슈티칼스 인코포레이티드 | 유전체 편집 효율을 증가시키기 위한 퀴녹살리논 화합물, 조성물, 방법 및 키트 |
| ES2980444T3 (es) | 2018-01-17 | 2024-10-01 | Vertex Pharma | Inhibidores de ADN-PK |
| EP4643644A3 (en) | 2019-11-01 | 2025-12-24 | Syngenta Crop Protection AG | Pesticidally active fused bicyclic heteroaromatic compounds |
| CR20240002A (es) | 2021-06-24 | 2024-02-13 | Syngenta Crop Protection Ag | Derivados de 2-[3-[1 [(quinazolin-4-il)amino]etil]pirazin-2-il]tiazol-5-carbonitrilo y compuestos similares como plaguicidas |
| EP4543873A1 (en) | 2022-06-21 | 2025-04-30 | Syngenta Crop Protection AG | Pesticidally active fused bicyclic heteroaromatic compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ400992A3 (en) | 1990-11-06 | 1993-12-15 | Pfizer | Quinazoline derivatives for enhancing anti-tumor activity |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| WO2002020500A2 (en) * | 2000-09-01 | 2002-03-14 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| US7291733B2 (en) * | 2003-10-10 | 2007-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted tricyclic heterocycles and their uses |
| CN101230045B (zh) * | 2008-02-14 | 2013-04-10 | 沈阳药科大学 | 芳环并三嗪类衍生物及其应用 |
| BR112012022868A2 (pt) * | 2010-03-16 | 2018-06-05 | Merck Patent Gmbh | morfolinilquinazolinas |
-
2011
- 2011-11-18 DE DE102011118830A patent/DE102011118830A1/de not_active Withdrawn
-
2012
- 2012-10-30 HK HK15100269.7A patent/HK1199875A1/xx unknown
- 2012-10-30 IN IN1287KON2014 patent/IN2014KN01287A/en unknown
- 2012-10-30 MX MX2014005838A patent/MX2014005838A/es not_active Application Discontinuation
- 2012-10-30 EA EA201400595A patent/EA201400595A1/ru unknown
- 2012-10-30 SI SI201230559A patent/SI2780332T1/sl unknown
- 2012-10-30 HR HRP20160495TT patent/HRP20160495T1/hr unknown
- 2012-10-30 RS RS20160351A patent/RS54768B1/sr unknown
- 2012-10-30 JP JP2014541555A patent/JP6096792B2/ja not_active Expired - Fee Related
- 2012-10-30 KR KR1020147016518A patent/KR20140097391A/ko not_active Withdrawn
- 2012-10-30 ES ES12783121.2T patent/ES2572605T3/es active Active
- 2012-10-30 DK DK12783121.2T patent/DK2780332T3/en active
- 2012-10-30 AU AU2012339196A patent/AU2012339196B2/en not_active Ceased
- 2012-10-30 BR BR112014011805A patent/BR112014011805A2/pt not_active Application Discontinuation
- 2012-10-30 CA CA2856103A patent/CA2856103C/en active Active
- 2012-10-30 WO PCT/EP2012/004542 patent/WO2013072015A1/de not_active Ceased
- 2012-10-30 HU HUE12783121A patent/HUE027577T2/en unknown
- 2012-10-30 PL PL12783121T patent/PL2780332T3/pl unknown
- 2012-10-30 SG SG11201402206YA patent/SG11201402206YA/en unknown
- 2012-10-30 EP EP12783121.2A patent/EP2780332B1/de active Active
- 2012-10-30 CN CN201280056504.4A patent/CN103930408B/zh not_active Expired - Fee Related
- 2012-10-30 US US14/351,773 patent/US9187469B2/en active Active
-
2014
- 2014-05-12 IL IL232577A patent/IL232577A/en active IP Right Grant
- 2014-06-17 ZA ZA2014/04438A patent/ZA201404438B/en unknown
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