JP2015502371A5 - - Google Patents
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- JP2015502371A5 JP2015502371A5 JP2014547736A JP2014547736A JP2015502371A5 JP 2015502371 A5 JP2015502371 A5 JP 2015502371A5 JP 2014547736 A JP2014547736 A JP 2014547736A JP 2014547736 A JP2014547736 A JP 2014547736A JP 2015502371 A5 JP2015502371 A5 JP 2015502371A5
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- JP
- Japan
- Prior art keywords
- formula
- hal
- compound
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- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 208000015114 central nervous system disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000007822 coupling agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000001845 4 membered carbocyclic group Chemical group 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 239000007821 HATU Substances 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578931P | 2011-12-22 | 2011-12-22 | |
| EP11195214.9 | 2011-12-22 | ||
| EP11195214.9A EP2607364A1 (en) | 2011-12-22 | 2011-12-22 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| US61/578,931 | 2011-12-22 | ||
| US201261657978P | 2012-06-11 | 2012-06-11 | |
| EP12171415.8A EP2674434A1 (en) | 2012-06-11 | 2012-06-11 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| EP12171415.8 | 2012-06-11 | ||
| US61/657,978 | 2012-06-11 | ||
| PCT/EP2012/004968 WO2013091773A1 (en) | 2011-12-22 | 2012-11-30 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502371A JP2015502371A (ja) | 2015-01-22 |
| JP2015502371A5 true JP2015502371A5 (cg-RX-API-DMAC10.html) | 2016-08-04 |
| JP6112316B2 JP6112316B2 (ja) | 2017-04-12 |
Family
ID=48667735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547736A Active JP6112316B2 (ja) | 2011-12-22 | 2012-11-30 | テトラアザ−シクロペンタ［ａ］インデニル及びポジティブアロステリックモジュレーターとしてのそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9403835B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2794608B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6112316B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN104039789B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2012357169B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2860008C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2606839T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2013091773A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2813505A1 (en) * | 2013-06-14 | 2014-12-17 | Asceneuron SA | Tetraaza-cyclopenta[a]indenyl derivatives |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| EP3196200B1 (en) | 2014-08-26 | 2019-05-08 | Astellas Pharma Inc. | 2-aminothiazole derivatives or salt thereof as muscarinic m3 ligands for the treatment of bladder diseases |
| DK3256476T3 (en) * | 2015-02-11 | 2019-03-11 | Sunovion Pharmaceuticals Inc | CONDENSED DIHYDRO-4H-PYRAZOLO [5,1-C] [1,4] OXAZINYL COMPOUNDS AND ANALOGS FOR TREATMENT OF CNS DISORDERS |
| KR102630720B1 (ko) | 2015-08-28 | 2024-01-29 | 세키스이 메디칼 가부시키가이샤 | 벤질 화합물 |
| JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 化合物および組成物ならびにそれらの使用 |
| AU2018312559B2 (en) | 2017-08-02 | 2022-06-02 | Pgi Drug Discovery Llc | Isochroman compounds and uses thereof |
| KR102835667B1 (ko) | 2017-12-21 | 2025-07-21 | 애브비 바이오테크놀로지 리미티드 | Parp14 억제제로서의 퀴나졸리논 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60216083T2 (de) * | 2001-03-27 | 2007-06-28 | Neurogen Corp., Branford | (OXOPYRAZOLOi1,5AöPYRIMIDIN-2-YL) ALKYLCARBONSÄUREAMIDE |
| ES2338139T3 (es) * | 2004-12-15 | 2010-05-04 | F. Hoffmann-La Roche Ag | Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador de la glicina i (glyt-1) para el tratamiento de la enfermedad de alzheimer. |
| EP2094081B1 (en) * | 2006-11-14 | 2012-07-11 | Merck Sharp & Dohme Corp. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| US8507494B2 (en) * | 2010-04-30 | 2013-08-13 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived M1 receptor positive allosteric modulators |
| EP2813505A1 (en) * | 2013-06-14 | 2014-12-17 | Asceneuron SA | Tetraaza-cyclopenta[a]indenyl derivatives |
-
2012
- 2012-11-30 US US14/366,901 patent/US9403835B2/en active Active
- 2012-11-30 CN CN201280062522.3A patent/CN104039789B/zh active Active
- 2012-11-30 CA CA2860008A patent/CA2860008C/en active Active
- 2012-11-30 JP JP2014547736A patent/JP6112316B2/ja active Active
- 2012-11-30 WO PCT/EP2012/004968 patent/WO2013091773A1/en not_active Ceased
- 2012-11-30 AU AU2012357169A patent/AU2012357169B2/en active Active
- 2012-11-30 EP EP12798612.3A patent/EP2794608B1/en active Active
- 2012-11-30 ES ES12798612.3T patent/ES2606839T3/es active Active