JP2015502233A - 粘着性インターフェース創傷被覆材 - Google Patents
粘着性インターフェース創傷被覆材 Download PDFInfo
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- JP2015502233A JP2015502233A JP2014548141A JP2014548141A JP2015502233A JP 2015502233 A JP2015502233 A JP 2015502233A JP 2014548141 A JP2014548141 A JP 2014548141A JP 2014548141 A JP2014548141 A JP 2014548141A JP 2015502233 A JP2015502233 A JP 2015502233A
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- wound dressing
- styrene
- ethylene
- knitted fabric
- elastomer
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Abstract
Description
・非粘着性コヒーシブゲル(cohesive gel)と、
・柔軟性を有するオープンメッシュ生地と
を含む粘着性インターフェース創傷被覆材であって、
上記非粘着性コヒーシブゲルは、スチレン−(エチレン/ブチレン)ジブロック共重合体またはスチレン−(エチレン/プロピレン)ジブロック共重合体を共に含んでもよい、スチレン−(エチレン/ブチレン)−スチレントリブロックエラストマーまたはスチレン−(エチレン/プロピレン)−スチレントリブロックエラストマーからなる疎水性エラストマーマトリクスで形成され、上記エラストマーは、鉱油によって高度に可塑化され、親水コロイドの親水性粒子を分散状態で少量含み、
上記生地は、メッシュが実質的に塞がらないように上記非粘着性コヒーシブゲルでコーティングされた糸を含み、
上記生地は、非弾性フィラメントを有する連続マルチフィラメント糸である緯糸を有するヒートセットされた編地であり、上記編地は、欧州規格(EN)13726−4に従って測定した横方向の伸張性が0.01〜0.5N/cmであることを特徴とする、創傷被覆材に関する。
・クレイトンポリマー社からポリ(スチレン−(−エチレン/ブチレン−)−スチレン)(SEBSと略す)ブロック共重合体として商品名KRATON G(R)、具体的には商品名KRATON G1651(R)、KRATON G1654(R)またはKRATON G1652(R)が販売されており、
・クラレ社からポリ(スチレン−(−エチレン/プロピレン−)−スチレン)(SEPSと略す)ブロック共重合体として商品名SEPTON(R)が販売されている。
・トリブロックSEBS(特にクレイトンポリマー社から商品名KRATON G1651(R)として販売されている製品等)および
・ポリ(スチレン−オレフィン)ジブロック共重合体(特にクレイトンポリマー社から商品名KRATON G1702(R)として販売されているポリ(スチレン−エチレン−プロピレン)等)
のブレンド物が挙げられる。
・フェノール系酸化防止剤、特にチバ・スペシャルティ・ケミカルズ社から商品名IRGANOX1010(R)、IRGANOX565(R)およびIRGANOX1076(R)として販売されている製品等が挙げられる。
比較例として、インターフェース創傷被覆材であるURGOTUL(R)を使用した。ゲルの組成および上記創傷被覆材の製造については、特許文献1の実施例1に説明されている。
マーキゼットの代わりに緯糸を有するヒートセットされたポリエステル糸製編地(601番、MDBテクシノヴ社製)を使用した以外は、特許文献1の実施例1と同様の製造プロセスに従い、同様のゲル組成を用いて本発明の創傷被覆材を製造した。上記編地の坪量は28g/m2であった。
URGOTUL(R)製品と比較して本発明の製品の粘着性が優れていることを示すために、比較インビボ試験を行った。
・10cm×10cmの大きさの創傷被覆材から、2枚の保護フィルムが剥がれないように、5cm×5cmの大きさのサンプルを4枚切り出し、
・1つのサンプルを選び、その2枚の保護フィルムのうち1枚を剥がし、
・(肘を前へ突き出すように)前腕を上腕の方に曲げ、
・もう片方の手で、サンプルの保護フィルムの無い方の面を肘に軽く押しつけながら貼り付け、
・残りの保護フィルムを剥がし、
・10秒経過後、サンプルが剥がれ落ちるか、その場に保たれるかを確認する。
(2) 編地の列
α 角度
Claims (11)
- 非粘着性コヒーシブゲルと、
柔軟性を有するオープンメッシュ生地と
を含む粘着性インターフェース創傷被覆材であって、
前記非粘着性コヒーシブゲルは、スチレン−(エチレン/ブチレン)ジブロック共重合体またはスチレン−(エチレン/プロピレン)ジブロック共重合体を共に含んでもよい、スチレン−(エチレン/ブチレン)−スチレントリブロックエラストマーまたはスチレン−(エチレン/プロピレン)−スチレントリブロックエラストマーからなる疎水性エラストマーマトリクスで形成され、前記エラストマーは、鉱油によって高度に可塑化され、親水コロイドの親水性粒子を分散状態で少量含み、
前記生地は、メッシュが実質的に塞がらないように前記非粘着性コヒーシブゲルでコーティングされた糸を含み、
前記生地は、非弾性フィラメントを有する連続マルチフィラメント糸である緯糸を有するヒートセットされた編布であり、前記編地は、欧州規格(EN)13726−4に従って測定した横方向の伸張性が0.01〜0.5N/cmであることを特徴とする、創傷被覆材。 - 前記編地を構成する糸は、12〜36本のフィラメントを含む33〜115dtexの糸から選択されることを特徴とする、請求項1に記載の創傷被覆材。
- 前記編地を構成する糸はポリアミドまたはポリエステル製であることを特徴とする、請求項1または2に記載の創傷被覆材。
- 前記編地は坪量が20〜40g/m2、好ましくは24〜32g/m2であることを特徴とする、請求項1〜3のいずれか1項に記載の創傷被覆材。
- 前記編地は、欧州規格(EN)13726−4に従って測定した縦方向の伸張性が15〜30N/cmであることを特徴とする、請求項1〜4のいずれか1項に記載の創傷被覆材。
- 前記鉱油は、液体パラフィン、または、液体パラフィンおよびワセリンの混合物であることを特徴とする、請求項1〜5のいずれか1項に記載の創傷被覆材。
- 前記ゲルのエラストマーマトリクスは、スチレン−(エチレン/ブチレン)−スチレントリブロックエラストマー100重量部につき、液体パラフィンを1000〜2000重量部、医薬品用ワセリンを0〜400重量部含むことを特徴とする、請求項1〜6のいずれか1項に記載の創傷被覆材。
- 前記親水コロイドはカルボキシメチルセルロースナトリウムであることを特徴とする、請求項1〜7のいずれか1項に記載の創傷被覆材。
- 前記親水コロイドは、前記エラストマーマトリクスの総重量に対して2〜20重量%の量で含まれることを特徴とする、請求項1〜8のいずれか1項に記載の創傷被覆材。
- 前記エラストマーマトリクスはさらに活性薬剤を含むことを特徴とする、請求項1〜9のいずれか1項に記載の創傷被覆材。
- 前記活性薬剤は、防腐剤、抗生物質、または、創傷治癒を促進する化合物であることを特徴とする、請求項10に記載の創傷被覆材。
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FRPCT/FR2011/053043 | 2011-12-19 | ||
PCT/FR2011/053043 WO2013093213A1 (fr) | 2011-12-19 | 2011-12-19 | Pansement interface adherent |
PCT/FR2012/052897 WO2013093298A1 (fr) | 2011-12-19 | 2012-12-12 | Pansement interface adherent |
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JP2015502233A true JP2015502233A (ja) | 2015-01-22 |
JP6200900B2 JP6200900B2 (ja) | 2017-09-20 |
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EP (2) | EP2959873B1 (ja) |
JP (1) | JP6200900B2 (ja) |
KR (1) | KR20140107269A (ja) |
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CL (1) | CL2014001604A1 (ja) |
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MY (1) | MY175014A (ja) |
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PL (1) | PL2793773T3 (ja) |
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JP6089262B2 (ja) | 2012-03-01 | 2017-03-08 | アルケア株式会社 | 傷手当用品 |
FR2993182B1 (fr) | 2012-07-13 | 2014-10-17 | Urgo Lab | Pansement a liberation prolongee d'actifs |
FR3015227B1 (fr) * | 2013-12-20 | 2017-03-24 | Urgo Lab | Materiau composite de remplissage des plaies cavitaires |
KR101645277B1 (ko) * | 2014-12-05 | 2016-08-04 | 주식회사 불스원 | 젤쿠션의 제조방법 |
FR3030225B1 (fr) * | 2014-12-19 | 2017-01-13 | Urgo Lab | Pansement comprenant un support et une matrice elastomerique hydrophobe |
FR3050937B1 (fr) * | 2016-05-04 | 2018-05-25 | Urgo Recherche Innovation Et Developpement | Composition optimisee pour pansement interface |
FR3053892A1 (fr) | 2016-07-12 | 2018-01-19 | Urgo Recherche Innovation Et Developpement | Pansement permettant la liberation controlee et prolongee de la metformine |
FR3066390B1 (fr) | 2017-05-17 | 2019-07-12 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour traiter les plaies des patients diabetiques arteriopatiques |
FR3082123B1 (fr) | 2018-06-07 | 2020-10-16 | Urgo Rech Innovation Et Developpement | Pansement cellularise et son procede de fabrication |
FR3113583A1 (fr) | 2020-08-26 | 2022-03-04 | Urgo Recherche Innovation Et Developpement | Utilisation de composes oligosaccharidiques pour augmenter l’oxygenation de la peau lors du traitement des plaies ischemiques |
CN112168494B (zh) * | 2020-09-27 | 2022-04-29 | 西安工程大学 | 一种3d间隔织物-气凝胶复合医用敷料及其制备方法 |
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US5512354A (en) * | 1993-01-25 | 1996-04-30 | Minnesota Mining And Manufacturing Company | Fabric backing for orthopedic support materials |
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FR2936158A1 (fr) | 2008-09-24 | 2010-03-26 | Plasto | Interface chirurgicale pour plaie, sans support |
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