JP2015500464A5 - - Google Patents
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- Publication number
- JP2015500464A5 JP2015500464A5 JP2014543985A JP2014543985A JP2015500464A5 JP 2015500464 A5 JP2015500464 A5 JP 2015500464A5 JP 2014543985 A JP2014543985 A JP 2014543985A JP 2014543985 A JP2014543985 A JP 2014543985A JP 2015500464 A5 JP2015500464 A5 JP 2015500464A5
- Authority
- JP
- Japan
- Prior art keywords
- selectin
- substrate
- stroke
- vcam
- biomarkers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000090 biomarker Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 25
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims description 12
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 12
- 208000032382 Ischaemic stroke Diseases 0.000 claims description 11
- 208000006011 Stroke Diseases 0.000 claims description 10
- 108090001005 Interleukin-6 Proteins 0.000 claims description 9
- 238000000338 in vitro Methods 0.000 claims description 5
- 238000003745 diagnosis Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims 17
- 239000000758 substrate Substances 0.000 claims 16
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 8
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 8
- 108010092694 L-Selectin Proteins 0.000 claims 8
- 102000016551 L-selectin Human genes 0.000 claims 8
- 108010035766 P-Selectin Proteins 0.000 claims 7
- 102100023472 P-selectin Human genes 0.000 claims 7
- 239000003154 D dimer Substances 0.000 claims 3
- 238000012896 Statistical algorithm Methods 0.000 claims 3
- 108010052295 fibrin fragment D Proteins 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- -1 sTNFR1 Proteins 0.000 claims 3
- 230000001052 transient effect Effects 0.000 claims 3
- 238000000018 DNA microarray Methods 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000007477 logistic regression Methods 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000032109 Transient ischaemic attack Diseases 0.000 description 2
- 201000010875 transient cerebral ischemia Diseases 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1120781.8A GB2497138A (en) | 2011-12-02 | 2011-12-02 | Biomarkers for stroke and stroke subtype diagnosis. |
| GB1120781.8 | 2011-12-02 | ||
| PCT/GB2012/052993 WO2013079981A2 (en) | 2011-12-02 | 2012-12-03 | Biomarker-based methods and biochips for aiding the diagnosis of stroke |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500464A JP2015500464A (ja) | 2015-01-05 |
| JP2015500464A5 true JP2015500464A5 (https=) | 2016-01-28 |
| JP6199880B2 JP6199880B2 (ja) | 2017-09-20 |
Family
ID=45509085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543985A Active JP6199880B2 (ja) | 2011-12-02 | 2012-12-03 | 脳卒中の診断を補助するためのバイオマーカーに基づく方法およびバイオチップ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20150126385A1 (https=) |
| EP (1) | EP2786155B1 (https=) |
| JP (1) | JP6199880B2 (https=) |
| CN (1) | CN104272112B (https=) |
| AU (2) | AU2012343537B2 (https=) |
| CA (1) | CA2857589C (https=) |
| GB (1) | GB2497138A (https=) |
| WO (1) | WO2013079981A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201309928D0 (en) * | 2013-06-04 | 2013-07-17 | Randox Lab Ltd | Method |
| JP6312302B2 (ja) * | 2014-01-06 | 2018-04-18 | 公益財団法人ヒューマンサイエンス振興財団 | 脳梗塞の診断マーカー |
| JP7109484B2 (ja) | 2017-06-13 | 2022-07-29 | エフ．ホフマン－ラ ロシュ アーゲー | 心房細動（ａｆ）の評価のための脂肪酸結合タンパク質３ |
| GB2563415A (en) * | 2017-06-14 | 2018-12-19 | Randox Laboratories Ltd | Combinations for use in stroke diagnosis |
| GB2563414A (en) * | 2017-06-14 | 2018-12-19 | Randox Laboratories Ltd | Improvements in stroke diagnostics |
| JP6499342B2 (ja) * | 2018-03-19 | 2019-04-10 | 隆樹 日和佐 | 脳梗塞の診断マーカー |
| KR102299968B1 (ko) * | 2019-11-19 | 2021-09-09 | 경북대학교 산학협력단 | 혈액성분 분리용 다중필터 및 그를 이용한 질병 진단키트 |
| US20240192231A1 (en) * | 2021-04-15 | 2024-06-13 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Markers for the diagnosis of large vessel occlusion |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5879010A (en) | 1997-07-22 | 1999-03-09 | Green Tweed Of Delaware, Inc. | Seal assembly with mechanically joined anti-extrusion rings |
| GB9929140D0 (en) | 1999-12-10 | 2000-02-02 | Univ Geneve | Diagnostic assay for stroke |
| AU2001280996A1 (en) | 2000-08-04 | 2002-02-18 | Cis Biotech, Inc. | Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke |
| AUPR005600A0 (en) * | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
| US20030199000A1 (en) * | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| DE60233949D1 (de) * | 2001-08-20 | 2009-11-19 | Biosite Inc | Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon |
| CA2358007C (en) * | 2001-10-02 | 2008-02-19 | Royce Technologies Llc, A Nevada Corporation | Ceramic biomolecule imaging chip |
| DK2341350T3 (en) * | 2003-09-20 | 2018-02-05 | Electrophoretics Ltd | DIAGNOSTIC PROCEDURE FOR BRAKE INJURY-RELATED DISORDERS BASED ON DJ-1 DETECTION |
| US20050181386A1 (en) * | 2003-09-23 | 2005-08-18 | Cornelius Diamond | Diagnostic markers of cardiovascular illness and methods of use thereof |
| US7634360B2 (en) * | 2003-09-23 | 2009-12-15 | Prediction Sciences, LL | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| US7392140B2 (en) * | 2003-09-23 | 2008-06-24 | Prediction Sciences, Llc | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| US20060099608A1 (en) * | 2004-03-29 | 2006-05-11 | Medstar Research Institute | Methods of diagnosing cardiovascular disease |
| WO2007124439A2 (en) * | 2006-04-21 | 2007-11-01 | Rules-Based Medicine, Inc. | Diagnosis of stroke using metalloproteinase or transaminase |
| CA2688433A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| WO2010012834A1 (en) | 2008-08-01 | 2010-02-04 | Bio-Rad Pasteur | Method for the in vitro diagnosis of stroke |
| CN102257386B (zh) * | 2008-10-24 | 2014-12-31 | B.R.A.H.M.S有限公司 | 通过测定标志肽的水平在已患过中风或短暂性缺血性发作的患者中进行预后和风险评估 |
| EP2206726A1 (en) * | 2009-01-08 | 2010-07-14 | Universite Joseph Fourier | Non-invasive tools for detecting vulnerable atherosclerotic plaques |
| CA2751090A1 (en) | 2009-01-30 | 2010-08-05 | Electrophoretics Limited | Method for the in vitro diagnosis of stroke |
-
2011
- 2011-12-02 GB GB1120781.8A patent/GB2497138A/en not_active Withdrawn
-
2012
- 2012-12-03 JP JP2014543985A patent/JP6199880B2/ja active Active
- 2012-12-03 CN CN201280068312.5A patent/CN104272112B/zh active Active
- 2012-12-03 WO PCT/GB2012/052993 patent/WO2013079981A2/en not_active Ceased
- 2012-12-03 US US14/361,880 patent/US20150126385A1/en not_active Abandoned
- 2012-12-03 CA CA2857589A patent/CA2857589C/en active Active
- 2012-12-03 EP EP12795609.2A patent/EP2786155B1/en active Active
- 2012-12-03 AU AU2012343537A patent/AU2012343537B2/en active Active
-
2017
- 2017-03-13 US US15/457,297 patent/US10914745B2/en active Active
-
2018
- 2018-10-11 AU AU2018247291A patent/AU2018247291A1/en not_active Abandoned
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