JP2015200527A - Clinical examination device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a clinical examination device capable of highly maintaining the reliability of measurement.SOLUTION: The clinical examination device includes: a sample container; a sample dispensing mechanism; measurement means; photographing means; storage means; detection means; and output means. A sample is stored in the sample container. The sample dispensing mechanism includes a sample dispensing probe for sucking the sample from the sample container, and for discharging the sample to a reaction container. The measurement means measures the components of mixed solution containing at least the sample stored in the reaction container. The photographing means photographs at least one of either the sample container or the sample dispensing probe as an object to be photographed, and generates a comparison video indicating the current state of the object to be photographed. The storage means preliminarily stores a reference video indicating the normal state of the object to be photographed. The detection means compares the comparison video with the reference video, and detects abnormality from the comparison result. The output means outputs the detection of abnormality to the outside.

Description

  Embodiments described herein relate generally to a clinical testing apparatus.

  A clinical test is performed in order to objectively evaluate the state of a subject such as a patient. A clinical laboratory apparatus is mainly used for this clinical examination. An example of a clinical examination apparatus is an automatic analyzer.

  The automatic analyzer measures a sample collected from a patient or the like. This sample measurement is performed by preparing a mixed solution, measuring the mixed solution by absorption, and outputting the measurement result. A sample and a reagent are dispensed into a reaction container, and a sample (hereinafter also referred to as a sample) and a reagent contained in the reaction container are stirred by a stirring means, whereby a mixed liquid is automatically prepared.

  As an example, a sample dispensing probe and a pump are used in the step of dispensing a sample. First, the sample dispensing probe is moved to the position of the sample container containing the sample. Next, the sample dispensing probe is lowered and immersed in the liquid, and a predetermined amount of sample is sucked by a pump connected to the sample dispensing probe. Further, after raising the sample dispensing probe, the sample dispensing probe is moved to the position of the reaction vessel. The sucked sample is discharged into the reaction container by a pump. Thus, the step of dispensing the sample is performed by moving the sample dispensing probe between the sample container and the reaction container.

  The automatic analyzer ensures high measurement performance by at least normally dispensing the sample into the reaction vessel. For this reason, the dispensing performance of the sample dispensing probe greatly affects the result of the sample measurement by the automatic analyzer.

JP 2011-237344 A

  However, when the use of the automatic analyzer is continued, the dispensing performance of the sample dispensing probe deteriorates. When the dispensing performance is lowered, the sample container is not normally dispensed from the reaction container. As a result, the sample measurement result by the automatic analyzer may become abnormal.

  One cause of the decrease in the dispensing performance is plastic deformation of the sample dispensing probe. The plastic deformation of the sample dispensing probe generally occurs when an external force is applied to the sample dispensing probe.

  For example, a sample container with a lid on the top may be transferred to an automatic analyzer. In this case, the automatic analyzer collides the sample dispensing probe with the lid and detects the presence or absence of the lid by detecting the collision. Since the automatic analyzer detects the presence or absence of a lid by such a collision, plastic deformation may occur in the sample dispensing probe during the detection.

  When high measurement accuracy is required for measurement such as micro-measurement of a sample, the measurement result often becomes abnormal due to deformation of the sample dispensing probe. For this reason, in order to maintain the accuracy of sample dispensing, the automatic analyzer needs to maintain at least the dispensing performance of the sample dispensing probe at a high level.

  This embodiment solves the above-described problem, and an object thereof is to provide a clinical test apparatus capable of maintaining high measurement reliability.

  In order to solve the above-described problem, the clinical examination apparatus according to this embodiment includes a sample container, a sample dispensing mechanism, a measurement unit, an imaging unit, a storage unit, a detection unit, and an output unit. A sample is accommodated in the sample container. The sample dispensing mechanism includes a sample dispensing probe that sucks a sample from the sample container and discharges the sample to the reaction container. The measuring means measures a component of the mixed solution containing at least the sample accommodated in the reaction container. The imaging unit images at least one of the sample container and the sample dispensing probe as an imaging target, and generates a comparative image indicating the current state of the imaging target. The storage means stores in advance a reference video indicating a normal state of the photographing target. The detection means compares the comparison video with the reference video and detects an abnormality from the comparison result. The output means outputs abnormality detection to the outside.

The block diagram which shows the functional structure of the automatic analyzer of 1st Embodiment. The perspective view which shows the detailed structure of an analysis part. The side view which shows an example of the sample dispensing probe which attracted | sucked the sample in which fibrin was mixed. The perspective view which showed the vicinity of the sample dispensing position in an automatic analyzer. FIG. 5 is a vertical sectional view taken along line A-A ′ in the diagram shown in FIG. 4. The perspective view which shows the positional relationship of a barcode reader, the imaging | photography object of a camera unit, and a camera unit. The top view which shows the positional relationship of a barcode reader, the imaging | photography object of a camera unit, and a camera unit. The top view of a sample container. The side view which showed the vicinity of the sample dispensing position in an automatic analyzer. The flowchart which showed an example of operation | movement of the automatic analyzer of 1st Embodiment. The flowchart which showed another example of operation | movement of the automatic analyzer of 1st Embodiment. The flowchart which showed other example of operation | movement of the automatic analyzer of 1st Embodiment. The block diagram which shows the functional structure of the automatic analyzer of 2nd Embodiment. The vertical sectional view which showed the vicinity of the sample dispensing position in an automatic analyzer. The flowchart which showed an example of operation | movement of the automatic analyzer of 2nd Embodiment. The figure which shows the example of a sample container. The table | surface which shows a response | compatibility with the reference image | video and the kind of sample container. The table | surface which shows a response | compatibility with the kind of sample container, and the position of the sample suction point in a perpendicular direction. The flowchart which showed another example of operation | movement of the automatic analyzer of 2nd Embodiment. The flowchart which showed another example of operation | movement of the automatic analyzer of 2nd Embodiment. The block diagram which shows the functional structure of the automatic analyzer of 3rd Embodiment.

<First Embodiment>
As an example of the clinical testing apparatus of this embodiment, an automatic analyzer will be described with reference to each drawing.

[Automatic analyzer]
A configuration of the automatic analyzer 10 will be described with reference to FIGS. 1 and 2. FIG. 1 is a block diagram showing a functional configuration of the automatic analyzer 10 of this embodiment. FIG. 2 is a perspective view showing a detailed configuration of the analysis unit 24. The automatic analyzer 10 is an apparatus for analyzing the components of the mixed solution by mixing and stirring the sample dispensed in the reaction vessel 51 and stirring the mixture to prepare a mixed solution and measuring the mixed solution. In the figure, a broken line arrow indicates that the sample dispensing probe 16 is imaged and its image is acquired.

[overall structure]
First, the overall configuration of the automatic analyzer 10 will be described with reference to the drawings. As shown in FIG. 1, the automatic analyzer 10 includes an analysis unit 24, an analysis control unit 25, a data processing unit 30, a photographing unit 40, an identification unit 20, a storage unit 50, a detection unit 60, A system control unit 70, an operation unit 80, and an output unit 90 are included.

  The analysis unit 24 generates a mixed solution containing the sample and reagent liquids, and measures the components of the mixed solution. The analysis control unit 25 includes a mechanism unit 26 and a control unit 27, and controls each analysis unit of the analysis unit 24. Detailed configurations of the analysis unit 24 and the analysis control unit 25 will be described later.

[System controller]
The system control unit 70 controls the analysis control unit 25, the data processing unit 30, the imaging unit 40, the identification unit 20, the storage unit 50, the detection unit 60, and the output unit 90 in an integrated manner. The operation unit 80 inputs various command signals to the system control unit 70.

[Data processing section]
The data processing unit 30 includes a calculation unit 31 and a data storage unit 32.

[Calculation section]
The calculation unit 31 receives the measurement result of the component of the mixed solution output from the analysis unit 24, calculates the concentration of the specific substance in the mixed solution, and generates measurement data, calibration data, and the like.

[Data storage section]
The data storage unit 32 temporarily stores measurement data, calibration data, and the like generated by the calculation unit 31.

[Operation section]
As the operation part 80, what has an independent operation input function, such as a mouse | mouth and a keyboard, is mentioned, for example. In addition, an operation input function such as a touch panel and a display function may be combined. The operation performed via the operation unit 80 is input as a command to the system control unit 70, for example. This input may be input directly from an operation device constituting the operation unit 80, or may be input indirectly such as selecting an object such as a button displayed on the display unit 91 with a mouse or the like. It may be what was done.

[Output section]
The output unit 90 includes a display unit 91, a printing unit 92, and a notification unit 93. The output unit 90 outputs information received from the data processing unit 30, the operation unit 80, and the detection unit 60 to the outside based on the control of the system control unit 70. Examples of the output include display output by the display unit 91, print output by the printing unit 92, notification output by the notification unit 93, and the like.

[Shooting Department]
The imaging unit 40 includes a solid-state imaging device (not shown) and an A / D converter (not shown). An example of the photographing unit 40 is a camera unit. Examples of the camera unit include a digital still camera that optically acquires a still image, a digital video camera that optically acquires a moving image, and the like. Camera units 40a to 40c described later are examples of the photographing unit 40. Here, one moving image includes a plurality of time-series still images. Further, a single moving image can be obtained by performing a process of combining a plurality of still images in time series. Hereinafter, at least one of a still image and a moving image may be referred to as a “video”.

  Examples of the solid-state imaging device include a charge-coupled device (CCD) image sensor and a complementary metal-oxide semiconductor (CMOS) image sensor. The solid-state imaging device receives light and outputs an analog video signal to the A / D converter. The A / D converter receives an analog video signal, digitally converts the video signal, and generates digital video data.

  The imaging unit 40 outputs the acquired video data to the detection unit 60. The photographing unit 40 may be anything as long as it has a configuration capable of photographing a video. In addition, the photographing unit 40 may store the acquired video data in the storage unit 50. Examples of the video data include reference video data and comparative image data. The reference video data is video data including an image of a normal sample dispensing probe 16.

  The imaging unit 40 acquires reference video data and outputs it to the storage unit 50 before measurement by the automatic analyzer 10. The imaging unit 40 optically captures an imaging target stopped at the imaging position and generates reference video data. The reference image is used to indicate a normal outer shape of at least one of the sample dispensing probe 16 and the sample container 61. The normal sample dispensing probe 16 is, for example, one that does not cause any abnormality when aspirating and discharging a sample. Examples of the sample dispensing probe 16 having a normal outer shape include those that are not plastically deformed. A specific example of the sample dispensing probe 16 having such a normal outer shape is an unused product. Moreover, it is an unused product and has no dirt on the surface.

  When capturing a reference video, for example, the imaging unit 40 is installed in a position where the sample dispensing probe 16 is at least included in the imaging range of the imaging unit 40. A sample container 61 may be further included in the imageable range. The position where the imaging unit 40 is installed may be, for example, the upper surface position of the housing of the automatic analyzer 10 or a position outside the automatic analyzer 10. The installation position of the imaging unit 40 is set, for example, such that the distal end portion of the sample dispensing probe 16 is included in the imaging area of the imaging unit 40. The installation position of the imaging unit 40 is set to a position opposite to the barcode reading unit with the sample container 61 interposed therebetween. At this time, the reading direction of the barcode and the photographing direction by the photographing unit 40 are opposed to each other.

  The imaging unit 40 acquires comparative image data that is an image of the sample dispensing probe 16 during the operation of the automatic analyzer 10. When shooting a comparative video, the position where the shooting unit 40 is installed is, for example, the position where the reference video is shot. That is, the photographing unit 40 is installed so that fixed point photographing can be performed at the position where the reference image is photographed during measurement by the automatic analyzer 10. In this case, the imaging unit 40 can capture the comparative video with the same angle of view as when the reference video is captured.

  The imaging unit 40 optically images at least one of the sample dispensing probe 16 and the sample container 61 during the operation of the automatic analyzer 10. The imaging unit 40 images, for example, the side surface of the sample dispensing probe 16. Imaging of the sample dispensing probe 16 by the imaging unit 40 is performed, for example, when the sample dispensing probe 16 stops at a predetermined position.

  The system control unit 70 controls the photographing unit 40 to photograph at least one of the sample dispensing probe 16 and the sample container 61 when the sample dispensing probe 16 stops for the first time after sucking the sample. . The suction of the sample is performed by inserting the sample dispensing probe 16 into the sample container 61 at the sample suction position. The post-aspiration stop position that stops first after the sample is aspirated is, for example, an upper position that is a predetermined distance away from the sample container 61 from which the sample has been aspirated. The stop position after suction is set in advance. The sample dispensing probe 16 stops at this position for a predetermined time each time the sample is sucked. Here, the sample suction position in the sample container 61 is a position where the sample container 61 stops because the sample accommodated in the sample container 61 is sucked by the sample dispensing probe 16. The sample suction position in the sample dispensing probe 16 is the position of the tip of the sample dispensing probe 16 when the sample stored in the sample container 61 is sucked.

  The imaging unit 40 performs fixed-point imaging of the sample dispensing probe 16 stopped at the stop position after aspiration, and generates comparison video data. The reference video data is acquired by photographing a normal sample dispensing probe 16 stopped at a stop position after aspiration with the imaging unit 40 at a fixed point. The shooting angle of view at this time is the same as when reference video data is acquired. That is, the imaging unit 40 acquires a reference video and a comparative video that are captured in the same imaging region.

  Further, the sample dispensing probe 16 stopped at the pre-aspiration stop position is photographed at a fixed point to generate a reference image. After the sample is aspirated, the sample dispensing probe 16 stopped at the post-aspiration stop position is photographed at a fixed point and a comparison image is taken. It may be generated. The acquired reference video is stored in the storage unit 50, for example. When the comparison video is generated after the reference video is stored in the storage unit 50, the comparison video and the reference video corresponding to the comparison video are output to the detection unit 60. Alternatively, the generated reference video may be output to the detection unit 60 and temporarily stored in a temporary storage unit (not shown), and then the generated comparison video may be output to the detection unit 60. Here, the pre-aspiration stop position is a position where the sample dispensing probe 16 temporarily stops immediately before performing a downward movement for aspirating the sample.

[Storage unit]
The storage unit 50 stores a reference video before measurement by the automatic analyzer 10. For example, the reference video is stored in the storage unit 50 before the measurement for each measurement. This reference image is stored for all the corresponding dispensing probes, for example. For example, when the automatic analyzer 10 includes a plurality of dispensing probes, the storage unit 50 stores reference images corresponding to the dispensing probes. Further, the storage unit 50 stores initial setting values for driving each unit of the automatic analyzer 10.

[Detection unit]
The detection unit 60 compares the image of the sample dispensing probe 16 shown in the reference image with the image of the sample dispensing probe 16 shown in the comparison image. Based on the comparison result, the detection unit 60 determines whether or not the factor causing the sample dispensing abnormality is in the sample dispensing. The detection unit 60 determines whether or not the factor causing the dispensing abnormality is in the sample dispensing, and detects that the sample dispensing is suspected of being abnormal based on this determination.

  As a case where the factor causing the dispensing abnormality is the sample dispensing, first, there is a case where the shape of the sample dispensing probe 16 is abnormal. An abnormality in the shape of the sample dispensing probe 16 occurs when the shape of the sample dispensing probe 16 changes from the initial shape. The change in the shape of the sample dispensing probe 16 may be caused by plastic deformation of the sample dispensing probe 16 due to, for example, contact or collision. Specific examples of this plastic deformation include crushing of the tip of the sample dispensing probe 16 or bending of the sample dispensing probe 16. When this plastic deformation occurs in the sample dispensing probe 16, dispensing abnormalities such as insufficient dispensing amount and scattering during sample dispensing occur.

  An example of a means for detecting a change in the shape of the sample dispensing probe 16 is a determination process by comparing the shape of the image of the sample dispensing probe 16. This determination processing is, for example, a comparison between the image of the sample dispensing probe 16 shown in the reference image and the sample dispensing probe 16 shown in the comparison image, so that the image of the two sample dispensing probes 16 is large. If there is a difference, it is determined that the shape of the sample dispensing probe 16 is abnormal.

  This comparison uses, for example, a difference image, and is performed as follows, for example. First, as a pre-process for generating a difference image, the comparison image and the reference image are normalized so that the pixel value ranges of the comparison image and the reference image are the same. The comparative image is a still image that forms a comparative moving image. The reference image is a still image constituting a reference video. Next, the normalized comparison image and reference image are converted from a color image to a monochrome image. At this time, if there is a positional shift between the image of the sample dispensing probe 16 shown in the comparison image and the image of the sample dispensing probe 16 shown in the reference image, for example, the position is registered in advance. Overlay by processing such as pattern matching based on. Then, the luminance value of the monochrome reference image is subtracted from the monochrome comparison image to generate monochrome difference image data. Further, by performing this process in time series on a plurality of images, a difference moving image in which the difference images are arranged in time series may be generated.

  The detection unit 60 determines the size (area) of the difference area between the image of the sample dispensing probe 16 shown in the comparison image and the image of the sample dispensing probe 16 shown in the reference image from the acquired difference image data. And processing for determining whether or not the shape of the dispensing probe is normal is performed based on the size. When the size (area) of the difference area between the image of the sample dispensing probe 16 shown in the comparative image and the image of the sample dispensing probe 16 shown in the reference image is 0, for example, It is determined that the shape is normal. Further, when the difference is other than 0, the detection unit 60 determines that the shape of the sample dispensing probe 16 is abnormal, and detects this abnormality. As another example, the detection unit 60 determines that the shape of the sample dispensing probe 16 is abnormal when, for example, the size (area) of the difference region exceeds a predetermined size, This abnormality may be detected. Further, the detection unit 60 determines that the shape of the sample dispensing probe 16 is abnormal when the shape of the difference image generated by pattern matching or the like is a predetermined shape. May be detected. Examples of the predetermined shape include a shape in which the tip of the sample dispensing probe 16 is crushed, a shape in which the tip of the sample dispensing probe 16 is bent, and a shape in which the sample dispensing probe 16 is warped.

  As a case where the factor causing the dispensing abnormality is the sample dispensing, secondly, there is a case where solid matter adheres to the sample dispensing probe 16 when the sample is sucked. As a case where solid matter adheres to the sample dispensing probe 16, for example, a case where a sample with insufficient measurement pretreatment is sucked. The sample dispensing probe 16 has a discharge port 16a for sucking and discharging a sample at the tip. For example, solids larger than the opening surface of the discharge port 16a of the sample dispensing probe 16 are mixed in the sample for which the measurement pretreatment is insufficient. When the sample dispensing probe 16 sucks the solid matter, the solid matter is adsorbed to the discharge port 16a, and the solid matter adheres to the sample dispensing probe 16.

  As a specific example, when the sample is plasma, if the measurement pretreatment is insufficient, a fibrous protein called fibrin remains in the sample. FIG. 3 is a side view showing an example of the sample dispensing probe 16 that sucks the sample S mixed with the fibrin 180. The hatched portion in the figure is for clearly showing the sample S and does not show a cross section. As shown in FIG. 3, when the sample dispensing probe 16 sucks the sample S, the fibrin 180 may be clogged in the discharge port 16 a of the sample dispensing probe 16. For example, when the fibrin 180 has a thread shape as shown in FIG. 3, the fibrin 180 is adsorbed to the tip of the sample dispensing probe 16. As a result, the form of the sample dispensing probe 16 viewed from the side is such that the tail extends from the tip of the sample dispensing probe 16.

  Thus, when solid matter adheres so as to block the discharge port 16a of the sample dispensing probe 16, the discharge port 16a provided at the tip of the sample dispensing probe 16 is clogged. Then, the sample dispensing probe 16 cannot suck a specified amount of sample. Further, the sample containing the solid matter is discharged into the reaction vessel 51 by the sample dispensing probe 16 to which the solid matter is adhered, whereby the solid matter is mixed into the reaction vessel 51. As a result, the measurement result of the mixed liquid containing this sample becomes abnormal. In order not to cause an abnormality in the measurement result, it is necessary to detect the adhesion of solid matter to the tip of the sample dispensing probe 16.

  As an example of a means for detecting the case where a solid substance adheres to the sample dispensing probe 16, there is a determination process based on comparison of images obtained by photographing a predetermined area including an image of the sample dispensing probe 16. Examples of the predetermined region include a region between the tip of the sample dispensing probe 16 and the bottom of the sample container 61. By imaging this area as an imaging area, an image including an image of a solid substance attached to the tip of the sample dispensing probe 16 is acquired. This determination process can be the same as the process shown as an example of a means for detecting a change in the shape of the dispensing probe, for example. For example, this determination processing is performed by comparing a video obtained by photographing a predetermined region including the image of the dispensing probe shown in the reference video and a video obtained by photographing the predetermined region including the image of the dispensing probe shown in the comparison video. To do. If there is a large difference between the two images in this comparison, it is determined that the solid material is attached to the sample dispensing probe 16. Examples of this difference include the following. First, the comparison image may include an image in which a thread-like image extends from the image of the tip of the sample dispensing probe 16. This is because the solid matter such as fibrin is the tip of the sample dispensing probe 16. It is thought that it adheres as if caught on. In this case, for example, the detection unit 60 detects that the discharge port 16a of the sample dispensing probe 16 is attached in a form in which fibrin closes it. The determination of the difference and the detection of the abnormality are performed using, for example, the above-described difference image between the comparison image and the reference image.

  Third, when the sample dispensing probe 16 is washed in the washing tank 19a, the cleaning liquid remains on the surface of the sample dispensing probe 16 after the washing. Is mentioned. When the sample is aspirated by the sample dispensing probe 16 with the cleaning liquid remaining on the surface, contamination of the sample, dilution, and the like occur due to mixing of the cleaning liquid into the sample. Further, the sample may be altered by the reaction between the cleaning component of the cleaning liquid and the sample. As a result, the measurement result of the mixed liquid containing this sample becomes abnormal.

  An example of means for detecting the cleaning liquid remaining on the surface of the sample dispensing probe 16 is a determination process based on a change in the luminance value of the image of the sample dispensing probe 16. In this determination processing, determination by shape comparison may be appropriately performed.

  For this comparison, for example, a difference video generated in the same manner as the above-described processing is used. From this difference video, a difference in luminance value between the comparison video and the reference video is acquired. For example, it is determined that the cleaning liquid remains on the surface of the sample dispensing probe 16 when there is a circular portion of the portion higher than the predetermined luminance value in the sample dispensing probe 16. The diameter of the cleaning liquid droplet falls within a predetermined range due to the wettability of the surface of the sample dispensing probe 16. Therefore, it is possible to determine that the portion having a circular shape having a high luminance value and having a diameter within a predetermined range is the remaining cleaning liquid. Further, a change in shape is acquired from the difference image in the same manner as the above-described processing. For example, in the comparative image, when a semicircle protrudes from the side surface, if the diameter of the semicircle is within a predetermined range, it can be determined that the protrusion is a droplet of the remaining cleaning liquid.

  Further, for example, the detection unit 60 detects the change in the shape of the sample dispensing probe 16 by image comparison and performs a determination process, and then detects the adhesion of the solid matter to the sample dispensing probe 16 by image comparison. May be performed. In this case, the two types of determination processing performed by the detection unit 60 may be performed by using different videos for each determination process, or may be performed based on the same video. When two types of determination processing are performed by the detection unit 60 based on the same image, an image obtained by capturing a predetermined area including the image of the sample dispensing probe 16 described above is used. For example, after detecting the change in the shape of the sample dispensing probe 16 by image comparison and performing the determination process, the detection unit 60 detects the cleaning liquid remaining on the surface of the sample dispensing probe 16 by image comparison and performs the determination process. May be performed. In this case, the two types of determination processes performed by the detection unit 60 are performed by using different videos for each determination process.

[Identifier]
The identification unit 20 acquires identification information from the information read by the reading unit 21. For example, the reading unit 21 acquires read information by reading from a label attached to the sample container 61 described later, and outputs the read information to the identification unit 20. The identification unit 20 receives the read information from the reading unit 21 and acquires a sample container ID that is sample container identification information corresponding to the sample container 61.

[Scanner]
The reading unit 21 reads the identifier and transmits the read information to the identification processing unit 22. The identifier is read without contact, for example. The reading unit 21 includes, for example, a light irradiation device (not shown). This light irradiation apparatus receives reflected light from an identifier by irradiating the identifier with infrared light or visible light. The received reflected light information is output to the identification processing unit 22. Further, the reading unit 21 includes, for example, a photographing device (not shown). This imaging device captures an identifier to obtain video information. This photographing information is transmitted to the identification processing unit 22.

  When the reading unit 21 has a configuration of a light irradiation device and a photographing device, for example, a barcode can be used as the identifier. In this case, the reading unit 21 is a bar code reader having this configuration. The barcode may be a one-dimensional barcode or a two-dimensional barcode. A bar code reader 62 a and a bar code reader 62 b described later are examples of the reading unit 21.

  The reading unit 21 is, for example, a reading device. The reading device reads the identifier information in a non-contact manner to obtain identification information. This identification information is transmitted to the identification processing unit 22. When the reading unit 21 has the configuration of a reading device, the identifier is, for example, an IC chip capable of exchanging information without contact with the reading unit 21. The IC chip transmits a carrier from the reading unit 21 and supplies power to the IC chip by electromagnetic induction. Further, communication is performed between the reading unit 21 and the IC chip by carrier modulation.

[Analysis Department]
Next, an example of the configuration of the analysis unit 24 will be described with reference to FIG. As shown in FIG. 2, the analysis unit 24 performs absorption measurement of a mixed solution of a sample and a reagent, and outputs measurement data. The measurement data is, for example, sample data. The specimen data is data obtained by measuring a mixed solution containing a sample in the above-described absorption measurement. Examples of the measurement data include preliminary measurement data such as calibration data, accuracy control data, sample blank data, and reagent blank data in addition to sample data. This absorbance measurement is performed by the photometric unit 12.

  The control unit 27 controls the driving of each unit included in the analysis unit 24 by instructing the mechanism unit 26. Each unit includes a first reagent container 1, a second reagent container 2, a reaction disk (reaction container) 4, a sample disk 5, and each arm (sample dispensing arm 17, first reagent dispensing arm 8, second reagent). A dispensing arm 9 and a stirring arm provided in the stirring unit 11).

  The analysis unit 24 includes a sample section 100, a first section 200, and a second section 300.

  Each of the sections includes a configuration movable in the vertical direction. Each of the sections is configured to be able to perform a cleaning operation. The cleaning operation means that parts constituting the automatic analyzer 10 are cleaned by a cleaning mechanism provided in the automatic analyzer 10.

  The sample section 100 includes a sample dispensing probe 16 and performs a sample dispensing operation by dispensing a sample from the sample container 61 to the reaction container 51. The sample dispensing probe 16 performs a cleaning operation by being cleaned in the cleaning tank 19a. Moreover, the camera unit 40a which image | photographs the external shape of the sample dispensing probe 16 after washing | cleaning is provided.

  The first section 200 includes a first reagent dispensing probe 14 and performs a reagent dispensing operation by dispensing the first reagent from the reagent container 6 to the reaction container 51. The first reagent dispensing probe 14 performs a cleaning operation by being cleaned in the cleaning tank 19b.

  The second section 300 includes a second reagent dispensing probe 15 and performs a reagent dispensing operation by dispensing the second reagent from the reagent container 7 to the reaction container 51. The second reagent dispensing probe 15 performs a cleaning operation by being cleaned in the cleaning tank 19c.

[Sample section]
First, the configuration of the sample section 100 will be described. The sample section 100 includes a sample disk 5, a sample container 61, a sample dispensing probe 16, a sample dispensing pump (not shown), a sample dispensing arm 17, a cleaning tank 19a, a camera unit 40a, A camera unit 40b and a camera unit 40c are provided. The sample section 100 includes a sample dispensing mechanism and an imaging mechanism. The sample dispensing mechanism includes a sample disk 5, a sample container 61, a sample dispensing probe 16, a sample dispensing pump (not shown), a sample dispensing arm 17, and a cleaning tank 19a. The photographing mechanism includes a camera unit 40a, a camera unit 40b, and a camera unit 40c.

[Sample dispensing probe]
The sample dispensing probe 16 sucks the sample from the sample container 61 conveyed to a specified sample suction position by the rotation of the sample disk 5 or the movement of the rack 63 by the rack sampler 65. The sample dispensing probe 16 moves to a specified discharge position while holding the sucked sample, and discharges the held sample into the reaction container 51 conveyed to the specified discharge position by the rotation of the reaction disk 4. .

  The sample dispensing probe 16 has an elongated shape with a flow path penetrating both ends. The lower end of both ends is an opening for sucking and discharging the sample. This opening becomes the discharge port 16a. The shape of the sample dispensing probe 16 is typically a straight cylinder shape, but may be a curved cylinder shape having a bent portion in advance. The sample dispensing probe 16 is connected to a sample dispensing pump (not shown). This sample dispensing pump is a pump mechanism for applying a pressure change to the discharge port 16a.

  A sample dispensing pump (not shown) changes the pressure in the sample dispensing probe 16 by being driven by the mechanism unit 26 or the like. As the pressure change propagates to the discharge port 16a of the sample dispensing probe 16, suction and discharge by the sample dispensing probe 16 are performed. The sample dispensing arm 17 holds the sample dispensing probe 16 so as to be movable. As the sample dispensing arm 17 is moved by driving by the mechanism unit 26, the sample dispensing probe 16 moves. Thereby, the sample dispensing probe 16 can be moved to the prescribed sample suction position and sample discharge position.

  The sample dispensing probe 16 moves up and down from the respective stop positions set in the sample container 61, the reaction container 51, and the washing tank 19a by the operation of the sample dispensing arm 17. This stop position is set in advance before the operation of the automatic analyzer 10. Examples of the stop position to be set include a stop position before suction, a sample suction position, a stop position after suction, a sample discharge position, a stop position before discharge, a stop position after discharge, a stop position before cleaning a sample dispensing probe, and a sample dispensing. Examples include the stop position after probe cleaning.

  The pre-aspiration stop position is a position where the sample dispensing probe 16 temporarily stops immediately before performing a downward movement for aspirating the sample. The pre-aspiration stop position is, for example, a position at which the sample dispensing probe 16 stops immediately before the tip of the sample dispensing probe 16 is inserted into the sample container 61 in order to suck the sample. At this time, the pre-aspiration stop position is set above the sample container 61 and at a distance from the sample container 61.

  The post-aspiration stop position is a position where the sample dispensing probe 16 first stops after sucking the sample from the sample container 61 and moving it upward. The post-aspiration stop position is, for example, a position where the sample dispensing probe 16 stops after the tip portion is exposed from the sample container 61. At this time, the stop position after suction is set to the same position as the stop position before suction.

  The pre-discharge stop position is a position where the sample dispensing probe 16 temporarily stops immediately before performing the downward movement for discharging the sample to the reaction vessel 51. The pre-discharge stop position is, for example, a position where the sample dispensing probe 16 stops immediately before the tip of the sample dispensing probe 16 is inserted into the reaction container 51 in order to discharge the sample. At this time, the pre-discharge stop position is set at a position above the reaction vessel 51 and away from the reaction vessel 51.

  The post-discharge stop position is a position where the sample dispensing probe 16 first stops after moving upward after discharging the sample into the reaction vessel 51. The post-discharge stop position is a position where the tip of the sample dispensing probe 16 stops after being exposed from the reaction vessel 51. At this time, the post-discharge stop position is set to a position similar to the pre-discharge stop position, for example.

  The stop position before cleaning the sample dispensing probe is a position where the sample dispensing probe 16 is temporarily stopped immediately before the sample dispensing probe 16 is moved downward to be cleaned in the cleaning tank 19a. The stop position before cleaning the sample dispensing probe is, for example, a position where the sample dispensing probe 16 stops immediately before the tip of the sample dispensing probe 16 is inserted into the cleaning tank 19a. At this time, the stop position before cleaning the sample dispensing probe is set above the cleaning tank 19a and away from the cleaning tank 19a.

  The stop position after cleaning the sample dispensing probe is a position where the sample dispensing probe 16 first stops after moving upward after cleaning in the cleaning tank 19a. The post-discharge stop position is, for example, a position where the sample dispensing probe 16 stops after the tip of the sample dispensing probe 16 is exposed from the reaction container 51. At this time, the post-discharge stop position is set to the same position as the pre-discharge stop position.

[Washing tank]
A cleaning liquid is accommodated in the cleaning tank 19a. The cleaning tank 19a cleans the portion including the tip of the sample dispensing probe 16 using this cleaning liquid. The cleaning liquid may be any liquid as long as it can clean the sample dispensing probe 16. The cleaning liquid is, for example, distilled water or water containing a detergent.

  The sample dispensing probe 16 is moved by driving by the mechanism unit 26, so that a portion including the tip of the sample dispensing probe 16 is accommodated in the cleaning tank 19a. Thereby, for example, the portion including the tip of the sample dispensing probe 16 is immersed in the cleaning liquid stored in the cleaning tank 19a. The cleaning tank 19a generates a flow in the cleaning liquid therein. When the flow of the cleaning liquid collides with a portion immersed in the cleaning liquid of the sample dispensing probe 16, the portion is cleaned. In addition, the tip of the sample dispensing probe 16 is inserted into a cleaning tank 19a in which no cleaning liquid is stored, and the cleaning liquid is sprayed into a portion including the tip in the cleaning tank 19a, thereby cleaning the sample dispensing probe 16. May be performed.

  An example of cleaning of the sample dispensing probe 16 by the cleaning tank 19a will be shown. When the dispensing process of the same sample by the sample dispensing probe 16 is completed, the control unit 27 controls the mechanism unit 26 to clean the sample dispensing probe 16.

  The mechanism unit 26 moves the sample dispensing arm 17 in the horizontal direction to stop the sample dispensing probe 16 at a position vertically above the cleaning tank 19a. The mechanism unit 26 further moves the sample dispensing probe 16 vertically downward, and inserts the sample dispensing probe 16 into the cleaning tank 19a. The cleaning tank 19a cleans the sample dispensing probe 16 inserted therein with a cleaning liquid or the like.

  When the cleaning of the sample dispensing probe 16 is completed, the mechanism unit 26 operates the sample dispensing probe 16 vertically upward to stop the sample dispensing probe 16 again at a position vertically above the cleaning tank 19a. The sample dispensing probe 16 stops at a position vertically above the cleaning tank 19a until the next sample container 61 is set at the sample suction position.

[Sample disc]
The automatic analyzer 10 has a sample transport mechanism. Examples of the sample transport mechanism include the sample disk 5 and the rack sampler 65 shown in FIG. The sample disk 5 holds a sample container 61. The sample container 61 accommodates a sample such as a standard sample or a test sample. The sample disk 5 includes a holding unit that holds the sample container 61 and is configured to be rotatable. By rotating the sample disk 5, each sample container 61 held on the sample disk 5 is transported to a preset position P. The position P is a sample suction position of the sample container 61 where suction is performed by the sample dispensing probe 16.

[Rack sampler]
A rack sampler 65 is disposed along the front edge of the front surface of the automatic analyzer 10. The rack sampler 65 is configured to store a plurality of racks 63 in a line on the transport path 64 so that each rack 63 can move on the transport path 64. Thereby, each rack 63 is configured to be transportable to a predetermined position. A plurality of sample containers 61 are accommodated in the rack 63. A sample (specimen) is stored in the sample container 61.

  The rack sampler 65 is configured to be able to transport one or more of the plurality of racks 63 in a horizontal direction (direction from the front edge to the center) orthogonal to the direction in which the racks are arranged. Thereby, the rack 63 is conveyed to the drawing-in part 41 shown in FIG. As a result, each sample container 61 in the rack 63 is sequentially transported to a preset position Q. The position Q is a sample suction position of the sample container 61 where suction is performed by the sample dispensing probe 16. The sample transport mechanism provided in the automatic analyzer 10 may be either the sample disk 5 or the rack sampler 65, or both.

[Sample container]
The sample is accommodated in the sample container 61. The sample container 61 is placed on at least one of the rotatable circular sample disk 5 and the rack 63 placed on the rack sampler 65. The sample disk 5 and the rack sampler 65 convey the sample container 61 containing a desired sample to the sample suction position.

  A label is attached to the sample container 61. This label includes information on the sample container ID for identifying the sample container 61. It is possible to identify from which subject the sample accommodated in the sample container 61 is collected by the sample container ID. The ID is, for example, a UID (Unique ID). For example, as shown in FIG. 5, a long label 66 printed with a barcode is attached to the sample container 61. The label 66 is pasted so that it can be read by a bar code reader or the like. This barcode includes, for example, information on the sample container ID. The label 66 is provided along the outer periphery of the side surface of the sample container 61, for example. Examples of the label include a label having a non-contact type IC in addition to the label on which the barcode is printed. A label having a non-contact type IC is read and written by an IC reader or writer.

[Barcode reader]
As shown in FIG. 2, the barcode reader 62 b is disposed so as to face the sample container 61 transported to the position P. Further, a barcode reader 62a is arranged so as to face the sample container 61 conveyed to the position Q. Hereinafter, the barcode reader 62a and the barcode reader 62b may be collectively referred to as “barcode reader”.

  The barcode reader 62a includes a reading surface 621a and a main body 622a. The reading surface 621a includes a light source (not shown), an optical sensor (not shown), and an optical system (not shown), and reads a barcode. The main body 622a identifies and outputs identification information (reading information) from the information read by the reading surface 621a. The barcode reader 62b includes a reading surface 62b1 and a main body 62b2. The barcode reader 62b is configured similarly to the barcode reader 62a. Hereinafter, the reading surface 621a and the reading surface 62b1 may be collectively referred to as a “reading surface”.

  The sample container 61 is provided with a long barcode label. The barcode is displayed on the barcode label. Here, the bar code refers to a one-dimensional symbol in which information is displayed by arranging rectangular bars and spaces in the long direction and can be read along the long direction. This barcode is an example of an identifier.

  Here, “reading along the long direction” includes the following examples. A first example is a mechanical scanning bar code reader. This bar code reader has a light source, a photodiode, and an optical system, and scans light along a long direction. Thereby, the reflected light from the barcode is read by the photodiode via the optical system. A second example is a linear CCD bar code reader. This bar code reader has a light source, a CCD sensor in which photoelectric conversion elements are arranged along a long direction, and an optical system. This bar code reader reads light by irradiating the bar code with light and projecting reflected light from the bar code on a CCD sensor via an optical system. The read information includes identification information. Examples of the identification information include identification information of the sample container 61, identification information of the sample accommodated in the sample container 61, and the like.

[Camera unit]
A camera unit 40a, which is an example of the imaging unit 40, includes a lens unit 401a and a main body unit 402a. The camera unit 40a optically captures one or both of the sample container 61 and the sample dispensing probe 16 to generate video data. The camera unit 40b and the camera unit 40c have the same configuration as the camera unit 40a. Specifically, the camera unit 40b includes a lens unit 401b and a main body unit 402b. The camera unit 40c includes a lens portion 401c and a main body portion 402c.

  The main body unit 402a includes a solid-state image sensor, generates a video signal by detecting light collected by the lens unit 401a with the image sensor, and generates video data based on the video signal. The camera unit 40a is installed at a position where a sample container 61 stopped at a predetermined sample suction position by being transported by the rack sampler 65 and a vertically upward region can be photographed at a fixed point. The camera unit 40a is, for example, fixed and installed at a position where the portion including the tip of the sample dispensing probe 16 stopped at a predetermined stop position can be photographed.

  The camera unit 40b is installed at a position where the sample container 61 stopped at a predetermined sample suction position by being conveyed by the sample disk 5 can be photographed at a fixed point. The camera unit 40c is installed at a position where a vertically upward region of the sample container 61 stopped at a predetermined sample suction position by being conveyed by the sample disk 5 can be photographed at a fixed point. The vertically upward region of the sample container 61 is, for example, a region where the sample dispensing probe 16 moves. For example, the camera unit 40c is fixed and installed at a position where a portion including the tip of the sample dispensing probe 16 stopped at a predetermined stop position can be photographed.

[Installation form of barcode reader and camera unit]
Next, an installation form of the barcode reader and the camera unit will be described. First, the installation form and positional relationship between the two at the position Q of the sample section 100 will be described.

(Installation form at position Q)
FIG. 4 is an enlarged perspective view of the vicinity of the position Q in the automatic analyzer 10. FIG. 5 is a vertical sectional view taken along line AA ′ shown in FIG. FIG. 6 is a perspective view showing the positional relationship among the barcode reader 62a, the photographing target of the camera unit 40a, and the camera unit 40a. FIG. 7 is a top view showing the positional relationship among the barcode reader 62a, the photographing target of the camera unit 40a, and the camera unit 40a. FIG. 8 is a top view of the sample container 61.

  As shown in FIG. 4, the sample container 61 placed on the rack 63 is stopped at the position Q. The position Q is a predetermined position in the retracting portion 41. The position Q is a sample suction position where the sample container 61 stops in order to suck the stored sample by the sample dispensing probe 16. The vertical line of the position Q includes, for example, a stop position before suction, a sample suction position, and a stop position after suction. The barcode reader 62a is provided so that the reading surface 621a faces the front surface (the surface on which the barcode label is affixed) of the sample container 61 transported to the position Q. In addition, the pull-in portion 41 has a first window portion 41 a provided so as to be able to read the label 66 attached to the sample container 61. As shown in FIG. 5, the first window portion 41 a is an opening provided in a part of the side surface of the retracting portion 41. The sample container 61 is placed on the rack 63 so that the side surface of the rack 63 facing the first window portion 41a faces the center of the label 66. As a result, the label 66 affixed to the sample container 61 is exposed from the first window 41a which is an opening. The exposed label 66 is opposed to the scanning direction of the barcode reader 62a.

  The camera unit 40a is provided on the opposite side of the barcode reader 62a with the sample container 61 stopped at the position Q interposed therebetween. The camera unit 40a is provided so that the sample container 61 can be photographed. The camera unit 40a is provided so that the sample dispensing probe 16 stopped at the pre-aspiration stop position at the position Q can be photographed. At this time, the tip of the sample dispensing probe 16 is opposed to the opening of the sample container 61 stopped at the position Q at a predetermined distance. In addition, the pull-in portion 41 has a second window portion 41 b provided so that the sample stored in the sample container 61 can be photographed. As shown in FIG. 5, the second window portion 41 b is an opening provided in a part of the side surface of the retracting portion 41. The sample container 61 is exposed from the first window 41a which is an opening.

  As shown in FIG. 8, the sample container 61 is provided with a label 66 so as to wrap around the outer periphery of the side surface. That is, the label 66 is attached so as to be wound around the outer periphery of the side surface of the sample container 61. The side end portion 66a and the side end portion 66b of the label 66 attached to the sample container 61 are separated from each other by a predetermined distance. That is, the sample container 61 has a region that is not covered with the label 66 on the outer periphery of the side surface to which the label 66 is attached. This region includes a range where the side surface is exposed in the outer periphery from the top to the bottom of the sample container 61. Since the side surface of the sample container 61 is exposed from the top to the bottom of the sample container 61, the area where the sample accommodated in the sample container 61 is hidden by the label 66 is small. Therefore, by setting this area as an imaging area by the camera unit 40a, it is possible to easily check the sample accommodated in the sample container 61 even when the label 66 is attached. The imaging range shown in FIG. 8 is a two-dimensional range when this imaging region is viewed from above.

  As shown in FIGS. 4 to 8, the camera unit 40 a is provided so that the shooting direction faces, for example, the scanning direction of the barcode reader 62 a. Further, the camera unit 40 a is provided, for example, such that the lens unit 401 a and the reading surface 621 a face each other with the sample container 61 interposed therebetween. At this time, the sample container 61 is placed on the rack 63 so that the side surface of the rack 63 facing the first window portion 41a faces the center of the label 66. With this arrangement, the sample container 61 is placed on the rack 63 so that the side surface of the rack 63 facing the second window portion 41b faces the center of the imaging range. Thereby, the imaging region set on the side surface of the sample container 61 is exposed from the second window 41b. As a result, when the sample container 61 stops at the position Q, the bar code reader 62a reads the barcode on the label 66, and the imaging set on the side surface of the sample container 61 and the side surface of the sample dispensing probe 16 is performed. The area can be photographed by the camera unit 40a. In this embodiment, an example of photographing the side portion of the sample container 61 will be described. However, at least the side portion of the sample dispensing probe 16 may be photographed. Therefore, it is good also as a structure which does not include the sample container 61 in the imaging | photography area | region of the camera unit 40a among the structures shown in FIGS. The form in which the side portion of the sample container 61 is photographed can be used as appropriate in the second embodiment to be described later.

  The conveyance of the sample container 61 to the position Q is performed as follows, for example. First, a mechanism (not shown) of the rack sampler 65 is driven by the mechanism unit 26, whereby the rack 63 is pulled into the pull-in unit 41. The pulled-in rack 63 stops at a predetermined position. As a result, as shown in FIGS. 4 to 7, the reading surface 621a faces the front surface (the surface on which the barcode label is attached) of the sample container 61 conveyed to the sample suction position, and the lens surface of the lens unit 401a. Is opposed to the back surface (surface having the imaging region) of the sample container 61 conveyed to a predetermined position.

  In the vertical direction, the barcode reader 62a may be provided at any position as long as the barcode provided in the sample container 61 can be read. Further, the barcode reader 62a may be configured to be movable in the vertical direction. Further, in the vertical direction, the camera unit 40a may be provided at any position as long as it can shoot a preset shooting target. The imaging target is one or both of the sample container 61 and the sample dispensing probe 16. Further, the camera unit 40a may be configured to be movable in the vertical direction in order to change the photographing target.

(Installation form at position P)
FIG. 9 is a side view of the vicinity of the position P of the automatic analyzer 10 as viewed from the side. As shown in FIG. 9, a camera unit 40b and a barcode reader 62b for photographing the sample container 61 are provided so as to sandwich the sample container 61. The sample container 61 is placed on the sample disk 5 and stopped at the position P. The position P is a predetermined position where the sample disk 5 is conveyed by rotating.

  The barcode reader 62b is provided so that the reading surface 621a faces the front surface (the surface on which the barcode label is affixed) of the sample container 61 conveyed to the position P. A camera unit 40c for photographing the sample dispensing probe 16 is provided above the barcode reader 62b. The camera unit 40c is provided so that the sample dispensing probe 16 stopped at the pre-aspiration stop position at the position P can be photographed. Further, the camera unit 40c may be configured not to be provided above the barcode reader 62b as long as the sample dispensing probe 16 is photographed. For example, as shown in FIG. 2, a form in which the barcode reader 62b and the camera unit 40c are separated from each other can be used.

  The camera unit 40b is provided on the opposite side of the barcode reader 62b with the sample container 61 stopped at the position P interposed therebetween. The camera unit 40 b is a camera for photographing the side portion of the sample container 61. The label 66 is provided such that its center faces the radially outer side of the sample disk 5. At this time, the center of the imaging region is directed inward in the radial direction of the sample disk 5. At this time, the positional relationship among the barcode reader 62b, the sample container 61, and the camera unit 40c can be appropriately used as described above as the positional relationship between the barcode reader 62a, the sample container 61, and the camera unit 40a. As a result, when the sample container 61 stops at the position P, it is possible to photograph the imaging region set on the side surface of the sample container 61 with the camera unit 40c while reading the barcode on the label 66 with the barcode reader 62b. In this embodiment, it is only necessary to photograph at least the side portion of the sample dispensing probe 16. Therefore, in the configuration illustrated in FIG. 9, the camera unit 40 c that is a camera for photographing the side portion of the sample container 61 may not be provided. The configuration in which the camera unit 40c is provided can be used as appropriate in the second embodiment to be described later.

[First section]
The first section 200 includes a first reagent container 1, a reagent container 6, a first reagent dispensing probe 14, a first reagent dispensing pump (not shown), a first reagent dispensing arm 8, and a washing. And a tank 19b.

[First reagent storage]
The first reagent storage 1 includes a reagent rack 1a. The reagent rack 1a rotatably holds the reagent container 6 stored in the first reagent storage 1. The reagent container 6 accommodates a 1-reagent system containing a component that reacts with a test item component included in the sample, and a 2-reagent-system first reagent.

[First reagent dispensing probe]
The first reagent dispensing probe 14 aspirates the first reagent accommodated in the reagent container 6 and discharges it into the reaction container 51. The first reagent dispensing probe 14 has an elongated shape with a flow path penetrating both ends. The lower end of both ends is an opening for discharging the reagent. The shape of the first reagent dispensing probe 14 is, for example, a cylindrical shape. The first reagent dispensing pump changes the pressure in the first reagent dispensing probe 14. By this pressure change, suction and discharge by the first reagent dispensing probe 14 are performed. The first reagent dispensing arm 8 holds the first reagent dispensing probe 14 so as to be movable. The suction and discharge of the first reagent are performed at a preset reagent suction position and a reagent discharge position. As the first reagent dispensing arm 8 operates, the first reagent dispensing probe 14 moves to the reagent aspirating position or the reagent discharging position.

[Washing tank]
A cleaning liquid is accommodated in the cleaning tank 19b. The cleaning tank 19b cleans the portion including the tip of the first reagent dispensing probe 14 using this cleaning liquid. The cleaning tank 19b can be configured similarly to the cleaning tank 19a by replacing the sample dispensing probe 16 with the first reagent dispensing probe 14, for example. Further, by this replacement, what has been described in the cleaning tank 19a can be applied to the cleaning tank 19b.

[Second section]
The second section 300 includes a second reagent storage 2, a reagent container 7, a second reagent dispensing probe 15, a second reagent dispensing pump (not shown), a second reagent dispensing arm 9, and a washing A tank 19c.

[Second reagent storage]
The second reagent storage 2 includes a reagent rack 2a. The reagent rack 2a rotatably holds the reagent container 7 stored in the second reagent storage 2. The reagent container 7 accommodates a first reagent system containing a component that reacts with a test item component contained in the sample, and a second reagent system second reagent.

[Second reagent dispensing probe]
The second reagent dispensing probe 15 sucks the second reagent accommodated in the reagent container 7 and discharges it into the reaction container 51. The second reagent dispensing probe 15 has the same configuration as the first reagent dispensing probe 14, for example. In addition, what has been described for the first reagent dispensing probe 14 can be applied to the second reagent dispensing probe 15. The second reagent dispensing pump changes the pressure in the second reagent dispensing probe 15. By this pressure change, suction and discharge by the second reagent dispensing probe 15 are performed. The second reagent dispensing arm 9 holds the second reagent dispensing probe 15 so as to be movable. The second reagent is aspirated and discharged at a preset reagent aspirating position and a reagent discharging position. As the second reagent dispensing arm 9 operates, the second reagent dispensing probe 15 moves to the reagent aspirating position or the reagent discharging position.

[Washing tank]
A cleaning liquid is accommodated in the cleaning tank 19c. The cleaning tank 19c cleans the portion including the tip of the second reagent dispensing probe 15 using this cleaning liquid. The cleaning tank 19c can be configured similarly to the cleaning tank 19a, for example, by replacing the sample dispensing probe 16 with the second reagent dispensing probe 15. In addition, by this replacement, what has been described in the cleaning tank 19a can be applied to the cleaning tank 19c.

[Agitator unit]
The agitation unit 11 is an agitation unit that agitates the mixed solution of the specimen and the reagent (first reagent, second reagent) in the reaction vessel 51 stopped at the agitation position for each cycle.

[Washing unit]
The cleaning unit 13 aspirates the mixed liquid that has been measured in the reaction container 51 stopped at the cleaning / drying position, and cleans / drys the reaction container 51.

[Metering unit]
The photometric unit 12 is a measuring unit that measures the mixed liquid at the photometric position. The photometric unit 12 measures the absorbance of the mixed solution and then outputs the measurement data to the data processing unit 30. The data processing unit 30 obtains the concentration of the mixed solution from the absorbance based on the calibration curve. Thereby, it becomes possible to measure the component of a liquid mixture.

[Analysis control section]
The analysis control unit 25 includes a mechanism unit 26 and a control unit 27. The analysis control unit 25 controls each mechanism of the sample section 100, the first section 200, and the second section 300 via the control unit 27 and the mechanism unit 26.

(Mechanism part)
The mechanism unit 26 includes a motor, a gear, and the like, and drives each analysis unit of the analysis unit 24. The mechanism unit 26 includes, for example, a mechanism for rotating the sample disk 5, the reagent rack 1a, and the reagent rack 2a, and a mechanism for rotating the reaction disk 4.

  In addition, the mechanism unit 26 rotates and vertically moves a stirring arm (not shown) provided in the sample dispensing arm 17, the first reagent dispensing arm 8, the second reagent dispensing arm 9, and the stirring unit 11. It has a mechanism.

  Further, the mechanism unit 26 includes, for example, a mechanism for sucking and discharging a sample dispensing pump, a first reagent dispensing pump, and a second reagent dispensing pump (all not shown). . The mechanism unit 26 further includes a mechanism for moving the cleaning unit 13 up and down.

(Control part)
The control unit 27 includes a control circuit that controls driving of each analysis unit by the mechanism unit 26. The control unit 27 moves the dispensing probe provided in each section by controlling the mechanism of the arm provided in each section. The control unit 27 is provided with a control circuit. This control circuit includes a control program.

[Operation of automatic analyzer]
Next, operation | movement of the automatic analyzer 10 in this embodiment is demonstrated. In the automatic analyzer 10 of this embodiment, the sample dispensing probe 16 is photographed by the photographing unit 40 at the sample dispensing position to obtain a comparative image. This comparison image is compared with a reference image indicating the normal state of the sample dispensing probe 16, and an abnormality of the sample dispensing probe 16 is detected when a predetermined condition is satisfied. This abnormality is detected, for example, as a sample dispensing suspected abnormality. The suspected abnormality in sample dispensing means that, for example, the amount of sample dispensed by the sample dispensing probe 16 does not satisfy a prescribed dispensing amount.

  FIG. 10 is a flowchart showing an example of the operation of the automatic analyzer 10 of this embodiment. FIG. 10 shows the flow of control and operation in the sample section 100 of the automatic analyzer 10 of this embodiment. This flowchart shows the flow of processing for determining the shape change of the sample dispensing probe 16 when the sample container 61 is transported to the position Q by the rack sampler 65.

  The sample dispensing arm 17 has a rotation mechanism and a vertical movement mechanism. The control circuit of the sample dispensing arm 17 rotates the sample dispensing arm 17 in the horizontal direction by controlling the rotation mechanism. The control circuit of the sample dispensing arm 17 moves the sample dispensing arm 17 up and down in the vertical direction by controlling the vertical movement mechanism of the sample dispensing arm 17.

  The sample dispensing probe 16 is stopped at a preset standby position before the analysis unit 24 operates. An example of the position of the standby position in the vertical direction is the position of the top dead center. The position of the top dead center is the highest position among the positions where the first reagent dispensing probe 14 moves.

  The automatic analyzer 10 starts measurement preparation (step S001). In this measurement preparation, a reference image of the sample dispensing probe 16 is acquired (step S002). Specifically, each control circuit provided in the control unit 27 controls the rotation mechanism or the like of the sample dispensing arm 17 to horizontally move the sample dispensing probe 16 and stop it above the position Q. This stop position corresponds to the stop position after suction. The post-aspiration stop position is a position where the sample dispensing probe 16 stops before moving to the next step (sample discharge step) after sucking the sample accommodated in the sample container 61. When the sample dispensing probe 16 stops at the stop position after aspiration, the camera unit 40a acquires a reference image by photographing the sample dispensing probe 16. The reference image includes at least an image of the side portion of the sample dispensing probe 16, and this image includes at least an image of the distal end portion of the sample dispensing probe 16. The position of the tip of the sample dispensing probe 16 stopped at the stop position after aspiration is, for example, a position facing the tip of the reagent container 6 with a predetermined distance in the vertical direction. In addition, when it is desired to detect the attachment of solid matter to the tip of the sample dispensing probe 16, the reference image includes an image of the tip of the sample dispensing probe and includes a predetermined area extending below the tip. This reference image is acquired when the camera unit 40a captures an area between the tip of the sample dispensing probe 16 and the sample container 61 together with the tip of the sample dispensing probe 16. The acquired reference video is stored in the storage unit 50.

  After acquiring the reference video, the operator starts the operation of the automatic analyzer 10 (step S003). Each control circuit provided in the control unit 27 controls the rotation mechanism of the sample dispensing arm 17 to move the rack 63 to the rack sampler 65. Thereby, the desired sample container 61 is transported to the position Q which is the sample suction position (step S004). Next, each control circuit provided in the control unit 27 controls the rotation mechanism and the vertical movement mechanism of the sample dispensing arm 17 to insert the tip of the sample dispensing probe 16 into the sample container 61. . Each control circuit provided in the control unit 27 controls the sample dispensing pump to generate a negative pressure at the discharge port 16a of the sample dispensing probe 16, and sucks the sample into the sample dispensing probe 16 (step S005). ). When the suction of the sample is completed, each control circuit provided in the control unit 27 controls the vertical movement mechanism of the sample dispensing arm 17 to move the sample dispensing probe 16 upward, and after sucking the sample dispensing probe Stop at the stop position (step S006). When the sample dispensing probe 16 stops at the post-aspiration stop position after the sample is aspirated, the camera unit 40a acquires a comparison image by photographing the sample dispensing probe 16 (step S007). Similar to the reference image, the comparative image includes an image of the side portion of the sample dispensing probe 16, and this image includes at least an image of the tip portion of the sample dispensing probe 16. The reference video is a fixed-point image taken at the same position as the comparative video. The acquired comparison video is output to the detection unit 60.

  The detection unit 60 receives the comparison video and acquires a reference video from the storage unit 50. The detection unit 60 compares the image of the sample dispensing probe 16 shown in the reference image with the image of the sample dispensing probe 16 shown in the comparison image (step S008). When the comparison result satisfies a predetermined condition (step S009), the detection unit 60 detects that there is a suspicion of abnormality in the sample dispensing by the sample dispensing probe 16 (step S010). This determination is performed, for example, by using the above-described difference video. In this case, the detection unit 60 generates a difference video between the comparison video and the reference video by pattern matching or the like. The detection unit 60 analyzes the difference video. In this analysis process, for example, the area of the shape difference between the sample dispensing probe 16 before sample suction and the sample dispensing probe after sample suction is measured. The detection unit 60 determines that the sample dispensing probe 16 has an abnormality when the shape difference is larger than a predetermined area. That is, the detection unit 60 determines that the sample dispensing probe 16 has a shape change such as bending or crushing when the shape difference is larger than a predetermined area. Further, the detection unit 60 receives this determination result and detects that there is a suspicion of abnormality in the sample dispensing by the sample dispensing probe 16. In this case, the determination of the type of shape change such as bending or crushing can be made from the position where the shape difference occurs and the shape difference shape. Further, in this difference video, when the shape difference in the region between the tip of the sample dispensing probe 16 and the sample container 61 is larger than a predetermined area, the detection unit 60 attaches solid matter to the sample dispensing probe 16. It is determined that This solid is, for example, fibrin contained in the sample. Further, the detection unit 60 receives this determination result and detects that there is a suspicion of abnormality in the sample dispensing by the sample dispensing probe 16.

  The detection unit 60 outputs a detection result that the sample dispensing by the sample dispensing probe 16 is suspected of being abnormal to the notification unit 93. In response to the detection result, the notification unit 93 notifies the outside that the sample dispensing by the sample dispensing probe 16 is suspected of being abnormal, thereby outputting the notification to the outside (step S011).

  The detection unit 60 can also temporarily store a detection result that there is a suspicion of abnormality in sample dispensing by the sample dispensing probe 16 in the storage unit 50 or the like. Thereby, when there is an abnormality in the measurement result by the photometry unit 12, the dispensing abnormality by the sample dispensing probe 16 can be actively examined for the cause. That is, when an abnormality of the sample dispensing probe 16 is detected in the detection unit 60, the calculation unit (not shown) provided in the detection unit 60 replaces the sample dispensing probe 16 based on the degree of deformation of the sample dispensing probe 16. Calculate the degree of necessity. The degree of necessity of exchanging the sample dispensing probe 16 calculated in the detection unit 60 is displayed on the display screen together with detection of an abnormality, for example. As a specific example, the detection unit 60 determines the deformation position and the degree of deformation of the sample dispensing probe 16 from the image of the shape difference of the sample dispensing probe 16 included in the difference video. Upon receiving this determination result, the detection unit 60 detects the replacement time of the sample dispensing probe 16. The detection result of the replacement time of the sample dispensing probe 16 is output to the display unit 91, and the replacement time of the sample dispensing probe 16 is displayed on the display screen. This display may be performed independently or may be performed together with the above notification.

  The automatic analyzer 10 externally outputs a detection result that the sample dispensing is suspected of being abnormal, and then performs a normal measurement operation to acquire the absorbance measurement result from the photometry unit 12 (step S012). The acquired measurement result of absorbance is appropriately output, and the automatic analyzer 10 ends the measurement operation. In addition, the detection unit 60 can output a detection result that the sample dispensing by the sample dispensing probe 16 is suspected of being abnormal to the system control unit 70. For example, the system control unit 70 can stop the operation of the automatic analyzer 10 based on the detection result. Further, the system control unit 70 can receive the detection result and control the automatic analyzer 10 as shown in the following example, for example.

  The system control unit 70 receives the detection result that the sample dispensing by the sample dispensing probe 16 is suspected of being abnormal, and changes the control content of the automatic analyzer 10 set in advance. The contents of this control are stored in the storage unit 50, for example. The change in the content of this control is performed when the detection unit 60 determines that there is no abnormality in the sample dispensing probe 16 and the sample sucked into the sample dispensing probe 16 is abnormal. As a case where there is an abnormality in the sample sucked by the sample dispensing probe 16, for example, a case where it is determined that the sucked sample contains a solid substance can be cited.

  For example, when it is detected that there is a suspicion of abnormality in the sample dispensing by the sample dispensing probe 16, the change of the control by the system control unit 70 is performed by the photometric unit 12 using a liquid mixture containing a sample corresponding to the detection result. Excluding it from the measurement target. The system control unit 70 controls the photometry unit 12 to measure the absorbance of the mixed solution. The order of the mixed solution for performing the absorbance measurement is set in advance, and is sequentially performed based on this order. This setting information is stored in the storage unit 50, for example. When the detection unit 60 detects that there is a suspicion of sample dispensing abnormality, the system control unit 70 performs control so as to skip the measurement of the liquid mixture containing the sample corresponding to the detection result. For example, the reaction container 51 into which the sample corresponding to this detection is dispensed is labeled. The system control unit 70 controls the photometric unit 12 so that absorbance measurement is not performed on the reaction container 51 that has been labeled.

  For example, when it is detected that there is a suspicion of abnormality in the sample dispensing by the sample dispensing probe 16, the change in the control by the system control unit 70 is again aspirated by the sample dispensing probe 16. Can be mentioned. Specifically, the system control unit 70 that has received the detection result that there is a suspicion of abnormality in the detection unit 60 changes the content of the preset control based on the detection result of the suspicion of abnormality, and the changed control Is output to the control unit 27. In response to the control change instruction, the control unit 27 controls the sample dispensing arm 17 so that the tip of the sample dispensing probe 16 is positioned in the cleaning tank 19a. Further, the control unit 27 controls the sample dispensing pump to discharge the sample (abnormal sample) held by the sample dispensing probe 16 into the cleaning tank 19a. Thereby, the abnormal sample is discarded in the cleaning tank 19a. The control unit 27 cleans the sample dispensing probe 16 by controlling the cleaning tank 19a. When the cleaning of the sample dispensing probe 16 is completed, the control unit 27 controls the sample dispensing arm 17 and the like so that the sample in the sample container 61 in which the abnormal sample is accommodated is again sucked by the sample dispensing probe 16. To do.

  FIG. 11 is a flowchart showing another example of the operation of the automatic analyzer 10 of this embodiment. FIG. 11 shows the flow of control and operation in the sample section 100 of the automatic analyzer 10 of this embodiment. In this flowchart, a case will be described in which when the sample container 61 is transported to the position Q by the rack sampler 65, a change in the shape of the sample dispensing probe 16 before and after sample suction is detected.

  The operator starts the operation of the automatic analyzer 10 (step S020). Each control circuit provided in the control unit 27 controls the rotation mechanism of the sample dispensing arm 17 to move the rack 63 to the rack sampler 65. As a result, the desired sample container 61 is transported to the position Q that is the sample suction position (step S021). Next, each control circuit provided in the control unit 27 controls the rotation mechanism and the vertical movement mechanism of the sample dispensing arm 17 to stop the sample dispensing probe 16 at the pre-aspiration stop position (step). S022). The pre-aspiration stop position is a position vertically above the sample container 61 transported to the position Q in step S021. When the sample dispensing probe 16 stops at the pre-aspiration stop position, the camera unit 40a acquires a reference image by photographing the sample dispensing probe 16 (step S023). The camera unit 40a outputs the acquired reference video to the storage unit 50.

  The subsequent processes can be performed in the same manner as steps S005 to S012 of the process shown in FIG. 10 (steps S024 to S031). Specifically, the sample dispensing probe 16 stopped at the post-aspiration stop position after the sample is aspirated is photographed by the camera unit 40a to obtain a comparative image.

  The detection unit 60 compares the comparison video with the acquired reference video, and if the comparison result satisfies a predetermined condition, the detection unit 60 indicates that there is a suspicion that the sample dispensing by the sample dispensing probe 16 is abnormal. Detect. A detection result that the sample dispensing detected by the detection unit 60 is suspected of being abnormal is output to the outside. For example, the system control unit that has received the detection result that there is a suspicion of abnormality in sample dispensing controls the automatic analyzer 10 based on the detection result.

  FIG. 12 is a flowchart showing still another example of the operation of the automatic analyzer 10 of this embodiment. FIG. 12 shows the flow of control and operation in the sample section 100 of the automatic analyzer 10 of this embodiment. In this flowchart, a case where the surface state of the sample dispensing probe 16 that has been cleaned in the cleaning tank 19a and stopped at the pre-aspiration stop position when the sample container 61 is transported to the position Q by the rack sampler 65 will be described.

  First, as in steps S001 to S003 of the process shown in FIG. 10, the normal sample dispensing probe 16 is photographed to obtain a reference video, and this reference video is stored in the storage unit 50. Thereafter, the measurement operation of the automatic analyzer 10 is started. (Steps S040 to S042) Each control circuit provided in the control unit 27 controls the rotation mechanism and the vertical movement mechanism of the sample dispensing arm 17 to clean the sample dispensing probe 16 in the cleaning tank 19a. Stop in position. Each control circuit provided in the control unit 27 controls the cleaning tank 19a to clean at least the side surface portion including the tip of the sample dispensing probe 16 (step S043). Each control circuit provided in the control unit 27 controls the rotation mechanism of the sample dispensing arm 17 to move the rack 63 to the rack sampler 65. Thereby, the desired sample container 61 is transported to the position Q which is the sample suction position (step S044). Next, each control circuit provided in the control unit 27 controls the rotation mechanism and the vertical movement mechanism of the sample dispensing arm 17 to stop the sample dispensing probe 16 at the pre-aspiration stop position (step). S045). When the sample dispensing probe 16 stops at the pre-aspiration stop position, the camera unit 40a acquires a reference image by photographing the sample dispensing probe 16 (step S046). The camera unit 40a outputs the acquired comparison video to the detection unit 60.

  The detection unit 60 receives the comparison video and acquires a reference video from the storage unit 50. The detection unit 60 compares the image of the sample dispensing probe 16 shown in the reference image with the image of the sample dispensing probe 16 shown in the comparison image (step S047). When the comparison result satisfies a predetermined condition (step S048), the detection unit 60 detects that there is a suspicion of abnormality in the dispensing by the sample dispensing probe 16 (step S049). In this case, the detection unit 60 performs the above-described processing as means for detecting the cleaning liquid remaining on the surface of the sample dispensing probe 16 as a predetermined condition, so that the cleaning liquid remains on the surface of the sample dispensing probe 16. Can be detected. That is, the detection unit 60 detects the detection of the cleaning liquid remaining on the surface of the sample dispensing probe 16 as a suspicion of abnormality in the dispensing by the sample dispensing probe 16.

  Subsequent processing is performed in the same manner as steps S011 to S012 of the processing shown in FIG. Specifically, the detection result that the sample dispensing detected by the detection unit 60 is suspected of being abnormal is output to the outside, and the system control unit 70 detects that the sample dispensing is suspected of being abnormal, for example. In response to the result, the suspicion of abnormality is notified to the outside (steps S050 to S051).

  Further, at least two of the processes shown in FIGS. 10 to 12 can be combined and processed. For example, by combining the process shown in FIG. 10 and the process shown in FIG. 11, the shape change between the sample dispensing probe 16 that is normal and the sample dispensing probe 16 during the measurement operation, and the sample dispensing. It is possible to simultaneously know the shape change of the probe 16 before and after sample dispensing. For example, even if there is no change in the shape of the sample dispensing probe 16 before and after sample dispensing, if there is a difference in shape with the sample dispensing probe 16 that is normal, measurement other than sample aspiration It can be seen that the deformation occurred in the operation, for example, the sample discharge. Thereby, the timing when the sample dispensing probe 16 is deformed can be known. For example, if it is determined that the sample dispensing probe 16 has been deformed during sample discharge from the timing at which the deformation has occurred, the sample discharge position may be lower than the bottom of the reaction vessel 51. From this, the sample discharge position in the reaction container 51 can be adjusted based on the timing at which the deformation occurs.

[Operation and effect of automatic analyzer]
The automatic analyzer 10 of this embodiment is configured to detect at least an abnormality of the sample dispensing probe 16 during the measurement operation by storing the normal state of the sample dispensing probe 16 in advance. The imaging unit 40 provided in the automatic analyzer 10 captures the sample dispensing probe 16 showing a normal shape and acquires a reference image. Furthermore, the imaging unit 40 captures the sample dispensing probe 16 during the measurement operation and acquires a comparison video corresponding to the reference video. The reference video is acquired before the comparison video. The detection unit 60 compares the reference image and the comparison image, and determines that the sample dispensing probe 16 is abnormal when the difference exceeds a predetermined amount. Thereby, the plastic deformation of the sample dispensing probe 16 can be detected.

  The automatic analyzer 10 can also photograph the space between the sample dispensing probe 16 and the bottom of the sample container 61. The imaging unit 40 provided in the automatic analyzer 10 captures a normal state in this space and uses it as a reference image. The normal state in this space is a state where there is no deposit on the tip of the sample dispensing probe 16. In addition, the imaging unit 40 acquires a comparative image by imaging the sample dispensing probe 16 during the measurement operation. The detection unit 60 compares the acquired comparison video with the reference video, and detects that a large solid matter is attached to the tip of the sample dispensing probe 16. At this time, a case where a large solid matter such as fibrin adheres to the tip of the sample dispensing probe 16 can be detected as a sample abnormality.

  The automatic analyzer 10 captures the normal sample dispensing probe 16 and acquires a reference image before the comparison image is acquired. Further, the imaging unit 40 captures the sample dispensing probe 16 stopped at the post-aspiration stop position after the sample aspiration operation, and acquires a comparative image. The detection unit 60 detects the abnormality of the sample dispensing probe 16 by comparing the comparison video with the reference video at the time when the comparison video is acquired. The sample dispensed by the sample dispensing probe 16 having an abnormality is suspected of causing a dispensing abnormality such that the dispensing amount does not reach the prescribed dispensing amount. Therefore, in this case, the detection unit 60 outputs an abnormality of the sample dispensing probe 16, a sample abnormality, or the like as a detection result that the sample dispensing is suspected of being abnormal. The detection result that the sample dispensing is suspected of being abnormal is output to the outside together with information on the type of abnormality.

  As described above, the automatic analyzer 10 detects that the sample dispensing is suspected of being abnormal at the time of sample dispensing. Therefore, an abnormality in the result of the absorption measurement of the liquid mixture containing the sample corresponding to the sample dispensing can be predicted at an early stage of the measurement operation in the automatic analyzer 10. Moreover, the detection result that there is a suspicion of abnormality in sample dispensing is stored in the storage unit 50 or the like as a log for each sample, for example. Thereby, when abnormality is recognized in the result of the absorption measurement of a liquid mixture, it can recognize that the possibility of sample dispensing is the cause.

  When it is detected that there is a suspicion of abnormality in sample dispensing at the time of sample dispensing, the automatic analyzer 10 can be controlled to change the handling of the sample corresponding to this sample dispensing. This control includes, for example, control for stopping the measurement operation of the automatic analyzer 10 when it is detected that the sample dispensing is suspected of being abnormal. In addition, when the type of abnormality is sample abnormality, for example, control for skipping absorption measurement of a mixed solution containing an abnormal sample can be given. As a result, it is not necessary to perform a measurement that is predicted to cause an abnormality in the measurement result of the absorption measurement, and the measurement waste can be reduced. Moreover, the control which discards the abnormal sample hold | maintained in the sample dispensing probe 16, and attracts the same sample again is mentioned. Thereby, it is possible to redo the measurement operation in which the measurement result of the absorption measurement becomes abnormal at an early stage of the sample dispensing stage.

  In an automatic analyzer, an abnormality in absorbance measurement due to dispensing is often due to sample dispensing. The first reason is that the sample dispensing probe 16 is plastically deformed. This plastic deformation occurs, for example, when the sample held in the sample dispensing probe 16 is discharged while pressing the tip of the sample against the bottom of the reaction vessel 51. In addition, when a sample is dispensed by the plastically deformed sample dispensing probe 16, for example, a sample dispensing abnormality such as the inability to dispense a sample with a specified dispensing amount occurs. Secondly, the reason is that the sample handled by the sample dispensing probe 16 has a larger amount of solid matter mixed than the reagent handled by the reagent dispensing probe. In this case, the sample dispensing probe 16 may handle a sample containing a large solid material that is not sufficiently purified such as a measurement pretreatment. Here, the large solid material refers to a solid material having a size such that the discharge port 16a of the sample dispensing probe 16 is clogged. When a sample containing a large solid is dispensed by the sample dispensing probe 16, for example, the large solid is clogged in the discharge port 16 a of the sample dispensing probe 16. When sample dispensing is performed with the sample dispensing probe 16 in which a large solid matter is clogged in the discharge port 16a, sample dispensing abnormality such as the inability to dispense a sample with a specified dispensing amount occurs. The third reason is that, when the sample dispensing probe 16 is washed in the washing tank 19a, the washing liquid remains on the surface of the sample dispensing probe 16 after the washing. When sample dispensing is performed with the sample dispensing probe 16 with the cleaning liquid remaining on the surface, sample dispensing abnormality occurs due to dilution, alteration, and the like of the sample with the cleaning liquid.

  On the other hand, according to the automatic analyzer of this embodiment, as described above, deformation of the sample dispensing probe 16, suction of large solids by the sample dispensing probe 16, adhesion of cleaning liquid on the surface of the sample dispensing probe 16, etc. Can be detected. Thereby, the abnormality of the absorption measurement result resulting from sample dispensing by the sample dispensing probe 16 can be reduced. Thus, the reliability of measurement can be maintained high by maintaining the sample dispensing performance high.

<Second Embodiment>
Next, the automatic analyzer 10 according to the second embodiment will be described.

[Automatic analyzer]
The configuration of the automatic analyzer 10 will be described with reference to FIG. FIG. 13 is a block diagram showing a functional configuration of the automatic analyzer 10 of this embodiment. The configuration of the automatic analyzer 10 is the same as that of the automatic analyzer 10 of the first embodiment except that the subject to be imaged is the sample container 61 and the sample accommodated in the sample container 61.

  In this embodiment, the comparison image stored in the storage unit 50 includes at least an image of the sample container 61 in which a normal sample is accommodated. Examples of normal samples include those that do not contain large solids such as fibrin. Examples of normal samples include those in which fine solids and liquid portions are sufficiently separated. When this sample is stored in the sample container 61, a fine solid is precipitated at the bottom of the sample container 61. Therefore, the light transmittance in the liquid portion becomes larger than a predetermined value. An example of a normal sample is a sample having a predetermined range of suspendability. This sample has a value in a predetermined range as light transmittance.

  At the position Q, the camera unit 40a is installed at a position where at least a part of the side portion of the sample container 61 can be photographed in the same manner as the configuration shown in FIG. The camera unit 40a is preferably installed at a position on the side portion of the sample container 61 where a whole image of the stored sample can be taken. In this embodiment, since the camera unit 40a only needs to photograph at least the sample container 61, the imaging region of the camera unit 40a may not include the sample dispensing probe.

  At the position P, the camera unit 40c is installed at a position where the side portion of the sample container 61 can be photographed in the same manner as the configuration shown in FIG. Moreover, the camera unit 40c may be installed in the side part of the sample container 61 in the position which can image | photograph the whole image of the accommodated sample. In this embodiment, at least the side part of the sample container 61 may be photographed. Therefore, in the configuration shown in FIG. 9, the camera unit 40 b that is a camera for photographing the side portion of the sample dispensing probe 16 may be omitted.

  Further, in order to measure the degree of suspension and the liquid level of the sample stored in the sample container 61, the light irradiation unit 140 may be provided at a position facing the camera unit 40a with the sample container 61 to be photographed in between.

  14 is a vertical sectional view showing the vicinity of the position Q in the automatic analyzer 10 in the same manner as FIG. As shown in FIG. 14, the light irradiation unit 140 is provided at the position where the barcode reader 62a is provided in FIG. The light irradiation unit 140 irradiates the sample container 61 with light, and the camera unit 40a measures the amount of light transmitted from the sample. From this transmitted light amount, the degree of suspension and the liquid level of the sample can be measured. In this case, it is preferable that the label 66 is not attached to the side surface of the sample container 61. At this time, the label 66 attached to the sample container 61 is provided on the bottom of the outer wall of the sample container 61, for example. The reading unit 21 is provided at a position facing the bottom of the sample container 61 conveyed to the sample suction position. The reading unit 21 reads the identifier included in the label 66 attached to the sample container 61 conveyed to the sample suction position. Any type of reading unit 21 and identifier may be used, but from the viewpoint of miniaturization, an IC chip is preferably selected as the identifier, and an IC chip reader is selected as the reading unit 21. Further, since the reading unit 21 is provided at a position facing the bottom of the sample container 61 conveyed to the sample suction position, the light irradiation unit 140 is positioned at the position facing the camera unit 40a with the sample container 61 to be imaged in between. Can be provided.

[Identification part]
The identification unit 20 reads the identifier (barcode) attached to the sample container 61 and acquires the sample container ID from the correspondence information stored in advance. When the type of the sample container 61 to be imaged is specified by the detection unit 60, the identification unit 20 can also store the type and the sample container ID in the storage unit 50 in association with each other.

[Operation of automatic analyzer]
Next, operation | movement of the automatic analyzer 10 of this embodiment is demonstrated. The automatic analyzer 10 according to this embodiment captures the sample container 61 by the photographing unit 40 at the sample dispensing position and acquires a comparative image. When the comparison image is compared with a reference image indicating a normal state and a predetermined condition is satisfied, an abnormality in one or both of the sample container 61 and the sample stored in the sample container 61 is detected. These abnormalities are detected as suspicion of dispensing abnormality, for example.

  FIG. 15 is a flowchart showing an example of the operation of the automatic analyzer 10 of this embodiment. FIG. 15 shows the flow of control and operation in the sample section 100 of the automatic analyzer 10 of this embodiment. This flowchart shows processing for determining the shape and the like of the sample container 61 when the sample container 61 is transported to the position Q by the rack sampler 65.

  The automatic analyzer 10 starts measurement preparation (step S060). In this measurement preparation, a reference image of the sample container 61 is acquired (step S061). Specifically, each control circuit provided in the control unit 27 controls the rotation mechanism of the sample dispensing arm 17 to move the rack 63 to the rack sampler 65. Thereby, the desired sample container 61 is conveyed to the position Q which is the sample suction position. The camera unit 40a acquires a reference image by photographing the sample container 61.

  Further, the sample containers 61 photographed by the camera unit 40a to acquire the reference image are all types of sample containers assumed to be used in the measurement as shown in FIG. By this imaging, reference images for all types of sample containers 61 that are assumed to be used in the measurement in the automatic analyzer 10 are acquired. Examples of the type of the sample container 61 include various types of tubes, various types of sample cups, types of combinations of sample cups and tubes, and the like. FIG. 16 is a diagram illustrating an example of the sample container 61. As shown in FIG. 16, examples of the sample container 61 include a blood collection tube 110, a blood collection tube 110 with a lid 150 attached thereto, a sample cup 120, and a complex 130 of the blood collection tube 110 and the sample cup 120. The acquired reference video is stored in the storage unit 50.

  Further, the camera unit 40 a acquires a reference image by photographing the sample dispensing probe 16 stopped at the stop position after the suction under the control of the control unit 27 together with the sample container 61. This reference image includes at least an image of the sample container 61 in which a normal sample is accommodated and an image of the sample dispensing probe 16.

  After acquiring the reference video, the operator starts the operation of the automatic analyzer 10 (step S062). Each control circuit provided in the control unit 27 controls the rotation mechanism of the sample dispensing arm 17 to move the rack 63 to the rack sampler 65. Thereby, the desired sample container 61 is conveyed to the position Q which is the sample suction position (step S063). The camera unit 40a acquires a comparison image by photographing the sample container 61 stopped at the position Q (step S064). The timing for photographing the sample container 61 is, for example, immediately after the sample container 61 stops at the position Q. The comparison video acquired by being photographed at this timing includes at least an image of the side portion of the sample container 61. Moreover, the timing which image | photographs the sample container 61 may be immediately after the sample dispensing probe 16 stops in the stop position after aspiration, for example. The comparison video acquired by photographing at this timing includes at least the side image of the sample container 61 and the side image of the sample dispensing probe 16. The acquired comparison video is output to the detection unit 60.

  The detection unit 60 receives the comparison video and acquires a reference video from the storage unit 50. The detection unit 60 compares the image of the sample container 61 shown in the reference image with the image of the sample container 61 shown in the comparison image (step S065). The detection unit 60 receives the comparison video and acquires a reference video corresponding to the comparison video from the storage unit 50. For example, when a comparison image including at least the image of the sample container 61 is input to the detection unit 60, the detection unit 60 acquires a reference image including at least the image of the sample container 61 from the storage unit 50. For example, when a comparison image including at least the image of the sample container 61 and the image of the sample dispensing probe 16 is input to the detection unit 60, the detection unit 60 reads the sample container 61 and the sample dispensing probe from the storage unit 50. A reference image including at least 16 images is acquired. Further, the process of this step may be performed simultaneously with the process of step S008 of the process shown in FIG. The detection unit 60 performs one or both of the shape comparison process of the sample container 61 and the comparison process of the sample accommodated in the sample container 61. In this flowchart, the detection unit 60 performs a shape comparison process of the sample container 61.

  When the result of the shape comparison or the like of the sample container 61 satisfies a predetermined condition, the detection unit 60 specifies the type of the sample container 61 (step S066) and outputs the result to the system control unit 70. Specifically, the detection unit 60 receives the comparison video and sequentially compares the comparison video with a plurality of reference videos stored in the storage unit 50. The plurality of reference videos include images of a plurality of types of sample containers 61, respectively. In this comparison, when the image of the sample container 61 included in the comparison image matches the image of the sample container 61 included in the reference image, the detection unit 60 corresponds to the image of the sample container 61 included in the reference image. The type of the sample container 61 is acquired. For example, the detection unit 60 acquires the type of the sample container 61 from the correspondence information between the reference image stored in the storage unit 50 and the type of the sample container 61.

  FIG. 17 is a table showing the correspondence between the reference image and the type of the sample container 61. The table shown in FIG. 17 is a correspondence table between the reference images A to D and the type of the sample container 61. In this case, the blood collection tube A1 is associated with the reference video A. In addition, a blood collection tube B1 is associated with the reference video B. A sample cup E1 is associated with the reference video C. In addition, a complex F1 of the sample cup C1 and the blood collection tube B1 is associated with the reference video D. For example, the complex F1 is configured in the same manner as the complex 130 illustrated in FIG. For example, when the detection unit 60 specifies the reference video B as a reference video that matches the comparison video, the detection unit 60 further determines the type of the sample container 61 stopped at the sample suction position based on the correspondence table. It is specified as “blood collection tube B1”.

  Receiving the specific result from the detection unit 60, the system control unit 70 changes the drive control of the sample dispensing probe 16 according to the type of the sample container 61 (step S067). Specifically, the position in the vertical direction of the sample suction point of the sample dispensing probe 16 is set in advance according to the type of the sample container 61, and the sample dispensing probe 16 stops at this position in the vertical direction. To be controlled. The position setting information is stored in the storage unit 50, for example. The position of the sample suction point in the vertical direction is, for example, the position of the tip of the sample dispensing probe 16 in the extension direction. That is, the sample suction point is the position of the discharge port 16 a of the sample dispensing probe 16 when the sample is sucked from the sample container 61. If the detection unit 60 cannot identify the type of the sample container 61, the system control unit 70 performs normal processing.

  FIG. 18 is a table showing the correspondence between the type of the sample container 61 and the position of the sample suction point in the vertical direction. The position of the sample suction point in the vertical direction is indicated by, for example, the moving distance of the sample dispensing probe 16 as shown in FIG. In the correspondence table, the type of the sample container is associated with the position of the sample suction point of the sample dispensing probe 16 in the vertical direction. The position of the sample suction point in the vertical direction may be an absolute position or a relative position. The absolute position is a position based on a predetermined position in the automatic analyzer 10, for example. The relative position is, for example, an amount by which the sample dispensing probe 16 moves in the vertical direction.

  The position in the vertical direction of the sample suction point shown in this correspondence table indicates the distance that the sample dispensing probe 16 moves downward from the stop position before suction. In the correspondence table shown in FIG. 18, when the type of the sample container 61 is the blood collection tube A1, the movement distance is 50 mm. From this correspondence, it can be seen that when the sample accommodated in the blood collection tube A1 is aspirated, the distance that the sample dispensing probe 16 moves downward from the pre-aspiration stop position is 50 mm. When the type of the sample container 61 is the blood collection tube B1, the moving distance is 40 mm. From this correspondence, it can be seen that when the sample accommodated in the blood collection tube B1 is aspirated, the distance that the sample dispensing probe 16 moves downward from the pre-aspiration stop position is 40 mm. Further, when the type of the sample container 61 is the sample cup E1, the moving distance is 30 mm. From this correspondence, it can be seen that when the sample stored in the sample cup E1 is sucked, the distance that the sample dispensing probe 16 moves downward from the pre-suction stop position is 30 mm. Further, when the type of the sample container 61 is the complex F1, the moving distance is 20 mm. From this correspondence, it can be seen that when the sample accommodated in the complex F1 is aspirated, the distance that the sample dispensing probe 16 moves downward from the pre-aspiration stop position is 20 mm. By these things, it turns out that the position in the vertical direction of a sample suction point becomes high in order of blood collection tube A1, blood collection tube B1, sample cup E1, and composite_body | complex F1.

  That is, the system control unit 70 changes the control of the vertical movement of the sample dispensing arm 17 by the control unit 27 according to the type of the sample container 61 specified based on the specification result received from the detection unit 60. By this control change, the tip of the sample dispensing probe 16 stops at the position of the sample suction point set for each sample container 61. Thereby, for example, even in the case of the sample container 61 where the position of the sample suction point in the vertical direction is high, such as the complex 130 shown in FIG. 16, the sample can be sucked without colliding with the bottom of the sample container 61. it can. As a result, unnecessary stress is less likely to be applied to the sample dispensing probe 16, and the chance of deformation of the sample dispensing probe 16 is reduced, so that the life of the sample dispensing probe 16 can be extended.

  Further, when a sufficient amount of sample is accommodated in the sample container 61 having a relatively large depth, such as a blood collection tube, the position of the sample suction point in the vertical direction can also be set as follows. The detection unit 60 detects the position of the liquid level of the sample stored in the sample container 61 from the image of the sample container 61 included in the comparison video. Next, the detection unit 60 acquires information on the type of the sample. The sample type information is acquired from, for example, the correspondence information between the sample container and the sample stored in the storage unit 50 and the sample container ID acquired by the identification unit 20. The detection unit 60 sets the position of the sample suction point in the vertical direction from the liquid level position of the sample in the sample container 61 and information on the type of the sample. As the position of the sample suction point in the vertical direction, for example, a position above the sample separation position is set. Thereby, the supernatant liquid of a sample can be acquired selectively.

  The automatic analyzer 10 acquires the absorbance measurement result from the photometry unit 12 by performing a normal measurement operation (step S068). The acquired absorbance measurement result is output as appropriate, and the automatic analyzer 10 ends the measurement operation.

  FIG. 19 is a flowchart showing another example of the operation of the automatic analyzer 10 of this embodiment. FIG. 19 shows the flow of control and operation in the sample section 100 of the automatic analyzer 10 of this embodiment. In this flowchart, a case will be described in which an abnormality of the sample container 61 such as a cover on the sample container 61 is determined when the sample container 61 is transported to the position Q by the rack sampler 65.

  First, similarly to steps S060 to S065 of the flowchart shown in FIG. 15, the sample container 61 transported to the sample suction position is photographed to obtain a reference image and a comparison image, and the two images are compared ( Steps S080 to S085).

  When the result of the shape comparison of the sample container 61 satisfies a predetermined condition (step S086), the detection unit 60 detects an abnormality of the sample container 61 (step S087), and the detection result is used as the system control unit 70. Output to. Specifically, the detection unit 60 receives the comparison video and sequentially compares the comparison video with a plurality of reference videos stored in the storage unit 50. The plurality of reference videos include images of a plurality of types of sample containers 61, respectively. The images of the plural types of sample containers 61 include an image of the sample container 61 with a lid. Examples of the sample container 61 with a lid attached include a blood collection tube 110 with a lid 150 as shown in FIG. The detection unit 60 detects an abnormality of the sample container 61 from the correspondence information between the reference image and the type of the sample container 61 as shown in FIG. The type of the sample container 61 is composed of a “sample container with a lid”. In the table of FIG. 17, for example, a blood collection tube with a lid is associated with the reference video E. When the detection unit 60 specifies the reference video E as the reference video that matches the comparison video, the detection unit 60 sets the type of the sample container 61 stopped at the sample suction position based on this correspondence table to “with lid”. Specified as “sample container”. The detection unit 60 outputs to the system control unit 70 that the abnormal sample container 61 is set at the sample suction position based on the specific result of “sample container with lid”.

  The system control unit 70 receives the detection result of the abnormality of the sample container 61 from the detection unit 60 and changes the operation of the automatic analyzer 10 (step S088). Examples of the change in the operation include changing the operation of the automatic analyzer 10 to stop. In this case, the system control unit 70 performs stop control on the automatic analyzer 10 before the dispensing operation (sample suction operation) by the sample dispensing probe 16 is performed.

  Further, the change of the operation includes, for example, changing the measurement operation to the next sample container 61 by skipping the measurement operation for the sample container 61 in which an abnormality is detected. In this case, the system control unit 70 skips the measurement operation for the sample container 61 in which an abnormality has been detected. In this case, the system control unit 70 performs the sample before the dispensing operation (sample suction operation) by the sample dispensing probe 16 is performed. After the dispensing probe 16 is stopped and the sample container 61 to be measured next is transported to the sample dispensing position, the sample dispensing operation is resumed. Thereby, for example, even if the sample container 61 with the lid attached is transported to the sample suction position, the dispensing operation for the sample container 61 (the sample accommodated therein) is not performed. Therefore, the sample dispensing probe 16 can be prevented from colliding with the lid of the sample container 61. Further, the detection unit 60 may notify the outside of the abnormality by outputting to the output unit 90 that the abnormal sample container 61 is set at the sample suction position. In this case, for example, the control change process of the automatic analyzer 10 shown in step S088 is performed together with this notification.

  Further, the image comparison process in step S086 may be performed simultaneously with the image comparison process in step S066 shown in FIG. In this case, the correspondence information between the reference image and the type of the sample container 61 referred to by the detection unit 60 includes “sample container with a lid” as one type in the type of the sample container 61.

  FIG. 20 is a flowchart showing another example of the operation of the automatic analyzer 10 of this embodiment. FIG. 20 shows the flow of control and operation in the sample section 100 of the automatic analyzer 10 of this embodiment. In this flowchart, a case will be described in which when the sample container 61 is transported to the position Q by the rack sampler 65, the detection unit 60 determines the abnormality of the sample stored in the sample container 61.

  First, similarly to steps S060 to S065 of the process shown in FIG. 15, the camera unit 40a captures a normal sample container 61 to acquire a reference image, and stores this reference image in the storage unit 50. . Thereafter, the measurement operation of the automatic analyzer 10 is started, and the camera unit 40a captures the sample container 61 stopped at the position Q, thereby acquiring a comparison image. The detection unit 60 compares the reference image with the comparison image (steps S100 to S105). When the comparison result of the sample container 61 satisfies a predetermined condition (Step S106), the detection unit 60 detects an abnormality of the sample stored in the sample container 61 (Step S107). The detection result of the abnormality of the sample detected by the detection unit 60 is output to the outside.

  The determination in this process is performed, for example, by using the above-described difference video. In this case, the detection unit 60 generates a difference video between the comparison video and the reference video. For example, the detection unit 60 determines that the sample is not contained in the sample container 61 included in the comparison image by performing an analysis process on the difference image. Based on this determination, the detection unit 60 detects an abnormality of the sample stored in the sample container 61. For example, when it is determined that the reference image includes only one image indicating the liquid level, the detection unit 60 performs a process of determining that the sample container 61 does not contain the sample. This process is performed, for example, by comparing the luminance value of the sample portion in the difference video with the luminance value of the sample portion in the reference video. As a result of the comparison, when the difference between the two luminance values is equal to or smaller than a certain value, the detection unit 60 determines that the sample is not stored in the sample container 61.

  In addition, by analyzing the difference video, for example, when it is determined that a large solid material such as fibrin is included in the sample stored in the sample container 61 included in the comparison video, the detection unit 60 Abnormality of the sample stored in the sample container 61 is detected. For example, when the difference image includes a fibrous fibrin image, the detection unit 60 determines that there is solid matter in the sample and detects an abnormality of the sample.

  Further, by analyzing the difference video, for example, when it is determined that the sample contained in the sample container 61 included in the comparison video is not sufficiently separated, the detection unit 60 is accommodated in the sample container 61. Detect abnormalities in the sample. In this case, the difference video includes, for example, an image showing two different separation positions. When the distance between the two separation positions is greater than or equal to a predetermined value, the detection unit 60 determines that the solid-liquid separation of the sample is not sufficient and detects a sample abnormality.

  In addition, by analyzing the difference video, for example, when it is determined that the degree of suspension of the sample contained in the sample container 61 included in the comparison video is abnormal, the detection unit 60 includes the inside of the sample container 61. An abnormality of the sample stored in the container is detected. In this case, the difference video includes, for example, an image indicating two different separation positions, and abnormality is determined according to the distance between the two separation positions. In this case, the difference image shows a suspension image indicating the difference in the degree of suspension. When the suspension degree of the suspension image exceeds a predetermined value, it is determined that the suspension degree of the sample is abnormal, and the abnormality of the sample is detected.

  Subsequent processing is performed similarly to step S088 of the processing shown in FIG. 19 (step S108). As the processing in step S108, the processing described in the processing in step S088 of the flowchart shown in FIG. 19 can be used as appropriate.

[Operation and effect of automatic analyzer]
Since the automatic analyzer 10 has the same configuration as that of the first embodiment, the same operation and effect as those of the first embodiment can be achieved.

  Further, the automatic analyzer 10 of this embodiment has a configuration for specifying the state of the sample container 61 during the measurement operation by storing the type of the sample container 61 and the normal state of the sample container 61 as comparison targets in advance. did. This specification includes firstly specifying the type of the sample container 61 during the measurement operation. In this case, the imaging unit 40 provided in the automatic analyzer 10 acquires in advance a reference video showing the sample container 61 whose type is clear. The imaging unit 40 acquires a comparison video corresponding to the reference video by imaging the sample container 61 during the measurement operation. The detection unit 60 identifies a reference image including a shape that matches the shape of the image of the sample container 61 included in the comparison image. Thereby, the type of the sample container 61 included in the comparison video is specified. At this time, since the sample dispensing probe 16 is controlled according to the specified type of the sample container 61, the operation of the sample dispensing probe 16 at the time of sample aspiration can be minimized.

  Secondly, this specification includes specifying the state of the sample accommodated in the sample container 61 during the measurement operation. The imaging unit 40 provided in the automatic analyzer 10 acquires a reference image by imaging a sample container 61 containing a normal sample. Further, the photographing unit 40 photographs the sample container 61 that contains the sample during the measurement operation, and obtains a comparative image corresponding to the reference image. The reference video is acquired before the comparison video. The detection unit 60 compares the reference image with the comparison image, and determines, for example, an abnormality of the sample stored in the sample container 61 when the difference in the degree of suspension of the sample exceeds a predetermined amount. As a result, it is possible to detect a case where a large solid matter such as fibrin is mixed in the sample finished in the sample container 61.

  The automatic analyzer tends to cause plastic deformation of the sample dispensing probe 16 as compared with other dispensing probes. The reason is that fatigue of the metal forming the sample dispensing probe 16 proceeds due to repeated large stress on the sample dispensing probe 16. The sample dispensing probe 16 in which the fatigue of the metal has progressed and the toughness is lowered is in a state where plastic deformation is likely to occur. For example, when the position of the sample suction point is determined in the vertical direction during sample suction, the repeated stress causes the tip of the sample dispensing probe 16 to come into contact with the bottom of the sample container 61, and the impact causes the bottom to be lowered. Receive when detecting.

  On the other hand, the automatic analyzer 10 of this embodiment identifies the type of the sample container 61 by the detection unit 60, identifies the position of the sample suction point in the vertical direction from the identification result, and based on this, the sample dispensing probe 16 is controlled. Therefore, it is possible to reduce the contact with the bottom of the sample container 61 when the sample is sucked. This makes it difficult for metal fatigue to occur in the sample dispensing probe 16 and reduces the chance that the sample dispensing probe 16 is plastically deformed.

<Third Embodiment>
Next, the automatic analyzer 10 according to the third embodiment will be described.

[Automatic analyzer]
The configuration of the automatic analyzer 10 will be described with reference to FIG. FIG. 21 is a block diagram showing a functional configuration of the automatic analyzer 10 of this embodiment. The configuration of the automatic analyzer 10 is the same as that of the automatic analyzer 10 of the first embodiment, except that the sample container 61 and the sample accommodated in the sample container 61 are included as the imaging target. That is, the reference image is an image including the image of the sample dispensing probe 16 and the image of the sample container 61, and the comparison image is a similar image.

  At the position Q, the camera unit 40a is at a position where at least a part of the side of the sample dispensing probe 16 and at least a part of the side of the sample container 61 can be photographed in the same manner as the configuration shown in FIG. Installed. The camera unit 40c is preferably installed at a position where the side portion including the distal end portion of the sample dispensing probe 16 can be photographed. The camera unit 40a is preferably installed at a position on the side portion of the sample container 61 where a whole image of the stored sample can be taken. The camera unit 40a is more preferably installed at a position where the side portion including the tip of the sample dispensing probe 16 can be photographed and the entire image of the stored sample can be photographed.

  At the position P, the camera unit 40c is installed at a position where at least a part of the side portion of the sample container 61 can be photographed in the same manner as the configuration shown in FIG. The camera unit 40b is preferably installed at a position on the side of the sample container 61 where a whole image of the stored sample can be taken. The camera unit 40c is preferably installed at a position on the side portion of the sample container 61 where a whole image of the stored sample can be taken.

[Operation of automatic analyzer]
Next, operation | movement of the automatic analyzer 10 of this embodiment is demonstrated. In the automatic analyzer 10 of this embodiment, the sample dispensing probe 16 and the sample container 61 are photographed by the photographing unit 40 at the sample dispensing position to obtain a comparison image, and the comparison image and the reference indicating the normal state are shown. Compared with the video, it is detected that the sample dispensing is suspected of being abnormal when a predetermined condition is satisfied.

  The operation of the automatic analyzer 10 of this embodiment includes the process shown in the operation of the automatic analyzer 10 of the first embodiment and the process shown in the operation of the automatic analyzer 10 of the second embodiment. It is possible to operate by appropriately combining. Thereby, the state of the sample dispensing probe 16 and the state of the sample container 61 can be detected by a set of images (reference image, comparison image). Specifically, at least two of the processes shown in the flowcharts of FIGS. 10 to 12 and 15 and FIGS. 19 to 20 can be combined. At this time, the image acquired as the reference image includes an image of the sample dispensing probe 16 and the sample container 61 at the sample dispensing position. Further, the image acquired as the comparison image includes the image of the sample dispensing probe 16 and the sample container 61 at the sample dispensing position. The detection unit 60 may detect, for example, the abnormality relating to the sample dispensing probe 16 and the abnormality relating to the sample container 61 as described above, or may be detected sequentially.

[Operation and effect of automatic analyzer]
Since the automatic analyzer 10 has the same configuration as that of the first and second embodiments, the same effect as that of the first and second embodiments can be achieved. The video acquired as the reference video is a video including the image of the sample dispensing probe 16 and the sample container 61 at the sample dispensing position, and the video acquired as the comparison image is the sample at the sample dispensing position. An image including images of the dispensing probe 16 and the sample container 61 was used. Thereby, the detection part 60 can detect the state of the sample dispensing probe 16 and the sample container 61 by one set of images (reference image, comparison image). As a result, sample dispensing abnormality can be detected quickly.

  The configuration described in the above embodiment can be applied to clinical examination apparatuses other than the automatic analyzer.

  Examples of clinical testing apparatuses include clinical analyzers such as automatic analyzers, blood gas analyzers, electrophoresis apparatuses, and liquid chromatography apparatuses, nuclear medicine apparatuses such as radioimmunoassay apparatuses, latex agglutination reaction measuring apparatuses, and nephelometers. Blood test equipment such as immune serum test equipment, automatic blood cell counter, blood coagulation measurement equipment, microbe classification and identification equipment, bacteria culture test equipment such as blood culture test equipment and DNA / RNA measurement equipment, urine analysis equipment, fecal occult blood measurement equipment, etc. Urinalysis equipment, pathological examination equipment such as automatic tissue cell staining equipment, physiological function testing equipment, other clinical examination equipment such as micropipette, washing device dispensing device, and centrifuge.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalents thereof.

DESCRIPTION OF SYMBOLS 1 1st reagent storage 1a Reagent rack 2 2nd reagent storage 2a Reagent rack 4 Reaction disk 5 Sample disk 6 Reagent container 7 Reagent container 8 1st reagent dispensing arm 9 2nd reagent dispensing arm 10 Automatic analyzer 11 Stirring unit 12 Photometric unit 13 Cleaning unit 14 First reagent dispensing probe 15 Second reagent dispensing probe 16 Sample dispensing probe 16a Discharge port 17 Sample dispensing arm 19a Cleaning tank 19b Cleaning tank 19c Cleaning tank 20 Identification section 21 Reading section 22 Identification processing Unit 24 analysis unit 25 analysis control unit 26 mechanism unit 27 control unit 30 data processing unit 31 calculation unit 32 data storage unit 40 photographing unit 40a camera unit 40b camera unit 40c camera unit 41 pull-in unit 41a first window unit 41b second Window unit 50 Storage unit 51 Reaction vessel 60 Detection unit 1 Sample container 62a Bar code reader 62b Bar code reader 63 Rack 65 Rack sampler 66 Label 66a Side end 66b Side end 70 System control unit 80 Operation unit 90 Output unit 91 Display unit 92 Printing unit 93 Notification unit 100 Sample section 110 Collection Blood vessel 120 Sample cup 130 Complex 140 Light irradiation unit 200 First section 300 Second section

Claims (11)

A sample container containing a sample; and
A sample dispensing mechanism including a sample dispensing probe that sucks the sample from the sample container and discharges the sample to a reaction container;
Measuring means for measuring a component of a mixed solution containing at least the sample contained in the reaction vessel;
Photographing means for photographing at least one of the sample container and the sample dispensing probe as a photographing target, and generating a comparison image indicating a current state of the photographing target;
Storage means in which a reference image indicating a normal state of the photographing target is stored in advance;
Detecting means for comparing the comparison video with the reference video and detecting an abnormality from the comparison result;
Output means for outputting the detection of the abnormality to the outside;
Clinical laboratory equipment with By controlling the sample dispensing mechanism, the sample dispensing probe is aspirated to the sample dispensing probe, and then the sample dispensing probe is placed at a stop position after the suction set in advance above the sample container. A control means for stopping the probe;
The imaging means generates the comparison image by performing the imaging after the suction until the sample dispensing probe stops at the stop position after the suction,
The detection means compares the image of the sample dispensing probe included in the reference image and the comparison image, respectively, and it is determined from the comparison result that the sample dispensing probe is deformed in the comparison image Detecting the abnormality in
The clinical examination apparatus according to claim 1 characterized by things. A cleaning mechanism for cleaning the sample dispensing probe;
The sample dispensing probe after the dispensing is washed with a washing liquid by controlling the washing mechanism, and the sample dispensing probe is inserted into the sample container by controlling the sample dispensing mechanism and the sample. Control means for aspirating the sample contained in the container,
The imaging means generates the comparison image by imaging the sample dispensing probe as the imaging target after the insertion and before the suction,
The detection means compares at least one of the image of the sample dispensing probe and the luminance value included in the reference image and the comparison image, respectively, and the comparison result indicates that the sample dispensing probe Detecting the abnormality when adhesion of the cleaning liquid is observed on the outer wall;
The clinical examination apparatus according to claim 1 characterized by things. A control means for controlling at least the sample dispensing mechanism;
The control means controls the sample dispensing mechanism so that the sample dispensing probe sucks the sample, and then the sample dispensing probe is set to a post-aspiration stop position set in advance above the sample container. To stop
The imaging unit generates the comparison image by imaging the sample dispensing probe as the imaging target after the suction until the sample dispensing probe stops at the stop position after the suction. ,
The detection means includes an image of the tip of the sample dispensing probe included in each of the reference image and the comparison image, compares a predetermined area extending below the tip, and from the comparison result in the comparison image, Detecting the abnormality when solid matter adheres to the tip.
The clinical examination apparatus according to claim 1 or 2, characterized by the above-mentioned. A calculation means for calculating the degree of necessity of replacing the sample dispensing probe from the degree of deformation of the sample dispensing probe when an abnormality is detected in the detection means;
The output means is a display means having a display screen, and displays the detection of the abnormality on the display screen and also displays the degree of necessity for replacement of the sample dispensing probe calculated by the calculation means. To
The clinical examination apparatus according to claim 2 or 4, characterized in that. The output means is a notification means for notifying the abnormality to the outside when the abnormality is detected by the detection means.
The clinical examination apparatus according to any one of claims 1 to 5, wherein The measurement means excludes, from the measurement target, a liquid mixture containing a sample in which the abnormality is detected when an abnormality is detected in the detection means;
The clinical examination apparatus according to any one of claims 1 to 6, wherein A cleaning mechanism for cleaning the sample dispensing probe;
A control means for controlling at least the sample dispensing mechanism and the cleaning mechanism;
The control means controls the sample dispensing mechanism when the detection means detects an abnormality, and discards the sample in which the abnormality held by the sample dispensing probe is detected as an abnormal sample. After cleaning the sample dispensing probe by controlling the cleaning mechanism, the sample dispensing mechanism is further controlled to suck the sample in the sample container in which the abnormal sample is stored with the sample dispensing probe.
The clinical examination apparatus according to any one of claims 4 to 6, wherein Control means for at least controlling the sample dispensing mechanism to insert the sample dispensing probe into the sample container in order to suck the sample,
The imaging means generates the comparison image by imaging the sample container before the insertion,
The storage means stores an image of the sample container with the lid removed as the reference video,
The detection means compares the image of the sample container included in the reference image and the comparison image, respectively, and when the comparison image shows that the lid is attached to the sample container in the comparison image Detecting the abnormality,
The clinical examination apparatus according to claim 1 characterized by things. Control means for at least controlling the sample dispensing mechanism to insert the sample dispensing probe into the sample container in order to suck the sample;
Identification means for identifying the sample container based on the sample container identification information acquired by reading the identifier attached to the sample container;
The imaging means generates the comparison image by imaging the sample container before the insertion,
In the storage means, the reference image including an image of the sample container is stored corresponding to the sample container identification information,
The detection means compares the image of the sample container included in the reference image and the comparison image corresponding to the sample container identification information, and the abnormality is detected when the image of the sample container is different from the comparison result. Detect
The clinical examination apparatus according to claim 1 characterized by things. An identification means for identifying the sample container based on the sample container identification information acquired by reading the identifier attached to the sample container;
The photographing unit is provided at a position opposite to the identification unit across the photographing target when the photographing is performed.
The clinical examination apparatus according to any one of claims 1 to 10, wherein

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