JP2015189708A - oral care composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral care composition which spreads to all corners in an oral cavity, has enhanced drug persistence in the oral cavity, and has high safety.SOLUTION: An oral care composition usable even to the oral cavity weak can reach interstice sites in an oral cavity because the viscosity of the composition is sufficiently low when applying into the oral cavity by using a liposomal suspension having interaction with a saliva component; can make a sufficient amount of the composition remain at the reached interstice sites because the viscosity of the composition is increased by the interaction with the saliva component; and can continuously exhibit an effect of a useful component by making a liposome contain the useful component; as well as can achieve an oral hygiene care of a high level because of also having high safety.

Description

  The present invention relates to an oral care composition comprising a liposome dispersion containing green tea polyphenol.

  In many countries as well as in Japan, the proportion of elderly people in the population structure is increasing, and accordingly, how to maintain a high QOL is being emphasized. Recent studies are revealing the importance of oral care as one of the means. Specifically, it is known that oral bacteria can cause systemic diseases such as bacterial endocarditis, subclinical pneumonia, glomerulonephritis, arthritis as well as infections in the oral cavity. is there. On the other hand, oral bacteria are known to be related to age, and are called so-called opportunistic bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa that are not normally present in the oral cavity in the elderly. Bacteria tend to be present at higher rates. In particular, Staphylococcus aureus is not only used for oral diseases such as cellulitis such as cheek cellulitis and cellulitis, jaw osteomyelitis, periodontitis after implant placement, and root abscess, but also aspiration. Control of Staphylococcus aureus is considered to be an important element in oral care in the elderly because it causes pneumonia.

  Many bacteria in the oral cavity are present in bacterial aggregates floating in the oral cavity or called biofilms. Although it is easy to remove floating bacteria, biofilms are resistant to both physical and chemical effects, and removing biofilms uses a powerful method. If not, it will be difficult. For example, a special mechanical tooth surface cleaning (PMTC) + 3DS removal method utilizing a chemical action and a physical action has been implemented. This method usually eliminates bacteria remaining after removing the biofilm by cleaning the inside of the oral cavity with a strong mechanical force using a dedicated exfoliating / cleaning composition by using a disinfectant-containing composition. Is the method. However, this method is not preferable for so-called weak oral persons, such as elderly people and persons having abnormalities in oral tissues, because it may cause various problems because the physical and chemical stimuli are too strong. In addition, in the inter-oral regions such as interdental parts and periodontal pockets, the oral care composition is difficult to reach even after being used after cleaning the region, or the amount of the active ingredient sufficient to exert the effect even if it reaches. In many cases, the oral hygiene state of the inter-oral region in the oral cavity tends to deteriorate.

  On the other hand, many technical developments for retaining an oral care composition in the oral cavity have been conducted. For example, a method of blending a polymer component (Patent Documents 1 to 7), a method of blending a specific nonionic surfactant (Patent Documents 8 and 9), and increasing the retention by covalent bonding to a polymer carrier Method (Patent Document 10) and a method for improving the retention of the medicinal component at the application site and the sustainability of the action by blending a water-soluble polymer that thickens the composition with calcium in the saliva component (Patent Document 11, 12). However, in the method of increasing the viscosity of the composition by adding a polymer, it is difficult to solve the above problem because the composition cannot sufficiently reach the intraoral site in the oral cavity, and a specific nonionic interface In the method of blending the active agent, even if the composition reaches the canyon site, the amount of the composition remaining in the site is small, so a sufficient effect cannot be expected, and further, it reacts with the calcium component in saliva and thickens In the technique of blending the polymer, there is a possibility that the amount of the composition that can easily reach the canyon site and remain at the site can be sufficiently secured, but there is a problem that the sustainability of the effect of the medicinal component is not sufficient.

Japanese Patent Laid-Open No. 11-12144 JP 2001-316235 A JP 2002-205929 A JP 2011-98921 A JP 2011-111418 A JP 2012-46433 A JP 2012-153677 A JP 2009-1511 A International Publication No. 2011/0777847 JP 2009-102282 A JP 2006-206581 A JP 2008-7413 A

  By using a liposome suspension that interacts with saliva components, the composition has a sufficiently low viscosity when applied to the oral cavity, so that it can reach the interoral site in the oral cavity and interact with the saliva components. Since the viscosity of the composition is increased, a sufficient amount of the composition can be left in the reached canyon site, and the useful component can be continuously exerted by including the useful component in the liposome. Therefore, an object of the present invention is to provide an oral care composition that can be used even for the vulnerable oral cavity who can realize high oral hygiene care.

  As a result of intensive studies in view of such circumstances, the present inventors surprisingly applied a liposome dispersion obtained by including green tea polyphenol in liposomes to the oral cavity, and the interaction between the composition and the saliva component resulted in The present inventors have found that the viscosity is greatly increased and have completed the present invention.

That is, this invention provides the oral care composition of claim | item 1 thru | or claim | item 4.
Item 1.
An oral care composition comprising an aqueous dispersion of liposomes containing green tea polyphenols and hydrogenated phospholipids.
Item 2.
Item 2. The oral care composition according to Item 1, wherein the phosphatidylcholine content in the hydrogenated phospholipid is 50% or more by mass ratio.
Item 3.
Item 3. The oral care composition according to Item 2, wherein the phosphatidylcholine content in the hydrogenated phospholipid is 50% to 90% by mass.
Item 4.
The green tea polyphenol is one or more polyphenols selected from catechins consisting of catechin, epicatechin, gallocatechin, epigallocatechin, and gallate catechins consisting of catechin gallate, epicatechin gallate, gallocatechin gallate, epigallocatechin gallate, Item 3. The oral care composition according to any one of Items 1 or 2, wherein the oral care composition contains 30% by mass or more in terms of dry matter with respect to the total amount of green tea polyphenol.
Item 5.
Item 5. The oral care composition according to any one of Items 1, 2, or 4, wherein the liposome contains an oil or fat.

  According to the present invention, the composition can be sufficiently reached even in the inter-orbital region such as the interdental portion and periodontal pocket in the oral cavity, and a sufficient amount can be left to exert the effect in the region. An oral care composition with sustained effects can be provided. In particular, the liposome contains useful ingredients that are often relatively irritating, and the useful ingredients are gradually released from the liposomes over time, making oral tissues sensitive to chemical irritation. Because it can be used every day with peace of mind even for patients with severe periodontal disease called so-called “orally vulnerable”, xerostomia and malignant tumors in the oral cavity, elderly people, infants, cared persons, etc. It is possible to provide an oral care composition that is useful even for people who are extremely prone to poor oral hygiene.

The green tea polyphenol used in the present invention comprises leaves of perennial evergreen Camellia sinensis (L.) O. kuntze of Camellia camellia, water and / or ethyl alcohol, preferably water-ethyl. It refers to the polyphenol obtained by extraction using an alcohol mixture, and the green tea polyphenol used in the present invention means a powder or granule containing 30% by mass or more of green tea polyphenol in a dry state. Higher polyphenol content is preferred, and also in green tea polyphenols, catechins consisting of catechin, epicatechin, gallocatechin, epigallocatechin, and gallate catechin consisting of catechin gallate, epicatechin gallate, gallocatechin gallate, epigallocatechin gallate One or more polyphenols selected from the group (hereinafter sometimes abbreviated as “EGCG”) are preferred, and the content of catechins and polyphenols combined with EGCG (hereinafter sometimes abbreviated as “total catechins”) is included. More preferably, the amount is 30% by mass or more in a dry state. The green tea polyphenol is, for example (the following “%” in parentheses means the content (% by mass) per dry weight. The name of the extraction solvent is described at the end of the parentheses), “Green tea polyphenol EGCG50 (Made by Medience Co., Ltd., green tea polyphenol (98% or more), EGCG (45% or more), total catechin (75% or more), water-ethyl alcohol mixture), "catechin 30" (Shiraimatsu Shinyaku Co., Ltd.) Manufactured by the company, green tea polyphenols (30% or more), EGCG (10% or more), water), "catechin 40" (manufactured by Shiraimatsu Shinyaku Co., Ltd., green tea polyphenols (40% or more), EGCG (10% or more), Water-ethyl alcohol mixture), “Polyphenone G” (Mitsui Norin Co., Ltd., total catechin (30% or more), water), “Polyphenon 70A” (Mitsui Norin Co., Ltd., total TEKIN (80% or more), water-ethyl alcohol mixture), “GREEN TEA PE” (PHI Corporation), green tea polyphenol (98% or more), EGCG (50% or more), total catechin (80% or more) ), “Tiacalon 30” (manufactured by Joban Plant Research Institute, Inc., green tea polyphenol (over 30%), EGCG (over 10%), water), “Teacalon 90” (manufactured by Joban Plant Research Institute, Ltd., Green tea polyphenols (90% or more), EGCG (35% or more)), “Teacalon 90S” (manufactured by Joban Plant Research Institute, Inc., green tea polyphenols (95% or more), EGCG (40% or more)), “PF- TP80 "(manufactured by Pharma Foods Co., Ltd., green tea polyphenols (80% or more), total catechin (70% or more))," PF-TP90 "(Pharmacies) Manufactured by Co., Ltd., green tea polyphenol (90% or more), total catechin (80% or more), “Purephenon 50W” (manufactured by Ogawa Fragrance Co., Ltd., green tea polyphenol (50% or more), EGCG (20% or more)), “Sanphenon 30S-OP” (manufactured by Taiyo Kagaku Co., Ltd., green tea polyphenol (30% or more), total catechin (20% or more)), “Sunphenon CT-T-OP” (manufactured by Taiyo Kagaku Co., Ltd., green tea Polyphenol (50% or more)), “Sunphenon BG-3” (manufactured by Taiyo Kagaku Co., Ltd., green tea polyphenol (80% or more), total catechin (70% or more)), “Sunphenon BG-5” (Taiyo Chemical ( Co., Ltd., green tea polyphenol (80% or more), total catechin (60% or more)), "Sunphenon 90S" (manufactured by Taiyo Kagaku Co., Ltd., green tea polyphenol (80% or more)) Total catechins (70% or more)), "Sanfenon EGCG-OP" (Taiyo Kagaku Co., Ltd., it is possible to obtain as EGCG (90% or higher)).

  Green tea polyphenols are present in a state substantially contained in liposomes. Here, the “included state” means a state in which the liposome is prepared using at least phospholipid and green tea polyphenol, and the green tea polyphenol is present in the obtained liposome. For example, the green tea polyphenol is adsorbed on the liposome surface. A state of being present as one of the membrane components of the liposome, or a state of being present in a continuous layer in the liposome formed by the lipid membrane of the liposome.

  The liposome of the present invention also contains at least a hydrogenated phospholipid. Examples of hydrogenated phospholipids include hydrogenated glycerophospholipid, hydrogenated phosphatidylethanolamine, hydrogenated phosphatidylserine, hydrogenated phosphatidylinositol, hydrogenated phosphatidylcholine (hydrogenated lecithin: hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, Examples thereof include hydrogenated corn lecithin, hydrogenated cottonseed oil lecithin and the like. Among these, hydrogenated phosphatidylcholine (hydrogenated lecithin: hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated corn lecithin, hydrogenated cottonseed oil lecithin, etc.)) is preferable. Usually, when the present invention is carried out on a commercial basis, hydrogenated phospholipids (eg, hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, etc.) having a phosphatidylcholine content of 60% by mass or more can be used. Can be preferably used, those having 80% by mass or more can be more preferably used, and those having 90% by mass or more can be more preferably used.

  The “liposome” in the present application is a lipid complex composed of a monolayer or a plurality of layers formed by self-assembly of phospholipids, and one multilamellar liposome (MLV) based on the number of lipid bilayers. There are two types of membrane liposomes. Single-membrane liposomes are further classified into SUV (small unilamella vesicle), LUV (large unilamella vesicle), GUV (giant unilamella vesicle), etc., and any of these can be used preferably. The size of the liposome that can be suitably used in the present invention is 10 to 1000 nm, preferably 10 to 600 nm, more preferably 10 to 600 nm as an average outer diameter when the average particle diameter or the spherical particle shape is not used. 20-300 nm. The average particle diameter or the average outer diameter of the liposome (hereinafter, sometimes abbreviated as “average particle system etc.”) can be set as appropriate within the above range, but from the viewpoint of stability, the liposome particle system may vary. The smaller one is preferable, and the difference between the upper limit value and the lower limit value of the average particle diameter and the like is within 1000 nm, preferably within 300 nm, and the number of liposome individuals of 60% or more (when the total value of all liposome numbers is 100) Means an abundance ratio), and preferably contains 80% or more of the liposome population. The average particle diameter and the number of liposomes can be measured with a commercially available particle size distribution meter or particle counter.

  The liposome used in the present invention can be produced by a conventional method. For example, as a method for producing a liposome suspension, (1) an aqueous solution containing a pH adjuster, a polyhydric alcohol, a saccharide, etc., after homogeneously mixing phospholipids, components encapsulated in liposomes, and other antioxidants. A method of hydration to form liposomes. (2) Phospholipids, components encapsulated in liposomes, and other antioxidants are dissolved in alcohol, polyhydric alcohol, etc., and hydrated with an aqueous solution containing a pH adjuster, polyhydric alcohol, saccharide, etc. to prepare liposomes. Method. (3) A method of preparing liposomes by complexing phospholipids, components encapsulated in liposomes, other antioxidants and the like in water using ultrasonic waves, a French press or a homogenizer. (4) A method of preparing liposomes by mixing and dissolving phospholipids, components encapsulated in liposomes and other antioxidants in ethanol, adding this ethanol solution to an aqueous potassium chloride solution, and preparing liposomes can be used. For example, a phospholipid containing a predetermined amount of hydrogenated phospholipid is solubilized with an appropriate organic solvent such as ethanol, and the solvent is removed under reduced pressure to create a membrane lipid, which is water, buffer solution, saccharide After adding the aqueous solution, etc., it can be obtained by, for example, stirring at about 1000 to 3000 rpm for about 2 to 5 minutes to prepare a liposome suspension. It can also be prepared by adding a predetermined amount of the phospholipid dissolved in, for example, ethanol to water, a buffer solution, or a saccharide-containing aqueous solution and stirring with a high-pressure homogenizer or the like. Liposomes include not only phenolic fungicides such as isopropylmethylphenol, but also oily ingredients, lipids, water-soluble substances, physiologically active substances, etc., for example, antioxidants such as tocopherol and ascorbic acid, lactic acid, citric acid, etc. Organic acids such as, lipids such as phosphatidylglycerol, phosphatidylethanolamine, natural polymers such as chitosan, fucoidan, hyaluronic acid, synthetic polymers such as polyethylene glycol, carboxyvinyl polymer, carbohydrates such as trehalose, lactulose, maltitol, A polyol such as glycerin or the like can be formulated by including it in a range not impairing the effects of the present invention. As used herein, “inclusion” means that other liposome constituents such as phospholipids and the constituents form liposomes, as shown above, and a hydrophilic region formed inside the liposome. Alternatively, it exists in a hydrophobic region, in a case where it coexists with a membrane constituent material of the liposome, or in a case where it is attached to the outermost membrane surface of the liposome constituent and includes various existing forms. Usually, liposomes are prepared as a liposome suspension having an aqueous solvent such as water as a continuous layer. The obtained liposome suspension may be used as it is, or may be used in a dried form using a conventional method such as freeze-drying or spray-drying, and an aqueous solvent containing no water is used as a continuous layer. It can be used in the form of having.

  Confirmation of the green tea polyphenol contained in the liposome can be performed using a conventional method. That is, the green tea polyphenol present in the continuous layer in which the liposome is suspended but not included in the liposome is removed using a conventional method, and then the liposome is disrupted using a conventional method. By examining, green tea polyphenol contained in the liposome can be confirmed. It is also possible to quantify using a similar method. A method for confirming or quantifying the salt green tea polyphenol is not limited, and examples thereof include a method using HPLC (for example, a liquid chromatograph mass spectrometer). In addition, as a method for removing green tea polyphenol present in the continuous layer in which the liposome is suspended without being included in the liposome, for example, a dialysis treatment using a dialysis membrane or the like “after removing the supernatant by centrifugation, etc. Examples include a method using centrifugation in which the residue is washed again with a tonic solution and the supernatant is removed again, and a method of performing gel filtration. Examples of the method for destroying the liposome include a method of adding an organic solvent such as chloroform and a nonionic or cationic surfactant.

It is preferable to add a polyhydric alcohol to the oral care composition of the present invention. Examples of the polyhydric alcohol include propylene glycol, 1,3-butylene glycol, isoprene glycol, 1,2-propanediol, 1,3-propanediol, dipropylene glycol, polyethylene glycol, glycerin, sorbitol and the like. A compounding quantity can be 1-20 mass% with respect to the composition whole quantity.

The oral care composition of the present invention is a solution in which liposomes are dispersed in an aqueous solvent, and the viscosity of the composition is preferably as low as possible in order to easily reach every corner of the oral tissue, for example, 50 mPa. S or less, among which 30 mPa · s or less is preferable, 20 mPa · s or less is more preferable, and 10 mPa · s or less is most preferable. The viscosity of the composition is measured using an E-type rotary viscometer in accordance with a conventional method (for example, JIS Z8803: 2011 “10. Cones-viscosity measurement method using a flat plate rotational viscometer”).

The oral care composition of the present invention is a dentifrice, mouthwash, mouth dryness relieving / preventing agent, oral cavity / throat disinfectant, oral anti-inflammatory agent, halitosis prevention / elimination agent, plaque formation inhibitor, caries inhibitor, tooth Oral care such as periodontal disease prevention agent, periodontal disease treatment agent, tongue coating remover, tongue coating formation prevention agent, denture mounting agent, denture coating agent, denture stabilizer, denture preservative, denture cleaning agent, implant care agent, etc. It can be used as a product, quasi-drug, pharmaceutical product, etc.

  The oral care composition of the present invention can be blended with known ingredients generally used in foods, oral care compositions, pharmaceuticals, etc., other than green tea polyphenols and phospholipids, as long as the effects of the present application are not impaired. . For example, conventionally known components such as surfactants, alcohols, water-soluble polymers, flavoring agents (fragrances), sweeteners, medicinal agents, fats and oils, acidulants, antioxidants, coloring agents, lubricants and the like can be mentioned. It is done.

  As the emulsifier, not only a nonionic surfactant but also an anionic surfactant and an amphoteric surfactant can be used. However, since surfactants (especially anionic surfactants) may reduce the bactericidal action of cetylpyridinium chloride, sufficient care must be taken when designing the chemical species to be blended, their blending methods, and blending amounts. Cost. The following can be mentioned as an example of surfactant which can be mix | blended. Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester; sorbitan ester surfactants such as sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester; glycerin mono Examples include glycerin fatty acid ester surfactants such as fatty acid esters, polyoxyethylene glycerin fatty acid esters, and polyglycerin fatty acid esters; polyoxyethylene sorbit fatty acid esters, polyethylene sterols, and alkyl glucosides. Examples of the anionic surfactant include sulfate ester surfactants, fatty acid soaps, amino acid surfactants, phosphate ester surfactants, and the like. Examples of amphoteric surfactants include betaine acetate type surfactants such as alkyldimethylaminoacetic acid betaines and alkylamidopyropyrudimethylaminoacetic acid betaines, and imidazoline type surfactants. These surfactants can be blended alone or in combination of two or more.

  Examples of alcohols include monohydric alcohols such as ethyl alcohol, butyl alcohol, isobutyl alcohol, and propyl alcohol, and sugar alcohols such as lactitol, mannitol, and xylitol. These alcohols can be blended alone or in combination of two or more.

  Examples of water-soluble polymers include cellulose-based water-soluble polymers such as hydroxyethyl cellulose and carboxymethyl cellulose, polysaccharide-based polymers such as pectin, agar, carrageenan, and gellan gum, and peptide-based polymers such as gelatin and hydrolyzed collagen peptides. Examples include molecules. These water-soluble polymers can be blended alone or in combination of two or more.

  As the flavoring agent used in the present invention, for example, menthol, anethole, carvone, eugenol, limonene, peppermint oil, spearmint oil, wintergreen, methyl salicylate, shioneer, thymol, clove oil, eucalyptus oil, rosemary oil, sage oil, Lemon oil, orange oil, cymen oil, citronellol, methyl eugenol and the like can be mentioned. These flavoring agents can be blended alone or in combination of two or more.

  Examples of the sweetener used in the present invention include saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartine, thaumatin, asparatylphenylalanyl methyl ester, α-methoxycinnamic aldehyde, xylit, sucrose. , Sucralose, palatinose, palatinit, erythritol, maltitol and the like. These sweeteners can be blended alone or in combination of two or more.

  Functional components other than green tea polyphenols can also be blended. Examples of medicinal agents that can be incorporated include fluorine compounds such as sodium fluoride, sodium monofluorophosphate and stannous fluoride; enzymes such as dextranase, mutanase, amylase, protease, and lytic enzyme (Litec Enzyme); tranexam Acid, ε-aminocaproic acid, aluminum chlorohydroxy allantoin, allantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid and other anti-inflammatory agents; cetylpyridinium chloride, bisabolol, chlorhexidine salts, triclosan, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol Antibacterial / bactericidal agents such as α-tocopherol, acetic acid-dl-α-tocopherol, vitamins such as pyridoxine, ascorbic acid or a salt thereof; glycerophosphoric acid, Chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphoric acid compounds, vegetable extracts. These may be used alone or in combination of two or more. Furthermore, you may make it contain in a liposome like green tea polyphenol, and may exist in the continuous layer of an oral care composition.

When applied to the oral cavity and throat, the oral care composition of the present invention interacts with existing saliva, and the oral care composition has a significantly high viscosity, so that the oral care composition surface and denture / implant surface By increasing the adhesion / residual amount of the composition, it becomes possible to sufficiently exert the action of useful components contained in the oral care composition. In particular, by making the viscosity of the composition as low as possible, it becomes possible to reach the intraoral site where cleaning is likely to be insufficient, and the oral hygiene environment can be significantly improved.
In addition, for the so-called weak oral people (specifically, elderly people, patients with oral diseases, young people, etc.) who are sensitive to chemical irritation because they greatly reduce the irritation of the composition. Even useful oral care compositions can be provided.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.

Evaluation of thickening action of liposomal catechins

(Subjects and raw materials and reagents used for evaluation)
Hydrogenated soybean phospholipid (phosphatidylcholine content of 60% by mass or more) was used as the phospholipid (described as “phospholipid (* 1)” in the chart). As the soybean green tea polyphenol (described as “green tea PP (* 2)” in the chart), a powder containing 90% by mass of green tea polyphenol (including 35% by mass of catechin gallates) was used. Rutin, quercetin and hesperidin used reagents, and grape seed polyphenol (denoted as “grape seed PP” in the chart) used Gravinol (manufactured by Kikkoman Corp.). In addition, for evaluating the thickening action, as a substitute for saliva, phosphate buffered saline (PBS (-); 0.02% by mass of potassium dihydrogen phosphate, 0.02% of potassium chloride, disodium hydrogen phosphate) 0.115% by mass, sodium chloride 0.8% by mass: described as “PBS” in the chart).

(About sample preparation methods)
The method for producing the specimen was performed according to the following method.
Each raw material included in the column of “Formulation at the time of liposome production” in Table 1 in Purified water is sequentially added while stirring, and after homogenization, a portable mixer (NGM-0.5TB; manufactured by Miki Co., Ltd.) Was used to prepare a liposome dispersion by stirring for 10 minutes at 1000 rpm.

(Viscosity measurement method)
4.5 ml of each of the obtained specimens was collected, 0.5 ml of purified water or phosphate buffered saline (PBS) was added to each, and the mixture was stirred until uniform. After stirring, an appropriate amount was quickly taken, and the viscosity was measured using an E-type rotational viscometer under the conditions of 20 ° C., rotor 1 ° 34 ′ × R24, rotational speed 1 rpm, 60 seconds. The obtained results are shown in Table 1.

  As shown in Table 1, the dispersion of liposome containing green tea polyphenol and hydrogenated soybean phospholipid (Example 1) did not thicken even when water was added, but by adding PBS, About 5.2 times thickened to 354 mPa · s. On the other hand, in Comparative Example 1 in which green tea polyphenol was removed from Example 1, the viscosity did not increase at all even when PBS was added. In addition, the liposome dispersion (Example 3) in which the amount of green tea polyphenol was doubled was 2.5 times thicker than that of Example 1 when PBS was added, even though the viscosity was low when water was added. Indicated. Furthermore, when the liquid paraffin was contained in the liposome of Example 3 (Example 4), the thickening effect was 1.4 times that of Example 3. Furthermore, a liposome dispersion liquid containing rutin, quercetin, or flavonoid hesperidin, which is a typical plant-derived polyphenol instead of green tea polyphenol, had no thickening effect in both water and PBS. In addition, about the liposome dispersion liquid (comparative example 5) which mix | blended grape seed polyphenol, although the thickening effect at the time of PBS addition was confirmed slightly, it remained at the thickening effect of about 50% of an Example. From the above, the dispersion of liposomes containing green tea polyphenols and hydrogenated phospholipids greatly increases in viscosity due to the interaction with saliva, and this effect can be obtained when the liposomes do not contain green tea polyphenols or other polyphenols. The case could not be confirmed.

  Hereinafter, although the prescription of the Example of the oral care composition concerning the present invention is given, the present invention is not limited to the following prescription. Unless otherwise specified, the blending amount represents mass%.

Formulation Example 1 (Mouthwash)

Component amount
Tea extract (* 1) 0.1
Hydrogenated soybean lecithin A (* 2) 1.5
Concentrated glycerin 10
Propylene glycol 5
Citric acid 0.01
Trisodium citrate 0.1
Methyl paraoxybenzoate 0.1
Saccharin sodium 0.02
Fragrance 0.05
Purified water balance
Total 100

* 1 Polyphenon 70A (Mitsui Norin Co., Ltd.)
* 2 SLP-PC70HS (manufactured by Sakai Oil Co., Ltd.): The phosphatidylcholine content is 70% by mass or more based on the total amount of phospholipid.

(Production method)
As a mechanism, tea extract, hydrogenated lecithin, and fragrance are added to propylene glycol, heated to 70 ° C. to dissolve, added to 10% purified water, and then uniformly stirred by a high-pressure emulsifier to suspend liposomes. Prepare a suspension. Separately, the remaining purified water and other components are mixed, and the liposome suspension is added to the solubilized mixture, followed by mixing and stirring until uniform.

Formulation Example 2 (Mouthwash)

Component amount
Green tea extract (* 3) 0.1
Hydrogenated soybean lecithin B (* 4) 1
Concentrated glycerin 10
Propylene glycol 5
Xylitol 2
Sodium hydroxide 0.2
Edetate disodium 0.05
Methyl paraoxybenzoate 0.1
Dipotassium glycyrrhizinate 0.05
Sodium bicarbonate 0.03
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100

* 3 Teacalon 90 (manufactured by Joban Plant Research Institute)
* 4 COATSOME NC-21 (manufactured by NOF Corporation): The phosphatidylcholine content is 90% by mass or more based on the total amount of phospholipid.

(Production method)
As a mechanism, green tea extract, hydrogenated lecithin, and fragrance are added to propylene glycol, heated to 70 ° C. to dissolve, added to 10% purified water, and then uniformly stirred by a high-pressure emulsifier. Prepare a suspension. Separately, the remaining purified water and other components are mixed, and the liposome suspension is added to the solubilized mixture, followed by mixing and stirring until uniform.

Formulation Example 3 (Moisturizing mouthwash)

Component amount
Green tea extract (* 5) 0.05
Hydrogenated soybean lecithin C (* 6) 0.8
Concentrated glycerin 10
Propylene glycol 5
Sodium hyaluronate 0.3
Trehalose 0.2
Methyl paraoxybenzoate 0.1
Citric acid 0.01
Trisodium citrate 0.1
Saccharin sodium 0.02
Fragrance 0.05
Purified water balance
Total 100

* 5 Sanphenon EGCG-OP (manufactured by Taiyo Chemical Co., Ltd.)
* 6 PHOSPHOLIPON 90H (manufactured by Lipoid): The phosphatidylcholine content is 90% by mass or more with respect to the total amount of phospholipid.

(Production method)
As a mechanism, green tea extract, hydrogenated lecithin, and fragrance are added to propylene glycol, heated to 70 ° C. to dissolve, added to 10% purified water, and then uniformly stirred by a high-pressure emulsifier. Prepare a suspension. Separately, after dissolving sodium alginate uniformly in the remaining purified water, the liposome suspension and other components are sequentially added, and mixed and stirred under reduced pressure until uniform.

Formulation Example 4 (Oral / Throat Spray)

Component amount
Cetylpyridinium chloride 150mg
Cha extract (* 7) 15mg
Hydrogenated soybean lecithin E (* 8) 1500mg
Propylene glycol 1000mg
Glycerin 5000mg
Fructose glucose liquid sugar 1000mg
Citric acid 800mg
Sodium citrate 400mg
Sodium benzoate 500mg
Sucralose 50mg
Platinum nanocolloid 2mg
Fragrance 250mg
Purified water balance part Total 50g

* 7 Purephenon 50W (Ogawa Fragrance Co., Ltd.)
* 8 SLP-PC92 (manufactured by Sakai Oil Co., Ltd.): The phosphatidylcholine content is 90% by mass or more based on the total amount of phospholipid.

(Production method)
Add cetylpyridinium chloride, tea extract, hydrogenated lecithin, and fragrance to propylene glycol as a mechanism, heat to 70 ° C to dissolve, add to purified water little by little under high-pressure emulsifier stirring, and stir uniformly Liposome suspension is prepared. Thereafter, the other components are added and mixed sequentially, and mixed and stirred until uniform.

Formulation Example 5 (Mouthwash)

Component amount
Cetylpyridinium chloride 0.1
Tea extract (* 9) 0.1
Hydrogenated egg yolk lecithin A (* 10) 2.5
Concentrated glycerin 10
Propylene glycol 5
Methyl paraoxybenzoate 0.1
Citric acid 0.01
Trisodium citrate 0.1
Saccharin sodium 0.02
Fragrance 0.05
Purified water balance
Total 100

* 9 Polyphenon G (Mitsui Norin Co., Ltd.)
* 10 Egg yolk lecithin PL-100P (manufactured by Kewpie Co., Ltd.): phosphatidylcholine content is 80% by mass or more based on the total amount of phospholipids

(Production method)
Add cetylpyridinium chloride, tea extract, hydrogenated lecithin, and fragrance to propylene glycol as a mechanism, heat to 70 ° C to dissolve, add to 5% purified water, and then stir uniformly with high-pressure emulsifier To prepare a liposome suspension. Separately, the remaining purified water and other components are mixed, and the liposome suspension is added to the solubilized mixture, followed by mixing and stirring until uniform.

Formulation Example 6 (Sterile application for oral cavity and throat for pump spray)

Component amount
Green tea extract (* 11) 0.2
Hydrogenated soybean lecithin G (* 12) 2
Concentrated glycerin 10
Sorbitol 10
Propylene glycol 5
Ethyl alcohol 3
Citric acid 0.1
Sodium citrate 0.01
Fragrance 0.2
Purified water balance section Total 100

* 11 Tea Calon 30 (manufactured by Tokiwa Plant Research Institute)
* 12 Basis LS-60HR (manufactured by Nisshin Oillio Group Co., Ltd.): The phosphatidylcholine content is 65% by mass or more based on the total amount of phospholipids.

(Production method)
Add the green tea extract, hydrogenated lecithin, and fragrance to propylene glycol as a mechanism, heat up to 70 ° C and dissolve uniformly, add to purified water, and stir uniformly with a high-pressure emulsifier. Prepare. Separately, citric acid and trisodium citrate are dissolved in a small amount of purified water, and the remaining purified water is added to the liposome suspension while sequentially stirring, and then a solution of sorbitol, citric acid, etc., glycerin And the fragrance | flavor melt | dissolved in ethyl alcohol is added in order, and it mixes and stirs until it becomes uniform.

Claims (5)

  An oral care composition comprising a dispersed aqueous solution of liposomes containing green tea polyphenols and hydrogenated phospholipids.   The oral care composition according to claim 1, wherein the phosphatidylcholine content in the hydrogenated phospholipid is 50% or more by mass ratio.   The oral care composition according to claim 2, wherein the phosphatidylcholine content in the hydrogenated phospholipid is 50% to 90% by mass ratio.   The green tea polyphenol is one or more polyphenols selected from catechins consisting of catechin, epicatechin, gallocatechin, epigallocatechin, and gallate catechins consisting of catechin gallate, epicatechin gallate, gallocatechin gallate, epigallocatechin gallate, The oral care composition according to claim 1, wherein the oral care composition is contained in an amount of 30% by mass or more in terms of dry matter based on the total amount of green tea polyphenols.   The oral care composition according to any one of claims 1, 2, and 4, wherein the liposome contains an oil or fat.