JP2015113331A - Hydrogen-containing composition and hydrogen addition method using the hydrogen-containing composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hydrogen-containing composition which can include hydrogen stably and easily, and to provide a hydrogen addition method using the hydrogen-containing composition.SOLUTION: The invention provides a hydrogen-containing composition having hydrogen and an interface formation agent, which includes hydrogen, and a hydrogen addition method using the hydrogen-containing composition. The interface formation agent is preferred to be one or more kinds selected from the group consisting of a surfactant and a high molecular compound. The surfactant is preferred to be one or more kinds selected from the group consisting of polyglycerol fatty acid ester, glycerine fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, propylene glycol ester of fatty acids, saponin, lecithin, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hardened castor oil, polyoxyethylene fatty acid ester, and polyoxyethylene polyoxypropylene glycol.

Description

  The present invention relates to a hydrogen-containing composition and a method for adding hydrogen using the hydrogen-containing composition, and in particular, a hydrogen-containing composition that can easily and stably contain hydrogen and a method for adding hydrogen using the hydrogen-containing composition. About.

  In recent years, beverages such as water and tea filled with hydrogen (hydrogen gas) have been sold. This is intended to reduce active oxygen present in the human body by ingesting hydrogen filled in a liquid.

  It has been found that active oxygen plays an important role in the production of ATP (adenosine triphosphate) in the citrate cycle and is essential for life support, and also plays a role in eliminating foreign substances that have entered the body. It is coming. In addition, active oxygen that has not been used in in vivo reactions or the like is usually decomposed by enzymes present in cells. However, not all active oxygen is decomposed by the enzyme, and surplus active oxygen is present without being decomposed. As a result, cells are damaged by surplus active oxygen, causing diseases such as cancer and lifestyle-related diseases, and aging, and eliminating surplus active oxygen is required for health maintenance.

  Therefore, in recent years, hydrogen has been used as a substance that eliminates such surplus active oxygen. This is because hydrogen has a very low molecular weight and is easily absorbed into the body, and further changes to water when it reacts with active oxygen, and has high safety reasons. Also, among the many active oxygens, only hydroxy radicals are selected and reduced, and the active oxygen useful for the body is not affected.

  In this way, the pathological effectiveness of hydrogen, which is thought to lead to disease prevention and health promotion without any particular harm, has been reported in many academic journals such as Non-Patent Documents 1-10. There is no excuse.

  As described above, ingestion of hydrogen has useful effects such as disease prevention and health promotion, but it is difficult to maintain a high dissolved hydrogen amount as it is after hydrogen is dissolved in a liquid. For example, if water filled with hydrogen is stored in a plastic container such as a PET (polyethylene terephthalate) bottle, most of the hydrogen will be removed in a few days even if it is sealed. However, high efficacy cannot be obtained.

  In this regard, in Patent Document 1, a liquid container having a flexible exterior is encapsulated with a liquid in which hydrogen molecules are dissolved, a pressure member is attached to a part or the whole of the liquid container, and pressure is applied from outside. Disclosed is a method for maintaining the amount of dissolved hydrogen by maintaining the added state.

  Further, Patent Documents 2 to 4 disclose cosmetics containing hydrogenated water containing 0.5 to 1.5 ppm of hydrogen and having a redox potential of −400 mV or less.

  Furthermore, Patent Documents 5 and 6 disclose a method for maintaining bubbles by gelling after enclosing hydrogen in fine bubbles.

"Nature Medicine, 2007, Vol. 13, p688-694" “Biochem. Biophys. Res. Comm., 411 (2011), 143-149”, T.A. Itoh et al. (Gifu International Institute for Biotechnology, Kinki University, Chubu University, Nagoya University, etc.) "Nutrition Research, 28 (2008) p137-143", Shizuo Hatakeyama et al. (Kunshan Internal Medicine Clinic, Kyoto Prefectural University of Medicine, etc.) “BJ. Heart and Lung Transplantation”, Atsumi Nakao et al. (University of Pittsburgh, Cleveland Clinic, etc.) "Anti-aging Medicine-Journal of the Japanese Society of Anti-Aging Medicine, Vol. 4, No. 1, p117-122", Katsuhiro Koyama et al. (Faculty of Education and Human Sciences, University of Yamanashi, Research Institute of Medical Engineering, Matsushita Electric Works, Ltd.) R & D Center) “Exp. Oncology, 2009, 31, p156-162” y. Saito, Hiroshima University "Experimental Medicine, Mol. 26, No. 13 (August issue), p2074- 2080, 2008" Nadao Ota, Goro Osawa (Nippon Medical University) “Investigative Ophthalmology & Visual Sci. 2010, 51, p 487-492,” Hideaki Oharazawa et al. (Nippon Medical University) “Science, New Series, 190, 4210 (Oct. 10, 1975), p152-154,” M.M. Dole (Baylor University, USA) "Life Sci. 324 (2001) p719-724" Ghrib et al. (University of Mediterranee, France)

JP 2011-136727 A JP 2007-230964 A JP 2007-238535 A JP 2007-308467 A Japanese Patent No. 4672084 JP 2011-245471 A

  The technique described in Patent Document 1 focuses on the proportional relationship between gas solubility and pressure (Henry's law), and by applying pressure from the outside to a container containing a hydrogen-dissolved liquid, Is trying to maintain a high amount of dissolved hydrogen. However, when this method is employed, a mechanism for applying pressure to the container is required. Also, the material of the container must be able to withstand this pressure, and it must be a flexible material that can convert external pressure to internal pressure. Furthermore, if the container itself for storing the liquid is not highly sealed or has low gas permeability, the external pressure may cause the hydrogen in the liquid to leak or permeate outside. .

  Moreover, although the technique of patent documents 2-4 can raise hydrogen concentration temporarily, there exists a problem that the fall of hydrogen concentration with time is remarkable. Therefore, in the techniques described in Patent Documents 5 and 6, hydrogen concentration is maintained by encapsulating hydrogen in fine bubbles and then added to gelation, but it is maintained by confining it in a solid gel. Therefore, there is a problem that the hydrogen concentration cannot be maintained in a state where the viscosity is low, such as when the gel is melted.

  Accordingly, an object of the present invention is to solve the above-described problems of the prior art and provide a hydrogen-containing composition that can easily and stably contain hydrogen and a method for adding hydrogen using the hydrogen-containing composition. .

  As a result of intensive studies to solve the above problems, the present inventors have found that the above object can be achieved by encapsulating hydrogen in a specific substance, and have completed the present invention.

  That is, the hydrogen-containing composition of the present invention has hydrogen and an interface forming agent, and the interface forming agent includes the hydrogen.

  In the hydrogen-containing composition of the present invention, the interface forming agent is preferably one or more selected from the group consisting of a surfactant and a polymer compound.

  Further, in the hydrogen-containing composition of the present invention, the surfactant is a polyglycerol fatty acid ester, glycerol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, propylene glycol fatty acid ester, saponin, lecithin, polyoxyethylene sorbitan fatty acid ester. , Polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, and polyoxyethylene polyoxypropylene glycol are preferably one or more selected from the group consisting of: It is preferably one or more selected from the group consisting of tussus, saikachi, ammarok, acacia concina, bellflower, janohige, hirohasenega and kiraya.

  Furthermore, in the hydrogen-containing composition of the present invention, the polymer compound comprises an acrylate copolymer, an acrylic acid / alkyl methacrylate copolymer, a carboxyvinyl polymer, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, It should be one or more selected from the group consisting of carboxymethylcellulose, sodium alginate, carrageenan, xanthan gum, quince seed gum, locust bean gum, polyvinyl alcohol, polymethacrylic acid soda, polyacrylic acid glycerin ester and polyvinylpyrrolidone. Is preferred.

  The method for adding hydrogen according to the present invention is characterized in that the hydrogen-containing composition is used.

  According to the present invention, it is possible to provide a hydrogen-containing composition that can easily and stably contain hydrogen, and a method for adding hydrogen using the hydrogen-containing composition.

Hereinafter, the hydrogen-containing composition of the present invention and a method for adding hydrogen using the hydrogen-containing composition will be specifically described.
The hydrogen-containing composition of the present invention has hydrogen and an interface forming agent, and the interface forming agent includes the hydrogen. By including hydrogen in the interface forming agent, hydrogen can be included easily and stably.

  The hydrogen addition method of the present invention uses the hydrogen-containing composition. Thereby, hydrogen can be added to foods such as beverages, cosmetics, etc. in a simple and stable state.

  Furthermore, in this invention, it is preferable that the said interface formation agent is 1 type (s) or 2 or more types selected from the group which consists of surfactant and a high molecular compound. By encapsulating hydrogen with a surfactant and / or a polymer compound, not only hydrogen can be encapsulated easily and stably, but also can be easily released when used in foods such as beverages, cosmetics, and the like.

  Furthermore, in the present invention, the surfactant is not particularly limited as long as the effect of the present invention can be obtained. For example, polyglycerin fatty acid ester (diglycerin monolaurate, diglycerin monostearate, diglycerin mono) Oleate, decaglycerin monolaurate, decaglycerin monostearate, decaglycerin monooleate, etc., glycerin fatty acid ester, sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan tristearate, sorbitan) Monooleate, sorbitan trioleate, etc.), sucrose fatty acid ester (sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, Sucrose oleic acid ester, sucrose behenic acid ester, sucrose erucic acid ester, etc.), propylene glycol fatty acid ester (propylene glycol monostearate etc.), saponin, lecithin (lecithin, enzymatically decomposed lecithin (phosphatidic acid), lysolecithin) , Soybean lecithin (soybean phospholipid), egg yolk lecithin, etc.), polyoxyethylene sorbitan fatty acid ester (polyoxyethylene sorbitan monolaurate (polysorbate 20, Tween 20), polyoxyethylene sorbitan monooleate (polysorbate 80, Tween 80), polyoxy Ethylene sorbitan monostearate (polysorbate 60, Tween 60), polyoxyethylene sorbitan tristearate (polysorbate 65, Tween 65) Etc.), polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, polyoxyethylene polyoxypropylene glycol, organic acid monoglyceride (acetic acid monoglyceride, citric acid monoglyceride, diacetyltartaric acid monoglyceride, succinic acid monoglyceride, lactic acid monoglyceride), mono-diglyceride ), Polyglycerin condensed (poly) ricinoleic acid ester, sodium stearoyl lactate and calcium stearoyl lactate, etc., but polyglycerin fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, propylene glycol fatty acid ester, Saponin, lecithin, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, It is preferable that it is 1 type, or 2 or more types selected from the group which consists of polyoxyethylene fatty acid ester and polyoxyethylene polyoxypropylene glycol.

  Furthermore, in the present invention, the origin of the saponin is not particularly limited. However, the saponin is selected from the group consisting of mukuroji, sapin strawberry trihorias, saikachi, ammarok, acacia concina, bellflower, janohige, hirohasenega and kiraya. It is preferable to originate from a seed or two or more plants. In addition, one or more plants selected from the group consisting of mukuroji, sapin ヅ strihoriatus, honey bee, ammarok, acacia concina, bellflower, janohige, hirohasenega and kiraya, extract in a state containing saponin, etc. May be used.

  Furthermore, in the present invention, the polymer compound is not particularly limited as long as the effects of the present invention can be obtained. For example, acrylate copolymers, acrylic acid / alkyl methacrylate copolymers, carboxyvinyl polymers, hydroxymethyl cellulose , Hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, alginic acid (kelp mucilage), sodium alginate, potassium alginate, calcium alginate, ammonium alginate, propylene glycol alginate, carrageenan (carrageenin, carrageenan), xanthan gum (xanthan gum) ), Heat-treated xanthan gum, quince seed gum, locust bean gum (carob bean gum, ina) Mamamu), polyvinyl alcohol, polymethacrylic acid soda, glyceryl acrylate ester, polyvinylpyrrolidone, pullulan, dextran, curdlan, deacylated gellan gum, native gellan gum, macrohomopsis gum, natto fungus gum (sticky natto fungus), Sclerogum (Scleroglucan), Ramzan gum, Welan gum (Welan polysaccharide), Levan, Agrobacterium succinoglycan, Azotobacter vinelanji gum (Azotobacter vinelanzy polysaccharide), Aureobasidium culture solution, Yeast Cell wall (yeast cell membrane), β-glucan (β1,3-glucan, β1,3 / 1,6 glucan), guar gum (guar flower, guar gum), guar gum enzyme degradation product (guar flower enzyme degradation product, guar gum enzyme degradation product) , Heat-treated locust bean gum, tara gum, tamarind seed gum (tamarind gum, tamarind seed polysaccharide), sesbania gum, cassia gum (cassia gum), amased gum, danmar resin, mackerel mugwort seed gum (artemisia seed gum, mackerel mugwort seed polysaccharide), tri Acanthus gum, psyllium seed gum (Phyllium husk), gum arabic (Acacia gum), arabino galactan, gati gum (Indian gum), tragacanth gum, karaya gum, almond gum (Sedow gum), Elemi resin, peach resin, Farseleran, processed Yukema algae , Agar, easily solubilized agar, agar partial degradation product, agarose, brown algae extract (brown algae mucilage), fucoidan, fukuronori extract (fukuronori polysaccharide, fukurofunori polysaccharide, fukurofunori extract) ), LM pectin, HM pectin, sugar beet pectin, heat-treated sugar beet pectin, polygalacturonic acid, aloe vera extract, okra extract, beetle aloe extract, trooaoi, soybean polysaccharide (soybean hemicellulose), chitin, chitosan, oligoglucosamine ( Chitosan oligosaccharide), glucosamine, konjac flour, glucomannan (konjac potato extract), cellulose, seaweed cellulose, sweet potato cellulose, methylcellulose, sodium carboxymethylcellulose (sodium fibrin glycolate), carboxymethylcellulose calcium (calcium fibrinoglycolate) , Fermented cellulose (brewed cellulose, nata de coco), microfibrous cellulose, starch, sodium starch glycolate, starch phosphorus Sodium ester, hydroxypropyl starch, hydroxypropyl phosphate crosslinked starch, acetylated adipic acid crosslinked starch, acetylated phosphorylated crosslinked starch, acetylated oxidized starch, oxidized starch, phosphate monoesterified phosphate crosslinked starch, phosphorylated starch, Phosphate cross-linked starch carboxymethyl starch, cationic starch, starch acetate, starch octenyl succinate, starch starch sodium octenyl succinate, phosphate starch, phosphate distarch, glycerol distarch, grafted starch, British gum, soluble starch, unmodified pregelatinized starch , Modified pregelatinized starch, sterilized dry starch, granular starch, oil-absorbing starch, dextrin, white dextrin, yellow dextrin, British Examples include gum, maltodextrin, cluster dextrin, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, glycogen, sodium polyacrylate, mucin, hyaluronic acid, polyglutamic acid, and the like. Acid / alkyl methacrylate copolymer, carboxyvinyl polymer, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, sodium alginate, carrageenan, xanthan gum, quince seed gum, locust bean gum, polyvinyl alcohol, polymethacryl Acid soda, polyacrylic acid glycerin ester and polyvinylpyrrolidone It is preferable that it is 1 type, or 2 or more types selected from a group.

  In the present invention, the amount of hydrogen to be included is not particularly limited as long as the effects of the present invention can be obtained, but it is preferably contained in the hydrogen-containing composition in an amount of 70 to 99 vol%. By encapsulating hydrogen in such a range, the effect of hydrogen can be sufficiently obtained even when the addition amount of the hydrogen-containing composition is small when added to foods, cosmetics and the like.

  In the present invention, the amount of the interface forming agent is not particularly limited as long as the effect of the present invention can be obtained, but is preferably 0.001 to 10% by mass, and 0.01 to 5% by mass. Is more preferable, and it is still more preferable that it is 0.1-3 mass%. By setting the amount of the interface forming agent in such a range, hydrogen can be included more stably.

  Furthermore, in the present invention, the method for producing the hydrogen-containing composition is not particularly limited as long as hydrogen can be easily and stably encapsulated in the interface forming agent. As such a method, for example, it can be produced by blowing hydrogen with a nozzle into a composition in which an interface forming agent is dissolved.

Furthermore, in the present invention, the origin of hydrogen to be included is not particularly limited. Furthermore, it is most preferable that only hydrogen is filled, but not only hydrogen but also an inert gas may be mixed. Examples of the inert gas include gases having poor reactivity such as nitrogen gas and carbon dioxide gas, in addition to group 0 elements of the periodic table. These gases are extremely stable and do not combine with other elements. In that case, the hydrogen concentration is preferably 3.9% by mass, which is the lower limit of explosion. Thereby, the danger of ignition etc. becomes lower.
Mixing ratio

  Further, in the present invention, the target to which the hydrogen-containing composition is added is not particularly limited as long as the effect of hydrogen can be obtained, but it is intended for foods such as beverages, cosmetics, quasi drugs, pharmaceuticals, and the like. It can be. Such foods such as beverages, cosmetics, quasi drugs, pharmaceuticals and the like include aerosols. Furthermore, other components and the like can be appropriately added within the range in which the effects of the present invention are not impaired, in accordance with the addition target such as foods such as beverages, cosmetics, quasi drugs, and pharmaceuticals. For example, when a hydrogen-containing composition is added to a cosmetic, any component other than those described above can be blended in a qualitative and quantitative range, and components that are usually blended in cosmetics, such as oily components and humectants. Antioxidants, preservatives, fragrances, various vitamins, chelating agents, coloring agents, ultraviolet absorbers, medicinal ingredients, inorganic salts and the like can be blended.

  Furthermore, in the present invention, the amount of the hydrogen-containing composition added to an object such as cosmetics is not particularly limited as long as the effect of the present invention is obtained and the effect of hydrogen is obtained in the object. Among these, 0.001 to 30% by mass is preferable, 0.01 to 10% by mass is more preferable, and 0.1 to 5% by mass is even more preferable. By setting the addition amount of the hydrogen-containing composition within such a range, hydrogen can be supplied more stably, and the effect of hydrogen can be realized when the object is used.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail using an Example, this invention is not limited to these Examples.

Example 1
A base composition was prepared according to the formulation described in Table 1 below. Hydrogen was blown into this through a nozzle at 90 vol% to prepare a hydrogen-containing composition 1.

(Example 2)
A base composition was prepared according to the formulation described in Table 2 below. Hydrogen was blown into this through a nozzle at 90 vol% to prepare a hydrogen-containing composition 2.

(Example 3)
A base composition was prepared according to the formulation described in Table 3 below. Hydrogen was blown into this through a nozzle at 90 vol% to prepare a hydrogen-containing composition 3.

Example 4
A lotion was prepared according to the formulation shown in Table 4 below.

(Example 5)
A lotion was prepared according to the formulation shown in Table 5 below.

(Example 6)
A cream was prepared according to the formulation described in Table 6 below.

(Example 7)
A cream was prepared according to the formulation described in Table 7 below.

(Example 8)
A cosmetic solution was prepared according to the prescription in Table 8 below.

Example 9
A cosmetic solution was prepared according to the prescription in Table 9 below.

(Example 10)
A cleansing foam was prepared according to the formulation shown in Table 10 below.

(Example 11)
A shampoo was prepared according to the formulation described in Table 11 below.

(Example 12)
A body soap was prepared according to the formulation shown in Table 12 below.

(Example 13)
Hydrogen-containing milk was prepared by adding 10 g of hydrogen-containing composition 3 to 90 g of commercially available milk.

(Example 14)
10 g of the hydrogen-containing composition 3 was added to 90 g of a commercially available green tea beverage to prepare a hydrogen-containing green tea beverage.

(Example 15)
A hydrogen-containing mousse was prepared by filling 10 g of the hydrogen-containing composition 1 into an aerosol container and further filling with hydrogen. The injection pressure of hydrogen at 20 ° C. was 0.7 MPa. An aqueous solution containing 25% KOH was placed in an alkaline electrolytic cell, and this was electrolyzed to generate hydrogen, and the hydrogen was filled as a propellant.

(Example 16)
A hydrogen-containing mousse was prepared by filling 10 g of the hydrogen-containing composition 2 into an aerosol container and further filling with hydrogen. The injection pressure of hydrogen at 20 ° C. was 0.7 MPa. An aqueous solution containing 25% KOH was placed in an alkaline electrolytic cell, and this was electrolyzed to generate hydrogen, and the hydrogen was filled as a propellant.

(Comparative Examples 4 to 16)
In the formulations described in Table 4 to Table 12, the hydrogen-containing composition 1 or the hydrogen-containing composition 2 was replaced with purified water, and hydrogen was blown so as to have the same concentration as the cosmetics of Examples 4 to 12, Cosmetics of Comparative Examples 4 to 12 were prepared. Further, the hydrogen-containing composition 3 was replaced with purified water, and hydrogen was blown so as to have the same concentration as in the beverages of Examples 13 and 14, thereby producing beverages of Comparative Examples 13 and 14. Further, the hydrogen-containing composition 1 or the hydrogen-containing composition 2 was replaced with purified water, and hydrogen was blown so as to have the same concentration as the hydrogen-containing mousse of Example 15 and Example 16, and Comparative Example 15 and Comparative Example 16 A hydrogen-containing mousse was prepared.

  Using the hydrogen determination method using methylene blue, cosmetics of Examples 4 to 12, cosmetics of Comparative Examples 4 to 12, beverages of Examples 13 and 14, Comparative Examples 13 and 14 The hydrogen concentrations of the beverages, the hydrogen-containing mousses of Examples 15 and 16, and the hydrogen-containing mousses of Comparative Examples 15 and 16 were measured. In the cosmetics of Examples 4 to 12, the beverages of Examples 13 and 14, and the hydrogen-containing mousses of Examples 15 and 16, the hydrogen concentration could be maintained even after standing at room temperature for 1 month. In the cosmetics of Comparative Examples 4 to 12, the beverages of Comparative Examples 13 and 14, and the hydrogen-containing mousses of Comparative Examples 15 and 16, the hydrogen concentration could not be maintained, and hydrogen decreased significantly.

Claims (6)

  A hydrogen-containing composition comprising hydrogen and an interface forming agent, wherein the interface forming agent includes the hydrogen.   The hydrogen-containing composition according to claim 1, wherein the interface forming agent is one or more selected from the group consisting of a surfactant and a polymer compound.   The surfactant is polyglycerin fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, propylene glycol fatty acid ester, saponin, lecithin, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene The hydrogen-containing composition according to claim 2, which is one or more selected from the group consisting of fatty acid esters and polyoxyethylene polyoxypropylene glycol.   4. The hydrogen-containing composition according to claim 3, wherein the saponin is one or more selected from the group consisting of mukuroji, sapin strawberry trihorias, saikachi, ammarok, acacia concina, bellflower, janohige, hirohasenega and kiraya. object.   The polymer compound is an acrylate copolymer, acrylic acid / alkyl methacrylate copolymer, carboxyvinyl polymer, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, sodium alginate, carrageenan, xanthan gum, quince seed. The hydrogen-containing composition according to claim 2, which is one or more selected from the group consisting of gum, locust bean gum, polyvinyl alcohol, polysodium methacrylate, polyglyceryl acrylate ester and polyvinylpyrrolidone. A method for adding hydrogen, wherein the hydrogen-containing composition according to any one of claims 1 to 5 is used.