WO2019069811A1

WO2019069811A1 - Cream and manufacturing method therefor

Info

Publication number: WO2019069811A1
Application number: PCT/JP2018/036288
Authority: WO
Inventors: 悠柴原; 健豊永; 大助西尾; 宏一豊島; 武田　徹
Original assignee: 株式会社新菱
Priority date: 2017-10-05
Filing date: 2018-09-28
Publication date: 2019-04-11
Also published as: TW201922201A; JPWO2019069811A1; JP6694118B2

Abstract

Provided are: a cream that contains a high percentage of hydrogen gas and has few harmful effects on the skin; and a manufacturing method therefor. The cream according to the present invention is one in which bubble-state hydrogen gas is incorporated into a composition that comprises a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium, wherein the content percentage of the bubble-state hydrogen gas with respect to the cream is 0.1-100 vol% [v/w]. The cream manufacturing method according to the present invention comprises: preparing a composition that comprises a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium; incorporating bubble-state hydrogen gas into the composition; and increasing the viscosity of the composition containing the bubble-state hydrogen gas.

Description

Cream and method for producing the same

The present invention relates to a cream and a method of manufacturing the same.

In recent years, hydrogen gas is expected to have various functions such as a function of removing active oxygen and a function of enhancing biological activity. Therefore, cosmetics, foods, beverages and the like containing hydrogen gas have attracted attention.

As a cream containing hydrogen gas or a cream capable of generating hydrogen gas, for example, the following are proposed.
(1) Water phase where dissolved hydrogen content is 0.5 to 1.5 ppm hydrogen water with moisturizing component, alkali agent etc. blended, oil component with surfactant, drug, preservative, antioxidant, perfume etc. A cream obtained by mixing and emulsifying the blended oil phase (Patent Document 1).
(2) The cream which mix | blended the microparticles | fine-particles of hydrogen storage alloys, such as magnesium hydride (patent document 2).

JP, 2007-308467, A International Publication No. 2012/111834

The cream of (1) contains 1.5 ppm (1.8% by volume [v / w]) of hydrogen gas as dissolved hydrogen which is the largest in hydrogen water and close to the saturation solubility of hydrogen gas in water. However, since the cream of (1) is manufactured through a heating step and a degassing step, the final product does not contain bubbled hydrogen gas other than dissolved hydrogen in hydrogen water.
In order to fully express the various functions that hydrogen gas has, it is desirable to further increase the content of hydrogen gas contained in the entire cream.

The cream of (2) is to generate hydrogen gas by a chemical reaction between the hydrogen storage alloy and the moisture of the skin, and there is a concern about an adverse effect on the skin.

The present invention provides a cream having a high hydrogen gas content and less adverse effects on the skin, and a method for producing the same.

The present invention has the following aspects.
<1> A cream containing hydrogen gas in a bubble state in a composition containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 carbon atoms or more, and a liquid medium, containing hydrogen gas in the bubble state in the cream Cream having a rate of 0.1 to 100% by volume [v / w].
<2> The cream of <1>, wherein the composition further comprises a higher alcohol.
<3> The cream of <1> or <2>, wherein the composition further comprises a surfactant.
<4> The cream according to any one of <1> to <3>, wherein the composition further comprises one or both of a fat and oil and a wax.
<5> The cream according to any one of <1> to <4>, wherein the average bubble diameter of hydrogen gas in the bubble state is 1 μm to 1 mm.
<6> The method for producing a cream according to any one of <1> to <5>, wherein a composition including a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium is prepared. A method for producing a cream, comprising incorporating hydrogen gas in a bubble state, and thickening the composition containing hydrogen gas in a bubble state.
The manufacturing method of the cream of the said <6> which mixes A liquid containing an alkaline agent and a liquid medium, and B liquid containing a C10 or more fatty acid in order to prepare <7> said composition.

The cream of the present invention has a high hydrogen gas content and is less harmful to the skin.
According to the method for producing a cream of the present invention, it is possible to produce a cream having a high hydrogen gas content and less adverse effects on the skin.

It is an external appearance photograph of the cream of Example 1 with which the head space vial was filled. It is a photograph of microscope observation of the cream of Example 1. It is a graph which shows the time change of the content rate of hydrogen gas in the cream of Example 1 stored in the glass-made sample bottle.

The following definitions of terms apply throughout the specification and claims.
The term "higher alcohol" refers to an alcohol having 6 or more carbon atoms.
The “content of bubbled hydrogen gas in the cream (volume% [v / w])] means the ratio of the volume (cm ³ ) of hydrogen gas contained in a bubbled state to a predetermined amount (100 g) of the cream. .
The "saturation solubility of hydrogen gas in water" refers to the saturation solubility of hydrogen gas in water at atmospheric pressure. In addition, "dissolution of gas" which prescribes | regulates saturation solubility is the state in which Henry's law is materialized and gas is melt | dissolving in molecular form according to a pressure.

The content of hydrogen gas in the bubble state in the cream is determined as follows. A small amount of cream is precisely weighed into a head space vial to be used in GC analysis and sealed under atmospheric pressure and room temperature conditions. Heat the headspace vial to 70 ° C. and continue heating at 70 ° C. until bubbles disappear from the cream. After the bubbles disappear, the gas phase gas in the head space vial is collected, and the hydrogen gas is quantified by gas chromatography (GC) analysis (TCD detector), and the content of hydrogen gas in the bubble state in the cream (volume Calculate% [v / w]). The saturated solubility of hydrogen gas in water is 1.6 ppm (2% by volume [v / w]) at 20 ° C. and 1.5 ppm (1.8% by volume [v / w]) at 70 ° C. That is, since the amount of dissolved hydrogen gas in the composition (almost water) hardly changes before and after the measurement, the content of hydrogen gas determined by the above method can be regarded as the content of hydrogen gas in a bubble state.
The average bubble size of hydrogen gas in the bubble state is determined by measuring the bubble sizes of 10 randomly selected bubbles by microscopic observation and calculating the average value thereof. When the observation bubble is an ellipse or the like which is not a true sphere, the average value of the maximum and minimum diameters thereof is taken as the bubble diameter.
In the present specification and claims, “to” indicating a numerical range means that the numerical values described before and after it are included as the lower limit value and the upper limit value.

<< Cream >>
The cream of the present invention includes hydrogen gas in a bubble state in a composition containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium.

<Hydrogen gas in bubble state>
1 micrometer or more is preferable, as for the average bubble diameter of hydrogen gas of a bubble state, 10 micrometers or more are more preferable, and 30 micrometers or more are more preferable. If the average bubble diameter of the bubbled hydrogen gas is equal to or more than the lower limit value of the above range, the content of the bubbled hydrogen gas in the cream can be easily increased.
1 mm or less is preferable, 500 micrometers or less are more preferable, 300 micrometers or less are more preferable, and, as for the average bubble diameter of hydrogen gas of a bubble state, 100 micrometers or less are especially preferable. If the average bubble diameter of the hydrogen gas in the bubble state is equal to or less than the upper limit value of the range, it is easy to hold the hydrogen gas in the bubble state in the cream for a long time. Further, hydrogen gas in the form of bubbles is uniformly dispersed in the cream, and a good cream having a milky white appearance due to fine bubbles is obtained.

The average cell diameter of hydrogen gas in the bubble state is preferably 1 μm to 1 mm, more preferably 10 μm to 500 μm, still more preferably 30 μm to 300 μm, and particularly preferably 30 μm to 100 μm.

The content of hydrogen gas in the bubble state in the cream is 0.1 to 100% by volume [v / w], preferably 10 to 100% by volume [v / w], and 20 to 95% by volume [v / w] Is more preferable, and 40 to 90% by volume [v / w] is further preferable. If the content of bubbled hydrogen gas in the cream is at least the lower limit of the above range, the content of total hydrogen gas in the cream combined with the amount of dissolved hydrogen gas in the composition is greater than that of the conventional cream. More than that, the various functions possessed by hydrogen gas can be sufficiently expressed. When the content of hydrogen gas in the bubble state in the cream is up to the upper limit value of the above range, the hydrogen gas can be dispersed in the bubble, and a good appearance is exhibited. The bubble dispersion exceeding this makes it difficult to form a stable bubble liquid film, and stable bubble formation can not be performed.

The bubble diameter of bubbled hydrogen gas and the content of bubbled hydrogen gas in the cream are the amounts of fatty acids having 10 or more carbon atoms, higher alcohols, surfactants, oils and fats, waxes, etc. It can adjust by changing supply_amount | feed_rate of hydrogen gas at the time of including the hydrogen gas of bubble state to things, and the stirring conditions (rotation speed, time, etc.) of a composition.

<Composition>
In the composition, an emulsion in which an oil component and an aqueous component are emulsified thickens and becomes a cream. The emulsion may be of W / O type or of O / W type.

General creams are based on creams; agents for imparting various functions to creams; sensory characterization materials for imparting a sense of satisfaction affecting vision, smell, etc .; and maintaining the quality of creams Including quality holding raw materials.
The composition in the present invention is a base for inclusion of hydrogen gas in the form of bubbles in the cream of the present invention, and is a fatty acid having 10 or more carbons and its salts classified as an oily component of a base, and groups It contains a liquid medium classified as an aqueous component of the agent as an essential component. The composition in the present invention preferably further contains a higher alcohol classified as an oily component of the base. The composition in the present invention preferably further comprises a surfactant classified as a base. It is preferable that the composition in the present invention further includes any one or both of a fat and oil and a wax classified as a base oil component. The composition in the present invention may be, if necessary, fatty acid having 10 or more carbon atoms, liquid medium, higher alcohol, surfactant, oil and fat, base other than oil and wax, drug, sensory characteristic imparting raw material, quality maintaining raw material Etc. may be included.

(Fatty acids with 10 or more carbon atoms and their salts)
The fatty acid having 10 or more carbon atoms is a raw material of the fatty acid salt having 10 or more carbon atoms. Unneutralized fatty acids that did not turn into fatty acid salts also act as thickeners to cream the composition. The thickened creamy composition can hold a large amount of bubbled hydrogen gas for a long time.
Examples of the fatty acid having 10 or more carbon atoms include capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachic acid, behenic acid, oleic acid, linoleic acid, isostearic acid, hydroxystearic acid and the like. One type of fatty acid may be used alone, or two or more types may be used in combination.
The fatty acid is preferably a fatty acid having 10 to 18 carbon atoms from the viewpoint of easily forming a good fatty acid salt (soap) as an emulsifying agent, and capric acid (carbon number 10), lauric acid (carbon number 12), myristic acid (carbon) Formula 14), palmitic acid (carbon number 16) and stearic acid (carbon number 18) are more preferable, and myristic acid (carbon number 14), palmitic acid (carbon number 16) and stearic acid (carbon number 18) are more preferable.

The fatty acid salt having 10 or more carbon atoms is produced by the reaction of a fatty acid having 10 or more carbon atoms and an alkaline agent in the production method described later. The fatty acid salt having 10 or more carbon atoms acts as an emulsifier for emulsifying the aqueous component and the oily component of the base.
Examples of fatty acid salts include sodium salts, potassium salts and triethanolamine salts of fatty acids.
As the fatty acid salt, salts of fatty acids having 10 to 18 carbon atoms are preferable, and capric acid (10 carbon atoms), lauric acid (12 carbon atoms), myristic acid (14 carbon atoms), palmitic acid (16 carbon atoms), stearin Salts of acid (carbon number 18) are more preferable, and salts of myristic acid (carbon number 14), palmitic acid (carbon number 16) and stearic acid (carbon number 18) are more preferable.

(Liquid medium)
The liquid medium is a medium for dissolving or dispersing other components.
As a liquid medium, an aqueous medium containing water is preferable in that it is easy to be emulsified with an oil component to form an emulsion. The aqueous medium may further contain lower alcohols and glycols.
As water, purified water etc. are mentioned. The lower alcohol includes ethyl alcohol, isopropyl alcohol and the like. Examples of the glycol include ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butanediol, 1,4-butanediol and the like.
The proportion of water in the aqueous medium is preferably 50% by mass or more, more preferably 70% by mass or more, and particularly preferably 100% by mass, of the aqueous medium (100% by mass).

(Higher alcohol)
Higher alcohols improve the feel of the cream of the invention. Higher alcohols also act as thickeners to adjust the viscosity of the composition.
Examples of higher alcohols include caproyl alcohol, caprylyl alcohol, capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, oleyl alcohol, hexyldecanol, isostearyl alcohol, octyl dodecanol and the like. . The higher alcohols may be used alone or in combination of two or more.
As the higher alcohol, an alcohol having 12 to 22 carbon atoms is preferable from the viewpoint of making the composition creamy, and at least cetyl alcohol from the viewpoint that the content of hydrogen gas in a bubble state in the cream can be sufficiently high. Is particularly preferred.

(Surfactant)
The surfactant has a solubilizing action to dissolve the oil component in water, an emulsifying action to disperse the oil component in water, a dispersing action to disperse the powder component in oil and water, a cleaning action to remove dirt, and foaming to improve foaming. It is an ingredient added to a cream to impart a function such as action.
In the cream of the present invention, the surfactant has a function of uniformly and finely dispersing the bubbled hydrogen gas in the composition and maintaining the bubbled hydrogen gas in the cream for a long time.

As surfactant, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant etc. are mentioned. As the surfactant, non-ionic surfactants are preferable in that they function as an emulsifier even at relatively low temperatures.

As nonionic surfactants, polyoxyethylene alkyl ether, polyoxyalkylene derivative, reactive surfactant, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, glycerin fatty acid ester, glycerin fatty acid Ester, polyoxyethylene fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkylamine, alkyl alkanolamide, fatty acid sucrose and the like can be mentioned. From the viewpoint of mildness, fatty acid sucrose is preferred as the nonionic surfactant.

Examples of anionic surfactants include alkyl sulfates, polyoxyethylene alkyl ether sulfates, alkyl benzene sulfonates, other sulfonates, reactive surfactants, fatty acid salts, naphthalene sulfonate formalin condensates, etc. Can be mentioned.
The cationic surfactant includes alkylamine salts, quaternary ammonium salts and the like.
Examples of amphoteric surfactants include alkyl betaines and alkyl amine oxides. As an amphoteric surfactant, alkyl betaine is preferable.
As the surfactant, one type may be used alone, or two or more types may be used in combination.

(Fat and oil)
Fats and oils are components (skin softeners: emollients) added for the purpose of smoothing the skin.
As fats and oils, natural fats and oils (castor oil, camellia oil, olive oil, apricot oil, shea oil, shepherd oil, avocado oil, almond oil, sesame oil, rice bran oil, safflower oil, soybean oil, soybean oil, corn oil, rapeseed oil, parsic oil, palm oil , Sunflower oil, grape seed oil, macadamia nut oil, meadowfoam oil, cottonseed oil, coconut oil, peanut oil, beef tallow, horse oil, mink oil etc., hydrocarbon (isodecane, dodecane, tetradecane, squalane, α-olefin oligomers, fluid And paraffin, petrolatum, isoparaffin, microcrystalline wax, ceresin and the like. The fats and oils may be used alone or in combination of two or more.
As fats and oils, castor oil, camellia oil, olive oil, apricot oil, shea oil, shepherd oil, avocado oil, almond oil, sesame oil, rice bran oil, rice bran oil, safflower oil, soybean oil, corn oil, rapeseed oil, persic oil, palm oil, sunflower oil , Grape seed oil, macadamia nut oil, meadowfoam oil, cotton seed oil, coconut oil, peanut oil, beef tallow, horse oil, mink oil, isodecane, dodecane, tetradecane, squalane, α-olefin oligomers, liquid paraffin, vaseline, isoparaffin, microcrystalline Wax and ceresin are preferred.

(Low)
Wax is an ingredient added to improve the feel of the cream.
Examples of the wax include beeswax, carnauba wax, candelilla wax, rice bran wax, lanolin, jojoba oil, orange raffin oil and the like. One type of wax may be used alone, or two or more types may be used in combination.
As the wax, beeswax, carnauba wax, candelilla wax, rice bran wax, lanolin, jojoba oil and orange raffi oil are preferable.

(Other base)
Other bases include purified water, aqueous components other than lower alcohols; fatty acids having 10 or more carbon atoms, higher alcohols, fats and oils, oil components other than waxes, powder components and the like.

Other aqueous components include thickeners.
A thickener is an ingredient added for viscosity adjustment of a cream, stabilization, and a feeling-of-use adjustment.
Examples of the thickener include water soluble polymers and the like. Examples of the water-soluble polymer include organic water-soluble polymers and inorganic water-soluble polymers.
Examples of organic water-soluble polymers include natural polymers (xanthan gum, mannan, pectin etc.), semi-synthetic polymers of cellulose series (sodium carboxymethylcellulose etc.), synthetic polymers of vinyl series (carboxy vinyl polymers and their derivatives, polyvinyl alcohol, Polyvinyl pyrrolidone and derivatives thereof and the like can be mentioned.
Examples of inorganic water-soluble polymers include pentonites, which are a type of clay mineral.

Other oily components include esters (fatty acid esters such as monoglycerides, diglycerides and triglycerides) and silicone oils (dimethylpolysiloxane, dimethylcyclopentasiloxane, amino-modified silicones, alkyl-modified silicones and the like).
Examples of the powder component include colored pigments (such as alumina), white pigments (such as titanium oxide and zinc oxide), pearlescent agents (such as iron oxide and mica synthetic pearls), and extender pigments such as talc, kaolin and mica. .

(Drug)
Examples of the drug include moisturizing ingredients, astringents (antiperspirants), refreshing agents, UV inhibitors, other drugs and the like.
Examples of the moisturizing component include hydrolyzed collagen, glycerin, stearic acid trimethyl ammonium chloride, propylene glycol, 1,3-butylene glycol, betaine, hyaluronic acid, lavender oil, ethylhexyl glycerin and the like.
As an astringent, citric acid, lactic acid, aluminum sulfate, lemon water, hamamelis etc. are mentioned.
As a refreshing agent, menthol, ethyl alcohol, camphor, eucalyptus oil etc. are mentioned.
Examples of UV inhibitors include titanium oxide, zinc oxide and octyl triazone.
Other agents include skin lightening agents (vitamin C or derivatives thereof), hair growth agents, acne agents, dandruff and itching agents, anti-odor agents, anti-inflammatory agents (such as dipotassium glycyrrhizinate), bactericides, nutritional agents, activators Agents, agents for improving biological physiological functions, and the like.

(Sensory characterization material)
As a sensory characterization material, perfumes, dyes and the like can be mentioned.
Examples of the flavor include natural flavors derived from plants or animals, synthetic flavors synthesized organically, and the like.
Examples of the pigment include tar pigments (organic synthetic pigments etc.) which can be used for cosmetics defined by the Ministry of Health, Labor and Welfare, natural pigments extracted from animals and plants or microorganisms, inorganic pigments and the like.

(Quality holding raw material)
As the quality maintaining raw material, preservatives, antioxidants, sequestering agents (metal ion element sealants), antifading agents, buffers and the like can be mentioned.
Examples of preservatives include parahydroxybenzoic acid ester (paraben), sorbic acid, sodium dehydroacetate, quaternary ammonium salt (benzalkonium chloride, benzethonium chloride, etc.), chloroxidine, pentylene glycol, phenoxyethanol, ethylhexylglycerin, etc. .
Examples of the antioxidant include tocopherol (vitamin E), ascorbic acid, dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA) and the like.
Examples of the metal sequestering agent include chelating agents (sodium edetate, ethylenediamine tetraacetate (EDTA), citric acid and the like) and the like.

(Proportion of each ingredient)
The proportion of the liquid medium in the composition is the remainder excluding the proportion of components other than the liquid medium.
The proportion of the liquid medium is preferably 80 to 99.99% by mass, more preferably 85 to 99.9% by mass, and still more preferably 92 to 99% by mass, of the composition (100% by mass). If the ratio of the liquid medium is not more than the upper limit value of the above range, the thickening effect is sufficiently exhibited, and it is easy to hold a large amount of hydrogen gas in bubble form in the composition for a long time. When the proportion of the liquid medium is at least the lower limit value of the above range, the viscosity of the composition does not become too high, and the feeling of use of the cream of the present invention becomes good.

The proportion of the total of the fatty acid having 10 or more carbon atoms and the salt thereof is preferably 0.01 to 20% by mass, and more preferably 1 to 8% by mass, based on the composition (100% by mass). If the total proportion of the fatty acid having 10 or more carbon atoms and the salt thereof is at least the lower limit value of the above range, the thickening effect is sufficiently exhibited, and a large amount of hydrogen gas in the form of bubbles in the composition and over a long time Easy to hold. If the total proportion of the fatty acid having 10 or more carbon atoms and the salt thereof is not more than the upper limit value of the above range, the viscosity of the composition does not become too high, and the feeling of use of the cream of the present invention becomes good.

The proportion of the fatty acid salt in the total of the fatty acid having 10 or more carbon atoms and the salt thereof is preferably 0.1 to 40 mol%, more preferably 0.5 to 25 mol%, and still more preferably 1 to 10 mol%. If the ratio of fatty acid salt is within the above range, the aqueous component and the oily component are sufficiently emulsified.
The proportion of the fatty acid in the total of the fatty acid having 10 or more carbon atoms and the salt thereof is preferably 60 to 99.9 mol%, more preferably 75 to 99.5 mol%, and still more preferably 90 to 99 mol%. If the proportion of fatty acid is within the above range, the aqueous component and the oil component are sufficiently emulsified.

When the composition contains a higher alcohol, the proportion of the higher alcohol is preferably 0.01 to 20% by mass, and more preferably 1 to 10% by mass of the composition (100% by mass). If the proportion of the higher alcohol is at least the lower limit value of the above range, the thickening effect is sufficiently exhibited, and it is easy to hold a large amount of bubbled hydrogen gas in the composition for a long time. If the proportion of the higher alcohol is below the upper limit value of the above range, the viscosity of the composition will not be too high, and the feeling of use of the cream of the present invention will be good.

When the composition contains a surfactant, the proportion of the surfactant is preferably 0.01 to 5% by mass, more preferably 0.1 to 3% by mass, of the composition (100% by mass). If the proportion of the surfactant is at least the lower limit value of the above range, the hydrogen gas in the bubble state is uniformly dispersed in the composition, and the hydrogen gas in the bubble state in the composition is easily retained for a long time. Addition of the amount whose surfactant ratio exceeds the upper limit of the above range is wasteful and may cause malfunction due to excess surfactant.

When the composition contains either or both of fat and oil and wax, the proportion of the total of fat and oil and wax is preferably 0.01 to 90% by mass of the composition (100% by mass), and 0.1 to 50 % By mass is more preferred. 1 to 20% by mass is more preferable, and 2 to 10% by mass is more preferable. If the ratio of the total of oil and fat and wax is equal to or more than the lower limit value of the above range, the feeling of use such as bulkiness when the cream is applied to the skin can be suppressed. If the ratio of the total of fats and oils and wax is below the upper limit value of the said range, the bad influence in terms of usability, such as stickiness, will be suppressed.

The proportions of the other base, drug, sensory characteristic-providing raw material, and quality-retaining raw material may be suitably selected within the range of known compounding proportions according to the properties, functions, etc. required of the cream.

<Use>
The creams of the present invention may be used in lip creams, eye creams, nail creams, massage / cold creams, moisture creams, other skin creams, cleansing creams, hair creams, sun creams, sun creams, shaving creams, etc. Can be mentioned.

<Mechanism of action>
In the cream of the present invention described above, the composition contains hydrogen gas in the form of bubbles in a composition containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium. A lot of hydrogen gas in bubble state can be held for a long time. And, the cream of the present invention contains hydrogen gas dissolved in the composition, and 0.1 to 100% by volume [v / w] of bubbled hydrogen gas contained in the composition. Since the cream of the present invention contains gas in the form of bubbles, in the composition, hydrogen gas in an amount equivalent to the saturation solubility of hydrogen gas in water is dissolved. That is, the total amount of the hydrogen gas dissolved in the composition and the hydrogen gas in the bubble state is an amount exceeding the saturation solubility of hydrogen gas in water (the amount of hydrogen gas contained in the conventional hydrogen gas dissolved cream). Thus, the cream containing a large amount of hydrogen gas can sufficiently exhibit various functions (a function of removing active oxygen, a function of enhancing biological activity, etc.) possessed by hydrogen gas.

<< How to make cream >>
The method for producing the cream of the present invention prepares a composition containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium, and includes hydrogen gas in the form of bubbles in the composition. It is a method of thickening a composition containing gas to obtain a cream.
Specifically, it has the following step (I) to step (III).
Step (I): A step of preparing a composition (emulsion) containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium.
Step (II): After step (I), a step of including hydrogen gas in bubble form in the emulsion.
Step (III): After step (II), thickening and creaming an emulsion containing hydrogen gas in a bubble state.

<Step (I)>
As a method of preparing a composition (emulsion), a method of mixing solution A containing an alkaline agent and a liquid medium with solution B containing a fatty acid having 10 or more carbon atoms is preferable, from the viewpoint of obtaining a good emulsion.
When a higher alcohol is used, the higher alcohol is preferably contained in solution B.
When a surfactant is used, it is preferable to include the surfactant in solution A.
When using fats and oils, it is preferable to include fats and oils in B liquid.
When a wax is used, the wax is preferably contained in solution B.
In the case of using other components (other base, drug, functional characterization material, and quality maintaining material), the water-soluble component is preferably contained in solution A, and the oil-soluble component is contained in solution B. It is preferable to

Examples of the alkaline agent include sodium hydroxide, potassium hydroxide, ammonia, amines (triethanolamine, triethylamine, diisopropanolamine, di (2-ethylhexyl) amine etc.) and the like. As the alkaline agent, sodium hydroxide, potassium hydroxide and triethanolamine are preferable.

It is preferable to heat solution A and solution B prior to mixing so as to be in a solution state. It is more preferable to heat the B liquid before mixing above melting | fusing point of a C10 or more fatty acid.
When mixing solution A and solution B, solution A may be added to solution B while stirring solution B, and solution B may be added to solution A while stirring solution A. For example, when the solution A is added to the solution B while stirring it, a fine and uniform emulsion is obtained.
By mixing the solution A and the solution B, a part of the fatty acid having 10 or more carbon atoms is neutralized by the alkali agent to form a fatty acid salt (emulsifier) having 10 or more carbon atoms.
The mixture of solution A and solution B is emulsified using a known emulsification device such as a homomixer to form an emulsion.
The amount of the alkali agent used in step (I) is the ratio of fatty acid salt to the total of fatty acids having 10 or more carbon atoms and their salts in the composition, and the total of fatty acids having 10 or more carbons and their salts. It can be determined according to the proportion of fatty acid in

<Step (II)>
By supplying hydrogen gas to the composition (emulsion), a composition containing hydrogen gas in a bubble state is obtained.

The viscosity of the composition when hydrogen gas is supplied is preferably 1 to 30,000 mPa · s, more preferably 10 to 25,000 mPa · s, still more preferably 300 to 20,000 mPa · s, and particularly preferably 500 to 15,000 mPa · s. If the viscosity of the composition is at least the lower limit value of the above range, it is easy to suppress the surface of the hydrogen gas from floating, and it is easy to make the hydrogen gas stay in the composition. If the viscosity of the composition is equal to or less than the upper limit value of the above range, it is easy to disperse hydrogen gas as bubbles in the composition, and uniform dispersion of hydrogen gas becomes easy.
The temperature of the composition at the time of hydrogen gas supply may be set appropriately as long as the viscosity range of the composition described above can be achieved.

The amount of hydrogen gas supplied is such that the total amount of hydrogen gas dissolved in the composition and hydrogen gas in a bubble state exceeds the saturation solubility of hydrogen gas in water, and the cream finally obtained The content of hydrogen gas in the bubble state is 0.1 to 100% by volume [v / w].

The charged amount of the fatty acid having 10 or more carbon atoms, the alkali agent, the liquid medium and the like, and the supplied amount of hydrogen gas may be appropriately set in accordance with the content of hydrogen gas in bubbled state in the desired composition and the bubble diameter. In addition, the temperature and viscosity of the composition may be appropriately set according to the type of fatty acid having 10 or more carbon atoms, an alkali agent, a liquid medium, etc., the content of hydrogen gas in the bubble state in the desired composition, and the cell diameter. Just do it.

As an apparatus used for process (II), if it is an apparatus which can disperse | distribute hydrogen gas to a composition uniformly as a desired bubble, the apparatus and installation which are used for well-known gas-liquid dispersion operation can be used. The material of the device is considered to be corrosion resistant to fatty acid having 10 or more carbon atoms, liquid medium, alkali agent, hydrogen gas, etc. within the range not to impair the effects of the present invention; Can be selected.

In the step (II), supplying hydrogen gas to the composition while stirring the composition; or supplying hydrogen gas to the composition without stirring the composition, and shaking the composition. preferable.
Examples of the stirring method include a method using a stirrer, a method using a homomixer, a method using a line mixer, and the like.
As a shaking method, a method using a shaking machine, etc. may be mentioned.

<Step (III)>
By thickening and creaming a composition (emulsion) containing gas in the form of foam, a cream containing hydrogen gas in the form of foam in the composition is obtained.
Thickening of the composition can be carried out, for example, by cooling the composition.
In order to minimize the loss of volatilization of hydrogen gas in the bubble state contained in the composition, it is preferable to thicken the composition as quickly as possible.

<Filling the container>
Fill the container with the cream if necessary and seal.
In order to suppress the loss of volatilization of bubbled hydrogen gas into the gas phase, it is preferable to carry out filling and sealing as quickly as possible.

As a container, in order to suppress the permeation | transmission loss of hydrogen gas, what consists of a material which is hard to permeate | transmit hydrogen gas is preferable. As a container, the pouch which has an aluminum layer, the bag body which consists of a film low in hydrogen gas permeability, a metal container, the composite container which combined these etc. are mentioned, for example.

As a filling method, from the point of suppressing the volatilization loss of hydrogen gas in the bubble state into the gas phase, it is preferable to fill the container with the cream as much as possible without gas phase space and seal it promptly.
As a sealing method, although it also depends on the type of container, for example, known sealing methods such as heat sealing, sealing with a lid with an inner lid, and the like can be mentioned.

1000 mPa * s or more is preferable, as for the viscosity at the time of storage of cream, 5000 mPa * s or more is more preferable, and 10000 mPa * s or more is more preferable. If the viscosity at the time of storage of the cream is at least the lower limit value of the above range, it is possible to stably hold the bubble-like hydrogen gas in the cream even during storage.
The temperature of the cream during storage may be set as appropriate as long as the viscosity range of the cream described above can be achieved.

<Mechanism of action>
In the method for producing the cream of the present invention described above, a composition containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms and a liquid medium is prepared, and hydrogen gas in bubble form is included in the composition. Since this method is a method of thickening a composition containing hydrogen gas in a bubble state, a cream having a high content of hydrogen gas can be produced as described below.
In general, hydrogen gas is more likely to move in the composition as the viscosity of the composition is lower and disperse as bubbles. However, the ease with which hydrogen gas moves in the composition is that it is difficult to stay in the composition and the possibility of volatilization into the gas phase is high. Conversely, if the viscosity of the composition is high, the hydrogen gas is not easily dispersed, which is not preferable for the formation of air bubbles. Of course, after the composition is thickened and creamed, dispersion of hydrogen gas becomes substantially impossible.
According to the method for producing a cream of the present invention, the composition before being thickened is uniformly dispersed in a high concentration of hydrogen gas as bubbles, and then the composition is quickly thickened and creamed. Hydrogen gas in a bubble state can be contained at a high concentration therein.

EXAMPLES Hereinafter, the present invention will be specifically described by way of examples, but the present invention is not limited thereto.

<Measurement>
The measuring method of each physical property in an Example is shown below.
(viscosity)
The viscosity was measured using an E-type viscometer (RV DV1M manufactured by BROOKFIELD).

(Observation of the dispersed state of bubbled hydrogen gas in cream)
The dispersion state of hydrogen gas in bubbled state is observed by observing the side of the bottle from above with a microscope (Digital Microscope VHX-900F manufactured by Keyence Corporation) with the head space vial filled with cream lying sideways. I observed it.

(Average bubble diameter of bubbled hydrogen gas)
The average bubble diameter of hydrogen gas in the bubble state was determined by measuring the bubble diameters of 10 randomly selected bubbles by microscopic observation (magnification: 175 times) and calculating the average value thereof. In the case where the observation bubble is not a true sphere or the like, the average value of the maximum diameter and the minimum diameter is taken as the bubble diameter.

(Content of bubbled hydrogen gas in cream)
In a head space vial (volume: 20 mL) used for GC analysis, 0.5 to 1 g of the cream is precisely weighed in under the conditions of atmospheric pressure and 25 ° C., and the head space vial is heated to 70 ° C. Heating was continued at 70 ° C. until extinguished. After the bubbles disappear, the gas phase gas in the head space vial is collected, and the hydrogen gas is quantified by GC analysis (TCD detector), and the content rate of hydrogen gas in the bubble state in the cream (volume% [v / w] was calculated.

<Evaluation>
(Dispersibility of air bubbles)
The dispersion state of air bubbles in the cream 24 hours after the preparation of the cream was evaluated based on the following criteria.
A: Air bubbles in the cream are uniformly dispersed.
B: Air bubbles in the cream rise, and a slight transparent layer is formed on the lower side.
C: Air bubbles in the cream rise and completely separate into the upper gas phase and the lower transparent layer.

(Feeling of use)
The feeling of use of the cream was evaluated by four persons in three levels (good: 3, normal: 2, bad: 1) for the following items, and their average was evaluated based on the following criteria.
Evaluation item:
1) Familiarity to skin 2) Slip feeling 3) Smoothness 4) Stickiness 5) Softness 6) Preference Evaluation criteria:
A: 2 or more B: 1.5 or more and less than 2 C: 1.5 or less

<Raw material>
(A solution)
Preservative 1: Ethylhexyl glycerin (manufactured by Schalke & Meyer, Inc. (obtained from Seiwa Kasei Co., Ltd.), SENSIVA (registered trademark) SC50JP).
Preservative 2: phenoxyethanol (manufactured by Yokkaichi Gosei Co., phenoxyethanol-S).
Moisturizing ingredient 1: concentrated glycerin (manufactured by Sakamoto Yakuhin Kogyo, concentrated glycerin for cosmetics).
Moisturizing ingredient 2: Propylene glycol (manufactured by Asahi Glass Co., Ltd., dipropylene glycol DPG-FC).
Surfactant 1: Nonionic surfactant (Mitsubishi Chemical Foods, Surfhope (registered trademark) SE COSME C-1811).
Hydrogen water: (Ito En Co., Ltd., evolving water (registered trademark) hydrogen water (bottle)).
Alkaline agent 1: potassium hydroxide aqueous solution (Wako Pure Chemical Industries, Ltd. make, potassium hydroxide) of 10 mass%.

(B liquid)
Wax 1: Jojoba oil (manufactured by Nikko Chemical Co., Ltd., NIKKOL (registered trademark) Jojoba oil S).
Fats and oils 1: Olive oil (containing a small amount of antioxidant tocopherol) (CRODURE JAPAN, CROPURE (registered trademark) MEADOWFOAM-LQ- (JP)).
Fats and oils 2: Shea oil (containing a small amount of antioxidant tocopherol) (CRODA JAPAN, CROPURE (registered trademark) SHEA BUTTER-SO- (JP)).
Fats and oils 3: mineral oil (liquid paraffin) (manufactured by Shima Trading Co., Ltd., Kaydol (registered trademark)).
Higher alcohol 1: Behenyl alcohol (Kao Corp., Calcoll (registered trademark) 220-80).
Higher alcohol 2: stearyl alcohol (manufactured by Kao Corporation, CALCOL (registered trademark) 8688).
Higher alcohol 3: cetyl alcohol (manufactured by Kao Corporation, CALCOL (registered trademark) 6098).
Fatty acid 1: stearic acid (manufactured by Kao Corporation, Lunack (registered trademark) S-70V).
Ester 1: butyl stearate (Kao Co., Exepearl (registered trademark) BS).
Surfactant 2: Nonionic surfactant (Kao, Leodol (registered trademark) MS-165V).
Preservative 3: methyl paraben (manufactured by Wako Pure Chemical Industries, Ltd., methyl p-hydroxybenzoate).

Examples 1 to 5
(Step (I))
The components of solution A shown in Table 1 were placed in the proportions shown in Table 1 in a glass beaker, and the mixture was heated to 70 ° C. with a water bath to give a solution.
The components of solution B shown in Table 1 were placed in the proportions shown in Table 1 in a separate glass beaker, and heated to 70 ° C. with a water bath to give a solution.
Solution A was added to the solution B while stirring it to form a mixed solution. The mixture is cooled to 55 ° C. while stirring the mixture at a rotational speed of 1,400 to 3,000 rpm using a homomixer (manufactured by Primix, Inc., lab solution) to obtain a composition (emulsion) having the viscosity shown in Table 1. The

(Step (II))
While bubbling hydrogen gas at a flow rate of 50 mL / min from the bottom of the glass beaker containing the emulsion, the emulsion is stirred for 4 minutes at a rotational speed of 3,000 to 6,000 rpm using a homomixer, Hydrogen gas was dispersed.

(Step (III))
The emulsion in which bubbled hydrogen gas was dispersed was allowed to cool to room temperature, and the emulsion having the viscosity shown in Table 1 was thickened to obtain a cream.
The cream was filled into head space vials (volume: 10 mL). The external appearance photograph of the cream of Example 1 is shown in FIG. Moreover, the photograph of microscope observation of the cream of Example 1 is shown in FIG.
The viscosity of the creams of Examples 1 to 5 at 25 ° C., the average bubble diameter of bubbled hydrogen gas The content of bubbled hydrogen gas in the cream, the dispersibility of the bubbles, and the feeling in use are shown in Table 1.

Comparative Example 1
The components of solution A shown in Table 1 were placed in the proportions shown in Table 1 in a glass beaker, and the mixture was heated to 70 ° C. with a water bath to give a solution.
The components of solution B shown in Table 1 were placed in the proportions shown in Table 1 in a separate glass beaker, and heated to 70 ° C. with a water bath to give a solution.
Solution A was added to solution A while stirring to give a mixture. The mixture was stirred at 3,000 rpm for 3 minutes using a homomixer (manufactured by Primix, Lab Solution (registered trademark)) and degassed to obtain a cream.

(Hydrogen gas retention)
The cream of Example 1 was filled into a glass sample bottle, sealed and stored in an incubator set at 25 ° C. After 2 weeks, it was opened to evaluate the content of bubbled hydrogen gas in the cream. The results are shown in FIG.
There was no change in the content of bubbled hydrogen gas in the cream after 2 weeks.

The cream of the present invention is useful as a creamy cosmetic that can fully express various functions of hydrogen gas.

Claims

It is a cream comprising hydrogen gas in a bubble state in a composition containing a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium,
The cream wherein the content of hydrogen gas in the bubble state in the cream is 0.1 to 100% by volume [v / w].
The cream of claim 1, wherein the composition further comprises a higher alcohol.
The cream according to claim 1 or 2, wherein the composition further comprises a surfactant.
The cream according to any one of claims 1 to 3, wherein the composition further comprises any one or both of a fat and oil and a wax.
The cream according to any one of claims 1 to 4, wherein the average bubble diameter of the hydrogen gas in the bubble state is 1 μm to 1 mm.
It is a manufacturing method of the cream as described in any one of Claims 1-5,
Preparing a composition comprising a fatty acid salt having 10 or more carbon atoms, a fatty acid having 10 or more carbon atoms, and a liquid medium,
Including hydrogen gas in bubble form in the composition,
A method of making a cream comprising thickening said composition comprising hydrogen gas in bubble form.
The method for producing a cream according to claim 6, wherein solution A containing an alkaline agent and a liquid medium is mixed with solution B containing a fatty acid having 10 or more carbon atoms to prepare the composition.