JP2014532665A5 - - Google Patents
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- JP2014532665A5 JP2014532665A5 JP2014539143A JP2014539143A JP2014532665A5 JP 2014532665 A5 JP2014532665 A5 JP 2014532665A5 JP 2014539143 A JP2014539143 A JP 2014539143A JP 2014539143 A JP2014539143 A JP 2014539143A JP 2014532665 A5 JP2014532665 A5 JP 2014532665A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- liposome
- combination according
- subject
- mol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims description 29
- 150000002632 lipids Chemical class 0.000 claims description 26
- 239000002105 nanoparticle Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 18
- 229940124597 therapeutic agent Drugs 0.000 claims description 18
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 11
- 235000012000 cholesterol Nutrition 0.000 claims description 8
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 8
- 150000003904 phospholipids Chemical class 0.000 claims description 8
- 150000003431 steroids Chemical class 0.000 claims description 8
- 239000000411 inducer Substances 0.000 claims description 7
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 6
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 6
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 6
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 6
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 4
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 4
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims description 4
- KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 claims description 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims description 4
- 101001000212 Rattus norvegicus Decorin Proteins 0.000 claims description 4
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical group OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 4
- 229960004316 cisplatin Drugs 0.000 claims description 4
- FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 claims description 4
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 4
- 229960001756 oxaliplatin Drugs 0.000 claims description 4
- 150000003905 phosphatidylinositols Chemical class 0.000 claims description 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 2
- 229940123237 Taxane Drugs 0.000 claims description 2
- 229960004562 carboplatin Drugs 0.000 claims description 2
- 190000008236 carboplatin Chemical compound 0.000 claims description 2
- -1 cationic lipid Chemical class 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- 229960002949 fluorouracil Drugs 0.000 claims description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
- 229960005277 gemcitabine Drugs 0.000 claims description 2
- 239000007928 intraperitoneal injection Substances 0.000 claims description 2
- 239000000693 micelle Substances 0.000 claims description 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 2
- 239000013066 combination product Substances 0.000 claims 2
- 229940127555 combination product Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 description 23
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161553786P | 2011-10-31 | 2011-10-31 | |
| US61/553,786 | 2011-10-31 | ||
| PCT/US2012/062635 WO2013066903A1 (en) | 2011-10-31 | 2012-10-31 | Combinational liposome compositions for cancer therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044663A Division JP6549172B2 (ja) | 2011-10-31 | 2017-03-09 | がん治療用組合せリポソーム組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532665A JP2014532665A (ja) | 2014-12-08 |
| JP2014532665A5 true JP2014532665A5 (https=) | 2015-09-24 |
| JP6143767B2 JP6143767B2 (ja) | 2017-06-07 |
Family
ID=47146747
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539143A Expired - Fee Related JP6143767B2 (ja) | 2011-10-31 | 2012-10-31 | がん治療用組合せリポソーム組成物 |
| JP2017044663A Expired - Fee Related JP6549172B2 (ja) | 2011-10-31 | 2017-03-09 | がん治療用組合せリポソーム組成物 |
| JP2018218127A Pending JP2019023243A (ja) | 2011-10-31 | 2018-11-21 | がん治療用組合せリポソーム組成物 |
| JP2019088222A Pending JP2019123753A (ja) | 2011-10-31 | 2019-05-08 | がん治療用組合せリポソーム組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044663A Expired - Fee Related JP6549172B2 (ja) | 2011-10-31 | 2017-03-09 | がん治療用組合せリポソーム組成物 |
| JP2018218127A Pending JP2019023243A (ja) | 2011-10-31 | 2018-11-21 | がん治療用組合せリポソーム組成物 |
| JP2019088222A Pending JP2019123753A (ja) | 2011-10-31 | 2019-05-08 | がん治療用組合せリポソーム組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9370489B2 (https=) |
| EP (2) | EP2773426B1 (https=) |
| JP (4) | JP6143767B2 (https=) |
| KR (1) | KR20140097215A (https=) |
| CN (1) | CN104023793B (https=) |
| BR (1) | BR112014010291A2 (https=) |
| CA (1) | CA2852564A1 (https=) |
| ES (1) | ES2694154T3 (https=) |
| IL (2) | IL232344B (https=) |
| MX (1) | MX360391B (https=) |
| RU (1) | RU2640934C2 (https=) |
| WO (1) | WO2013066903A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2011006510A1 (en) * | 2009-07-17 | 2011-01-20 | Technical University Of Denmark | Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
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| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| EP3388834B1 (en) | 2013-03-15 | 2020-04-15 | Translate Bio, Inc. | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
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| CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
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| WO2015166986A1 (ja) | 2014-04-30 | 2015-11-05 | 富士フイルム株式会社 | リポソーム組成物及びその製造方法 |
| AU2016219004A1 (en) * | 2015-02-13 | 2017-09-07 | Op Nano Co., Ltd. | Compositions and methods of tumor treatment utilizing nanoparticles |
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| US9895313B2 (en) | 2015-03-03 | 2018-02-20 | Cureport, Inc. | Combination liposomal pharmaceutical formulations |
| EP3270891A1 (en) * | 2015-03-17 | 2018-01-24 | Leon-Nanodrugs GmbH | Nanoparticles comprising a stabilized boronic acid compound |
| US10918599B2 (en) * | 2015-04-02 | 2021-02-16 | The Research Foundation For The State University Of New York | Serum-stable compositions and methods for light-triggered release of materials |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| DK3372232T3 (da) | 2015-11-02 | 2021-06-07 | Fujifilm Corp | Tumorterapeutisk middel omfattende gemcitabinliposomsammensætning og kit |
| WO2017087685A1 (en) * | 2015-11-20 | 2017-05-26 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| JP6721907B2 (ja) * | 2015-12-18 | 2020-07-15 | メディギア・インターナショナル株式会社 | 生体分解性腫瘍封止剤 |
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| KR101630397B1 (ko) * | 2015-12-31 | 2016-06-24 | 한국과학기술원 | 항암제-인도시아닌 그린-리포좀 복합체를 포함하는 암 치료용 조성물 |
| ES2897983T3 (es) | 2016-02-15 | 2022-03-03 | Univ Georgia | Liposomas cargados con IPA-3 y procedimientos de uso de los mismos |
| WO2017200957A1 (en) | 2016-05-16 | 2017-11-23 | Infectious Disease Research Institute | Pegylated liposomes and methods of use |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| CN106474057A (zh) * | 2016-12-02 | 2017-03-08 | 中国药科大学 | 一种奥沙利铂热敏长循环脂质体的蔗糖溶液制剂及其制备方法 |
| US11331272B2 (en) * | 2017-01-18 | 2022-05-17 | Temasek Life Sciences Laboratory Limited | Hyperstabilized liposomes increase targeting of mitotic cells |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| CA3055653A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| CA3058782A1 (en) | 2017-04-03 | 2018-10-11 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| US10925831B2 (en) * | 2017-08-28 | 2021-02-23 | Wake Forest University | Liposomal formulations of platinum-acridine anticancer agents and methods thereof |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| US11110060B2 (en) * | 2017-10-25 | 2021-09-07 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for delivering pharmaceutical agents |
| US10606661B2 (en) * | 2017-12-15 | 2020-03-31 | Rubrik, Inc. | On-demand provisioning of customized developer environments |
| EP3731846A4 (en) | 2017-12-29 | 2022-03-02 | Wayne State University | DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF INFECTION |
| ES2984147T3 (es) | 2018-06-20 | 2024-10-29 | Fujifilm Corp | Medicamento combinado que comprende una composición liposómica de gemcitabina encapsulada y bloqueo de punto de control inmunitario |
| WO2020061367A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061295A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US20220000779A1 (en) * | 2018-12-06 | 2022-01-06 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
| RU2706427C1 (ru) * | 2018-12-27 | 2019-11-19 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС" | Способ лечения онкологических заболеваний с помощью инъекций лекарственного препарата |
| TWI757739B (zh) * | 2019-05-14 | 2022-03-11 | 國邑藥品科技股份有限公司 | 包含弱酸藥物之醫藥組成物及其用途 |
| JP7253735B2 (ja) | 2019-07-02 | 2023-04-07 | パナソニックＩｐマネジメント株式会社 | 通過可否判定装置、通過管理システム、通過可否判定方法、及び、コンピュータプログラム |
| WO2021053163A1 (en) | 2019-09-19 | 2021-03-25 | Danmarks Tekniske Universitet | Immune stimulating micelle composition |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
| US20220364139A1 (en) * | 2019-09-24 | 2022-11-17 | Pataigin, Llc | Methods for determining growth and response |
| CN110571005B (zh) * | 2019-09-27 | 2021-01-01 | 广西科技大学 | 一种固定化金属离子-磁性脂质体及其制备方法和应用 |
| WO2022038605A1 (en) * | 2020-08-20 | 2022-02-24 | Bionanosim (Bns) Ltd | Lipid delivery systems for delivery of oxaliplatin palmitate acetate |
| KR102560135B1 (ko) | 2020-12-04 | 2023-07-27 | 가톨릭대학교 산학협력단 | 표적 치료제의 효과적인 전달을 위한 다기능성 리포좀 조성물 |
| US20240229154A9 (en) | 2021-02-12 | 2024-07-11 | Institut National de la Santé et de la Recherche Médicale | Method for prognosis and treating a patient suffering from cancer |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| EP4306126A1 (en) | 2021-03-08 | 2024-01-17 | Eyegene Inc. | Vaccine composition for preventing sars-cov-2 |
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| US7273620B1 (en) * | 2002-05-20 | 2007-09-25 | University Of British Columbia | Triggered release of liposomal drugs following mixing of cationic and anionic liposomes |
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| JPWO2005053643A1 (ja) * | 2003-12-01 | 2007-06-28 | 三菱ウェルファーマ株式会社 | リポソーム |
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| WO2007049279A2 (en) * | 2005-10-26 | 2007-05-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A liposomal combination and uses thereof |
-
2012
- 2012-10-31 CN CN201280064482.6A patent/CN104023793B/zh not_active Expired - Fee Related
- 2012-10-31 BR BR112014010291A patent/BR112014010291A2/pt not_active Application Discontinuation
- 2012-10-31 US US13/664,457 patent/US9370489B2/en not_active Expired - Fee Related
- 2012-10-31 EP EP12783805.0A patent/EP2773426B1/en not_active Not-in-force
- 2012-10-31 RU RU2014120216A patent/RU2640934C2/ru not_active IP Right Cessation
- 2012-10-31 JP JP2014539143A patent/JP6143767B2/ja not_active Expired - Fee Related
- 2012-10-31 EP EP18189596.2A patent/EP3424564A1/en not_active Withdrawn
- 2012-10-31 CA CA2852564A patent/CA2852564A1/en not_active Abandoned
- 2012-10-31 ES ES12783805.0T patent/ES2694154T3/es active Active
- 2012-10-31 KR KR1020147014027A patent/KR20140097215A/ko not_active Ceased
- 2012-10-31 MX MX2014004960A patent/MX360391B/es active IP Right Grant
- 2012-10-31 WO PCT/US2012/062635 patent/WO2013066903A1/en not_active Ceased
-
2014
- 2014-04-29 IL IL232344A patent/IL232344B/en active IP Right Grant
-
2016
- 2016-05-23 US US15/162,072 patent/US9717686B2/en not_active Expired - Fee Related
-
2017
- 2017-03-09 JP JP2017044663A patent/JP6549172B2/ja not_active Expired - Fee Related
- 2017-07-28 US US15/663,472 patent/US10213385B2/en not_active Expired - Fee Related
-
2018
- 2018-04-16 IL IL258740A patent/IL258740B/en unknown
- 2018-11-21 JP JP2018218127A patent/JP2019023243A/ja active Pending
-
2019
- 2019-02-19 US US16/279,977 patent/US20190175505A1/en not_active Abandoned
- 2019-05-08 JP JP2019088222A patent/JP2019123753A/ja active Pending
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