JP2014530717A - 動脈血ガス試料採取のための可壊性プランジャーを持つ注射器 - Google Patents
動脈血ガス試料採取のための可壊性プランジャーを持つ注射器 Download PDFInfo
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- JP2014530717A JP2014530717A JP2014537235A JP2014537235A JP2014530717A JP 2014530717 A JP2014530717 A JP 2014530717A JP 2014537235 A JP2014537235 A JP 2014537235A JP 2014537235 A JP2014537235 A JP 2014537235A JP 2014530717 A JP2014530717 A JP 2014530717A
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- fluid
- stopper
- plunger rod
- distal end
- collection assembly
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Images
Classifications
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- A61B5/15003—Source of blood for venous or arterial blood
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- A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
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- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
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- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
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Abstract
Description
Claims (18)
- 基端部および末端部およびこれら基端部と末端部との間に延在する側壁を有し、この側壁が内側チャンバーを画成する内側面を含む筒体と、
この筒体内に配されるストッパーと、
基端部および前記ストッパーにつながる末端部を有するプランジャーロッドと、
このプランジャーロッドの基端部および末端部をつなぎ、当該プランジャーロッドに破壊力を加えることによって壊れるようになっている可壊性結合部と、
前記内側面から前記チャンバーへと延在し、前記ストッパーの基端部側への移動を制限するように形成された環状のフランジと
を具えたことを特徴とする流体採取アセンブリー。 - 前記内側面は、ストッパーをそれと共に流体封止係合状態で滑動可能に収容するために形成されていることを特徴とする請求項1に記載の流体採取アセンブリー。
- 前記筒体の基端部および前記側壁の内側面の少なくとも一部および前記ストッパーは、流体処理添加剤および流体試料の少なくとも一方を保持するために形成された内側リザーバーを画成することを特徴とする請求項1に記載の流体採取アセンブリー。
- 前記筒体の基端部は、医療器具と協力するための構造体を含むことを特徴とする請求項3に記載の流体採取アセンブリー。
- 前記医療器具は内腔を有する針アセンブリーを具え、前記プランジャーロッドは、流体試料の採取前に前記内腔および前記内側リザーバーを前記流体処理添加剤で満たし、そこからすべての空気を除去するように形成されていることを特徴とする請求項4に記載の流体採取アセンブリー。
- 前記ストッパーは、前記筒体の内側基端面と協力して前記リザーバー内のデッドスペースの量を最小にするように形成された末端面を有することを特徴とする請求項5に記載の流体採取アセンブリー。
- 前記環状のフランジは、前記プランジャーロッドに破壊力を加えた後および流体試料の採取中に、前記ストッパーの基端側への移動を制限するように形成されていることを特徴とする請求項1に記載の流体採取アセンブリー。
- 前記プランジャーロッドの基端部が親指フランジを含むことを特徴とする請求項1に記載の流体採取アセンブリー。
- 前記ストッパーが低抵抗ストッパーであることを特徴とする請求項1に記載の流体採取アセンブリー。
- 前記筒体の末端部と協力するように形成され、取扱いおよび保管および移送中の流体試料のあらゆる流出を阻止するための先端キャップを含むことを特徴とする請求項1に記載の流体採取アセンブリー。
- 基端部および末端部およびこれら基端部と末端部との間に延在する側壁および前記末端部から延在する末端部の先端を有し、前記側壁が内側チャンバーを画成する内側面を含み、前記末端部の先端が前記内側チャンバーと流体連通状態の通路をそこに有する筒体と、
この筒体内に配されるストッパーと、
基端部および前記ストッパーにつながる末端部を有するプランジャーロッドと、
このプランジャーロッドの基端部および末端部をつなぎ、当該プランジャーロッドに破壊力を加えることによって壊れるようになっている可壊性結合部と、
前記筒体の末端部の先端に装着される針アセンブリーと
を含む流体採取アセンブリーを用意するステップと、
この流体採取アセンブリーを流体処理添加剤で満たすステップと、
前記可壊性結合部を破壊するステップと、
前記内側チャンバーに流体試料を導入するステップと
を具えたことを特徴とする流体試料を採取する方法。 - 前記流体処理添加剤は、抗凝固剤と、凝固剤と、安定化添加剤とからなるグループから選択されることを特徴とする請求項11に記載の方法。
- 前記流体処理添加剤が液相であって抗凝固剤を具えていることを特徴とする請求項12に記載の方法。
- 前記筒体の基端部と、前記側壁の内側面の少なくとも一部と、前記ストッパーとが内側リザーバーを画成することを特徴とする請求項11に記載の方法。
- 前記流体採取アセンブリーを満たす前記ステップは、液体抗凝固剤を前記内側リザーバーへと引き入れて空気を内側リザーバーおよび前記通路および前記針アセンブリーの内腔から追い出すステップをさらに具えていることを特徴とする請求項14に記載の方法。
- 前記可壊性結合部を破壊する前記ステップは、前記基端部が前記末端部から機械的に分離するのに充分な大きさの力をプランジャーロッドに対して末端方向に加えるステップと、前記流体採取アセンブリーから前記基端部を除去するステップとを含むことを特徴とする請求項11に記載の方法。
- 流体試料を導入する前記ステップは、前記針アセンブリーの末端部を供給源に挿入して流体が前記内側リザーバーへと流れることをもたらすステップを含み、この流体流動力は、前記ストッパーおよび前記プランジャーロッドの末端部が前記内側面から前記内側チャンバーへと内側に延在する環状のフランジに接触するまで、前記ストッパーおよび前記プランジャーロッドの末端部が前記内側チャンバーを通って前記筒体の基端へと移動することをもたらすことを特徴とする請求項14に記載の方法。
- 前記針アセンブリーを前記筒体の末端部の先端から取り外して前記筒体の末端部の先端に先端キャップを装着するステップを含むことを特徴とする請求項17に記載の方法。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61113431A (ja) * | 1984-11-07 | 1986-05-31 | 株式会社 ニツシヨ− | 血液ガス測定用採血器具 |
US6217550B1 (en) * | 1998-07-29 | 2001-04-17 | Becton, Dickinson And Company | Single-use syringe |
US20040176722A1 (en) * | 2003-03-05 | 2004-09-09 | Capes David Francis | Single-use syringe |
JP2006500161A (ja) * | 2002-09-27 | 2006-01-05 | ベクトン・ディキンソン・アンド・カンパニー | 使い捨て注射器 |
US20080097242A1 (en) * | 2006-10-20 | 2008-04-24 | Jian Cai | Disposable Blood Sampling Device |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4159713A (en) * | 1977-06-02 | 1979-07-03 | Becton, Dickinson And Company | Blood gas syringe |
US4821738A (en) | 1987-11-19 | 1989-04-18 | Marquest Medical Products, Inc. | Arterial blood gas syringe |
US5314416A (en) | 1992-06-22 | 1994-05-24 | Sherwood Medical Company | Low friction syring assembly |
US5377689A (en) | 1993-12-27 | 1995-01-03 | Mercereau; Steven F. | Sampling syringe |
US8202257B2 (en) | 1998-07-29 | 2012-06-19 | Becton, Dickinson And Company | Splatter prevention mechanism for a syringe |
US7798993B2 (en) | 1998-07-29 | 2010-09-21 | Becton, Dickinson And Company | Single use syringe |
DE20110872U1 (de) | 2001-06-30 | 2002-11-07 | Medizintechnik Promedt GmbH, 25436 Tornesch | Blutentnahmespritze |
US7972302B2 (en) * | 2007-06-12 | 2011-07-05 | Becton, Dickinson And Company | Syringe with disabling mechanism |
-
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61113431A (ja) * | 1984-11-07 | 1986-05-31 | 株式会社 ニツシヨ− | 血液ガス測定用採血器具 |
US6217550B1 (en) * | 1998-07-29 | 2001-04-17 | Becton, Dickinson And Company | Single-use syringe |
JP2006500161A (ja) * | 2002-09-27 | 2006-01-05 | ベクトン・ディキンソン・アンド・カンパニー | 使い捨て注射器 |
US20040176722A1 (en) * | 2003-03-05 | 2004-09-09 | Capes David Francis | Single-use syringe |
US20080097242A1 (en) * | 2006-10-20 | 2008-04-24 | Jian Cai | Disposable Blood Sampling Device |
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