JP2014527831A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014527831A5 JP2014527831A5 JP2014532073A JP2014532073A JP2014527831A5 JP 2014527831 A5 JP2014527831 A5 JP 2014527831A5 JP 2014532073 A JP2014532073 A JP 2014532073A JP 2014532073 A JP2014532073 A JP 2014532073A JP 2014527831 A5 JP2014527831 A5 JP 2014527831A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- sequencing
- biological sample
- blood
- isotype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 47
- 108060003951 Immunoglobulin Proteins 0.000 claims description 18
- 102000018358 immunoglobulin Human genes 0.000 claims description 18
- 210000004369 blood Anatomy 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 14
- 238000012163 sequencing technique Methods 0.000 claims description 12
- 239000012472 biological sample Substances 0.000 claims description 10
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 5
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 4
- 238000003786 synthesis reaction Methods 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims 4
- 108091093088 Amplicon Proteins 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 208000037765 diseases and disorders Diseases 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 4
- 201000006417 multiple sclerosis Diseases 0.000 description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 2
- 206010052779 Transplant rejections Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537878P | 2011-09-22 | 2011-09-22 | |
| US61/537,878 | 2011-09-22 | ||
| PCT/US2012/056911 WO2013044234A1 (en) | 2011-09-22 | 2012-09-24 | Detection of isotype profiles as signatures for disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017159019A Division JP2018007689A (ja) | 2011-09-22 | 2017-08-22 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527831A JP2014527831A (ja) | 2014-10-23 |
| JP2014527831A5 true JP2014527831A5 (enExample) | 2015-11-12 |
| JP6198736B2 JP6198736B2 (ja) | 2017-09-20 |
Family
ID=47080791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532073A Active JP6198736B2 (ja) | 2011-09-22 | 2012-09-24 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
| JP2017159019A Pending JP2018007689A (ja) | 2011-09-22 | 2017-08-22 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017159019A Pending JP2018007689A (ja) | 2011-09-22 | 2017-08-22 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130078633A1 (enExample) |
| EP (1) | EP2758550B1 (enExample) |
| JP (2) | JP6198736B2 (enExample) |
| CN (1) | CN104271759B (enExample) |
| AU (1) | AU2012312028A1 (enExample) |
| CA (1) | CA2848516C (enExample) |
| WO (1) | WO2013044234A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014144495A1 (en) | 2013-03-15 | 2014-09-18 | Abvitro, Inc. | Single cell bar-coding for antibody discovery |
| WO2014144822A2 (en) | 2013-03-15 | 2014-09-18 | Immumetrix, Inc. | Methods and compositions for tagging and analyzing samples |
| US11203783B2 (en) | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| WO2015138803A1 (en) * | 2014-03-12 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| AU2015279542B2 (en) | 2014-06-26 | 2021-07-29 | Icahn School Of Medicine At Mount Sinai | Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets |
| WO2016044227A1 (en) | 2014-09-15 | 2016-03-24 | Abvitro, Inc. | High-throughput nucleotide library sequencing |
| CN105040111B (zh) * | 2015-05-28 | 2017-07-14 | 眭维国 | 系统性红斑狼疮图谱模型的构建方法 |
| GB201612242D0 (en) * | 2016-07-14 | 2016-08-31 | Genome Res Ltd And Cambridge Entpr Ltd | Novel kit |
| CN107179288A (zh) * | 2017-07-03 | 2017-09-19 | 中国人民解放军第三军医大学 | 一种唾液中分泌型免疫球蛋白的检测方法 |
| JP7464279B2 (ja) | 2018-04-16 | 2024-04-09 | アイカーン スクール オブ メディスン アット マウント シナイ | レシピエント血液における移植前トランスクリプトームシグネチャーを使用した急性拒絶反応および腎臓同種異系移植喪失の予測のための方法およびキット |
| CN110400600A (zh) * | 2019-08-01 | 2019-11-01 | 枣庄学院 | 一种基于旋转森林算法的miRNA-疾病相关性预测方法 |
| CN115335535A (zh) * | 2020-01-22 | 2022-11-11 | 生命科技公司 | 自身免疫疾病和免疫缺陷病症中的免疫组库生物标志物 |
| CN112485304B (zh) * | 2020-12-14 | 2022-08-09 | 河北工业大学 | 一种基于电导法的牛奶检测方法及系统 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5018067A (en) | 1987-01-12 | 1991-05-21 | Iameter Incorporated | Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators |
| US20020038227A1 (en) | 2000-02-25 | 2002-03-28 | Fey Christopher T. | Method for centralized health data management |
| US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
| US20040122296A1 (en) | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for triaging health-related data |
| CA2544708A1 (en) * | 2003-11-03 | 2005-05-12 | Genenews, Inc. | Liver cancer biomarkers |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| EP2719774B8 (en) * | 2008-11-07 | 2020-04-22 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
| WO2011031786A2 (en) * | 2009-09-08 | 2011-03-17 | Laboratory Corporation Of America Holdings | Compositions and methods for diagnosing autism spectrum disorders |
-
2012
- 2012-09-24 WO PCT/US2012/056911 patent/WO2013044234A1/en not_active Ceased
- 2012-09-24 JP JP2014532073A patent/JP6198736B2/ja active Active
- 2012-09-24 CN CN201280055957.5A patent/CN104271759B/zh active Active
- 2012-09-24 CA CA2848516A patent/CA2848516C/en active Active
- 2012-09-24 AU AU2012312028A patent/AU2012312028A1/en not_active Abandoned
- 2012-09-24 EP EP12778840.4A patent/EP2758550B1/en active Active
- 2012-09-24 US US13/625,645 patent/US20130078633A1/en not_active Abandoned
-
2017
- 2017-08-22 JP JP2017159019A patent/JP2018007689A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014527831A5 (enExample) | ||
| US20230313291A1 (en) | System and method for massively parallel analysis for nucleic acids in single cells | |
| US10246701B2 (en) | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture | |
| JP6533272B2 (ja) | クロノタイププロファイルを用いた健康状態および疾患状態のモニタリング | |
| EP2758550B1 (en) | Detection of isotype profiles as signatures for disease | |
| EP3212790B1 (en) | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples | |
| JP2012508011A5 (enExample) | ||
| US20150154352A1 (en) | System and Methods for Genetic Analysis of Mixed Cell Populations | |
| JP2015501644A5 (enExample) | ||
| US20200131564A1 (en) | High-coverage and ultra-accurate immune repertoire sequencing using molecular identifiers | |
| CN103797366A (zh) | 免疫多样性评估方法及其用途 | |
| JP6667813B2 (ja) | アルツハイマー病又は軽度認知症の検出を補助する方法 | |
| WO2015106161A1 (en) | Methods for defining and predicting immune response to allograft | |
| Briney et al. | Tissue-specific expressed antibody variable gene repertoires | |
| CN104114703A (zh) | 全基因组扩增方法及其应用 | |
| KR20210131242A (ko) | 상향조절된 mirna의 진단 및 치료를 위한 용도 | |
| JPWO2021217181A5 (enExample) | ||
| CN104508141A (zh) | 确定个体是否患有异常状态的方法及系统 | |
| EP4584397A1 (en) | Methods of detecting sjögren's syndrome using salivary exosomes | |
| D’Argenio | MOLECULAR ALTERATIONS IN HUMAN GENETIC DISEASES THROUGH NEXT GENERATION SEQUENCING TECHNOLOGIES | |
| US20180051336A1 (en) | Methods for diagnosing multiple sclerosis using vh4 antibody genes | |
| KR20190021750A (ko) | 중증 열성 혈소판 감소 증후군 바이러스의 감염을 진단하기 위한 프라이머 세트, 이를 포함하는 진단용 키트 및 방법 | |
| JP2016049025A5 (enExample) |