CN104271759B - 作为疾病信号的同种型谱的检测 - Google Patents

作为疾病信号的同种型谱的检测 Download PDF

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Publication number
CN104271759B
CN104271759B CN201280055957.5A CN201280055957A CN104271759B CN 104271759 B CN104271759 B CN 104271759B CN 201280055957 A CN201280055957 A CN 201280055957A CN 104271759 B CN104271759 B CN 104271759B
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Prior art keywords
sequencing
disease
isotype
cells
immunoglobulin
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Chinese (zh)
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CN104271759A (zh
Inventor
M·U·赫钦斯
D·赛里格森
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ImmuMetrix LLC
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ImmuMetrix LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201280055957.5A 2011-09-22 2012-09-24 作为疾病信号的同种型谱的检测 Active CN104271759B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161537878P 2011-09-22 2011-09-22
US61/537,878 2011-09-22
PCT/US2012/056911 WO2013044234A1 (en) 2011-09-22 2012-09-24 Detection of isotype profiles as signatures for disease

Publications (2)

Publication Number Publication Date
CN104271759A CN104271759A (zh) 2015-01-07
CN104271759B true CN104271759B (zh) 2018-01-16

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CN201280055957.5A Active CN104271759B (zh) 2011-09-22 2012-09-24 作为疾病信号的同种型谱的检测

Country Status (7)

Country Link
US (1) US20130078633A1 (enExample)
EP (1) EP2758550B1 (enExample)
JP (2) JP6198736B2 (enExample)
CN (1) CN104271759B (enExample)
AU (1) AU2012312028A1 (enExample)
CA (1) CA2848516C (enExample)
WO (1) WO2013044234A1 (enExample)

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WO2014144495A1 (en) 2013-03-15 2014-09-18 Abvitro, Inc. Single cell bar-coding for antibody discovery
WO2014144822A2 (en) 2013-03-15 2014-09-18 Immumetrix, Inc. Methods and compositions for tagging and analyzing samples
US11203783B2 (en) 2013-11-21 2021-12-21 Repertoire Genesis Incorporation T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis
WO2015138803A1 (en) * 2014-03-12 2015-09-17 Icahn School Of Medicine At Mount Sinai Method for identifying kidney allograft recipients at risk for chronic injury
AU2015279542B2 (en) 2014-06-26 2021-07-29 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
WO2016044227A1 (en) 2014-09-15 2016-03-24 Abvitro, Inc. High-throughput nucleotide library sequencing
CN105040111B (zh) * 2015-05-28 2017-07-14 眭维国 系统性红斑狼疮图谱模型的构建方法
GB201612242D0 (en) * 2016-07-14 2016-08-31 Genome Res Ltd And Cambridge Entpr Ltd Novel kit
CN107179288A (zh) * 2017-07-03 2017-09-19 中国人民解放军第三军医大学 一种唾液中分泌型免疫球蛋白的检测方法
JP7464279B2 (ja) 2018-04-16 2024-04-09 アイカーン スクール オブ メディスン アット マウント シナイ レシピエント血液における移植前トランスクリプトームシグネチャーを使用した急性拒絶反応および腎臓同種異系移植喪失の予測のための方法およびキット
CN110400600A (zh) * 2019-08-01 2019-11-01 枣庄学院 一种基于旋转森林算法的miRNA-疾病相关性预测方法
CN115335535A (zh) * 2020-01-22 2022-11-11 生命科技公司 自身免疫疾病和免疫缺陷病症中的免疫组库生物标志物
CN112485304B (zh) * 2020-12-14 2022-08-09 河北工业大学 一种基于电导法的牛奶检测方法及系统

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US20020038227A1 (en) 2000-02-25 2002-03-28 Fey Christopher T. Method for centralized health data management
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US20040122296A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for triaging health-related data
CA2544708A1 (en) * 2003-11-03 2005-05-12 Genenews, Inc. Liver cancer biomarkers
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2719774B8 (en) * 2008-11-07 2020-04-22 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
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Title
A custom 148 gene-based resquencing chip and the SNP explorer software : new tools to study antibody deficiency.;HONG-ying;《Human mutaion》;20100722;摘要，第1081页材料与方法部分，1087页最后一段，图1 *
Quantifiable analysis of human immunoglobulin heavy chain class-switch recombination to all isotypes.;Heidi A. Weckert et.al;《Journal of immunological methods》;20000101;摘要，第142页2.1-144页2.5,155页 *
多囊卵巢综合征表型谱：3种主要亚型临床及生化特点;knochenhauer et.al;《世界核心医学期刊文摘.妇产科学分册》;20051231;第22页 *
肾移植后急性排斥反应发生相关术前因素分析;徐莹等;《中华移植杂志.电子版》;20101231;30-33页 *

Also Published As

Publication number Publication date
EP2758550B1 (en) 2016-10-26
AU2012312028A8 (en) 2014-04-24
CA2848516A1 (en) 2013-03-28
JP2018007689A (ja) 2018-01-18
AU2012312028A1 (en) 2014-04-10
EP2758550A1 (en) 2014-07-30
JP6198736B2 (ja) 2017-09-20
WO2013044234A1 (en) 2013-03-28
US20130078633A1 (en) 2013-03-28
JP2014527831A (ja) 2014-10-23
CA2848516C (en) 2021-06-15
CN104271759A (zh) 2015-01-07

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Patentee before: IMMUMETRIX LLC