JP2014527408A5 - - Google Patents
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- Publication number
- JP2014527408A5 JP2014527408A5 JP2014525261A JP2014525261A JP2014527408A5 JP 2014527408 A5 JP2014527408 A5 JP 2014527408A5 JP 2014525261 A JP2014525261 A JP 2014525261A JP 2014525261 A JP2014525261 A JP 2014525261A JP 2014527408 A5 JP2014527408 A5 JP 2014527408A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- region
- variable region
- iglv3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 49
- 229920001184 polypeptide Polymers 0.000 claims 47
- 102000004196 processed proteins & peptides Human genes 0.000 claims 47
- 210000004027 cell Anatomy 0.000 claims 20
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 102000040430 polynucleotide Human genes 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 230000001580 bacterial effect Effects 0.000 claims 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 7
- 101001005360 Homo sapiens Immunoglobulin lambda variable 3-1 Proteins 0.000 claims 6
- 102100025921 Immunoglobulin lambda variable 3-1 Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 101001054843 Homo sapiens Immunoglobulin lambda variable 1-40 Proteins 0.000 claims 5
- 101001054838 Homo sapiens Immunoglobulin lambda variable 1-44 Proteins 0.000 claims 5
- 101001054837 Homo sapiens Immunoglobulin lambda variable 1-47 Proteins 0.000 claims 5
- 101001005364 Homo sapiens Immunoglobulin lambda variable 3-19 Proteins 0.000 claims 5
- 101000978133 Homo sapiens Immunoglobulin lambda variable 6-57 Proteins 0.000 claims 5
- 102100026911 Immunoglobulin lambda variable 1-40 Human genes 0.000 claims 5
- 102100026921 Immunoglobulin lambda variable 1-44 Human genes 0.000 claims 5
- 102100026809 Immunoglobulin lambda variable 1-47 Human genes 0.000 claims 5
- 102100025937 Immunoglobulin lambda variable 3-19 Human genes 0.000 claims 5
- 102100023747 Immunoglobulin lambda variable 6-57 Human genes 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002824 mRNA display Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000001322 periplasm Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 238000002702 ribosome display Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011903298 | 2011-08-18 | ||
| AU2011903298A AU2011903298A0 (en) | 2011-08-18 | Soluble polypeptides | |
| PCT/AU2012/000970 WO2013023251A1 (en) | 2011-08-18 | 2012-08-17 | Soluble polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527408A JP2014527408A (ja) | 2014-10-16 |
| JP2014527408A5 true JP2014527408A5 (https=) | 2016-06-16 |
| JP6244301B2 JP6244301B2 (ja) | 2017-12-06 |
Family
ID=47714621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014525261A Active JP6244301B2 (ja) | 2011-08-18 | 2012-08-17 | 可溶性ポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10087261B2 (https=) |
| EP (1) | EP2744931B1 (https=) |
| JP (1) | JP6244301B2 (https=) |
| CN (1) | CN103890246A (https=) |
| CA (1) | CA2845391C (https=) |
| DK (1) | DK2744931T3 (https=) |
| ES (1) | ES2682254T3 (https=) |
| WO (1) | WO2013023251A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103890246A (zh) | 2011-08-18 | 2014-06-25 | 亲和生物科学公司 | 可溶性多肽 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| CA2898100C (en) | 2013-01-14 | 2023-10-10 | Xencor, Inc. | Novel heterodimeric proteins |
| AU2014220306A1 (en) * | 2013-02-20 | 2015-08-27 | Affinity Biosciences Pty Ltd | Cytoplasmic expression of Fab proteins |
| CA2902739C (en) * | 2013-03-15 | 2022-11-22 | Xencor, Inc. | Heterodimeric proteins |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| HRP20251426T1 (hr) | 2013-05-06 | 2026-01-02 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| JP6775422B2 (ja) | 2014-03-28 | 2020-10-28 | ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． | Ｃｄ３８及びｃｄ３に結合する二重特異性抗体 |
| US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| IL313511A (en) | 2014-11-12 | 2024-08-01 | Seagen Inc | Compounds acting on glycans and methods of using them |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| CN110894240B (zh) | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| JP6664467B2 (ja) | 2015-08-19 | 2020-03-13 | ファイザー・インク | 組織因子経路インヒビター抗体およびその使用 |
| EP3373969A4 (en) | 2015-11-12 | 2019-08-14 | Siamab Therapeutics, Inc. | GLYCANINTERAGING COMPOUNDS AND METHOD OF USE |
| JP7058219B2 (ja) | 2015-12-07 | 2022-04-21 | ゼンコア インコーポレイテッド | Ｃｄ３及びｐｓｍａに結合するヘテロ二量体抗体 |
| SI3468586T1 (sl) | 2016-06-14 | 2025-01-31 | Xencor, Inc. | Bispecifična protitelesa za zaviralce kontrolnih točk |
| WO2018005706A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
| EP3541847A4 (en) | 2016-11-17 | 2020-07-08 | Seattle Genetics, Inc. | COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE |
| KR102653141B1 (ko) | 2017-03-03 | 2024-04-01 | 씨젠 인크. | 글리칸-상호작용 화합물 및 사용 방법 |
| JP2021502100A (ja) | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体 |
| US11795579B2 (en) | 2017-12-11 | 2023-10-24 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| WO2019195623A2 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| UA128825C2 (uk) | 2019-03-01 | 2024-10-30 | Ксенкор, Інк. | Гетеродимерні антитіла, що зв'язують enpp3 та cd3 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| CA3192204A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Ｃｄ３及びｃｌｄｎ６に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631190A (en) | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5194594A (en) | 1990-09-07 | 1993-03-16 | Techniclone, Inc. | Modified antibodies |
| FI101678B1 (fi) | 1990-12-31 | 1998-08-14 | Akzo Nv | Happolabiileja kytkentämolekyylejä |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| US5556623A (en) | 1993-03-30 | 1996-09-17 | Eli Lilly And Company | Antibody-drug conjugates |
| US20060228364A1 (en) | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| IT1307309B1 (it) * | 1999-12-30 | 2001-10-30 | Enea Ente Nuove Tec | Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono. |
| ES2430857T3 (es) * | 2000-12-18 | 2013-11-22 | Dyax Corp. | Bibliotecas focalizadas de paquetes genéticos |
| US8178098B2 (en) | 2001-04-03 | 2012-05-15 | National Jewish Health | Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies |
| SI2332989T1 (sl) | 2002-05-22 | 2015-06-30 | Esbatech, An Alcon Biomedical Research Unit Llc | Imunoglobulinski bralni okvirji, ki kaĺ˝ejo izboljĺ ano stabilnost v intraceliäśnem okolju, in postopki za njihovo identifikacijo |
| AU2003256299A1 (en) * | 2002-07-01 | 2004-01-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
| EA012622B1 (ru) | 2004-06-01 | 2009-10-30 | Домэнтис Лимитед | Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки |
| EP2331570B1 (en) | 2008-09-10 | 2014-08-27 | Philochem AG | Display library for antibody selection |
| DK2356270T3 (da) * | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| US8716196B2 (en) | 2009-05-20 | 2014-05-06 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
| CA2762837C (en) | 2009-05-20 | 2021-08-03 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
| FR2945961B1 (fr) | 2009-05-29 | 2012-07-13 | Air Liquide | Epuration d'un gaz contenant des oxydes d'azote |
| SG175407A1 (en) | 2009-05-29 | 2011-11-28 | Morphosys Ag | A collection and methods for its use |
| SG181862A1 (en) | 2009-12-23 | 2012-07-30 | Affinity Biosciences Pty Ltd | Protein display |
| JP5195798B2 (ja) * | 2010-03-23 | 2013-05-15 | 豊田合成株式会社 | 半導体発光素子の製造方法 |
| WO2013000023A1 (en) | 2011-06-29 | 2013-01-03 | Affinity Biosciences Pty Ltd | Method of protein display |
| CN103890246A (zh) | 2011-08-18 | 2014-06-25 | 亲和生物科学公司 | 可溶性多肽 |
| AU2014220306A1 (en) | 2013-02-20 | 2015-08-27 | Affinity Biosciences Pty Ltd | Cytoplasmic expression of Fab proteins |
| US9705121B2 (en) | 2014-08-18 | 2017-07-11 | Johnson Controls Technology Company | Lead frame for a battery module |
-
2012
- 2012-08-17 CN CN201280047892.XA patent/CN103890246A/zh active Pending
- 2012-08-17 WO PCT/AU2012/000970 patent/WO2013023251A1/en not_active Ceased
- 2012-08-17 DK DK12824386.2T patent/DK2744931T3/en active
- 2012-08-17 EP EP12824386.2A patent/EP2744931B1/en active Active
- 2012-08-17 ES ES12824386.2T patent/ES2682254T3/es active Active
- 2012-08-17 JP JP2014525261A patent/JP6244301B2/ja active Active
- 2012-08-17 CA CA2845391A patent/CA2845391C/en active Active
-
2014
- 2014-02-14 US US14/181,026 patent/US10087261B2/en active Active
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