JP2014525402A - 非経口投与のための濃縮されたフェルバメート製剤 - Google Patents

非経口投与のための濃縮されたフェルバメート製剤 Download PDF

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Publication number
JP2014525402A
JP2014525402A JP2014525143A JP2014525143A JP2014525402A JP 2014525402 A JP2014525402 A JP 2014525402A JP 2014525143 A JP2014525143 A JP 2014525143A JP 2014525143 A JP2014525143 A JP 2014525143A JP 2014525402 A JP2014525402 A JP 2014525402A
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Prior art keywords
solvent
neuroprotective agent
microparticles
solution
surfactant
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Japanese (ja)
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JP2014525402A5 (OSRAM
Inventor
サシャ エイチ． バクル，
ブライアン イー． ローリクト，
エディス マシオウィッツ，
ソロモン エス． スタイナー，
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ペロスフィア インコーポレイテッド
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Publication of JP2014525402A publication Critical patent/JP2014525402A/ja
Publication of JP2014525402A5 publication Critical patent/JP2014525402A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014525143A 2011-08-12 2012-08-09 非経口投与のための濃縮されたフェルバメート製剤 Withdrawn JP2014525402A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161522811P 2011-08-12 2011-08-12
US61/522,811 2011-08-12
PCT/US2012/050148 WO2013025442A2 (en) 2011-08-12 2012-08-09 Concentrated felbamate formulations for parenteral administration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017079599A Division JP2017122127A (ja) 2011-08-12 2017-04-13 非経口投与のための濃縮されたフェルバメート製剤

Publications (2)

Publication Number Publication Date
JP2014525402A true JP2014525402A (ja) 2014-09-29
JP2014525402A5 JP2014525402A5 (OSRAM) 2015-09-24

Family

ID=47715640

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014525143A Withdrawn JP2014525402A (ja) 2011-08-12 2012-08-09 非経口投与のための濃縮されたフェルバメート製剤
JP2017079599A Ceased JP2017122127A (ja) 2011-08-12 2017-04-13 非経口投与のための濃縮されたフェルバメート製剤
JP2019022430A Pending JP2019085416A (ja) 2011-08-12 2019-02-12 非経口投与のための濃縮されたフェルバメート製剤

Family Applications After (2)

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JP2017079599A Ceased JP2017122127A (ja) 2011-08-12 2017-04-13 非経口投与のための濃縮されたフェルバメート製剤
JP2019022430A Pending JP2019085416A (ja) 2011-08-12 2019-02-12 非経口投与のための濃縮されたフェルバメート製剤

Country Status (7)

Country Link
US (2) US20140178479A1 (OSRAM)
EP (1) EP2741751A4 (OSRAM)
JP (3) JP2014525402A (OSRAM)
AU (1) AU2012295390B2 (OSRAM)
CA (1) CA2844907A1 (OSRAM)
HK (1) HK1198942A1 (OSRAM)
WO (1) WO2013025442A2 (OSRAM)

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DK3202898T3 (en) 2009-11-02 2019-01-14 Univ Washington THERAPEUTIC NUCLEASE COMPOSITIONS AND PROCEDURES
PH12013502441B1 (en) 2011-04-29 2019-02-08 Univ Washington Therapeutic nuclease compositions and methods
SI3063275T1 (sl) 2013-10-31 2020-02-28 Resolve Therapeutics, Llc Terapevtske fuzije nukleaza-albumin in postopki
WO2015100252A1 (en) * 2013-12-23 2015-07-02 Perosphere, Inc. Deuterated felbamate, compositions containing the same, and methods of use thereof
GB201604359D0 (en) * 2016-03-15 2016-04-27 Univ Newcastle Treatment of tissue disorders
AU2017290389B2 (en) 2016-07-01 2024-09-26 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
US10947295B2 (en) 2017-08-22 2021-03-16 Sanabio, Llc Heterodimers of soluble interferon receptors and uses thereof

Citations (3)

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JP2002536409A (ja) * 1999-02-09 2002-10-29 ユニバーシティ オブ バージニア パテント ファウンデーション フェルバメートから誘導される化合物
JP2006528985A (ja) * 2003-05-19 2006-12-28 バクスター・インターナショナル・インコーポレイテッド １つ以上の界面改変剤でコーティングされた、抗癲癇剤または免疫抑制剤を含有する固体粒子
JP2009523802A (ja) * 2006-01-17 2009-06-25 リージェンツ オブ ザ ユニバーシティー オブ コロラド Ｃｎｓ状態のための治療剤の安定製剤の中枢投与

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US1904257A (en) * 1926-10-29 1933-04-18 Firm Of Chemical Works Formerl Supersaturated calcium gluconate solution
US3017323A (en) * 1957-07-02 1962-01-16 Pfizer & Co C Therapeutic compositions comprising polyhydric alcohol solutions of tetracycline-type antibiotics
US5308621A (en) * 1991-02-18 1994-05-03 Commonwealth Scientific And Industrial Research Organisation Ascorbic acid composition and transdermal administration method
US6020367A (en) * 1997-12-02 2000-02-01 Avon Products, Inc. Supersaturated ascorbic acid solutions
ES2303527T3 (es) * 2000-05-10 2008-08-16 Jagotec Ag Procedimiento de molienda.
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
MXPA04009968A (es) * 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
US7259153B2 (en) * 2003-02-03 2007-08-21 Supernus Pharmaceuticals Drug formulation and delivery using crystalline methylated cyclodextrins
US20060160776A1 (en) * 2003-05-28 2006-07-20 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a cannabinoid agent for the treatment of central nervous system damage
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CN101309691A (zh) * 2005-09-30 2008-11-19 奥瓦什医药品公司 新的胃肠外的卡马西平制剂
GB0607105D0 (en) * 2006-04-10 2006-05-17 Leuven K U Res & Dev Enhancing solubility and dissolution rate of poorly soluble drugs
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EP2273993A4 (en) * 2008-04-01 2011-06-15 Univ Colorado Regents METHOD AND COMPOSITIONS FOR THE INTRA-CEREBRUCTIVE ADMINISTRATION OF FELBAMATE
US8637569B2 (en) * 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
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JP2002536409A (ja) * 1999-02-09 2002-10-29 ユニバーシティ オブ バージニア パテント ファウンデーション フェルバメートから誘導される化合物
JP2006528985A (ja) * 2003-05-19 2006-12-28 バクスター・インターナショナル・インコーポレイテッド １つ以上の界面改変剤でコーティングされた、抗癲癇剤または免疫抑制剤を含有する固体粒子
JP2009523802A (ja) * 2006-01-17 2009-06-25 リージェンツ オブ ザ ユニバーシティー オブ コロラド Ｃｎｓ状態のための治療剤の安定製剤の中枢投与

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Also Published As

Publication number Publication date
US20170157083A1 (en) 2017-06-08
JP2019085416A (ja) 2019-06-06
HK1198942A1 (en) 2015-06-19
US20140178479A1 (en) 2014-06-26
CA2844907A1 (en) 2013-02-21
JP2017122127A (ja) 2017-07-13
EP2741751A2 (en) 2014-06-18
WO2013025442A2 (en) 2013-02-21
AU2012295390B2 (en) 2015-12-24
WO2013025442A3 (en) 2013-04-25
EP2741751A4 (en) 2015-03-25
AU2012295390A1 (en) 2014-03-13

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