JP2014524902A - Ｔｅｍ８抗体、そのコンジュゲートおよびそれらの使用 - Google Patents

Ｔｅｍ８抗体、そのコンジュゲートおよびそれらの使用 Download PDF

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JP2014524902A
JP2014524902A JP2014515968A JP2014515968A JP2014524902A JP 2014524902 A JP2014524902 A JP 2014524902A JP 2014515968 A JP2014515968 A JP 2014515968A JP 2014515968 A JP2014515968 A JP 2014515968A JP 2014524902 A JP2014524902 A JP 2014524902A
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seq
amino acid
variable region
chain variable
acid sequence
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JP2014524902A5 (enExample
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ブラッド セントクロイ
トニー フレミング
アミト チャウダリー
ソラブ サハ
シャオヤン ミシェル チャン
ロウ‐ファン クォン
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Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014515968A 2011-06-14 2012-06-13 Ｔｅｍ８抗体、そのコンジュゲートおよびそれらの使用 Pending JP2014524902A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161496986P 2011-06-14 2011-06-14
US201161496737P 2011-06-14 2011-06-14
US61/496,986 2011-06-14
US61/496,737 2011-06-14
PCT/US2012/042315 WO2012174160A1 (en) 2011-06-14 2012-06-13 Tem8 antibodies, conjugates thereof, and their use

Publications (2)

Publication Number Publication Date
JP2014524902A true JP2014524902A (ja) 2014-09-25
JP2014524902A5 JP2014524902A5 (enExample) 2015-07-09

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JP2014515968A Pending JP2014524902A (ja) 2011-06-14 2012-06-13 Ｔｅｍ８抗体、そのコンジュゲートおよびそれらの使用

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Country Link
US (1) US9181340B2 (enExample)
EP (1) EP2721071A4 (enExample)
JP (1) JP2014524902A (enExample)
CA (1) CA2837892A1 (enExample)
WO (1) WO2012174160A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015144243A (ja) * 2013-12-25 2015-08-06 東京応化工業株式会社 表面被覆膜の形成方法及び表面被覆膜を有する太陽電池
JP2022101576A (ja) * 2016-02-09 2022-07-06 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド スギ花粉エピトープを封入するｔｉｍｐ（組織性メタロプロテアーゼ阻害因子）

Families Citing this family (16)

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WO2012065161A2 (en) 2010-11-12 2012-05-18 Scott & White Healthcare Antibodies to tumor endothelial marker 8
HK1219980A1 (zh) * 2013-03-09 2017-04-21 Baylor College Of Medicine 靶向血管的t细胞疗法
US9862951B2 (en) 2013-06-14 2018-01-09 Texas Tech University System RNA interference-based therapeutic against anthrax
CN105813654B (zh) 2013-10-11 2019-05-31 美国政府(由卫生和人类服务部的部长所代表) Tem8抗体及其用途
US10434174B2 (en) 2014-06-09 2019-10-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapies using platinum agents and agents that target tumor-associated stroma or tumor cells
US10799584B2 (en) 2014-06-09 2020-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health Combination therapies using agents that target tumor-associated stroma or tumor cells and alkylating agents
WO2015191583A2 (en) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase
WO2015191568A2 (en) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature
WO2015191617A2 (en) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies using anti-metabolites and agents that target tumor-associated stroma or tumor cells
WO2015191590A2 (en) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies targeting tumor-associated stroma or tumor cells and microtubules
WO2015191602A2 (en) * 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies targeting tumor-associated stroma or tumor cells
US10758526B2 (en) 2014-06-09 2020-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways
CN110234348B (zh) 2016-12-16 2024-06-25 蓝鳍生物医药公司 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法
CN108707199A (zh) * 2018-05-29 2018-10-26 廊坊康宝汇泰生物技术有限公司 靶向tem8的嵌合抗原受体t细胞及其应用
WO2024245342A1 (zh) * 2023-05-31 2024-12-05 应世生物科技(南京)有限公司 一种靶向tem8的抗体或其抗原结合片段及其应用
WO2025179281A1 (en) * 2024-02-23 2025-08-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment of cardiovascular disease with antxr1 antibodies

Citations (1)

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CN101591395A (zh) * 2009-07-13 2009-12-02 杭州屹源生物技术有限公司 抗人肿瘤血管内皮标志分子8胞外区的人源性单链抗体及其应用

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FR2810195B1 (fr) 2000-06-16 2002-08-30 Kuhn Audureau Sa Machine de coupe pouvant etre accrochee a un tracteur et comprenant un mecanisme de coupe a rotor et couteaux perfectionne
AU2001283062A1 (en) 2000-08-02 2002-02-13 The Johns Hopkins University Endothelial cell expression patterns
ATE360071T1 (de) 2000-12-05 2007-05-15 Wisconsin Alumni Res Found Rezeptor für ein toxin aus bacillus anthracis
EP1572867B1 (en) 2001-04-11 2014-07-23 The Johns Hopkins University Endothelial cell expression patterns
US20030220287A1 (en) 2002-03-28 2003-11-27 Phillips M. Ian Antisense nucleic acids
US20070020271A1 (en) 2003-03-04 2007-01-25 Beverly Teicher Endothelial cell specific antibodies and uses thereof
JP4411280B2 (ja) * 2003-10-20 2010-02-10 帝人ファーマ株式会社 骨及び／又は関節疾患関連遺伝子
WO2005081749A2 (en) 2004-01-23 2005-09-09 Avanir Pharmaceuticals, Inc. Neutralizing human antibodies to anthraxtoxin
ITRM20060337A1 (it) * 2006-06-27 2007-12-28 Biosoot Srl Gene tem8 (tumor endotelial marker 8) e sue forme di espressione ed usi diagnostici e terapeutici
WO2012065161A2 (en) 2010-11-12 2012-05-18 Scott & White Healthcare Antibodies to tumor endothelial marker 8
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8

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CN101591395A (zh) * 2009-07-13 2009-12-02 杭州屹源生物技术有限公司 抗人肿瘤血管内皮标志分子8胞外区的人源性单链抗体及其应用

Non-Patent Citations (3)

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JPN6016009220; ＹＡＮＧ，　Ｍ．　ｅｔ　ａｌ．: '"Ｔｈｅ　ｃｅｌｌ　ｓｕｒｆａｃｅ　ｓｔｒｕｃｔｕｒｅ　ｏｆ　ｔｕｍｏｒ　ｅｎｄｏｔｈｅｌｉａｌ　ｍａｒｋｅｒ　８　（ＴＥＭ８）　ｉｓ　ｒｅｇｕｌａｔｅｄ　ｂｙ　ｔｈｅ　ａｃｔｉｎ　ｃｙｔｏｓｋｅｌｅ' Ｂｉｏｃｈｉｍ．　Ｂｉｏｐｈｙｓ．　Ａｃｔａ Ｖｏｌ．　１８１３, 2011, ｐｐ．　３９-４９ *
JPN6016009221; ＦＥＲＮＡＮＤＯ，　Ｓ．　ｅｔ　ａｌ．: '"Ｔａｒｇｅｔｉｎｇ　Ｔｕｍｏｒ　Ｅｎｄｏｔｈｅｌｉａｌ　Ｍａｒｋｅｒ　８　ｉｎ　ｔｈｅ　Ｔｕｍｏｒ　Ｖａｓｃｕａｌｔｕｒｅ　ｏｆ　Ｃｏｌｏｒｅｃｔａｌ　Ｃａｒｃｉｎｏｍａｓ　ｉｎ　Ｍｉｃｅ"' Ｃａｎｃｅｒ　Ｒｅｓ． Ｖｏｌ．　６９, 2009, ｐｐ．　５１２６-５１３２ *
JPN6016009223; ＬＩ，　Ｇ．　ｅｔ　ａｌ．: '"Ｔｈｅ　ｉｎｈｉｂｉｔｉｏｎ　ｏｆ　ｔｈｅ　ｉｎｔｅｒａｃｔｉｏｎ　ｂｅｔｗｅｅｎ　ｔｈｅ　ａｎｔｈｒａｘ　ｔｏｘｉｎ　ａｎｄ　ｉｔｓ　ｃｅｌｌｕｌａｒ　ｒｅｃｅｐｔｏｒ　ｂｙ　ａｎ　ａｎｔｉ-ｒｅ' Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．　３８５, 2009, ｐｐ．　５９１-５９５ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015144243A (ja) * 2013-12-25 2015-08-06 東京応化工業株式会社 表面被覆膜の形成方法及び表面被覆膜を有する太陽電池
JP2022101576A (ja) * 2016-02-09 2022-07-06 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド スギ花粉エピトープを封入するｔｉｍｐ（組織性メタロプロテアーゼ阻害因子）

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Publication number Publication date
EP2721071A1 (en) 2014-04-23
WO2012174160A1 (en) 2012-12-20
EP2721071A4 (en) 2015-01-21
CA2837892A1 (en) 2012-12-20
US20140134179A1 (en) 2014-05-15
US9181340B2 (en) 2015-11-10

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