JP2014524287A - 透析用容器 - Google Patents
透析用容器 Download PDFInfo
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- JP2014524287A JP2014524287A JP2014524367A JP2014524367A JP2014524287A JP 2014524287 A JP2014524287 A JP 2014524287A JP 2014524367 A JP2014524367 A JP 2014524367A JP 2014524367 A JP2014524367 A JP 2014524367A JP 2014524287 A JP2014524287 A JP 2014524287A
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- 238000000502 dialysis Methods 0.000 title claims abstract description 49
- 239000000243 solution Substances 0.000 claims abstract description 33
- 239000012141 concentrate Substances 0.000 claims abstract description 24
- 239000007787 solid Substances 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 239000000385 dialysis solution Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 6
- 230000002093 peripheral effect Effects 0.000 claims description 27
- 238000007789 sealing Methods 0.000 claims description 25
- 239000012530 fluid Substances 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 10
- 239000008103 glucose Substances 0.000 claims description 10
- 238000009423 ventilation Methods 0.000 claims description 8
- 230000000903 blocking effect Effects 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 3
- 238000013022 venting Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 description 22
- 239000000047 product Substances 0.000 description 22
- 235000008504 concentrate Nutrition 0.000 description 16
- 238000003860 storage Methods 0.000 description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
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- 230000035622 drinking Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
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- 230000003449 preventive effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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- A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- External Artificial Organs (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
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Abstract
【選択図】図2
Description
10、20、30、40 ストッパ
11、21、31、41 円筒壁
12、22、32、42 半径方向の下部壁
13、23、33、43 半径方向の上部壁
24、34、44 ロッド
25、35 クリップ
91 連結部分
92 連結部分
93 閉じられるべき開口部
111、211、311 環状シール
112、212、312、412 周縁部
124 脆弱ゾーン
128、228、328、428 外側開口部
131 第二の円筒壁
132 安全タブ
213、313 環状溝
221、321 ハウジング開口部
222、322 ハウジング開口部を取り囲むスリーブ
223 閉鎖膜
231、331 蓋開口部
232、332 蓋開口部を取り囲むスリーブ
233、333 円筒フランジ
234、334 環状リブ
241、341 ノブ
242、342 ロッドの下端部
243、343 第一のシール
244、344 軸方向の製品排出用凹部
245、345 軸方向の空気取入れ用凹部
247 引き抜き防止用環状肩部
346 第二のシール
414 第一のセクター
415 第二のセクター
416 第三のセクター/切込み
425 下部フランジ
426 環状シール
427 環状肩部
435 上部フランジ
436 環状シール
437 ノブ
438 ガイド要素
A1、A2、A3、A4 ハウジング
B1、B4 ピストン
B2、B3 蓋
N1、N2 封止用リブ
O1、O2 通気用開口部
R1、R2、R3、R4 タンク
Claims (22)
- 透析用濃縮物を格納する容器において、
−透析溶液の組成の構成成分の固体濃縮物を格納するパウチまたはカートリッジと、
−パウチまたはカートリッジを閉じるコネクタ(9)であって、
−コネクタを完全に通って延在して、固体濃縮物をパウチまたはカートリッジに充填するように意図された充填用チャネル(93)と、
−パウチまたはカートリッジに溶液形成用の液体を導入しパウチまたはカートリッジから得られた溶液を抽出するための手段であって、透析装置の対応するポートへの連結のための少なくとも一つの連結部分が具備されている導入および抽出手段と
が具備されたコネクタ(9)と
を含み、
充填用チャネル(93)が、
−透析溶液の組成の第二の構成成分または構成成分群を格納するタンク(R1、R2、R3、R4)と、
−容器に位置づけられたストッパの側面とタンクの内側を接触させる出口開口部(128、228、328、428)をタンクに作るための手段(131、24、34、44)と
を備えたストッパ(10、20、30、40)により閉じられることを特徴とする容器。 - パウチがグルコースを含む固体濃縮物を格納すること、および/またはストッパのタンクが、好ましくは液体の形で酸を格納することを特徴とする、請求項1に記載の容器。
- 開口手段(131、24、34、44)が、開口部が作られる前に少なくとも部分的にタンクに設置されることを特徴とする、請求項1または2に記載の容器。
- 導入および抽出手段が、
−パウチまたはカートリッジに溶液形成用の液体を導入するための流体ラインと、
−パウチまたはカートリッジから得られた溶液を抽出するための流体ラインと
を含み、
−各流体ラインが、パウチまたはカートリッジにあるオリフィスから容器の外側にある連結部分(91、92)まで延在し、これらの連結部分が、透析装置の対応するポートに各流体ラインを連結するために構成されていることを特徴とする、請求項1〜3のいずれか一つに記載の容器。 - 二本の流体ラインが組み合わされて単一の流体ラインになることを特徴とする、請求項4に記載の容器。
- 開口手段(131、24、34、44)が、容器の内側に向かって移動させられて出口開口部を作るように設計されていることを特徴とする、請求項1〜5のいずれか一つに記載の容器。
- ストッパ(10、20、30、40)に、第一の円筒壁(11、21、31、41)、半径方向または斜め方向の下部壁(12、22、32、42)、および半径方向または斜め方向の上部壁(13、23、33、43)が具備されており、下部壁および上部壁が、円筒壁を閉じて円筒壁内およびこれら二つの壁の間に含まれる空間にタンク(R1、R2、R3、R4)を形成することができ、出口開口部(128、228、328、428)が、下部壁(22、32)に、または下部壁(12、42)と第一の円筒壁(11、41)の接合部に形成されていることを特徴とする、請求項1〜6のいずれか一つに記載の容器。
- ストッパと容器の開口部(93)との間の封止を確実に行うために第一の円筒壁(11、21、31、41)に封止手段(111、211、311)が具備されており、これらの封止手段が、第一の円筒壁(41)のために使用される材料および/または環状シール(111、211、311)により構成されることを特徴とする、請求項7に記載の容器。
- ストッパ(10、20、30、40)に、開口手段(131、24、34、44)が始動するのを防ぐための遮断手段(132、25、35、438)が具備されており、これらの遮断手段を取り除いてまたは移動させてそれらを無効にすることが可能であることを特徴とする、請求項1〜8のいずれか一つに記載の容器。
- ストッパ(10、20、30、40)に、開口部(93)への入り込みを既定の深さに限定するための手段(112、212、312、412)が、その上部部分において具備されており、これらの手段が、好ましくは、容器の開口部(93)の寸法よりも大きい寸法を有する半径方向の周縁部(112、212、312、412)により構成されていることを特徴とする、請求項1〜9のいずれか一つに記載の容器。
- 開口手段(131、24、34、44)からのストッパの引き抜きを防ぐために、引き抜き防止手段(247、427)が具備されていることを特徴とする、請求項1〜10のいずれか一つに記載の容器。
- ストッパ(10)がハウジング(A1)とピストン(B1)により構成されており、ハウジングが、下部壁(12)と呼ばれる半径方向または斜め方向の壁によりその下縁部の部分において閉じられた第一の円筒壁(11)により構成されており、下部壁が、第一の円筒壁(11)との接合部の近辺に脆弱ゾーン(124)を有しており、第一の円筒壁には、閉じられるべき開口部(93)の寸法よりも大きい寸法を有する、外側の方へと向けられた半径方向の周縁部(112)が、その上縁部の部分において具備されており、ピストン(B1)が、上部壁と呼ばれる半径方向または斜め方向の壁(13)によりその上縁部の部分において閉じられた第二の円筒壁(131)により構成されており、第二の円筒壁の下縁部がベベルが付いて傾斜し、こうして第二の円筒壁の高さが最大の高さと最小の高さとの間で変動し、上部壁(13)の周囲には、取り外し可能な安全タブ(132)が固定されて第二の円筒壁を取り囲んでおり、第二の円筒壁(131)が、第一の円筒壁(11)に入ることができるように寸法決定され、安全タブ(132)が、ピストン(B1)がハウジング(A1)に導入されてタンク(R1)を形成する時に周縁部(112)に接して位置することができるように、寸法決定されており、第二の円筒壁(131)の最大の高さと安全タブ(132)の高さが、これら二つの高さの間の差が下部壁(12)と周縁部(112)との間で測定された第一の円筒壁(11)の高さよりも小さくなるように、一方、下部壁(12)と周縁部(112)との間で測定された第一の円筒壁(11)の高さが第二の円筒壁の最小の高さと最大の高さとの間にあるように、選択されることを特徴とする、請求項1〜11のいずれか一つに記載の容器。
- 下部壁(12)が、第二の円筒壁(131)の断面と同一の輪郭を有する脆弱ゾーン(124)を有することを特徴とする、請求項12に記載の容器。
- タンク(R1、R2、R3、R4)に出口開口部(128、228、328、428)を作るための手段が始動した時に容器の内側と外側との間に空気の通路を作るために、通気用手段(O1、O2、245、345)が具備されていることを特徴とする、請求項1〜13のいずれか一つに記載の容器。
- 通気用手段が、容器およびコネクタ(9)の外側に位置づけられたストッパの側面とタンクの内側を接触させる、タンクに具備された通気用開口部の形状であり、取り除き可能なキャップがこの通気用開口部を閉じることを特徴とする、請求項14に記載の容器。
- 通気用手段(O1、O2)が、円筒壁(131)の外側で、ピストン(B1)の上部壁(13)を通って延在する開口部の形状であること、および封止用リブ(N1、N2)がピストンの円筒壁(131)の外面に具備されていること、封止用リブの寸法が、出口開口部(128)を作るための手段の始動前に、封止用リブがハウジング(A1)の円筒壁の内部壁に接して封止する形で位置するような寸法であることを特徴とする、請求項12を引用する請求項14に記載の容器。
- コネクタ(9)の一つまたは複数の連結部分(91、92)を収容するために寸法決定された一つ以上のポートが具備された透析装置での、請求項1〜16のいずれか一つに記載の容器の使用。
- 請求項1〜16のいずれか一つに記載の容器が具備された透析装置での透析溶液の即時調製方法において、
a)透析装置の所定の場所に容器を置き、一つまたは複数の連結部分(91、92)を装置の対応するポートに導入するステップと;
b)導入用流体ラインを介して容器に溶液形成用の液体を導入するステップと;
が実施される方法であって、
c)ストッパ(10、20、30、40)に格納されたタンク(R1、R2、R3、R4)を開口して、開口部(128、228、328、428)を作るための手段(131、24、34、44)を始動させるステップと;
d)タンクの中身をパウチまたはカートリッジの中に流入させるステップ
という追加のステップが、ステップa)の前に、またはステップa)とステップb)との間に実施されることを特徴とする方法。 - ステップc)が、ステップa)の後に透析装置により自動的に実施されることを特徴とする、請求項18に記載の方法。
- ステップc)が、透析中に容器を保持するように意図されている、透析装置に存在する保持用カバーを閉じる間に実施されることを特徴とする、請求項18に記載の方法。
- ステップc)が、ステップa)の前または後に手動で実施されることを特徴とする、請求項18に記載の方法。
- ストッパが、好ましくは液体の形で酸を格納すること、および/またはパウチまたはカートリッジが、グルコースを含む固体濃縮物を格納することを特徴とする、請求項18〜21のいずれか一つに記載の方法。
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US201161522495P | 2011-08-11 | 2011-08-11 | |
US61/522,495 | 2011-08-11 | ||
FR1157309A FR2978914B1 (fr) | 2011-08-11 | 2011-08-11 | Recipient pour dialyse |
FR1157309 | 2011-08-11 | ||
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2012
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2003275299A (ja) * | 2002-03-11 | 2003-09-30 | Fresenius Medical Care Deutsche Gmbh | コネクタ、容器及び流体調製装置 |
JP2009518252A (ja) * | 2005-12-12 | 2009-05-07 | リー、ジュンミン | 作動部非分離形の異種物質貯蔵空間を備える受容装置 |
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