JP2014523330A5 - - Google Patents
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- Publication number
- JP2014523330A5 JP2014523330A5 JP2014521814A JP2014521814A JP2014523330A5 JP 2014523330 A5 JP2014523330 A5 JP 2014523330A5 JP 2014521814 A JP2014521814 A JP 2014521814A JP 2014521814 A JP2014521814 A JP 2014521814A JP 2014523330 A5 JP2014523330 A5 JP 2014523330A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- tyrosine
- derived
- lactide
- pga
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 claims description 20
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 18
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 13
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims description 13
- 229960001225 rifampicin Drugs 0.000 claims description 13
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 12
- 229920000954 Polyglycolide Polymers 0.000 claims description 12
- 229960004023 minocycline Drugs 0.000 claims description 12
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 10
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 8
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 8
- 229920001610 polycaprolactone Polymers 0.000 claims description 8
- 239000004632 polycaprolactone Substances 0.000 claims description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 6
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 5
- -1 Polypropylene fumarate Polymers 0.000 claims description 4
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 239000003805 procoagulant Substances 0.000 claims description 3
- HCZQSLKOEQURLM-ZETCQYMHSA-N (4S)-4-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)COC(=O)[C@@H](N)CCC(O)=O HCZQSLKOEQURLM-ZETCQYMHSA-N 0.000 claims description 2
- JRFXQKZEGILCCO-UHFFFAOYSA-N 5,5-dimethyl-1,3-dioxan-2-one Chemical compound CC1(C)COC(=O)OC1 JRFXQKZEGILCCO-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229930182555 Penicillin Natural products 0.000 claims description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 2
- 229920001710 Polyorthoester Polymers 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 229940049954 penicillin Drugs 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 229920006210 poly(glycolide-co-caprolactone) Polymers 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 239000000622 polydioxanone Substances 0.000 claims description 2
- 229920002643 polyglutamic acid Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920001299 polypropylene fumarate Polymers 0.000 claims description 2
- 210000000278 spinal cord Anatomy 0.000 claims description 2
- 229960002180 tetracycline Drugs 0.000 claims description 2
- 229930101283 tetracycline Natural products 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 2
- 210000001186 vagus nerve Anatomy 0.000 claims description 2
- 230000002861 ventricular Effects 0.000 claims description 2
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229960003085 meticillin Drugs 0.000 description 2
- 239000006071 cream Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509843P | 2011-07-20 | 2011-07-20 | |
| US61/509,843 | 2011-07-20 | ||
| PCT/US2012/047542 WO2013013123A1 (en) | 2011-07-20 | 2012-07-20 | Drug eluting mesh to prevent infection of indwelling transdermal devices |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137619A Division JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014523330A JP2014523330A (ja) | 2014-09-11 |
| JP2014523330A5 true JP2014523330A5 (cg-RX-API-DMAC7.html) | 2015-08-20 |
Family
ID=46650881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521814A Pending JP2014523330A (ja) | 2011-07-20 | 2012-07-20 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
| JP2016137619A Pending JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137619A Pending JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9381281B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2734248B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2014523330A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012283875B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2842107C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013013123A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014137454A1 (en) * | 2013-03-07 | 2014-09-12 | Tyrx, Inc. | Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices |
| GB201505527D0 (en) * | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| US20160367800A1 (en) | 2015-06-18 | 2016-12-22 | Cardiac Pacemakers, Inc. | Infection fighting bioresorbable polymer device for medical implants |
| EP3319655B1 (en) | 2015-07-11 | 2019-05-22 | Cardiac Pacemakers, Inc. | Polymer coating with antimicrobial materials and methods for producing |
| US9999899B2 (en) | 2016-11-01 | 2018-06-19 | International Business Machines Corporation | Controlled exposure of in-vivo sensors |
| AU2018321578A1 (en) * | 2017-08-24 | 2020-03-05 | Boulos & Cooper Pharmaceuticals Pty Ltd | Antimicrobial coating |
| CN111432807A (zh) | 2017-10-06 | 2020-07-17 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| US9919080B1 (en) * | 2017-10-27 | 2018-03-20 | Tyrx, Inc. | Kits for local delivery of water soluble agents and methods of use |
| CN111655303A (zh) | 2018-01-08 | 2020-09-11 | 铸造疗法股份有限公司 | 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法 |
| CN112367980A (zh) | 2018-05-12 | 2021-02-12 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| WO2020047013A1 (en) | 2018-08-28 | 2020-03-05 | Foundry Therapeutics, Inc. | Polymer implants |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980449A (en) | 1988-07-14 | 1990-12-25 | Rutgers, The State University | Polyiminocarbonate synthesis |
| US5587507A (en) | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5216115A (en) | 1990-06-12 | 1993-06-01 | Rutgers, The State University Of New Jersey | Polyarylate containing derivatives of the natural amino acid L-tyrosine |
| US5099060A (en) | 1990-06-12 | 1992-03-24 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| USRE37160E1 (en) | 1990-06-12 | 2001-05-01 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5658995A (en) | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
| US6120491A (en) | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| US6319492B1 (en) | 1996-11-27 | 2001-11-20 | Rutgers, The State University | Copolymers of tyrosine-based polyarylates and poly(alkylene oxides) |
| US6048521A (en) | 1997-11-07 | 2000-04-11 | Rutgers, The State University | Copolymers of tyrosine-based polyarlates and poly(alkylene oxides) |
| DE69825619T2 (de) | 1997-11-07 | 2005-09-01 | Rutgers, The State University | Strikt alternierende poly(alkylenoxid)copolymere |
| US6602497B1 (en) | 1997-11-07 | 2003-08-05 | Rutgers, The State University | Strictly alternating poly(alkylene oxide ether) copolymers |
| AU761458B2 (en) | 1998-04-13 | 2003-06-05 | Rutgers, The State University | The construction of copolymer libraries |
| EP1251864A4 (en) | 1999-12-31 | 2006-02-22 | Univ Rutgers | PHARMACEUTICAL FORMULATION COMPRISING A POLYMERIC MIXTURE AND AN ACTIVE COMPOUND FOR TIME-RELEASED RELEASE |
| US7521061B2 (en) | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| AU784226B2 (en) | 1999-12-31 | 2006-02-23 | Rutgers, The State University | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| US7271234B2 (en) | 2002-04-24 | 2007-09-18 | Rutgers, The State University Of New Jersey | Polyarylates for drug delivery and tissue engineering |
| US8315700B2 (en) * | 2006-02-08 | 2012-11-20 | Tyrx, Inc. | Preventing biofilm formation on implantable medical devices |
| US9486560B2 (en) * | 2006-02-08 | 2016-11-08 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| US8636753B2 (en) * | 2006-02-08 | 2014-01-28 | Tyrx, Inc. | Temporarily stiffened mesh prostheses |
| US8591531B2 (en) * | 2006-02-08 | 2013-11-26 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| JP5165686B2 (ja) * | 2006-10-17 | 2013-03-21 | ラトガース，ザ ステート ユニバーシティ | Ｎ−置換モノマーおよびポリマー |
| US20080146869A1 (en) * | 2006-10-30 | 2008-06-19 | Hector Chow | Adjustable Gastric Band Having Anti-Microbial Coatings |
| EP2079387B1 (en) * | 2006-11-06 | 2017-04-12 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| EP2437724B1 (en) * | 2009-06-01 | 2015-09-30 | Tyrx, Inc. | Compositions and methods for preventing sternal wound infections |
| EP2459638B1 (en) * | 2009-07-31 | 2017-09-27 | Rutgers, The State University of New Jersey | Monomers and phase-separated biocompatible polymer compositions prepared therefrom for medical uses |
| JP6397190B2 (ja) * | 2010-11-12 | 2018-09-26 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 有効医薬品成分を含む固着装置 |
-
2012
- 2012-07-20 AU AU2012283875A patent/AU2012283875B2/en active Active
- 2012-07-20 WO PCT/US2012/047542 patent/WO2013013123A1/en not_active Ceased
- 2012-07-20 EP EP12746171.3A patent/EP2734248B1/en active Active
- 2012-07-20 CA CA2842107A patent/CA2842107C/en active Active
- 2012-07-20 US US14/233,856 patent/US9381281B2/en active Active
- 2012-07-20 JP JP2014521814A patent/JP2014523330A/ja active Pending
-
2016
- 2016-07-12 JP JP2016137619A patent/JP2016221297A/ja active Pending
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