CA2842107C - Drug eluting mesh to prevent infection of indwelling transdermal devices - Google Patents

Drug eluting mesh to prevent infection of indwelling transdermal devices Download PDF

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Publication number
CA2842107C
CA2842107C CA2842107A CA2842107A CA2842107C CA 2842107 C CA2842107 C CA 2842107C CA 2842107 A CA2842107 A CA 2842107A CA 2842107 A CA2842107 A CA 2842107A CA 2842107 C CA2842107 C CA 2842107C
Authority
CA
Canada
Prior art keywords
poly
hours
active agent
rifampin
mesh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2842107A
Other languages
English (en)
French (fr)
Other versions
CA2842107A1 (en
Inventor
Daniel Jeremy Lerner
William Mcjames
Randy MANSFIELD
Robert S. White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
TYRX Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TYRX Inc filed Critical TYRX Inc
Publication of CA2842107A1 publication Critical patent/CA2842107A1/en
Application granted granted Critical
Publication of CA2842107C publication Critical patent/CA2842107C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers & Plastics (AREA)
CA2842107A 2011-07-20 2012-07-20 Drug eluting mesh to prevent infection of indwelling transdermal devices Active CA2842107C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509843P 2011-07-20 2011-07-20
US61/509,843 2011-07-20
PCT/US2012/047542 WO2013013123A1 (en) 2011-07-20 2012-07-20 Drug eluting mesh to prevent infection of indwelling transdermal devices

Publications (2)

Publication Number Publication Date
CA2842107A1 CA2842107A1 (en) 2013-01-24
CA2842107C true CA2842107C (en) 2018-01-16

Family

ID=46650881

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2842107A Active CA2842107C (en) 2011-07-20 2012-07-20 Drug eluting mesh to prevent infection of indwelling transdermal devices

Country Status (6)

Country Link
US (1) US9381281B2 (cg-RX-API-DMAC7.html)
EP (1) EP2734248B1 (cg-RX-API-DMAC7.html)
JP (2) JP2014523330A (cg-RX-API-DMAC7.html)
AU (1) AU2012283875B2 (cg-RX-API-DMAC7.html)
CA (1) CA2842107C (cg-RX-API-DMAC7.html)
WO (1) WO2013013123A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014137454A1 (en) * 2013-03-07 2014-09-12 Tyrx, Inc. Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices
GB201505527D0 (en) * 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US20160367800A1 (en) 2015-06-18 2016-12-22 Cardiac Pacemakers, Inc. Infection fighting bioresorbable polymer device for medical implants
EP3319655B1 (en) 2015-07-11 2019-05-22 Cardiac Pacemakers, Inc. Polymer coating with antimicrobial materials and methods for producing
US9999899B2 (en) 2016-11-01 2018-06-19 International Business Machines Corporation Controlled exposure of in-vivo sensors
AU2018321578A1 (en) * 2017-08-24 2020-03-05 Boulos & Cooper Pharmaceuticals Pty Ltd Antimicrobial coating
CN111432807A (zh) 2017-10-06 2020-07-17 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
US9919080B1 (en) * 2017-10-27 2018-03-20 Tyrx, Inc. Kits for local delivery of water soluble agents and methods of use
CN111655303A (zh) 2018-01-08 2020-09-11 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
CN112367980A (zh) 2018-05-12 2021-02-12 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
WO2020047013A1 (en) 2018-08-28 2020-03-05 Foundry Therapeutics, Inc. Polymer implants

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980449A (en) 1988-07-14 1990-12-25 Rutgers, The State University Polyiminocarbonate synthesis
US5587507A (en) 1995-03-31 1996-12-24 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US5216115A (en) 1990-06-12 1993-06-01 Rutgers, The State University Of New Jersey Polyarylate containing derivatives of the natural amino acid L-tyrosine
US5099060A (en) 1990-06-12 1992-03-24 Rutgers, The State University Of New Jersey Synthesis of amino acid-derived bioerodible polymers
USRE37160E1 (en) 1990-06-12 2001-05-01 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US5658995A (en) 1995-11-27 1997-08-19 Rutgers, The State University Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide)
US6120491A (en) 1997-11-07 2000-09-19 The State University Rutgers Biodegradable, anionic polymers derived from the amino acid L-tyrosine
US6319492B1 (en) 1996-11-27 2001-11-20 Rutgers, The State University Copolymers of tyrosine-based polyarylates and poly(alkylene oxides)
US6048521A (en) 1997-11-07 2000-04-11 Rutgers, The State University Copolymers of tyrosine-based polyarlates and poly(alkylene oxides)
DE69825619T2 (de) 1997-11-07 2005-09-01 Rutgers, The State University Strikt alternierende poly(alkylenoxid)copolymere
US6602497B1 (en) 1997-11-07 2003-08-05 Rutgers, The State University Strictly alternating poly(alkylene oxide ether) copolymers
AU761458B2 (en) 1998-04-13 2003-06-05 Rutgers, The State University The construction of copolymer libraries
EP1251864A4 (en) 1999-12-31 2006-02-22 Univ Rutgers PHARMACEUTICAL FORMULATION COMPRISING A POLYMERIC MIXTURE AND AN ACTIVE COMPOUND FOR TIME-RELEASED RELEASE
US7521061B2 (en) 1999-12-31 2009-04-21 Rutgers, The State University Of New Jersey Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix
AU784226B2 (en) 1999-12-31 2006-02-23 Rutgers, The State University Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix
US7271234B2 (en) 2002-04-24 2007-09-18 Rutgers, The State University Of New Jersey Polyarylates for drug delivery and tissue engineering
US8315700B2 (en) * 2006-02-08 2012-11-20 Tyrx, Inc. Preventing biofilm formation on implantable medical devices
US9486560B2 (en) * 2006-02-08 2016-11-08 Tyrx, Inc. Mesh pouches for implantable medical devices
US8636753B2 (en) * 2006-02-08 2014-01-28 Tyrx, Inc. Temporarily stiffened mesh prostheses
US8591531B2 (en) * 2006-02-08 2013-11-26 Tyrx, Inc. Mesh pouches for implantable medical devices
JP5165686B2 (ja) * 2006-10-17 2013-03-21 ラトガース，ザ ステート ユニバーシティ Ｎ−置換モノマーおよびポリマー
US20080146869A1 (en) * 2006-10-30 2008-06-19 Hector Chow Adjustable Gastric Band Having Anti-Microbial Coatings
EP2079387B1 (en) * 2006-11-06 2017-04-12 Tyrx, Inc. Mesh pouches for implantable medical devices
EP2437724B1 (en) * 2009-06-01 2015-09-30 Tyrx, Inc. Compositions and methods for preventing sternal wound infections
EP2459638B1 (en) * 2009-07-31 2017-09-27 Rutgers, The State University of New Jersey Monomers and phase-separated biocompatible polymer compositions prepared therefrom for medical uses
JP6397190B2 (ja) * 2010-11-12 2018-09-26 タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． 有効医薬品成分を含む固着装置

Also Published As

Publication number Publication date
AU2012283875A1 (en) 2014-02-13
WO2013013123A1 (en) 2013-01-24
JP2016221297A (ja) 2016-12-28
US9381281B2 (en) 2016-07-05
US20140220098A1 (en) 2014-08-07
AU2012283875B2 (en) 2016-05-12
EP2734248A1 (en) 2014-05-28
JP2014523330A (ja) 2014-09-11
EP2734248B1 (en) 2018-10-17
CA2842107A1 (en) 2013-01-24

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Effective date: 20140115