JP2014518883A - T細胞媒介疾病の病態を改善させるためのtl1a−dr3相互作用の遮断及びその抗体 - Google Patents

T細胞媒介疾病の病態を改善させるためのtl1a−dr3相互作用の遮断及びその抗体 Download PDF

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JP2014518883A
JP2014518883A JP2014512833A JP2014512833A JP2014518883A JP 2014518883 A JP2014518883 A JP 2014518883A JP 2014512833 A JP2014512833 A JP 2014512833A JP 2014512833 A JP2014512833 A JP 2014512833A JP 2014518883 A JP2014518883 A JP 2014518883A
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tl1a
antibody
cells
inflammatory
disclosed
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シーゲル,リチャード・エム
メイラン,フランソワーズ
ソン,ユン−ジョン
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ガバメント・オブ・ザ・ユナイテッド・ステイツ,アズ・リプリゼンテッド・バイ・ザ・セクレタリー,デパートメント・オブ・ヘルス・アンド・ヒューマン・サーヴィシズ
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00Drugs for skeletal disorders
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • C07K2317/00Immunoglobulins specific features
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
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JP2014512833A 2011-05-20 2012-03-13 T細胞媒介疾病の病態を改善させるためのtl1a−dr3相互作用の遮断及びその抗体 Withdrawn JP2014518883A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488671P 2011-05-20 2011-05-20
US61/488,671 2011-05-20
PCT/US2012/028926 WO2012161856A1 (en) 2011-05-20 2012-03-13 Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof

Publications (2)

Publication Number Publication Date
JP2014518883A true JP2014518883A (ja) 2014-08-07
JP2014518883A5 JP2014518883A5 (enExample) 2015-03-19

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US (1) US9068003B2 (enExample)
EP (1) EP2709664A4 (enExample)
JP (1) JP2014518883A (enExample)
KR (1) KR20140104344A (enExample)
AU (1) AU2012259312A1 (enExample)
CA (1) CA2836898A1 (enExample)
MX (1) MX2013013329A (enExample)
WO (1) WO2012161856A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020504076A (ja) * 2016-10-26 2020-02-06 シーダーズ—シナイ メディカル センター 抗tl1aモノクローナル抗体の中和
JP2025515510A (ja) * 2022-06-17 2025-05-15 セレクシン インコーポレイテッド ヒトdr3に特異的に結合する抗体及びその用途

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AP2015008605A0 (en) * 2013-01-02 2015-07-31 Glenmark Pharmaceuticals Sa Antibodies that bind to tl1a and their uses
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KR20210157418A (ko) * 2013-03-27 2021-12-28 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
EP2996717A4 (en) * 2013-05-17 2016-11-23 Cedars Sinai Medical Center DIFFERENT EFFECTS OF IFN-GAMMA AND IL-17 ON TL1A-MODULATED INFLAMMATION AND FIBROSIS
EP3988673A3 (en) * 2013-05-17 2022-08-03 Cedars-Sinai Medical Center Variants of tnfsf15 and dcr3 associated with crohn's disease
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CN106536548A (zh) * 2014-04-28 2017-03-22 国家生物技术研究所公司 Dr3变体及其用途
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KR20240095481A (ko) 2016-03-17 2024-06-25 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법
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Publication number Priority date Publication date Assignee Title
JP2020504076A (ja) * 2016-10-26 2020-02-06 シーダーズ—シナイ メディカル センター 抗tl1aモノクローナル抗体の中和
JP7194104B2 (ja) 2016-10-26 2022-12-21 シーダーズ―シナイ メディカル センター 抗tl1aモノクローナル抗体の中和
JP2023002562A (ja) * 2016-10-26 2023-01-10 シーダーズ―シナイ メディカル センター 抗tl1aモノクローナル抗体の中和
JP2024161402A (ja) * 2016-10-26 2024-11-19 シーダーズ―シナイ メディカル センター 抗tl1aモノクローナル抗体の中和
JP2025515510A (ja) * 2022-06-17 2025-05-15 セレクシン インコーポレイテッド ヒトdr3に特異的に結合する抗体及びその用途

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AU2012259312A8 (en) 2014-02-27
WO2012161856A1 (en) 2012-11-29
AU2012259312A1 (en) 2013-12-12
EP2709664A4 (en) 2015-06-10
EP2709664A1 (en) 2014-03-26
US20120263718A1 (en) 2012-10-18
US9068003B2 (en) 2015-06-30
MX2013013329A (es) 2014-04-16
KR20140104344A (ko) 2014-08-28
CA2836898A1 (en) 2012-11-29

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