JP2014518255A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014518255A5 JP2014518255A5 JP2014518000A JP2014518000A JP2014518255A5 JP 2014518255 A5 JP2014518255 A5 JP 2014518255A5 JP 2014518000 A JP2014518000 A JP 2014518000A JP 2014518000 A JP2014518000 A JP 2014518000A JP 2014518255 A5 JP2014518255 A5 JP 2014518255A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- methoxyphenyl
- dihydro
- trifluoromethyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PRQZENXGVVLPIF-UHFFFAOYSA-N 1-chloro-3h-indol-2-one Chemical compound C1=CC=C2N(Cl)C(=O)CC2=C1 PRQZENXGVVLPIF-UHFFFAOYSA-N 0.000 claims 2
- SCRXASNUPJPFGP-UHFFFAOYSA-N 1-fluoro-3h-indol-2-one Chemical compound C1=CC=C2N(F)C(=O)CC2=C1 SCRXASNUPJPFGP-UHFFFAOYSA-N 0.000 claims 2
- HWSLMIXAPNOWGU-AWEZNQCLSA-N (3s)-1-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2[C@H](F)C1=O HWSLMIXAPNOWGU-AWEZNQCLSA-N 0.000 claims 1
- MJKHLWVXDGUTSW-AWEZNQCLSA-N (3s)-3-chloro-1-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2[C@H](Cl)C1=O MJKHLWVXDGUTSW-AWEZNQCLSA-N 0.000 claims 1
- HWSLMIXAPNOWGU-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2C(F)C1=O HWSLMIXAPNOWGU-UHFFFAOYSA-N 0.000 claims 1
- MJKHLWVXDGUTSW-UHFFFAOYSA-N 3-chloro-1-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2C(Cl)C1=O MJKHLWVXDGUTSW-UHFFFAOYSA-N 0.000 claims 1
- 208000001914 Fragile X syndrome Diseases 0.000 claims 1
- 102000004257 Potassium Channel Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108020001213 potassium channel Proteins 0.000 claims 1
- 239000004036 potassium channel stimulating agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11171532A EP2540295A1 (en) | 2011-06-27 | 2011-06-27 | Compositions for the treatment of Fragile X syndrome |
| EP11171532.2 | 2011-06-27 | ||
| PCT/IB2012/053089 WO2013001412A1 (en) | 2011-06-27 | 2012-06-19 | Compositions for the treatment of fragile x syndrome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518255A JP2014518255A (ja) | 2014-07-28 |
| JP2014518255A5 true JP2014518255A5 (enExample) | 2015-07-16 |
| JP6012726B2 JP6012726B2 (ja) | 2016-10-25 |
Family
ID=44840530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518000A Active JP6012726B2 (ja) | 2011-06-27 | 2012-06-19 | 脆弱ｘ症候群の治療用組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10435366B2 (enExample) |
| EP (2) | EP2540295A1 (enExample) |
| JP (1) | JP6012726B2 (enExample) |
| DK (1) | DK2723336T3 (enExample) |
| ES (1) | ES2797395T3 (enExample) |
| PL (1) | PL2723336T3 (enExample) |
| PT (1) | PT2723336T (enExample) |
| WO (1) | WO2013001412A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2540295A1 (en) * | 2011-06-27 | 2013-01-02 | Centre national de la recherche scientifique | Compositions for the treatment of Fragile X syndrome |
| AU2014233048B2 (en) * | 2013-03-15 | 2019-01-03 | The Children's Hospital Of Philadelphia | Magnetoencephalography biomarkers of GABA-B agonist drug activity in autism spectrum disorders |
| WO2016128771A1 (en) | 2015-02-13 | 2016-08-18 | Canbex Therapeutics Limited | Compounds for treating disorders associated with bk channel modulation |
| WO2018157046A1 (en) | 2017-02-24 | 2018-08-30 | Ovid Therapeutics Inc. | Methods of treating seizure disorders |
| EP3727587A4 (en) * | 2017-12-22 | 2022-02-23 | Massachusetts Institute Of Technology | COMPOSITIONS AND METHODS FOR THERAPY OF WILLIAMS SYNDROME (WS) |
| EP3912625A1 (en) | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
| WO2025233532A1 (en) | 2024-05-10 | 2025-11-13 | Les Laboratoires Servier | Maxi-k potassium channel openers and therapeutic applications thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565483A (en) | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| US20020045566A1 (en) * | 2000-10-13 | 2002-04-18 | Gribkoff Valentin K. | Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof |
| JP2005507853A (ja) * | 2001-02-20 | 2005-03-24 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャンネルモジュレーター並びに片頭痛および機構的に関連する疾患の治療におけるそれらの使用 |
| JP2004531483A (ja) * | 2001-02-20 | 2004-10-14 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャネルのモジュレーターとしてのフルオロオキシンドール誘導体 |
| FR2857452B1 (fr) * | 2003-07-11 | 2005-09-30 | Univ Rabelais Francois | Test de depistage de l'autisme, methode de selection de patients repondant audit test et utilisation des medicaments activateurs de canaux bkca pour le traitement de ladite maladie |
| DE102004053673A1 (de) * | 2004-11-03 | 2006-05-04 | Endress + Hauser Flowtec Ag | Vorrichtung zur Bestimmung und/oder Überwachung des Volumen- und/oder Massendurchflusses eines Mediums |
| EP2433635A1 (en) | 2006-11-10 | 2012-03-28 | Massachusetts Institute Of Technology | PAK Modulators |
| US20100316678A1 (en) * | 2007-06-28 | 2010-12-16 | Cnsbio Pty Ltd. | Combination methods and compositions for treatment of neuropathic pain |
| EP2540295A1 (en) * | 2011-06-27 | 2013-01-02 | Centre national de la recherche scientifique | Compositions for the treatment of Fragile X syndrome |
-
2011
- 2011-06-27 EP EP11171532A patent/EP2540295A1/en not_active Withdrawn
-
2012
- 2012-06-19 EP EP12735048.6A patent/EP2723336B1/en active Active
- 2012-06-19 JP JP2014518000A patent/JP6012726B2/ja active Active
- 2012-06-19 US US14/128,154 patent/US10435366B2/en active Active
- 2012-06-19 WO PCT/IB2012/053089 patent/WO2013001412A1/en not_active Ceased
- 2012-06-19 DK DK12735048.6T patent/DK2723336T3/da active
- 2012-06-19 PT PT127350486T patent/PT2723336T/pt unknown
- 2012-06-19 PL PL12735048T patent/PL2723336T3/pl unknown
- 2012-06-19 ES ES12735048T patent/ES2797395T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014518255A5 (enExample) | ||
| CL2013001316A1 (es) | Composicion que comprende micro-organismo probioticos no replicantes que protegen contra las infecciones del tracto respiratorio superior. | |
| EP2440210A4 (en) | METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES | |
| CL2007003686A1 (es) | Compuestos derivados de indol con anillo unido en las posiciones 4,5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para tratar una infeccion viral. | |
| ZA201100176B (en) | Compounds and pharmaceutical compositions for the treatment of viral infections | |
| CL2013001715A1 (es) | Compuestos derivados de indol, inhibidores de la replicacion del rsv; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la infeccion por el virus sincicial respiratorio. | |
| CL2013003650A1 (es) | Composición para el tratamiento de una infección por staphylococcus aureus que contiene solo un anticuerpo anti leucocidina luke y un portador farmaceuticamente aceptable. | |
| IL233677A (en) | Benzysacazole Compounds Aminopyrazolo-Primidine Converted, Pharmaceuticals Containing Them, and Use of Drug Manufacturing Composition | |
| WO2013123215A3 (en) | Antiviral drugs for treatment of arenavirus infection | |
| WO2008115281A3 (en) | Compounds for treating viral infections | |
| EA201001847A1 (ru) | Соединения и композиции, применяемые для лечения малярии | |
| WO2011113060A3 (en) | Antiviral compounds and methods of use thereof | |
| IL195272A0 (en) | Methods and compositions for the treatment of viral infections | |
| EP2496251A4 (en) | METHOD, COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY DISEASES | |
| CL2012003523A1 (es) | Método para la preparación de una composición farmacéutica que contiene un portador de oxígeno termoestable; composicion farmaceutica que contiene un portador de oxigeno altamente purificado y termoestable. | |
| CL2014000819A1 (es) | Compuestos heterociclicos derivados de etinilo, moduladores alostericos mglur5; proceso de preparacion; composicion farmaceutica; uso en la prevencion o el tratamiento de esquizofrenia, enfermedades cognitivas, sindrome de la x fragil o autismo. | |
| HK1201477A1 (en) | Pharmaceutical composition of omeprazole | |
| EA201000391A1 (ru) | Соединение, представляющее собой ингибитор гликогенфосфорилазы, и его фармацевтическая композиция | |
| WO2013022550A3 (en) | Small molecule inhibitors of ebola and lassa fever viruses | |
| CL2016000300A1 (es) | Métodos terapéuticos | |
| CN302152011S (zh) | 包装罐（1） | |
| CN302339401S (zh) | 瓶子（天工臻赏） | |
| CN302044245S (zh) | 笔夹(楼梯形) | |
| CN302028212S (zh) | 酒瓶（201201） | |
| CN302082376S (zh) | 喷头（三层次反射喷头） |