JP2014517954A5 - - Google Patents
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- JP2014517954A5 JP2014517954A5 JP2014505670A JP2014505670A JP2014517954A5 JP 2014517954 A5 JP2014517954 A5 JP 2014517954A5 JP 2014505670 A JP2014505670 A JP 2014505670A JP 2014505670 A JP2014505670 A JP 2014505670A JP 2014517954 A5 JP2014517954 A5 JP 2014517954A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- cluster
- intensity
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 40
- 210000001519 tissue Anatomy 0.000 claims 13
- 239000012528 membrane Substances 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000000090 biomarker Substances 0.000 claims 9
- 210000000805 cytoplasm Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 238000004393 prognosis Methods 0.000 claims 7
- 238000003745 diagnosis Methods 0.000 claims 6
- 102000015735 Beta-catenin Human genes 0.000 claims 5
- 108060000903 Beta-catenin Proteins 0.000 claims 5
- 238000011156 evaluation Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000036210 malignancy Effects 0.000 claims 3
- AVPYQKSLYISFPO-UHFFFAOYSA-N 4-chlorobenzaldehyde Chemical compound ClC1=CC=C(C=O)C=C1 AVPYQKSLYISFPO-UHFFFAOYSA-N 0.000 claims 2
- 102100036360 Cadherin-3 Human genes 0.000 claims 2
- 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 claims 2
- 102000011782 Keratins Human genes 0.000 claims 2
- 108010076876 Keratins Proteins 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 238000009877 rendering Methods 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478224P | 2011-04-22 | 2011-04-22 | |
| US61/478,224 | 2011-04-22 | ||
| US13/252,069 US20120270752A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with moments |
| US13/252,080 US20120271553A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with clusters |
| US13/252,078 US20120269419A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with moments |
| US13/252,080 | 2011-10-03 | ||
| US13/252,072 | 2011-10-03 | ||
| US13/252,069 | 2011-10-03 | ||
| US13/252,072 US20120269418A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with clusters |
| US13/252,078 | 2011-10-03 | ||
| PCT/EP2012/057394 WO2012143561A2 (en) | 2011-04-22 | 2012-04-23 | Analyzing the expression of biomarkers in cells with clusters |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517954A JP2014517954A (ja) | 2014-07-24 |
| JP2014517954A5 true JP2014517954A5 (cg-RX-API-DMAC7.html) | 2015-06-18 |
| JP6143743B2 JP6143743B2 (ja) | 2017-06-07 |
Family
ID=47021377
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505671A Active JP6063447B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現のクラスターによる解析 |
| JP2014505669A Active JP6063446B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現の積率による解析 |
| JP2014505668A Active JP6163152B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現の積率による解析 |
| JP2014505670A Active JP6143743B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現のクラスターによる解析 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505671A Active JP6063447B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現のクラスターによる解析 |
| JP2014505669A Active JP6063446B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現の積率による解析 |
| JP2014505668A Active JP6163152B2 (ja) | 2011-04-22 | 2012-04-23 | 細胞におけるバイオマーカーの発現の積率による解析 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20120270752A1 (cg-RX-API-DMAC7.html) |
| EP (4) | EP2700042B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6063447B2 (cg-RX-API-DMAC7.html) |
| BR (4) | BR112013027123A2 (cg-RX-API-DMAC7.html) |
| CA (4) | CA2833428A1 (cg-RX-API-DMAC7.html) |
| RU (3) | RU2013145154A (cg-RX-API-DMAC7.html) |
| SG (4) | SG194594A1 (cg-RX-API-DMAC7.html) |
| WO (4) | WO2012143558A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201111594D0 (en) * | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
| KR20150094618A (ko) * | 2012-12-06 | 2015-08-19 | 클래리언트 다이아그노스틱 서비시즈, 인크. | 생물학적 시편의 분할 스크린 디스플레이와 그 레코드를 포착하기 위한 시스템 및 방법 |
| US9488639B2 (en) * | 2013-02-25 | 2016-11-08 | Flagship Biosciences, Inc. | Cell-based tissue analysis |
| US8995740B2 (en) * | 2013-04-17 | 2015-03-31 | General Electric Company | System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue |
| EP3017302B1 (en) * | 2013-07-03 | 2019-04-24 | Coyne Scientific, LLC | Methods for predicting responses to chemical or biologic substances |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| US9298968B1 (en) * | 2014-09-12 | 2016-03-29 | Flagship Biosciences, Inc. | Digital image analysis of inflammatory cells and mediators of inflammation |
| US10167514B2 (en) | 2015-01-22 | 2019-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for determining proportions of distinct cell subsets |
| US9953133B2 (en) | 2015-06-03 | 2018-04-24 | General Electric Company | Biological data annotation and visualization |
| US10672505B2 (en) | 2015-06-03 | 2020-06-02 | General Electric Company | Biological data annotation and visualization |
| US10796130B2 (en) * | 2015-12-22 | 2020-10-06 | Nikon Corporation | Image processing apparatus |
| US20180032681A1 (en) * | 2016-07-29 | 2018-02-01 | General Electric Company | Biological feature analysis technique |
| WO2018151223A1 (ja) * | 2017-02-16 | 2018-08-23 | 国立大学法人京都大学 | 細胞評価方法、細胞評価装置、及び細胞評価プログラム |
| US10242473B2 (en) * | 2017-03-22 | 2019-03-26 | Sas Institute Inc. | Computer system to generate scalable plots using clustering |
| EP3616213A2 (en) * | 2017-04-28 | 2020-03-04 | 4D Path Inc. | Apparatus, systems, and methods for rapid cancer detection |
| KR101990430B1 (ko) * | 2017-06-22 | 2019-06-18 | 한국과학기술원 | 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법 |
| EP4546353A3 (en) | 2017-07-21 | 2025-07-23 | The Board of Trustees of the Leland Stanford Junior University | Systems and methods for analyzing mixed cell populations |
| US10706328B2 (en) * | 2018-05-07 | 2020-07-07 | Google Llc | Focus-weighted, machine learning disease classifier error prediction for microscope slide images |
| US10971255B2 (en) * | 2018-09-14 | 2021-04-06 | Zasti Inc. | Multimodal learning framework for analysis of clinical trials |
| WO2020068684A2 (en) | 2018-09-24 | 2020-04-02 | Krishnan Ramanathan | Hybrid analysis framework for prediction of outcomes in clinical trials |
| WO2020112478A1 (en) * | 2018-11-29 | 2020-06-04 | Somalogic, Inc. | Methods for determining disease risk combining downsampling of class-imbalanced sets with survival analysis |
| US11128667B2 (en) * | 2018-11-29 | 2021-09-21 | Rapid7, Inc. | Cluster detection and elimination in security environments |
| CN113158982A (zh) * | 2021-05-17 | 2021-07-23 | 广东中卡云计算有限公司 | 一种半介入式的目标关键点标注方法 |
| WO2023033056A1 (ja) * | 2021-09-01 | 2023-03-09 | イミュニティリサーチ株式会社 | 細胞集団同定システム、方法、およびプログラム |
| IT202200001817A1 (it) | 2022-02-02 | 2023-08-02 | Aizoon S R L | Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico |
| IT202200005861A1 (it) | 2022-03-24 | 2023-09-24 | Aizoon S R L | Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico |
| US20240028964A1 (en) | 2022-07-25 | 2024-01-25 | Aizoon S.r.l. | Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6463438B1 (en) * | 1994-06-03 | 2002-10-08 | Urocor, Inc. | Neural network for cell image analysis for identification of abnormal cells |
| US5740269A (en) * | 1994-09-20 | 1998-04-14 | Neopath, Inc. | Method and apparatus for robust biological specimen classification |
| US6996549B2 (en) * | 1998-05-01 | 2006-02-07 | Health Discovery Corporation | Computer-aided image analysis |
| US6282305B1 (en) * | 1998-06-05 | 2001-08-28 | Arch Development Corporation | Method and system for the computerized assessment of breast cancer risk |
| US6337472B1 (en) * | 1998-10-19 | 2002-01-08 | The University Of Texas System Board Of Regents | Light imaging microscope having spatially resolved images |
| WO2002059377A2 (en) * | 2001-01-24 | 2002-08-01 | Protein Design Labs | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
| US20060210129A1 (en) * | 2002-07-30 | 2006-09-21 | Deutsches Krebsforschungzentrum | Method and apparatus for multiple labeling detection and evaluation of a plurality of particles |
| US20040121413A1 (en) * | 2002-12-20 | 2004-06-24 | Aebersold Rudolf H. | Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions |
| US20050265588A1 (en) * | 2004-02-03 | 2005-12-01 | Bioimagene, Inc. | Method and system for digital image based flourescent in situ hybridization (FISH) analysis |
| EP1872124A4 (en) * | 2005-04-19 | 2008-06-11 | Prediction Sciences Llc | DIAGNOSTIC MARKERS FOR THE TREATMENT AND EVOLUTION OF BREAST CANCER AND METHODS OF USE |
| US8041090B2 (en) * | 2005-09-10 | 2011-10-18 | Ge Healthcare Uk Limited | Method of, and apparatus and computer software for, performing image processing |
| US7933435B2 (en) * | 2005-11-21 | 2011-04-26 | Vala Sciences, Inc. | System, method, and kit for processing a magnified image of biological material to identify components of a biological object |
| CN101484806A (zh) * | 2006-05-17 | 2009-07-15 | 协乐民公司 | 一种对组织进行自动分析的方法 |
| US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US8019134B2 (en) * | 2006-11-16 | 2011-09-13 | Definiens Ag | Automatic image analysis and quantification for fluorescence in situ hybridization |
| EP2132327A2 (en) * | 2007-03-27 | 2009-12-16 | Rosetta Genomics Ltd | Gene expression signature for classification of cancers |
| AU2008247379A1 (en) * | 2007-05-07 | 2008-11-13 | Ge Healthcare Bio-Sciences Corp. | System and method for the automated analysis of cellular assays and tissues |
| ATE528722T1 (de) * | 2007-05-14 | 2011-10-15 | Historx Inc | Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung |
| ES2618353T3 (es) * | 2007-09-06 | 2017-06-21 | Biotheranostics, Inc. | Clasificación de tumores y pronóstico del cáncer de mama |
| US9779213B2 (en) * | 2008-07-25 | 2017-10-03 | Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | System for evaluating a pathological stage of prostate cancer |
| US9858389B2 (en) * | 2008-07-25 | 2018-01-02 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Method and system for determining the risk of occurrence of prostate cancer |
| US8320655B2 (en) * | 2009-10-16 | 2012-11-27 | General Electric Company | Process and system for analyzing the expression of biomarkers in cells |
| US20110091081A1 (en) * | 2009-10-16 | 2011-04-21 | General Electric Company | Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin |
| WO2011087778A1 (en) * | 2009-12-22 | 2011-07-21 | The Children's Hospital Of Philadelphia | Automated quantitative multidimensional volumetric analysis and visualization |
-
2011
- 2011-10-03 US US13/252,069 patent/US20120270752A1/en not_active Abandoned
- 2011-10-03 US US13/252,072 patent/US20120269418A1/en not_active Abandoned
- 2011-10-03 US US13/252,080 patent/US20120271553A1/en not_active Abandoned
- 2011-10-03 US US13/252,078 patent/US20120269419A1/en not_active Abandoned
-
2012
- 2012-04-23 EP EP12719316.7A patent/EP2700042B1/en active Active
- 2012-04-23 CA CA2833428A patent/CA2833428A1/en not_active Abandoned
- 2012-04-23 RU RU2013145154/15A patent/RU2013145154A/ru not_active Application Discontinuation
- 2012-04-23 EP EP12716028.1A patent/EP2700037A2/en not_active Withdrawn
- 2012-04-23 SG SG2013078753A patent/SG194594A1/en unknown
- 2012-04-23 RU RU2013145162/15A patent/RU2013145162A/ru not_active Application Discontinuation
- 2012-04-23 BR BR112013027123A patent/BR112013027123A2/pt not_active IP Right Cessation
- 2012-04-23 EP EP12716027.3A patent/EP2700036A2/en not_active Withdrawn
- 2012-04-23 BR BR112013027125A patent/BR112013027125A2/pt not_active IP Right Cessation
- 2012-04-23 SG SG2013078688A patent/SG194588A1/en unknown
- 2012-04-23 WO PCT/EP2012/057390 patent/WO2012143558A2/en not_active Ceased
- 2012-04-23 BR BR112013027124A patent/BR112013027124A2/pt not_active IP Right Cessation
- 2012-04-23 JP JP2014505671A patent/JP6063447B2/ja active Active
- 2012-04-23 SG SG2013078712A patent/SG194590A1/en unknown
- 2012-04-23 WO PCT/EP2012/057394 patent/WO2012143561A2/en not_active Ceased
- 2012-04-23 WO PCT/EP2012/057395 patent/WO2012143562A2/en not_active Ceased
- 2012-04-23 CA CA2833295A patent/CA2833295A1/en not_active Abandoned
- 2012-04-23 JP JP2014505669A patent/JP6063446B2/ja active Active
- 2012-04-23 JP JP2014505668A patent/JP6163152B2/ja active Active
- 2012-04-23 JP JP2014505670A patent/JP6143743B2/ja active Active
- 2012-04-23 CA CA2833804A patent/CA2833804A1/en not_active Abandoned
- 2012-04-23 SG SG2013078738A patent/SG194592A1/en unknown
- 2012-04-23 EP EP12717662.6A patent/EP2700038B1/en active Active
- 2012-04-23 CA CA2833497A patent/CA2833497A1/en not_active Abandoned
- 2012-04-23 WO PCT/EP2012/057387 patent/WO2012143556A2/en not_active Ceased
- 2012-04-23 BR BR112013027122A patent/BR112013027122A2/pt not_active IP Right Cessation
- 2012-04-23 RU RU2013145151/15A patent/RU2013145151A/ru not_active Application Discontinuation
-
2014
- 2014-03-05 US US14/197,558 patent/US20140185905A1/en not_active Abandoned
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