JP2014517832A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014517832A5 JP2014517832A5 JP2014509736A JP2014509736A JP2014517832A5 JP 2014517832 A5 JP2014517832 A5 JP 2014517832A5 JP 2014509736 A JP2014509736 A JP 2014509736A JP 2014509736 A JP2014509736 A JP 2014509736A JP 2014517832 A5 JP2014517832 A5 JP 2014517832A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- composition according
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100010215 ENO1 Human genes 0.000 claims 4
- 101700068129 ENO1 Proteins 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000000069 prophylaxis Effects 0.000 claims 1
Claims (5)
- 非シトルリン化α−エノラーゼポリペプチドを含む、自己免疫疾患の予防的治療のための医薬組成物。
- 非シトルリン化α−エノラーゼポリペプチドが、配列番号１における５位〜２１位の範囲のアミノ酸配列、配列番号２における６位〜２１位の範囲のアミノ酸配列、又は配列番号３における５位〜２１位の範囲のアミノ酸配列からなる群より選択されるアミノ酸配列を含む、請求項１に記載の医薬組成物。
- 非シトルリン化α−エノラーゼポリペプチドが、２つのシステイン残基の間のジスルフィド結合により環化しているＣＫＩＨＡＲＥＩＦＤＳＲＧＮＰＴＶＥＣ（配列番号４）、ＣＩＨＡＲＥＩＦＤＳＲＧＮＰＴＶＥＣ（配列番号５）又はＣＫＩＩＧＲＥＩＬＤＳＲＧＮＰＴＶＥＣ（配列番号６）からなる群より選択されるアミノ酸配列を含む、請求項１に記載の医薬組成物。
- 非シトルリン化α−エノラーゼポリペプチドが、配列番号１のアミノ酸配列又は配列番号２のアミノ酸配列又はそれらの機能保存的変異体からなる、請求項１に記載の医薬組成物。
- 前記自己免疫疾患が関節リウマチである、請求項１〜４のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305557 | 2011-05-10 | ||
| EP11305557.8 | 2011-05-10 | ||
| PCT/EP2012/058678 WO2012152882A1 (en) | 2011-05-10 | 2012-05-10 | Methods and pharmaceutical compositions for the treatment of autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014517832A JP2014517832A (ja) | 2014-07-24 |
| JP2014517832A5 true JP2014517832A5 (ja) | 2015-05-28 |
Family
ID=44653630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509736A Pending JP2014517832A (ja) | 2011-05-10 | 2012-05-10 | 自己免疫疾患を治療するための方法及び医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140086895A1 (ja) |
| EP (1) | EP2707018B1 (ja) |
| JP (1) | JP2014517832A (ja) |
| ES (1) | ES2560012T3 (ja) |
| WO (1) | WO2012152882A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150218546A1 (en) * | 2011-04-05 | 2015-08-06 | Lars Klareskog | Novel peptides that bind to types of mhc class ii and their use on diagnosis and treatment |
| EA201691420A1 (ru) | 2014-01-13 | 2016-12-30 | Берг Ллк | Композиции енолазы 1 (eno1) и их применение |
| CN107847560A (zh) * | 2015-06-22 | 2018-03-27 | 博格有限责任公司 | 包括eno1的组合物以及其在治疗肥胖症或超重和减少体重增加的方法中的用途 |
| CA3195040A1 (en) * | 2020-10-06 | 2022-04-14 | Matthias W. Hentze | Screening method for the identification of novel therapeutic compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929758A (en) | 1974-09-12 | 1975-12-30 | Armour Pharma | Cyclization of cysteine-containing peptides |
| US4102877A (en) | 1976-07-28 | 1978-07-25 | Merck & Co., Inc. | Cyclization of peptides |
| US4216141A (en) | 1978-07-19 | 1980-08-05 | The Salk Institute For Biological Studies | Method for cyclization of peptides |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| AU651596B2 (en) | 1990-06-05 | 1994-07-28 | Immunex Corporation | Type II interleukin-1 receptors |
| TWI304443B (en) * | 2005-12-30 | 2008-12-21 | Nat Health Research Institutes | Alpha-enolase specific antibody and method of use |
| US20100047256A1 (en) * | 2007-01-25 | 2010-02-25 | Imperial Innovations Limited | Methods |
| NZ595310A (en) * | 2009-03-30 | 2013-05-31 | Nestec Sa | Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis; vimentin fragments |
| US20150218546A1 (en) * | 2011-04-05 | 2015-08-06 | Lars Klareskog | Novel peptides that bind to types of mhc class ii and their use on diagnosis and treatment |
-
2012
- 2012-05-10 US US14/116,380 patent/US20140086895A1/en not_active Abandoned
- 2012-05-10 JP JP2014509736A patent/JP2014517832A/ja active Pending
- 2012-05-10 EP EP12719752.3A patent/EP2707018B1/en not_active Not-in-force
- 2012-05-10 ES ES12719752.3T patent/ES2560012T3/es active Active
- 2012-05-10 WO PCT/EP2012/058678 patent/WO2012152882A1/en active Application Filing
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017048194A5 (ja) | ||
| JP2014501510A5 (ja) | ||
| HRP20170468T1 (hr) | Bispecifična protutijela protiv baff i protiv il-17 | |
| JP2012126742A5 (ja) | ||
| JP2015514395A5 (ja) | ||
| RU2016146198A (ru) | Терапевтические dll4-связывающие белки | |
| JP2012136541A5 (ja) | ||
| JP2013523179A5 (ja) | ||
| JP2010166916A5 (ja) | ||
| WO2012168430A3 (en) | Polypeptides | |
| JP2015533791A5 (ja) | ||
| JP2012115277A5 (ja) | ||
| EP3266464A3 (en) | Yeast-based therapeutic for chronic hepatitis b infection | |
| WO2013000922A9 (en) | Ccr2 antagonist peptides | |
| JP2013048638A5 (ja) | ||
| EA201692359A1 (ru) | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса | |
| WO2011036445A3 (en) | Polypeptides and uses thereof | |
| HRP20210734T1 (hr) | Koštani morfogenetski proteini | |
| JP2013539454A5 (ja) | ||
| JP2014517832A5 (ja) | ||
| HRP20150664T1 (hr) | Antikancerogeni fuzijski protein | |
| WO2012123959A3 (en) | Copolymer-1, process for preparation and analytical methods thereof | |
| JP2014529399A5 (ja) | ||
| JP2010265269A5 (ja) | ||
| JP2014525439A5 (ja) |