JP2014516538A - 調節された免疫優勢療法 - Google Patents

調節された免疫優勢療法 Download PDF

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JP2014516538A
JP2014516538A JP2014512143A JP2014512143A JP2014516538A JP 2014516538 A JP2014516538 A JP 2014516538A JP 2014512143 A JP2014512143 A JP 2014512143A JP 2014512143 A JP2014512143 A JP 2014512143A JP 2014516538 A JP2014516538 A JP 2014516538A
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cells
antigen
patient
subdominant
epitope
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JP2014516538A5 (enExample
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アルフレッド イー． スラネッツ
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ジーニウス バイオテクノロジー インベストメンツ リミテッド ライアビリティ カンパニー
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519246A (ja) * 2016-06-28 2019-07-11 ジーニアス・バイオテクノロジー・インコーポレイテッド 免疫療法向けのｔ細胞組成物
JP2024527098A (ja) * 2021-07-30 2024-07-19 テヴォジェン バイオ インコーポレイテッド 以前の免疫から逃れるように進化する変異体を含むウイルス感染症を治療するための複数のウイルスエピトープに対するｃｄ３＋ｃｄ８＋細胞を開発するための方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109475578A (zh) * 2016-05-25 2019-03-15 昆士兰医学研究所理事会 使用同种异体t细胞治疗自身免疫疾病的方法
EP3465203B1 (en) 2016-05-25 2026-03-18 The Council of the Queensland Institute of Medical Research Methods of immunotherapy
CN109715196A (zh) 2016-06-13 2019-05-03 转矩医疗股份有限公司 用于促进免疫细胞功能的组合物和方法
CA3074826A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
EP3700553A1 (en) 2017-10-23 2020-09-02 Atara Biotherapeutics, Inc. Methods of managing tumor flare in adoptive immunotherapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001509677A (ja) * 1997-01-31 2001-07-24 エピミューン，インコーポレイティド Ｃｔｌを活性化するためのペプチドおよびペプチド担持抗原提示細胞
US20040072240A1 (en) * 2000-07-21 2004-04-15 Kostas Kosmatopoulos Method for screening peptides for use in immunotherapy
JP2009108097A (ja) * 1996-03-11 2009-05-21 Epimmune Inc Ｈｌａ分子への結合アフィニティーが増加したペプチド

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2330678C (en) 1998-05-11 2009-04-07 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific t cells
KR100731820B1 (ko) * 1998-10-05 2007-06-25 파멕사 에이/에스 치료적 백신화를 위한 새로운 방법
CN1440462A (zh) * 2000-04-28 2003-09-03 麦康公司 鉴定和生产抗原肽的方法并且将其用作疫苗
AU2003275767A1 (en) 2002-11-07 2004-06-07 Johnson & Johnson Research Pty Limited A means of producing and utilising a population of disease specific cytotoxic T-lymphocytes
CN100591761C (zh) * 2004-08-19 2010-02-24 加的夫大学学院咨询有限公司 呈递抗原的人γδT细胞的制备和在免疫治疗中的用途
WO2006071989A2 (en) * 2004-12-29 2006-07-06 Mannkind Corporation Methods to elicit, enhance and sustain immune responses against mhc class i-restricted epitopes, for prophylactic or therapeutic purposes
EP2385059A3 (en) * 2005-06-17 2012-02-15 Mannkind Corporation Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma
CA2772076A1 (en) 2009-08-24 2011-03-10 Baylor College Of Medicine Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009108097A (ja) * 1996-03-11 2009-05-21 Epimmune Inc Ｈｌａ分子への結合アフィニティーが増加したペプチド
JP2001509677A (ja) * 1997-01-31 2001-07-24 エピミューン，インコーポレイティド Ｃｔｌを活性化するためのペプチドおよびペプチド担持抗原提示細胞
US20040072240A1 (en) * 2000-07-21 2004-04-15 Kostas Kosmatopoulos Method for screening peptides for use in immunotherapy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 101, JPN6016017046, 2003, pages 1905 - 1912, ISSN: 0003314664 *
BLOOD, vol. 110, JPN6016017048, 2007, pages 2838 - 2845, ISSN: 0003314665 *
EUR. J. IMMUNOL., vol. 25, JPN6016017051, 1995, pages 2638 - 2642, ISSN: 0003314666 *
HUMAN IMMUNOLOGY, vol. 66(9), JPN6016017042, 2005, pages 938 - 949, ISSN: 0003314662 *
JOURNAL OF IMMUNOLOGY, vol. 183, JPN6016017043, 2009, pages 2837 - 2850, ISSN: 0003314663 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519246A (ja) * 2016-06-28 2019-07-11 ジーニアス・バイオテクノロジー・インコーポレイテッド 免疫療法向けのｔ細胞組成物
JP7034955B2 (ja) 2016-06-28 2022-03-14 ジーニアス・バイオテクノロジー・インコーポレイテッド 免疫療法向けのｔ細胞組成物
JP2022066355A (ja) * 2016-06-28 2022-04-28 ジーニアス・バイオテクノロジー・インコーポレイテッド 免疫療法向けのｔ細胞組成物
JP2024527098A (ja) * 2021-07-30 2024-07-19 テヴォジェン バイオ インコーポレイテッド 以前の免疫から逃れるように進化する変異体を含むウイルス感染症を治療するための複数のウイルスエピトープに対するｃｄ３＋ｃｄ８＋細胞を開発するための方法

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