JP2014513958A5 - - Google Patents
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- Publication number
- JP2014513958A5 JP2014513958A5 JP2014508602A JP2014508602A JP2014513958A5 JP 2014513958 A5 JP2014513958 A5 JP 2014513958A5 JP 2014508602 A JP2014508602 A JP 2014508602A JP 2014508602 A JP2014508602 A JP 2014508602A JP 2014513958 A5 JP2014513958 A5 JP 2014513958A5
- Authority
- JP
- Japan
- Prior art keywords
- snp
- subject
- complement
- age
- related macular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000054766 genetic haplotypes Human genes 0.000 claims 37
- 230000000295 complement effect Effects 0.000 claims 29
- 206010064930 age-related macular degeneration Diseases 0.000 claims 25
- 208000002780 macular degeneration Diseases 0.000 claims 25
- 102220005747 rs1061170 Human genes 0.000 claims 24
- 238000000034 method Methods 0.000 claims 19
- 102100029058 Coagulation factor XIII B chain Human genes 0.000 claims 13
- 101000918350 Homo sapiens Coagulation factor XIII B chain Proteins 0.000 claims 13
- 102100035432 Complement factor H Human genes 0.000 claims 12
- 238000011282 treatment Methods 0.000 claims 12
- 102220005751 rs2274700 Human genes 0.000 claims 9
- 102210014998 rs3753395 Human genes 0.000 claims 9
- 238000011321 prophylaxis Methods 0.000 claims 6
- 102220130080 rs3753396 Human genes 0.000 claims 6
- 102220005752 rs1410996 Human genes 0.000 claims 5
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161480929P | 2011-04-29 | 2011-04-29 | |
| US61/480,929 | 2011-04-29 | ||
| PCT/US2012/035467 WO2012149329A2 (en) | 2011-04-29 | 2012-04-27 | Methods of predicting the development of complement-mediated disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513958A JP2014513958A (ja) | 2014-06-19 |
| JP2014513958A5 true JP2014513958A5 (https=) | 2015-07-16 |
Family
ID=47073084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508602A Pending JP2014513958A (ja) | 2011-04-29 | 2012-04-27 | 補体媒介性疾患の発症を予測する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20140357732A1 (https=) |
| EP (1) | EP2704800B1 (https=) |
| JP (1) | JP2014513958A (https=) |
| KR (1) | KR20140074258A (https=) |
| CN (1) | CN103874526A (https=) |
| AU (1) | AU2012249521A1 (https=) |
| BR (1) | BR112013027851A2 (https=) |
| CA (1) | CA2834676A1 (https=) |
| DK (1) | DK2704800T3 (https=) |
| SG (1) | SG194235A1 (https=) |
| WO (1) | WO2012149329A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
| JP6829878B2 (ja) * | 2017-03-10 | 2021-02-17 | 国立大学法人浜松医科大学 | 加齢黄斑変性の発症リスクの評価方法 |
| EP3824095A4 (en) | 2018-07-20 | 2022-04-20 | University of Utah Research Foundation | GENE THERAPY FOR MACULATE GENERATION |
| KR102333953B1 (ko) * | 2020-07-10 | 2021-12-02 | 인제대학교 산학협력단 | 신규한 황반변성 진단용 유전자 마커 |
| US12518859B2 (en) * | 2023-07-26 | 2026-01-06 | Helix, Inc. | Systems and methods for providing test results of gene sequencing data on a recurring basis |
| CN119694384B (zh) * | 2024-12-03 | 2025-10-03 | 南京医科大学 | 基于汇总统计数据的复杂性状关联基因检测方法及系统 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2357254A1 (en) * | 2005-02-14 | 2011-08-17 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| US8088587B2 (en) * | 2005-03-04 | 2012-01-03 | Vanderbilt University | Genetic variants increase the risk of age-related macular degeneration |
| JP5431151B2 (ja) * | 2006-07-13 | 2014-03-05 | ユニバーシティー オブ アイオワ リサーチ ファンデーション | 血管障害および加齢黄斑変性症の治療および診断のための方法および試薬 |
| EP2217720A4 (en) * | 2007-11-01 | 2010-12-08 | Univ Iowa Res Found | RNA LOCUS ANALYSIS TO ASSESS THE STUNNING FOR AMD AND MPGNII |
| US8114592B2 (en) * | 2008-03-18 | 2012-02-14 | Cambridge Enterprise Limited | Genetic markers associated with age-related macular degeneration, methods of detection and uses thereof |
| US20120115925A1 (en) * | 2008-12-23 | 2012-05-10 | Massachusetts Eye And Ear Infirmary | Allelic Variants Associated with Advanced Age-Related Macular Degeneration |
| US20120202708A1 (en) * | 2010-10-14 | 2012-08-09 | Sequenom, Inc. | Complement factor h copy number variants found in the rca locus |
| WO2012082912A2 (en) * | 2010-12-14 | 2012-06-21 | Tufts Medical Center, Inc. | Markers related to age-related macular degeneration and uses therefor |
| SG193499A1 (en) * | 2011-03-15 | 2013-10-30 | Univ Utah Res Found | Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof |
| EP2895624B1 (en) * | 2012-09-14 | 2022-06-01 | University Of Utah Research Foundation | Methods of predicting the development of amd based on chromosome 1 and chromosome 10 |
| US9896728B2 (en) * | 2013-01-29 | 2018-02-20 | Arcticrx Ltd. | Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD) |
-
2012
- 2012-04-27 CA CA2834676A patent/CA2834676A1/en not_active Abandoned
- 2012-04-27 KR KR1020137031638A patent/KR20140074258A/ko not_active Withdrawn
- 2012-04-27 DK DK12776262.3T patent/DK2704800T3/en active
- 2012-04-27 BR BR112013027851A patent/BR112013027851A2/pt not_active IP Right Cessation
- 2012-04-27 CN CN201280031235.6A patent/CN103874526A/zh active Pending
- 2012-04-27 JP JP2014508602A patent/JP2014513958A/ja active Pending
- 2012-04-27 EP EP12776262.3A patent/EP2704800B1/en active Active
- 2012-04-27 WO PCT/US2012/035467 patent/WO2012149329A2/en not_active Ceased
- 2012-04-27 US US14/114,751 patent/US20140357732A1/en not_active Abandoned
- 2012-04-27 SG SG2013080502A patent/SG194235A1/en unknown
- 2012-04-27 AU AU2012249521A patent/AU2012249521A1/en not_active Abandoned
-
2017
- 2017-06-27 US US15/634,892 patent/US20180155788A1/en not_active Abandoned
-
2020
- 2020-01-03 US US16/734,168 patent/US20200239958A1/en not_active Abandoned
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