JP2014513958A5 - - Google Patents
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- Publication number
- JP2014513958A5 JP2014513958A5 JP2014508602A JP2014508602A JP2014513958A5 JP 2014513958 A5 JP2014513958 A5 JP 2014513958A5 JP 2014508602 A JP2014508602 A JP 2014508602A JP 2014508602 A JP2014508602 A JP 2014508602A JP 2014513958 A5 JP2014513958 A5 JP 2014513958A5
- Authority
- JP
- Japan
- Prior art keywords
- snp
- subject
- complement
- age
- related macular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000054766 genetic haplotypes Human genes 0.000 claims 37
- 230000000295 complement effect Effects 0.000 claims 29
- 206010064930 age-related macular degeneration Diseases 0.000 claims 25
- 208000002780 macular degeneration Diseases 0.000 claims 25
- 102220005747 rs1061170 Human genes 0.000 claims 24
- 238000000034 method Methods 0.000 claims 19
- 102100029058 Coagulation factor XIII B chain Human genes 0.000 claims 13
- 101000918350 Homo sapiens Coagulation factor XIII B chain Proteins 0.000 claims 13
- 102100035432 Complement factor H Human genes 0.000 claims 12
- 238000011282 treatment Methods 0.000 claims 12
- 102220005751 rs2274700 Human genes 0.000 claims 9
- 102210014998 rs3753395 Human genes 0.000 claims 9
- 238000011321 prophylaxis Methods 0.000 claims 6
- 102220130080 rs3753396 Human genes 0.000 claims 6
- 102220005752 rs1410996 Human genes 0.000 claims 5
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161480929P | 2011-04-29 | 2011-04-29 | |
| US61/480,929 | 2011-04-29 | ||
| PCT/US2012/035467 WO2012149329A2 (en) | 2011-04-29 | 2012-04-27 | Methods of predicting the development of complement-mediated disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513958A JP2014513958A (ja) | 2014-06-19 |
| JP2014513958A5 true JP2014513958A5 (https=) | 2015-07-16 |
Family
ID=47073084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508602A Pending JP2014513958A (ja) | 2011-04-29 | 2012-04-27 | 補体媒介性疾患の発症を予測する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20140357732A1 (https=) |
| EP (1) | EP2704800B1 (https=) |
| JP (1) | JP2014513958A (https=) |
| KR (1) | KR20140074258A (https=) |
| CN (1) | CN103874526A (https=) |
| AU (1) | AU2012249521A1 (https=) |
| BR (1) | BR112013027851A2 (https=) |
| CA (1) | CA2834676A1 (https=) |
| DK (1) | DK2704800T3 (https=) |
| SG (1) | SG194235A1 (https=) |
| WO (1) | WO2012149329A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
| JP6829878B2 (ja) * | 2017-03-10 | 2021-02-17 | 国立大学法人浜松医科大学 | 加齢黄斑変性の発症リスクの評価方法 |
| US20210338838A1 (en) | 2018-07-20 | 2021-11-04 | University Of Utah Research Foundation | Gene therapy for macular degeneration |
| KR102333953B1 (ko) * | 2020-07-10 | 2021-12-02 | 인제대학교 산학협력단 | 신규한 황반변성 진단용 유전자 마커 |
| US12518859B2 (en) * | 2023-07-26 | 2026-01-06 | Helix, Inc. | Systems and methods for providing test results of gene sequencing data on a recurring basis |
| CN119694384B (zh) * | 2024-12-03 | 2025-10-03 | 南京医科大学 | 基于汇总统计数据的复杂性状关联基因检测方法及系统 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745389B2 (en) * | 2005-02-14 | 2010-06-29 | University Of Iowa Research Foundation | Methods for treatment of age-related macular degeneration |
| US8088587B2 (en) * | 2005-03-04 | 2012-01-03 | Vanderbilt University | Genetic variants increase the risk of age-related macular degeneration |
| EP2479284B1 (en) * | 2006-07-13 | 2017-09-20 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
| WO2009059321A2 (en) * | 2007-11-01 | 2009-05-07 | University Of Iowa Research Foundation | Rca locus analysis to assess susceptibility to amd and mpgnii |
| US8114592B2 (en) * | 2008-03-18 | 2012-02-14 | Cambridge Enterprise Limited | Genetic markers associated with age-related macular degeneration, methods of detection and uses thereof |
| US20120115925A1 (en) * | 2008-12-23 | 2012-05-10 | Massachusetts Eye And Ear Infirmary | Allelic Variants Associated with Advanced Age-Related Macular Degeneration |
| US20120202708A1 (en) * | 2010-10-14 | 2012-08-09 | Sequenom, Inc. | Complement factor h copy number variants found in the rca locus |
| US20140087960A1 (en) * | 2010-12-14 | 2014-03-27 | Johanna M. Seddon | Markers Related to Age-Related Macular Degeneration and Uses Therefor |
| BR112013023724A2 (pt) * | 2011-03-15 | 2019-09-24 | Univ Utah Res Found | métodos para tratar doença ou sintoma, detriagem para um agente ou uma combinação de agentes, e para determinar a eficácia de um agente e de um tratamento |
| EP2895624B1 (en) * | 2012-09-14 | 2022-06-01 | University Of Utah Research Foundation | Methods of predicting the development of amd based on chromosome 1 and chromosome 10 |
| US9896728B2 (en) * | 2013-01-29 | 2018-02-20 | Arcticrx Ltd. | Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD) |
-
2012
- 2012-04-27 CN CN201280031235.6A patent/CN103874526A/zh active Pending
- 2012-04-27 WO PCT/US2012/035467 patent/WO2012149329A2/en not_active Ceased
- 2012-04-27 AU AU2012249521A patent/AU2012249521A1/en not_active Abandoned
- 2012-04-27 DK DK12776262.3T patent/DK2704800T3/en active
- 2012-04-27 US US14/114,751 patent/US20140357732A1/en not_active Abandoned
- 2012-04-27 JP JP2014508602A patent/JP2014513958A/ja active Pending
- 2012-04-27 CA CA2834676A patent/CA2834676A1/en not_active Abandoned
- 2012-04-27 EP EP12776262.3A patent/EP2704800B1/en active Active
- 2012-04-27 BR BR112013027851A patent/BR112013027851A2/pt not_active IP Right Cessation
- 2012-04-27 SG SG2013080502A patent/SG194235A1/en unknown
- 2012-04-27 KR KR1020137031638A patent/KR20140074258A/ko not_active Withdrawn
-
2017
- 2017-06-27 US US15/634,892 patent/US20180155788A1/en not_active Abandoned
-
2020
- 2020-01-03 US US16/734,168 patent/US20200239958A1/en not_active Abandoned
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