JP2014511118A5 - - Google Patents

Download PDF

Info

Publication number
JP2014511118A5
JP2014511118A5 JP2013535151A JP2013535151A JP2014511118A5 JP 2014511118 A5 JP2014511118 A5 JP 2014511118A5 JP 2013535151 A JP2013535151 A JP 2013535151A JP 2013535151 A JP2013535151 A JP 2013535151A JP 2014511118 A5 JP2014511118 A5 JP 2014511118A5
Authority
JP
Japan
Prior art keywords
gata
cell
cells
megakaryocyte
stem cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013535151A
Other languages
English (en)
Japanese (ja)
Other versions
JP6126004B2 (ja
JP2014511118A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/057716 external-priority patent/WO2012061146A1/en
Publication of JP2014511118A publication Critical patent/JP2014511118A/ja
Publication of JP2014511118A5 publication Critical patent/JP2014511118A5/ja
Application granted granted Critical
Publication of JP6126004B2 publication Critical patent/JP6126004B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013535151A 2010-10-25 2011-10-25 血小板の生成のための組成物および方法、およびそれらの使用の方法 Expired - Fee Related JP6126004B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40651410P 2010-10-25 2010-10-25
US61/406,514 2010-10-25
PCT/US2011/057716 WO2012061146A1 (en) 2010-10-25 2011-10-25 Compositions and methods for the generation of platelets and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2014511118A JP2014511118A (ja) 2014-05-08
JP2014511118A5 true JP2014511118A5 (enExample) 2014-12-11
JP6126004B2 JP6126004B2 (ja) 2017-05-10

Family

ID=46024776

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013535151A Expired - Fee Related JP6126004B2 (ja) 2010-10-25 2011-10-25 血小板の生成のための組成物および方法、およびそれらの使用の方法

Country Status (6)

Country Link
US (1) US9259443B2 (enExample)
EP (1) EP2633047A4 (enExample)
JP (1) JP6126004B2 (enExample)
AU (1) AU2011323729B2 (enExample)
CA (1) CA2815426A1 (enExample)
WO (1) WO2012061146A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
US9074186B2 (en) * 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
EP3973967A1 (en) 2012-12-21 2022-03-30 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
US11319528B2 (en) 2015-07-13 2022-05-03 University Of Utah Research Foundation Methods of making red blood cells and platelets in vitro and uses thereof
WO2018053288A1 (en) * 2016-09-16 2018-03-22 The Children's Hospital Of Philadelphia Methods and compositions for identification and enrichment of platelet-producing megakaryocytes (mks)
MX2020007071A (es) 2018-01-05 2020-11-11 Platelet Biogenesis Inc Composiciones y metodos para producir megacariocitos.
WO2020006539A1 (en) 2018-06-29 2020-01-02 Platelet Biogenesis, Inc. Compositions for drug delivery and methods of use thereof
AU2019354370A1 (en) * 2018-10-05 2021-05-13 University Of Utah Research Foundation Methods of making platelets comprising modified receptors and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824297A (en) 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
US5817662A (en) 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5772992A (en) 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
DE69635899T2 (de) 1995-11-17 2006-11-23 Asahi Kasei Kabushiki Kaisha Polypeptid, das die differenzierung unterdrueckt
US5811297A (en) 1996-03-07 1998-09-22 Amba Biosciences, Llc Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US6291210B1 (en) 1996-07-16 2001-09-18 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
US6066778A (en) 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
US6335195B1 (en) 1997-01-28 2002-01-01 Maret Corporation Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
US6248587B1 (en) 1997-11-26 2001-06-19 University Of Southern Cailfornia Method for promoting mesenchymal stem and lineage-specific cell proliferation
JPH11180877A (ja) 1997-12-17 1999-07-06 Asahi Chem Ind Co Ltd 巨核球前駆細胞を含む細胞製剤及びその製造方法
EP1090992A4 (en) 1998-04-28 2004-05-19 Ono Pharmaceutical Co NEW POLYPEPTIDE, DNA CODING IT, AND ITS USE
EP1980617A1 (en) 1998-12-31 2008-10-15 Novartis Vaccines and Diagnostics, Inc. Improved expression of HIV polypeptides and production of virus-like particles
US6586390B1 (en) 2000-01-21 2003-07-01 Hyseq, Inc. Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides
US6465620B1 (en) 2000-01-21 2002-10-15 Hyseq, Inc. Methods and materials relating to novel von Willebrand/Thrombospondin-like polypeptides and polynucleotides
US6569662B1 (en) 2000-01-21 2003-05-27 Hyseq, Inc. Nucleic acids and polypeptides
US6673904B2 (en) 2000-12-23 2004-01-06 Kirin Beer Kabushiki Kaisha Stem cell growth factor-like polypeptides
US20040192599A1 (en) 2001-06-15 2004-09-30 Schuh Andre C Gene therapy for hemophilia a
CA2457694A1 (en) 2001-08-09 2003-02-20 Cornell Research Foundation, Inc. Platelet-derived growth factor protection of cardiac myocardium
EP1336846A1 (en) 2002-02-13 2003-08-20 Procorde GmbH Method for generating recombinant human platelets for identifying therapeutic target proteins
WO2003087333A2 (en) 2002-04-12 2003-10-23 Celgene Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2003231950A1 (en) 2002-05-30 2003-12-19 Celgene Corporation Modulating cell differentiation and treating myeloproliferative disorders with JNK/MKK inhibitors
US7012005B2 (en) 2002-06-25 2006-03-14 Siliconix Incorporated Self-aligned differential oxidation in trenches by ion implantation
WO2005103234A1 (en) 2004-04-23 2005-11-03 Héma-Québec A new method of expanding cord blood cells
CN105168250B (zh) 2004-10-25 2019-02-05 塞勒兰特治疗公司 增殖骨髓细胞群体的方法及其应用
WO2006050330A2 (en) 2004-11-01 2006-05-11 Wisconsin Alumni Research Foundation Platelets from stem cells
US20070077654A1 (en) 2004-11-01 2007-04-05 Thomson James A Platelets from stem cells
JPWO2007049749A1 (ja) 2005-10-28 2009-04-30 ディナベック株式会社 血液凝固異常の治療方法
US20080275049A1 (en) 2007-05-04 2008-11-06 Reddy Us Therapeutics, Inc. Methods and Compositions for Upregulation of GATA Activity
WO2008151386A1 (en) * 2007-06-15 2008-12-18 Australian Stem Cell Centre Ltd Megakaryocyte differentiation
EP2315829B1 (en) 2008-08-08 2015-02-11 Mayo Foundation For Medical Education And Research Induced pluripotent stem cells
CN102712904A (zh) 2009-11-11 2012-10-03 桑福德—伯恩哈姆医学研究协会 用于产生和调节iPS细胞的方法及其组合物

Similar Documents

Publication Publication Date Title
JP2014511118A5 (enExample)
JP6713073B2 (ja) 異常ヘモグロビン症を治療するための組成物および方法
US20230048730A1 (en) Platelets transfected by exogenous genetic material and platelet microparticles obtained by said transfected platelets, method for the preparation and uses thereof
Åkerblom et al. Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9
JP7428712B2 (ja) 低/最小操作による遺伝子改変細胞の製造
JP2012065652A5 (enExample)
WO2016204256A1 (ja) 高機能性血小板の製造方法
JP2018529340A (ja) 核酸のエキソソームパッケージング
WO2012157586A1 (ja) 多核化巨核球細胞、及び血小板の製造方法
JP2017536826A5 (enExample)
JP6126004B2 (ja) 血小板の生成のための組成物および方法、およびそれらの使用の方法
Luo et al. Targeted inhibition of the miR‐199a/214 cluster by CRISPR interference augments the tumor tropism of human induced pluripotent stem cell‐derived neural stem cells under hypoxic condition
Summer et al. Embryonic lung side population cells are hematopoietic and vascular precursors
CN115835872A (zh) 使用rbcev将核酸递送至免疫细胞的方法
CN103436555B (zh) 携带miR-122的脂肪来源的间充质干细胞在制备肝纤维化治疗制剂的应用
JP2014515258A5 (enExample)
CN107119020A (zh) 一种基于miR‑9的肝损伤靶向间充质干细胞及其制备方法与应用
Xu et al. In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery
JP7356626B2 (ja) 体細胞から肺胞上皮細胞への分化用試薬及びその使用
CN104745635B (zh) 一种沉默df-1细胞系中oasl基因的方法
AU2022264498A1 (en) Compositions and methods related to megakaryocyte-derived extracellular vesicles for fanconi anemia
Jiang et al. Administration of bone marrow derived mesenchymal stem cells into the liver: Potential to rescue pseudoxanthoma elasticum in a mouse model (Abcc6−/−)
JP2014128210A5 (enExample)
CN103993028A (zh) 非病毒载体与cxcr4质粒的复合物及其制备方法和应用
Tian et al. Purification and functional assessment of smooth muscle cells derived from mouse embryonic stem cells