JP2014509311A - 低キャビテーション閾値の音響応答性粒子 - Google Patents

低キャビテーション閾値の音響応答性粒子 Download PDF

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Publication number
JP2014509311A
JP2014509311A JP2013548555A JP2013548555A JP2014509311A JP 2014509311 A JP2014509311 A JP 2014509311A JP 2013548555 A JP2013548555 A JP 2013548555A JP 2013548555 A JP2013548555 A JP 2013548555A JP 2014509311 A JP2014509311 A JP 2014509311A
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Japan
Prior art keywords
ultrasound
outer membrane
particles
liposome
responsive
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Pending
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JP2013548555A
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English (en)
Japanese (ja)
Inventor
ベンチモル マイケル
シー． エセナ サディク
シンベリ ドミトリ
イプセン スチュアート
Original Assignee
ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア
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Publication of JP2014509311A publication Critical patent/JP2014509311A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2013548555A 2011-01-05 2012-01-05 低キャビテーション閾値の音響応答性粒子 Pending JP2014509311A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430073P 2011-01-05 2011-01-05
US61/430,073 2011-01-05
PCT/US2012/020389 WO2012094541A2 (fr) 2011-01-05 2012-01-05 Particules à sensibilité acoustique ayant un seuil de cavitation réduit

Publications (1)

Publication Number Publication Date
JP2014509311A true JP2014509311A (ja) 2014-04-17

Family

ID=46457973

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013548555A Pending JP2014509311A (ja) 2011-01-05 2012-01-05 低キャビテーション閾値の音響応答性粒子

Country Status (5)

Country Link
US (1) US20140046181A1 (fr)
EP (1) EP2661259A4 (fr)
JP (1) JP2014509311A (fr)
IL (1) IL227340A0 (fr)
WO (1) WO2012094541A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101978270B1 (ko) * 2017-12-27 2019-05-14 연세대학교 산학협력단 3차원 세포 배양에서의 물질 전달 장치 및 방법
JP2021509084A (ja) * 2018-01-02 2021-03-18 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響定在波プロセスに用いるための粒子

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KR102076069B1 (ko) 2011-08-24 2020-02-11 캘리포니아 인스티튜트 오브 테크놀로지 타기팅 미세버블
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
JP6525959B2 (ja) * 2013-04-18 2019-06-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生物学的実体のカプセル化のためのナノスケールコーティング
WO2015027164A1 (fr) 2013-08-22 2015-02-26 The Regents Of The University Of Michigan Histotripsie au moyen d'impulsions d'ultrasons très courtes
GB201320413D0 (en) * 2013-11-19 2014-01-01 Isis Innovation Cavitation-inducing polymeric nanoparticles
WO2016061383A1 (fr) * 2014-10-17 2016-04-21 Sonrgy, Inc. Système et procédé de distribution d'ultrason
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
WO2016205820A1 (fr) 2015-06-18 2016-12-22 Califorina Institute Of Technology Synthèse et application de composés de formation de microbulles
EP3337457A4 (fr) * 2015-08-21 2019-01-02 University of Otago Systèmes d'administration de médicament entraînés par voie acoustique
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
NO342271B1 (en) * 2016-09-29 2018-04-30 Sintef Tto As A new drug delivery system for treatment of cancer
US10449349B2 (en) * 2016-12-14 2019-10-22 L'oreal Systems, devices, and methods including encapsulated cosmetics
CN107485779B (zh) * 2017-09-04 2021-02-02 云南靖创液态金属热控技术研发有限公司 纳米机器人及其制备方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11813484B2 (en) * 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
CN110522992B (zh) * 2019-07-22 2021-02-19 西安交通大学 基于空间非均匀聚焦涡旋声场的相变纳米液滴调控方法
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
GB202106412D0 (en) * 2021-05-05 2021-06-16 Biocompatibles Ltd Distributing microparticles
WO2024047580A1 (fr) * 2022-08-31 2024-03-07 Insightec Ltd. Résidence tissulaire forcée de molécules de charge utile par rupture acoustique

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US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) * 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
WO2004089345A1 (fr) * 2003-04-03 2004-10-21 Semafore Pharmaceuticals Inc. Ciblage osseux de nanoparticules biodegradables contenant un medicament
US7358226B2 (en) * 2003-08-27 2008-04-15 The Regents Of The University Of California Ultrasonic concentration of drug delivery capsules
US20070145618A1 (en) * 2005-12-28 2007-06-28 Kimberly-Clark Worldwide, Inc. Methods of making microencapsulated delivery vehicles
WO2008120998A2 (fr) * 2007-03-30 2008-10-09 Epitarget As Particules administrant des médicaments acoustiquement sensibles
US20090009965A1 (en) * 2007-07-02 2009-01-08 Ta-Yang Cheng Heat dissipating structure of microcomputer
US20090099651A1 (en) * 2007-10-10 2009-04-16 Miv Therapeutics, Inc. Lipid coatings for implantable medical devices
WO2009091927A1 (fr) * 2008-01-15 2009-07-23 Eugene Tu Microparticules actives par ultrasons et procédé d'utilisation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101978270B1 (ko) * 2017-12-27 2019-05-14 연세대학교 산학협력단 3차원 세포 배양에서의 물질 전달 장치 및 방법
JP2021509084A (ja) * 2018-01-02 2021-03-18 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響定在波プロセスに用いるための粒子

Also Published As

Publication number Publication date
WO2012094541A3 (fr) 2012-10-04
EP2661259A4 (fr) 2015-04-01
US20140046181A1 (en) 2014-02-13
WO2012094541A2 (fr) 2012-07-12
IL227340A0 (en) 2013-09-30
EP2661259A2 (fr) 2013-11-13

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