JP2014508521A - 細胞内へのカーゴ送達のためのシステム - Google Patents
細胞内へのカーゴ送達のためのシステム Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
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- Zoology (AREA)
- Wood Science & Technology (AREA)
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- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11155275.8 | 2011-02-22 | ||
| EP11155275A EP2491952A1 (en) | 2011-02-22 | 2011-02-22 | A system for cargo delivery into the cells |
| PCT/EP2012/053036 WO2012113846A1 (en) | 2011-02-22 | 2012-02-22 | A system for cargo delivery into the cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508521A true JP2014508521A (ja) | 2014-04-10 |
| JP2014508521A5 JP2014508521A5 (cg-RX-API-DMAC10.html) | 2015-11-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554886A Pending JP2014508521A (ja) | 2011-02-22 | 2012-02-22 | 細胞内へのカーゴ送達のためのシステム |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140038281A1 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2491952A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2014508521A (cg-RX-API-DMAC10.html) |
| CN (1) | CN103813808A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012113846A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010039088A1 (en) * | 2008-09-16 | 2010-04-08 | Kariem Ahmed | Chemically modified cell-penetrating peptides for improved delivery of gene modulating compounds |
| WO2013110005A1 (en) | 2012-01-18 | 2013-07-25 | Wisconsin Alumni Research Foundation | Boronate-mediated delivery of molecules into cells |
| US9732101B2 (en) | 2012-01-18 | 2017-08-15 | Wisconsin Alumni Research Foundation | Bioreversible boronates for delivery of molecules into cells |
| CN103656662A (zh) * | 2013-11-27 | 2014-03-26 | 上海纳米技术及应用国家工程研究中心有限公司 | 利用多肽介导的dna纳米结构用作抗肿瘤药物载体的方法 |
| CA3002073A1 (en) * | 2015-10-20 | 2017-04-27 | Sorrento Therapeutics, Inc. | Intracellular delivery compounds |
| TW201809013A (zh) | 2016-06-06 | 2018-03-16 | 艾斯克立必恩股份有限公司 | 用於藥物遞送之抗體融合蛋白 |
| WO2018129440A1 (en) * | 2017-01-09 | 2018-07-12 | University Of Massachusetts | Complexes for gene deletion and editing |
| GB201900443D0 (en) | 2019-01-11 | 2019-02-27 | Univ Tartu | Cell-penetrating peptides |
| US20230221307A1 (en) * | 2019-09-06 | 2023-07-13 | Alessandro GORI | Conjugated composed of membrane-targeting peptides for extracellular vesicles isolation, analysis and their integration thereof |
| GB202019864D0 (en) | 2020-12-16 | 2021-01-27 | Anastasis Biotec Ltd | Improved cell-penetrating peptides and fusion proteins |
| GB202214599D0 (en) | 2022-10-04 | 2022-11-16 | Univ Tartu | Novel cell penetrating peptides and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007525941A (ja) * | 2003-04-09 | 2007-09-13 | ネオス テクノロジーズ インコーポレイテッド | グリコペギレ−ション法およびその方法により生成されたタンパク質／ペプチド |
| WO2010039088A1 (en) * | 2008-09-16 | 2010-04-08 | Kariem Ahmed | Chemically modified cell-penetrating peptides for improved delivery of gene modulating compounds |
-
2011
- 2011-02-22 EP EP11155275A patent/EP2491952A1/en not_active Withdrawn
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2012
- 2012-02-22 JP JP2013554886A patent/JP2014508521A/ja active Pending
- 2012-02-22 WO PCT/EP2012/053036 patent/WO2012113846A1/en not_active Ceased
- 2012-02-22 EP EP12709299.7A patent/EP2678040A1/en not_active Withdrawn
- 2012-02-22 CN CN201280018078.5A patent/CN103813808A/zh active Pending
- 2012-02-22 US US14/001,090 patent/US20140038281A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007525941A (ja) * | 2003-04-09 | 2007-09-13 | ネオス テクノロジーズ インコーポレイテッド | グリコペギレ−ション法およびその方法により生成されたタンパク質／ペプチド |
| WO2010039088A1 (en) * | 2008-09-16 | 2010-04-08 | Kariem Ahmed | Chemically modified cell-penetrating peptides for improved delivery of gene modulating compounds |
Non-Patent Citations (3)
| Title |
|---|
| JPN6016005756; ＭＡＥ Ｍ． ｅｔ ａｌ．: Ｊ． Ｃｏｎｔｒｏｌ． Ｒｅｌｅａｓｅ １３４（２００９）, ｐ．２２１-２２７ * |
| JPN6016005757; ＭＯＮＴＥＮＥＧＲＯ Ｊ． ｅｔ ａｌ．: Ｃｈｅｍ． Ａｓｉａｎ Ｊ． ６（２）, 20110201, ｐ．６８１-６８９ * |
| JPN6016005762; Ｉｎｔ． Ｊ． Ｐｅｐｔ． Ｒｅｓ． Ｔｈｅｒ． １７（２０１１．０６）, ｐ．１４７-１５７ * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2678040A1 (en) | 2014-01-01 |
| EP2491952A1 (en) | 2012-08-29 |
| CN103813808A (zh) | 2014-05-21 |
| US20140038281A1 (en) | 2014-02-06 |
| WO2012113846A1 (en) | 2012-08-30 |
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