JP2014506671A5 - - Google Patents
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- JP2014506671A5 JP2014506671A5 JP2013552696A JP2013552696A JP2014506671A5 JP 2014506671 A5 JP2014506671 A5 JP 2014506671A5 JP 2013552696 A JP2013552696 A JP 2013552696A JP 2013552696 A JP2013552696 A JP 2013552696A JP 2014506671 A5 JP2014506671 A5 JP 2014506671A5
- Authority
- JP
- Japan
- Prior art keywords
- branched polymer
- molecules
- molecule
- biological material
- conjugated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920000642 polymer Polymers 0.000 claims description 61
- 239000000017 hydrogel Substances 0.000 claims description 45
- 239000011230 binding agent Substances 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 38
- 229920000615 alginic acid Polymers 0.000 claims description 34
- 235000010443 alginic acid Nutrition 0.000 claims description 34
- 239000012620 biological material Substances 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 30
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 19
- 229940072056 alginate Drugs 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 239000000783 alginic acid Substances 0.000 claims description 15
- 229960001126 alginic acid Drugs 0.000 claims description 15
- 150000004781 alginic acids Chemical class 0.000 claims description 15
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims description 12
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 210000000130 stem cell Anatomy 0.000 claims description 7
- -1 CD31 Proteins 0.000 claims description 6
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 6
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 6
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 6
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims description 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 6
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 6
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 6
- 102100038081 Signal transducer CD24 Human genes 0.000 claims description 6
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 6
- 150000003384 small molecules Chemical class 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000003472 neutralizing effect Effects 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 210000004504 adult stem cell Anatomy 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000003511 endothelial effect Effects 0.000 claims description 2
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 210000004966 intestinal stem cell Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000001178 neural stem cell Anatomy 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 239000013077 target material Substances 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- 210000003663 amniotic stem cell Anatomy 0.000 description 1
- 210000002358 circulating endothelial cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000000604 fetal stem cell Anatomy 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920005596 polymer binder Polymers 0.000 description 1
- 239000002491 polymer binding agent Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161439166P | 2011-02-03 | 2011-02-03 | |
| US61/439,166 | 2011-02-03 | ||
| PCT/US2012/023859 WO2012106658A1 (en) | 2011-02-03 | 2012-02-03 | Methods and compositions for highly specific capture and release of biological materials |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016238320A Division JP2017077245A (ja) | 2011-02-03 | 2016-12-08 | 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506671A JP2014506671A (ja) | 2014-03-17 |
| JP2014506671A5 true JP2014506671A5 (https=) | 2015-03-26 |
| JP6120778B2 JP6120778B2 (ja) | 2017-04-26 |
Family
ID=46603107
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552696A Active JP6120778B2 (ja) | 2011-02-03 | 2012-02-03 | 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物 |
| JP2016238320A Abandoned JP2017077245A (ja) | 2011-02-03 | 2016-12-08 | 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016238320A Abandoned JP2017077245A (ja) | 2011-02-03 | 2016-12-08 | 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9927334B2 (https=) |
| EP (1) | EP2670856B1 (https=) |
| JP (2) | JP6120778B2 (https=) |
| KR (1) | KR101922741B1 (https=) |
| ES (1) | ES2687144T3 (https=) |
| SG (2) | SG10201600803SA (https=) |
| WO (1) | WO2012106658A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2891028C (en) | 2012-11-09 | 2017-02-07 | F. Hoffmann-La Roche Ag | In vitro capture and analysis of circulating tumor cells |
| US10551376B2 (en) | 2013-02-01 | 2020-02-04 | The General Hospital Corporation | Capture and release of particles from liquid samples |
| US20170074870A1 (en) | 2014-03-14 | 2017-03-16 | Northeastern University | Microfluidic System and Method for Real-Time Measurement of Antibody-Antigen Binding and Analyte Detection |
| WO2015148512A1 (en) | 2014-03-24 | 2015-10-01 | Qt Holdings Corp | Shaped articles including hydrogels and methods of manufacture and use thereof |
| JP7089240B2 (ja) * | 2014-12-22 | 2022-06-22 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ （ウ・ペ・エフ・エル） | 高い収集能力で哺乳動物細胞を操作（マニピュレーション）する装置 |
| US9790467B2 (en) | 2015-09-22 | 2017-10-17 | Qt Holdings Corp | Methods and compositions for activation or expansion of T lymphocytes |
| ES2871137T3 (es) * | 2015-12-14 | 2021-10-28 | Quanta Matrix Co Ltd | Método de diferenciación de células particulares a partir de la mezcla de células heterogéneas |
| CN109154614B (zh) | 2016-03-18 | 2022-01-28 | 四方控股公司 | 用于细胞分离的组合物、装置和方法 |
| US10429387B2 (en) * | 2016-07-27 | 2019-10-01 | Universiteit Tweate | Simple and affordable method for immuophenotyping using a microfluidic chip sample preparation with image cytometry |
| US11118163B2 (en) | 2017-02-02 | 2021-09-14 | Sartorius Stedim Biotech Gmbh | Separation of cell populations by marker identification and sedimentation velocity |
| DE102017105195A1 (de) | 2017-03-10 | 2018-09-13 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Verfahren zur differenzierten Sequestrierung von Stoffen verschiedener Stoffgruppen mit Hilfe von sulfatierte oder sulfonierte Komponenten enthaltenden Hydrogelen |
| JP7321937B2 (ja) * | 2017-03-20 | 2023-08-07 | キューティー ホールディングス コーポレーション | 増殖した免疫細胞の集団の生成方法 |
| WO2019239359A2 (en) | 2018-06-13 | 2019-12-19 | University Of Washington | Extruded hydrogel tubes and coaxial fibers and applications thereof |
| DK3626814T3 (da) * | 2018-09-21 | 2023-06-06 | Univ Wien Tech | Fremstilling af cellesfæroider |
| JP7120547B2 (ja) * | 2019-02-22 | 2022-08-17 | 国立研究開発法人理化学研究所 | 物質固定化剤、及び当該物質固定化剤を用いた物質固定化方法 |
| US11976269B2 (en) * | 2019-03-18 | 2024-05-07 | Cellular Research, Inc. | Precise delivery of components into fluids |
| US11668676B2 (en) * | 2019-05-30 | 2023-06-06 | The Regents Of The University Of California | Microfluidic acoustic devices and methods |
| CN112708150B (zh) * | 2020-12-08 | 2021-11-16 | 济南国科医工科技发展有限公司 | 用于循环肿瘤细胞的捕获及定点释放的水凝胶体系 |
| CN117957247A (zh) | 2021-09-01 | 2024-04-30 | 博奥泰克尼公司 | 人玻连蛋白片段及其用途 |
| US11805995B1 (en) | 2022-11-22 | 2023-11-07 | King Faisal University | Saliva collection kit |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2317657T3 (es) * | 1996-09-19 | 2009-04-16 | The Regents Of The University Of Michigan | Polimeros que contienen polisacaridos tales como alginatos o alginatos modificados. |
| KR101054023B1 (ko) | 2001-11-07 | 2011-08-04 | 아이드게노시셰 테크시셰 호흐쉘 취리히 | 세포 내증식 및 조직 재생을 제어하기 위한 합성 매트릭스 |
| JP4560291B2 (ja) * | 2001-12-18 | 2010-10-13 | イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ | 組織操作のための成長因子改変タンパク質マトリクス |
| WO2004008142A1 (ja) * | 2002-07-12 | 2004-01-22 | Mitsubishi Chemical Corporation | 分析用チップ、分析用チップユニット、分析装置及びそれを用いた分析方法並びに分析用チップの作製方法 |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| TW200605910A (en) | 2004-04-30 | 2006-02-16 | Orbus Medical Technologies Inc | Medical device with coating for capturing genetically-altered cells and methods for using same |
| SE0402476D0 (sv) * | 2004-10-13 | 2004-10-13 | Biacore Ab | Preparation and use of a reactive solid support surface |
| CN101338036B (zh) * | 2007-07-06 | 2010-11-03 | 常州百瑞吉生物医药有限公司 | 生物相容快速凝胶化水凝胶及其喷雾剂的制备方法 |
| US9267109B2 (en) * | 2007-12-10 | 2016-02-23 | Koninklijke Philips N.V. | Patterned cell sheets and a method for production of the same |
| WO2010124227A2 (en) * | 2009-04-24 | 2010-10-28 | The Board Of Trustees Of The University Of Illinois | Methods and devices for capturing circulating tumor cells |
| WO2012094642A2 (en) * | 2011-01-06 | 2012-07-12 | On-Q-ity | Circulating tumor cell capture on a microfluidic chip incorporating both affinity and size |
-
2012
- 2012-02-03 JP JP2013552696A patent/JP6120778B2/ja active Active
- 2012-02-03 EP EP12742728.4A patent/EP2670856B1/en active Active
- 2012-02-03 SG SG10201600803SA patent/SG10201600803SA/en unknown
- 2012-02-03 SG SG2013058797A patent/SG192587A1/en unknown
- 2012-02-03 KR KR1020137023006A patent/KR101922741B1/ko active Active
- 2012-02-03 ES ES12742728.4T patent/ES2687144T3/es active Active
- 2012-02-03 US US13/982,680 patent/US9927334B2/en active Active
- 2012-02-03 WO PCT/US2012/023859 patent/WO2012106658A1/en not_active Ceased
-
2016
- 2016-12-08 JP JP2016238320A patent/JP2017077245A/ja not_active Abandoned
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