JP2014503500A - 低酸素状態に基づく酸素感受性薬剤による治療に適した被験体の事前選択 - Google Patents

低酸素状態に基づく酸素感受性薬剤による治療に適した被験体の事前選択 Download PDF

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JP2014503500A
JP2014503500A JP2013540062A JP2013540062A JP2014503500A JP 2014503500 A JP2014503500 A JP 2014503500A JP 2013540062 A JP2013540062 A JP 2013540062A JP 2013540062 A JP2013540062 A JP 2013540062A JP 2014503500 A JP2014503500 A JP 2014503500A
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cancer
ldh
hypoxia
tumor
ldh5
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JP2014503500A5 (enExample
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ブラックマン，ロナルド，ケー．
ブコビック，ボジョ
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シンタ ファーマスーティカルズ コーポレーション
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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JP2013540062A 2010-11-18 2011-11-18 低酸素状態に基づく酸素感受性薬剤による治療に適した被験体の事前選択 Pending JP2014503500A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US41512710P 2010-11-18 2010-11-18
US61/415,127 2010-11-18
US201161510660P 2011-07-22 2011-07-22
US201161510648P 2011-07-22 2011-07-22
US201161510653P 2011-07-22 2011-07-22
US61/510,660 2011-07-22
US61/510,648 2011-07-22
US61/510,653 2011-07-22
PCT/US2011/061446 WO2012068487A1 (en) 2010-11-18 2011-11-18 Preselection of subjects for therapeutic treatment with oxygen sensitive agents based on hypoxic status

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JP2014503500A true JP2014503500A (ja) 2014-02-13
JP2014503500A5 JP2014503500A5 (enExample) 2015-01-15

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US (1) US20140024030A1 (enExample)
EP (1) EP2640384A1 (enExample)
JP (1) JP2014503500A (enExample)
WO (1) WO2012068487A1 (enExample)

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