JP2014502599A5 - - Google Patents
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- Publication number
- JP2014502599A5 JP2014502599A5 JP2013543471A JP2013543471A JP2014502599A5 JP 2014502599 A5 JP2014502599 A5 JP 2014502599A5 JP 2013543471 A JP2013543471 A JP 2013543471A JP 2013543471 A JP2013543471 A JP 2013543471A JP 2014502599 A5 JP2014502599 A5 JP 2014502599A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- methyl
- thiosemicarbazone
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- QPOWUYJWCJRLEE-UHFFFAOYSA-N dipyridin-2-ylmethanone Chemical compound C=1C=CC=NC=1C(=O)C1=CC=CC=N1 QPOWUYJWCJRLEE-UHFFFAOYSA-N 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- GNLZNQJBZNOUBM-UHFFFAOYSA-N 1-cyclohexyl-3-(dipyridin-2-ylmethylideneamino)-1-methylthiourea Chemical compound C=1C=CC=NC=1C(C=1N=CC=CC=1)=NNC(=S)N(C)C1CCCCC1 GNLZNQJBZNOUBM-UHFFFAOYSA-N 0.000 claims 1
- GUBMTJGHYSVNRX-UHFFFAOYSA-N 1-cyclohexyl-3-(dipyridin-2-ylmethylideneamino)-1-methylthiourea;hydrochloride Chemical compound Cl.C=1C=CC=NC=1C(C=1N=CC=CC=1)=NNC(=S)N(C)C1CCCCC1 GUBMTJGHYSVNRX-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 0 CN(*)C(NN=C(c1ncccc1)c1ncccc1)=S Chemical compound CN(*)C(NN=C(c1ncccc1)c1ncccc1)=S 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2010905539A AU2010905539A0 (en) | 2010-12-17 | Dipyridyl Thiosemicarbazone compounds and use in therapy | |
| AU2010905539 | 2010-12-17 | ||
| PCT/AU2011/001631 WO2012079128A1 (en) | 2010-12-17 | 2011-12-16 | Thiosemicarbazone compounds and use in the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502599A JP2014502599A (ja) | 2014-02-03 |
| JP2014502599A5 true JP2014502599A5 (OSRAM) | 2014-11-27 |
| JP5883457B2 JP5883457B2 (ja) | 2016-03-15 |
Family
ID=46243892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543471A Expired - Fee Related JP5883457B2 (ja) | 2010-12-17 | 2011-12-16 | チオセミカルバゾン化合物および癌の治療における使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8927580B2 (OSRAM) |
| EP (2) | EP2651894B1 (OSRAM) |
| JP (1) | JP5883457B2 (OSRAM) |
| KR (1) | KR20140022786A (OSRAM) |
| CN (1) | CN103370308B (OSRAM) |
| AU (1) | AU2011342378B2 (OSRAM) |
| BR (1) | BR112013015174A2 (OSRAM) |
| CA (1) | CA2821984A1 (OSRAM) |
| NZ (1) | NZ613085A (OSRAM) |
| WO (1) | WO2012079128A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012079128A1 (en) | 2010-12-17 | 2012-06-21 | Des R Richardson | Thiosemicarbazone compounds and use in the treatment of cancer |
| AU2013350315A1 (en) * | 2012-11-22 | 2015-06-04 | Oncochel Therapeutics LLC | Chemotherapy for drug-resistant cancer cells |
| CN104177288B (zh) * | 2013-05-23 | 2020-05-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 缩氨基硒脲衍生物及其药物组合物和用途 |
| US11504346B2 (en) | 2013-11-03 | 2022-11-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redox-activated pro-chelators |
| US12383518B2 (en) | 2013-11-03 | 2025-08-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Disulfide-masked pro-chelator compositions and methods of use |
| EP3125920B1 (en) | 2014-04-04 | 2020-12-23 | Del Mar Pharmaceuticals | Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer |
| WO2017058748A1 (en) * | 2015-09-29 | 2017-04-06 | Oncochel Therapeutics, Llc | Thiosemicarbazones |
| CN109052605A (zh) * | 2018-07-26 | 2018-12-21 | 雷晓琳 | 一种重金属捕集剂及其制备方法 |
| CN110698511B (zh) * | 2019-11-15 | 2021-09-14 | 广西师范大学 | 以2-吡啶甲醛缩氨基硫脲为配体的锡配合物及其合成方法 |
| KR102555030B1 (ko) * | 2020-10-19 | 2023-07-14 | 고려대학교 산학협력단 | 티오세미카바존 유도체 또는 이의 약학적으로 허용가능한 염 및 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4207400A1 (de) * | 1992-03-09 | 1993-09-16 | Bayer Ag | Hydrazone |
| AU2003900495A0 (en) * | 2003-02-05 | 2003-02-20 | Unisearch Limited | Aroylhydrazone derivatives and therapeutic uses thereof |
| DE602004031095D1 (de) * | 2003-02-05 | 2011-03-03 | David Benn Lovejoy | Metallionenchelatoren und ihre therapeutische verwendung |
| CN1891701A (zh) * | 2005-07-07 | 2007-01-10 | 桑迪亚医药技术（上海）有限责任公司 | 杂芳环缩氨基硫脲类化合物及其衍生物和它们在制备抗肿瘤药物中的应用 |
| WO2010000008A1 (en) * | 2008-06-30 | 2010-01-07 | Desi Raymond Richardson | Thiosemicarbazone compounds and use thereof |
| WO2012079128A1 (en) | 2010-12-17 | 2012-06-21 | Des R Richardson | Thiosemicarbazone compounds and use in the treatment of cancer |
-
2011
- 2011-12-16 WO PCT/AU2011/001631 patent/WO2012079128A1/en not_active Ceased
- 2011-12-16 CN CN201180067592.3A patent/CN103370308B/zh not_active Expired - Fee Related
- 2011-12-16 BR BR112013015174-9A patent/BR112013015174A2/pt not_active IP Right Cessation
- 2011-12-16 AU AU2011342378A patent/AU2011342378B2/en not_active Ceased
- 2011-12-16 EP EP11849434.3A patent/EP2651894B1/en not_active Not-in-force
- 2011-12-16 JP JP2013543471A patent/JP5883457B2/ja not_active Expired - Fee Related
- 2011-12-16 NZ NZ613085A patent/NZ613085A/en not_active IP Right Cessation
- 2011-12-16 KR KR1020137018832A patent/KR20140022786A/ko not_active Ceased
- 2011-12-16 EP EP17182667.0A patent/EP3287442A1/en not_active Withdrawn
- 2011-12-16 CA CA2821984A patent/CA2821984A1/en not_active Abandoned
- 2011-12-16 US US13/994,355 patent/US8927580B2/en not_active Expired - Fee Related
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