JP2014501765A5 - - Google Patents
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- Publication number
- JP2014501765A5 JP2014501765A5 JP2013546457A JP2013546457A JP2014501765A5 JP 2014501765 A5 JP2014501765 A5 JP 2014501765A5 JP 2013546457 A JP2013546457 A JP 2013546457A JP 2013546457 A JP2013546457 A JP 2013546457A JP 2014501765 A5 JP2014501765 A5 JP 2014501765A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- soluble non
- compound
- poly
- peptide polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 37
- 229920000642 polymer Polymers 0.000 claims description 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 33
- 125000006850 spacer group Chemical group 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000006242 amine protecting group Chemical group 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 125000005647 linker group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229920000768 polyamine Polymers 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 229920006295 polythiol Polymers 0.000 claims description 2
- 150000003568 thioethers Chemical class 0.000 claims description 2
- 150000003573 thiols Chemical class 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 235000013877 carbamide Nutrition 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical group CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
- 229960001796 sunitinib Drugs 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
- 0 CCCC(C)C(C)(*)***N(CC)CCNC(c1c(C)[n]c(C=C(c(cc(cc2)F)c2N2)C2=O)c1C)=O Chemical compound CCCC(C)C(C)(*)***N(CC)CCNC(c1c(C)[n]c(C=C(c(cc(cc2)F)c2N2)C2=O)c1C)=O 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426893P | 2010-12-23 | 2010-12-23 | |
| US61/426,893 | 2010-12-23 | ||
| PCT/US2011/067240 WO2012088522A1 (en) | 2010-12-23 | 2011-12-23 | Polymer-des-ethyl sunitinib conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501765A JP2014501765A (ja) | 2014-01-23 |
| JP2014501765A5 true JP2014501765A5 (https=) | 2014-12-25 |
| JP6009457B2 JP6009457B2 (ja) | 2016-10-19 |
Family
ID=45496320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546457A Active JP6009457B2 (ja) | 2010-12-23 | 2011-12-23 | ポリマー−デスエチルスニチニブコンジュゲート |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10220020B2 (https=) |
| EP (1) | EP2654797B1 (https=) |
| JP (1) | JP6009457B2 (https=) |
| WO (1) | WO2012088522A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9943605B2 (en) | 2010-12-23 | 2018-04-17 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| WO2012088522A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-des-ethyl sunitinib conjugates |
| US9295731B2 (en) * | 2013-04-01 | 2016-03-29 | Mark Quang Nguyen | Cleavable drug conjugates, compositions thereof and methods of use |
| PT3039424T (pt) | 2013-08-28 | 2020-09-03 | Crown Bioscience Inc Taicang | Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo |
| JP6542799B2 (ja) * | 2014-12-04 | 2019-07-10 | Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 | 新規ｐｅｇ誘導体 |
| US9808531B2 (en) * | 2015-09-22 | 2017-11-07 | Graybug Vision, Inc. | Compounds and compositions for the treatment of ocular disorders |
| CA3056923A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| CN111995513B (zh) * | 2019-05-27 | 2022-11-01 | 天津键凯科技有限公司 | 一种9-羟甲基-芴二酸的制备方法 |
| GB201916046D0 (en) * | 2019-11-04 | 2019-12-18 | Amazentis Sa | Diagnostic method |
| WO2022103983A2 (en) * | 2020-11-11 | 2022-05-19 | Sutro Biopharma, Inc. | Fluorenylmethyloxycarbonyl and fluorenylmethylaminocarbonyl compounds, protein conjugates thereof, and methods for their use |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| EP1255536B1 (en) | 1999-12-22 | 2006-06-28 | Sugen, Inc. | Indolinone derivatives for modulation of c-kit tyrosine protein kinase |
| SI1255752T1 (sl) | 2000-02-15 | 2007-12-31 | Pharmacia & Upjohn Co Llc | S pirolom substituirani zaviralci 2-indolinon protein kinaza |
| CA2407799A1 (en) | 2000-05-02 | 2001-11-08 | Sugen, Inc. | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| AU2002352524B2 (en) | 2001-11-07 | 2007-10-04 | Nektar Therapeutics | Branched polymers and their conjugates |
| US7053144B1 (en) | 2002-06-13 | 2006-05-30 | Cmi Rubber Company, Inc. | High density rubber compounds |
| WO2004084949A2 (en) | 2003-03-20 | 2004-10-07 | Xencor | Generating protein pro-drugs using reversible ppg linkages |
| TR201907313T4 (tr) | 2003-05-23 | 2019-06-21 | Nektar Therapeutics | İki PEG zinciri içeren PEG türevleri. |
| ES2629696T3 (es) | 2003-09-17 | 2017-08-14 | Nektar Therapeutics | Profármacos poliméricos multibrazo |
| US8562965B2 (en) | 2004-05-03 | 2013-10-22 | Nektar Therapeutics | Polymer derivatives comprising an acetal or ketal branching point |
| WO2005107815A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Polymer derivatives comprising an imide branching point |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| BRPI0611872B8 (pt) | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
| KR101513732B1 (ko) | 2006-02-21 | 2015-04-21 | 넥타르 테라퓨틱스 | 분할된 분해가능한 폴리머 및 이로부터 제조된 컨주게이트 |
| WO2007109564A2 (en) | 2006-03-17 | 2007-09-27 | University Of Massachusetts | Yeast cell particles as oral delivery vehicles for antigens |
| MX2009007145A (es) | 2006-12-27 | 2009-08-27 | Nektar Therapeutics Al Corp | Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable. |
| AU2008331868B2 (en) * | 2007-11-28 | 2015-02-12 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
| JP5704925B2 (ja) | 2008-02-08 | 2015-04-22 | ウェルズ ファーゴ バンク ナショナル アソシエイション | オリゴマー−カンナビノイドコンジュゲート |
| AU2009234322B2 (en) * | 2008-04-11 | 2014-12-04 | Nektar Therapeutics | Oligomer-aryloxy-substituted propanamine conjugates |
| EP2303288A4 (en) | 2008-05-22 | 2015-04-22 | Univ Ramot | CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESE MEDIUM AND ITS USE IN THE TREATMENT AND CONTROL OF ILLNESSES RELATED TO BONE |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| US20120052041A1 (en) | 2009-02-04 | 2012-03-01 | The Brigham And Women's Hospital, Inc. | Polymeric nanoparticles with enhanced drug-loading and methods of use thereof |
| US20120094998A1 (en) * | 2009-04-17 | 2012-04-19 | Nektar Therapeutics | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates |
| US8816077B2 (en) | 2009-04-17 | 2014-08-26 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| WO2012088522A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-des-ethyl sunitinib conjugates |
| WO2012088529A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-sunitinib conjugates |
| US20140331425A1 (en) | 2013-05-09 | 2014-11-13 | DeAndre Charles Baker | Sqeeky kleen toilet brush |
-
2011
- 2011-12-23 WO PCT/US2011/067240 patent/WO2012088522A1/en not_active Ceased
- 2011-12-23 US US13/995,819 patent/US10220020B2/en active Active
- 2011-12-23 JP JP2013546457A patent/JP6009457B2/ja active Active
- 2011-12-23 EP EP11809055.4A patent/EP2654797B1/en active Active
-
2019
- 2019-01-09 US US16/243,914 patent/US11406618B2/en active Active
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