JP2014501716A5 - - Google Patents
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- Publication number
- JP2014501716A5 JP2014501716A5 JP2013538794A JP2013538794A JP2014501716A5 JP 2014501716 A5 JP2014501716 A5 JP 2014501716A5 JP 2013538794 A JP2013538794 A JP 2013538794A JP 2013538794 A JP2013538794 A JP 2013538794A JP 2014501716 A5 JP2014501716 A5 JP 2014501716A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyamino
- methyl
- benzamide
- hydroxymethyl
- diynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 66
- -1 buta-1,3-diynyl Chemical group 0.000 claims description 63
- 150000001875 compounds Chemical class 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 19
- 239000011780 sodium chloride Substances 0.000 claims description 19
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 17
- 206010060945 Bacterial infection Diseases 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 10
- 125000004429 atoms Chemical group 0.000 claims description 8
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- LUQVCHRDAGWYMG-UHFFFAOYSA-N 4-phenylbenzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CC=CC=C1 LUQVCHRDAGWYMG-UHFFFAOYSA-N 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 6
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 229940081190 Rifampin Drugs 0.000 claims description 4
- MYPYJXKWCTUITO-LYRMYLQWSA-N VANCOMYCIN Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 4
- 229960003165 Vancomycin Drugs 0.000 claims description 4
- 108010059993 Vancomycin Proteins 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- BMBANPOHPFKVTA-UHFFFAOYSA-N benzamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NC(=O)C1=CC=CC=C1 BMBANPOHPFKVTA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims description 4
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 150000003138 primary alcohols Chemical class 0.000 claims description 4
- 229960001225 rifampicin Drugs 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 2
- 229940055023 Pseudomonas aeruginosa Drugs 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 3
- 206010061126 Escherichia infection Diseases 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N RIFAMPICIN Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- JQXXHWHPUNPDRT-ZNQWNCHJSA-N O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)Nc2c(O)c3c(O)c4C)C)OC)c4c1c3c(O)c2C=NN1CCN(C)CC1 Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)Nc2c(O)c3c(O)c4C)C)OC)c4c1c3c(O)c2C=NN1CCN(C)CC1 JQXXHWHPUNPDRT-ZNQWNCHJSA-N 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 230000002195 synergetic Effects 0.000 description 2
- MQTOSJVFKKJCRP-BICOPXKESA-N Azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N Cathomycin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 description 1
- GPRBEKHLDVQUJE-VINNURBNSA-N Cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 description 1
- 229960004261 Cefotaxime Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N Clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- DOAKLVKFURWEDJ-QCMAZARJSA-N DAPTOMYCIN Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 description 1
- 229960005484 Daptomycin Drugs 0.000 description 1
- 108010013198 Daptomycin Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229960002182 IMIPENEM Drugs 0.000 description 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N IMIPENEM Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N Linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 description 1
- 229960002950 Novobiocin Drugs 0.000 description 1
- 229960001608 Teicoplanin Drugs 0.000 description 1
- 108010053950 Teicoplanin Proteins 0.000 description 1
- 229960004099 azithromycin Drugs 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960003907 linezolid Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41231110P | 2010-11-10 | 2010-11-10 | |
| US61/412,311 | 2010-11-10 | ||
| PCT/US2011/059280 WO2012154204A1 (en) | 2010-11-10 | 2011-11-04 | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014501716A JP2014501716A (ja) | 2014-01-23 |
| JP2014501716A5 true JP2014501716A5 (zh) | 2014-12-18 |
Family
ID=46317476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538794A Pending JP2014501716A (ja) | 2010-11-10 | 2011-11-04 | ヒドロキサム酸誘導体および細菌感染の処置におけるその使用 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2638006A1 (zh) |
| JP (1) | JP2014501716A (zh) |
| KR (1) | KR20140023869A (zh) |
| CN (1) | CN103298780A (zh) |
| AR (1) | AR083760A1 (zh) |
| AU (1) | AU2011367819A1 (zh) |
| BR (1) | BR112013011693A2 (zh) |
| CA (1) | CA2817211A1 (zh) |
| EA (1) | EA201390626A1 (zh) |
| IL (1) | IL226270A0 (zh) |
| MX (1) | MX2013005200A (zh) |
| SG (1) | SG190243A1 (zh) |
| TW (1) | TW201249786A (zh) |
| WO (1) | WO2012154204A1 (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI519508B (zh) | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| WO2013170030A1 (en) * | 2012-05-09 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| JP6407288B2 (ja) | 2013-12-19 | 2018-10-17 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体 |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| US9539305B1 (en) | 2014-03-14 | 2017-01-10 | Fleurir Abx Llc | Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof |
| EP3143007B1 (en) | 2014-05-16 | 2018-07-11 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| MX2017006413A (es) | 2014-11-19 | 2017-09-12 | Idorsia Pharmaceuticals Ltd | Derivados de benzotiazol antibacterianos. |
| SG11201704053WA (en) | 2014-12-16 | 2017-06-29 | Novartis Ag | Isoxazole hydroxamic acid compounds as lpxc inhibitors |
| ES2961564T3 (es) | 2016-04-25 | 2024-03-12 | Univ Duke | Derivados de benzoilglicina y métodos de preparación y uso de los mismos |
| PL3468957T3 (pl) | 2016-06-14 | 2021-01-25 | Novartis Ag | Krystaliczna postać (r)-4-(5-(cyklopropyloetynylo)izoksa-zol-3- ilo)- n-hydroksy-2-metylo-2-(metylosulfonylo)butano-amidu jako środek przeciwbakteryjny |
| WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
| CN112074507B (zh) * | 2018-02-10 | 2023-09-05 | 山东亨利医药科技有限责任公司 | 作为抗菌素的化合物 |
| CN110563611B (zh) * | 2019-09-19 | 2021-02-02 | 中国医学科学院医药生物技术研究所 | 一种异羟肟酸类衍生物及其制备方法和应用 |
| CN113957098A (zh) * | 2021-09-13 | 2022-01-21 | 湖南工业大学 | 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用 |
| CN116730870B (zh) * | 2023-08-08 | 2023-10-13 | 中国医学科学院医药生物技术研究所 | 异羟肟酸类化合物或其可药用盐、及其用途和制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| WO1998018754A1 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| EP1169031A1 (en) | 1999-04-09 | 2002-01-09 | British Biotech Pharmaceuticals Limited | Antimicrobial agents |
| KR101076018B1 (ko) | 2003-01-08 | 2011-10-21 | 유니버시티 오브 워싱톤 | 항균제 |
| DE102006032709A1 (de) | 2006-07-14 | 2008-01-17 | BSH Bosch und Siemens Hausgeräte GmbH | Luftschallgedämmte Lebensmittelmühle |
| CN101209974A (zh) * | 2006-12-31 | 2008-07-02 | 天津药物研究院 | 异羟肟酸类衍生物及其用途 |
| TWI519508B (zh) * | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| WO2011005355A1 (en) * | 2009-05-07 | 2011-01-13 | Achaogen, Inc. | Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria |
| SI2562155T1 (sl) * | 2010-04-20 | 2019-08-30 | Fujifilm Toyama Chemical Co., Ltd. | Derivat hidroksamske kisline |
-
2011
- 2011-11-04 KR KR1020137012799A patent/KR20140023869A/ko not_active Application Discontinuation
- 2011-11-04 BR BR112013011693A patent/BR112013011693A2/pt not_active IP Right Cessation
- 2011-11-04 CA CA2817211A patent/CA2817211A1/en not_active Abandoned
- 2011-11-04 AU AU2011367819A patent/AU2011367819A1/en not_active Abandoned
- 2011-11-04 EP EP11849908.6A patent/EP2638006A1/en not_active Withdrawn
- 2011-11-04 CN CN2011800639128A patent/CN103298780A/zh active Pending
- 2011-11-04 WO PCT/US2011/059280 patent/WO2012154204A1/en active Application Filing
- 2011-11-04 EA EA201390626A patent/EA201390626A1/ru unknown
- 2011-11-04 TW TW100140449A patent/TW201249786A/zh unknown
- 2011-11-04 AR ARP110104117A patent/AR083760A1/es not_active Application Discontinuation
- 2011-11-04 MX MX2013005200A patent/MX2013005200A/es not_active Application Discontinuation
- 2011-11-04 SG SG2013036272A patent/SG190243A1/en unknown
- 2011-11-04 JP JP2013538794A patent/JP2014501716A/ja active Pending
-
2013
- 2013-05-09 IL IL226270A patent/IL226270A0/en unknown
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