JP2014501246A5 - - Google Patents
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- Publication number
- JP2014501246A5 JP2014501246A5 JP2013544634A JP2013544634A JP2014501246A5 JP 2014501246 A5 JP2014501246 A5 JP 2014501246A5 JP 2013544634 A JP2013544634 A JP 2013544634A JP 2013544634 A JP2013544634 A JP 2013544634A JP 2014501246 A5 JP2014501246 A5 JP 2014501246A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- ring
- methyl
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C**1CN(C)CCC(C)C1 Chemical compound C**1CN(C)CCC(C)C1 0.000 description 94
- HNJOAIYFUCQZAA-UHFFFAOYSA-N Cc1n[o]c(C)n1 Chemical compound Cc1n[o]c(C)n1 HNJOAIYFUCQZAA-UHFFFAOYSA-N 0.000 description 3
- ZRLDBDZSLLGDOX-UHFFFAOYSA-N Cc1c(C)[o]c(C)n1 Chemical compound Cc1c(C)[o]c(C)n1 ZRLDBDZSLLGDOX-UHFFFAOYSA-N 0.000 description 2
- MPBPVACPFBSAFW-UHFFFAOYSA-N Cc1n[s]c(C)n1 Chemical compound Cc1n[s]c(C)n1 MPBPVACPFBSAFW-UHFFFAOYSA-N 0.000 description 2
- CBYWEALASLZHEC-UHFFFAOYSA-N C1=C[I]=CC2=C1N=[I]N=C2 Chemical compound C1=C[I]=CC2=C1N=[I]N=C2 CBYWEALASLZHEC-UHFFFAOYSA-N 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N C1CCNCC1 Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- BGMLUCPALPKNOV-UHFFFAOYSA-N C1CNN=CC1 Chemical compound C1CNN=CC1 BGMLUCPALPKNOV-UHFFFAOYSA-N 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N C1NCCSC1 Chemical compound C1NCCSC1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- LOZWAPSEEHRYPG-UHFFFAOYSA-N C1SCCSC1 Chemical compound C1SCCSC1 LOZWAPSEEHRYPG-UHFFFAOYSA-N 0.000 description 1
- WCOYYNFBSQRKAM-UHFFFAOYSA-N CC(C(NC)=O)[I]1CC1 Chemical compound CC(C(NC)=O)[I]1CC1 WCOYYNFBSQRKAM-UHFFFAOYSA-N 0.000 description 1
- JDACNXBXJJCRRY-UHFFFAOYSA-N CC(C=C1)C=CC(S2)=C1N(C)C2=S Chemical compound CC(C=C1)C=CC(S2)=C1N(C)C2=S JDACNXBXJJCRRY-UHFFFAOYSA-N 0.000 description 1
- AVOYWAMQSZGHIX-UHFFFAOYSA-N CC(CCC(c(cccc1)c1S1)=C)C1=[U] Chemical compound CC(CCC(c(cccc1)c1S1)=C)C1=[U] AVOYWAMQSZGHIX-UHFFFAOYSA-N 0.000 description 1
- URRRULOPONLMTJ-UHFFFAOYSA-N CC(CCc1c(CS2)cccc1)C2=O Chemical compound CC(CCc1c(CS2)cccc1)C2=O URRRULOPONLMTJ-UHFFFAOYSA-N 0.000 description 1
- ACKGMPFWFSFTGT-UHFFFAOYSA-N CC1=CC=N[I]=N1 Chemical compound CC1=CC=N[I]=N1 ACKGMPFWFSFTGT-UHFFFAOYSA-N 0.000 description 1
- RRXMFAUGACOEAH-UHFFFAOYSA-N CC1=CCN(C)CC1 Chemical compound CC1=CCN(C)CC1 RRXMFAUGACOEAH-UHFFFAOYSA-N 0.000 description 1
- GUVQOWCAVAKCTI-UHFFFAOYSA-N CC1=CN=N[I]=N1 Chemical compound CC1=CN=N[I]=N1 GUVQOWCAVAKCTI-UHFFFAOYSA-N 0.000 description 1
- DXRXXQBRMQCKIS-UHFFFAOYSA-N CCNC(C)NC(C)=O Chemical compound CCNC(C)NC(C)=O DXRXXQBRMQCKIS-UHFFFAOYSA-N 0.000 description 1
- SURZCVYFPAXNGN-UHFFFAOYSA-N CCOC(NC)=O Chemical compound CCOC(NC)=O SURZCVYFPAXNGN-UHFFFAOYSA-N 0.000 description 1
- RSQUAQMIGSMNNE-UHFFFAOYSA-N CN(C(C1)=O)c2c1cccc2 Chemical compound CN(C(C1)=O)c2c1cccc2 RSQUAQMIGSMNNE-UHFFFAOYSA-N 0.000 description 1
- NWGNHPNGCDJCRH-UHFFFAOYSA-N CN(C(CC1)=N)C1=O Chemical compound CN(C(CC1)=N)C1=O NWGNHPNGCDJCRH-UHFFFAOYSA-N 0.000 description 1
- JARWBOSIMBOMRK-UHFFFAOYSA-N CN(C(CC1)=[U])c2c1cccc2 Chemical compound CN(C(CC1)=[U])c2c1cccc2 JARWBOSIMBOMRK-UHFFFAOYSA-N 0.000 description 1
- XRYKNRLGZZNWEE-UHFFFAOYSA-N CN(C(N=N1)=O)C1=O Chemical compound CN(C(N=N1)=O)C1=O XRYKNRLGZZNWEE-UHFFFAOYSA-N 0.000 description 1
- DORVZFVQNUHJNY-UHFFFAOYSA-N CN(C(c1c2cccc1)=S)C2=S Chemical compound CN(C(c1c2cccc1)=S)C2=S DORVZFVQNUHJNY-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N CN(CCC1)C1=O Chemical compound CN(CCC1)C1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- ITKKIAIATBKBEO-UHFFFAOYSA-N CN(CCS1)C1=O Chemical compound CN(CCS1)C1=O ITKKIAIATBKBEO-UHFFFAOYSA-N 0.000 description 1
- ZXZJJLXBVBPLEZ-UHFFFAOYSA-N CN(CCc1c2cccc1)C2=N Chemical compound CN(CCc1c2cccc1)C2=N ZXZJJLXBVBPLEZ-UHFFFAOYSA-N 0.000 description 1
- FOCZWAAXMRNTNY-UHFFFAOYSA-N CN(Cc(cccc1)c1O1)C1=O Chemical compound CN(Cc(cccc1)c1O1)C1=O FOCZWAAXMRNTNY-UHFFFAOYSA-N 0.000 description 1
- JHMBTUMIVBSJFS-UHFFFAOYSA-N CN(Cc1c2cccc1)C2=O Chemical compound CN(Cc1c2cccc1)C2=O JHMBTUMIVBSJFS-UHFFFAOYSA-N 0.000 description 1
- YETAFEXUUSHLCX-UHFFFAOYSA-N CN(c(cccc1)c1C(O1)=O)C1=N Chemical compound CN(c(cccc1)c1C(O1)=O)C1=N YETAFEXUUSHLCX-UHFFFAOYSA-N 0.000 description 1
- CDNHLXOFELOEOL-UHFFFAOYSA-N CN(c(cccc1)c1N1)C1=S Chemical compound CN(c(cccc1)c1N1)C1=S CDNHLXOFELOEOL-UHFFFAOYSA-N 0.000 description 1
- VYFQTZSQRZCAGR-UHFFFAOYSA-N CN(c(cccc1)c1S1)C1=N Chemical compound CN(c(cccc1)c1S1)C1=N VYFQTZSQRZCAGR-UHFFFAOYSA-N 0.000 description 1
- NELNEJVXXHYLSO-ARJAWSKDSA-N CN/C=C\NNC Chemical compound CN/C=C\NNC NELNEJVXXHYLSO-ARJAWSKDSA-N 0.000 description 1
- NUJXZSYQMRCPSE-UHFFFAOYSA-N CN1S[I]=NC1 Chemical compound CN1S[I]=NC1 NUJXZSYQMRCPSE-UHFFFAOYSA-N 0.000 description 1
- VJVOTXQQGNTUSX-UHFFFAOYSA-N CNC(N(C)C)=[U] Chemical compound CNC(N(C)C)=[U] VJVOTXQQGNTUSX-UHFFFAOYSA-N 0.000 description 1
- YIQUMUUNUABFRF-UHFFFAOYSA-N CNC(NC)=[U] Chemical compound CNC(NC)=[U] YIQUMUUNUABFRF-UHFFFAOYSA-N 0.000 description 1
- MWZDIEIXRBWPLG-UHFFFAOYSA-N C[n]1ncnc1 Chemical compound C[n]1ncnc1 MWZDIEIXRBWPLG-UHFFFAOYSA-N 0.000 description 1
- RUOGLHMRBURIEQ-UHFFFAOYSA-N Cc([n](C)nc1C)c1I Chemical compound Cc([n](C)nc1C)c1I RUOGLHMRBURIEQ-UHFFFAOYSA-N 0.000 description 1
- IFEXEVPFINMYJV-UHFFFAOYSA-N Cc(cc1)c[n]1N Chemical compound Cc(cc1)c[n]1N IFEXEVPFINMYJV-UHFFFAOYSA-N 0.000 description 1
- BDXJANJAHYKTMI-UHFFFAOYSA-N Cc1c(C)[nH]c(C)c1C Chemical compound Cc1c(C)[nH]c(C)c1C BDXJANJAHYKTMI-UHFFFAOYSA-N 0.000 description 1
- BAMPVSWRQZNDQC-UHFFFAOYSA-N Cc1c(C)[s]c(C)n1 Chemical compound Cc1c(C)[s]c(C)n1 BAMPVSWRQZNDQC-UHFFFAOYSA-N 0.000 description 1
- SEBRPHZZSLCDRQ-UHFFFAOYSA-N Cc1c[s]c2c1cccc2 Chemical compound Cc1c[s]c2c1cccc2 SEBRPHZZSLCDRQ-UHFFFAOYSA-N 0.000 description 1
- YUTQRQJTFPEEPB-UHFFFAOYSA-N Cc1c[s]nc1 Chemical compound Cc1c[s]nc1 YUTQRQJTFPEEPB-UHFFFAOYSA-N 0.000 description 1
- VQKFNUFAXTZWDK-UHFFFAOYSA-N Cc1ccc[o]1 Chemical compound Cc1ccc[o]1 VQKFNUFAXTZWDK-UHFFFAOYSA-N 0.000 description 1
- XQQBUAPQHNYYRS-UHFFFAOYSA-N Cc1ccc[s]1 Chemical compound Cc1ccc[s]1 XQQBUAPQHNYYRS-UHFFFAOYSA-N 0.000 description 1
- AGQOIYCTCOEHGR-UHFFFAOYSA-N Cc1ccn[o]1 Chemical compound Cc1ccn[o]1 AGQOIYCTCOEHGR-UHFFFAOYSA-N 0.000 description 1
- AIKUBOPKWKZULG-UHFFFAOYSA-N Cc1cnncc1 Chemical compound Cc1cnncc1 AIKUBOPKWKZULG-UHFFFAOYSA-N 0.000 description 1
- INSUSOZBMWJGDG-UHFFFAOYSA-N Cc1n[o]c(C)c1N Chemical compound Cc1n[o]c(C)c1N INSUSOZBMWJGDG-UHFFFAOYSA-N 0.000 description 1
- GAUKCDPSYQUYQL-UHFFFAOYSA-N Cc1n[o]c2c1cccc2 Chemical compound Cc1n[o]c2c1cccc2 GAUKCDPSYQUYQL-UHFFFAOYSA-N 0.000 description 1
- XYYXDARQOHWBPO-UHFFFAOYSA-N Cc1nc(C)n[nH]1 Chemical compound Cc1nc(C)n[nH]1 XYYXDARQOHWBPO-UHFFFAOYSA-N 0.000 description 1
- LDZYRENCLPUXAX-UHFFFAOYSA-N Cc1nc(cccc2)c2[nH]1 Chemical compound Cc1nc(cccc2)c2[nH]1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 description 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
- DJRVNXDTTXOZRZ-UHFFFAOYSA-N Cc1ncc(CN[IH]I)[n]1N Chemical compound Cc1ncc(CN[IH]I)[n]1N DJRVNXDTTXOZRZ-UHFFFAOYSA-N 0.000 description 1
- VZWOXDYRBDIHMA-UHFFFAOYSA-N Cc1ncc[s]1 Chemical compound Cc1ncc[s]1 VZWOXDYRBDIHMA-UHFFFAOYSA-N 0.000 description 1
- YIUOAAUFVBZQPM-UHFFFAOYSA-N Cc1ncncn1 Chemical compound Cc1ncncn1 YIUOAAUFVBZQPM-UHFFFAOYSA-N 0.000 description 1
- YVDWFZIVIIKYBQ-UHFFFAOYSA-N Cc1nnc(C)[o]1 Chemical compound Cc1nnc(C)[o]1 YVDWFZIVIIKYBQ-UHFFFAOYSA-N 0.000 description 1
- JXQGICFGPUAVLJ-UHFFFAOYSA-N Cc1nnc(C)[s]1 Chemical compound Cc1nnc(C)[s]1 JXQGICFGPUAVLJ-UHFFFAOYSA-N 0.000 description 1
- VJRHHVGPZXCQSS-UHFFFAOYSA-N Cc1nnc(NC)[s]1 Chemical compound Cc1nnc(NC)[s]1 VJRHHVGPZXCQSS-UHFFFAOYSA-N 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N O=C(CC1)NC1=O Chemical compound O=C(CC1)NC1=O KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- BLHSDXZNFGDHNB-UHFFFAOYSA-N O=C(CN1)NC1=[U] Chemical compound O=C(CN1)NC1=[U] BLHSDXZNFGDHNB-UHFFFAOYSA-N 0.000 description 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N O=C1NCCN1 Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 description 1
- HOBCFUWDNJPFHB-UHFFFAOYSA-N c1c[n](cccc2)c2c1 Chemical compound c1c[n](cccc2)c2c1 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 description 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N c1c[s]c2ccccc12 Chemical compound c1c[s]c2ccccc12 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424228P | 2010-12-17 | 2010-12-17 | |
| US61/424,228 | 2010-12-17 | ||
| PCT/US2011/064324 WO2012082580A2 (en) | 2010-12-17 | 2011-12-12 | Fungicidal azocyclic amides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014501246A JP2014501246A (ja) | 2014-01-20 |
| JP2014501246A5 true JP2014501246A5 (enExample) | 2015-01-15 |
Family
ID=45446208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544634A Pending JP2014501246A (ja) | 2010-12-17 | 2011-12-12 | 殺菌・殺カビ性アゾ環式アミド |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130261154A1 (enExample) |
| EP (1) | EP2651219A2 (enExample) |
| JP (1) | JP2014501246A (enExample) |
| KR (1) | KR20140017520A (enExample) |
| CN (1) | CN103384470A (enExample) |
| AU (1) | AU2011344161A1 (enExample) |
| BR (1) | BR112013015166A2 (enExample) |
| CL (1) | CL2013001722A1 (enExample) |
| MX (1) | MX2013006936A (enExample) |
| WO (1) | WO2012082580A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2358709B1 (en) * | 2008-12-02 | 2014-01-22 | E. I. du Pont de Nemours and Company | Fungicidal heterocyclic compounds |
| SG190856A1 (en) | 2010-12-17 | 2013-07-31 | Novartis Ag | Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine |
| SI2651902T1 (en) | 2010-12-17 | 2018-02-28 | Reata Pharmaceuticals, Inc. | Tricyclic pyrazolyl and pyrimidinylenones as antioxidant inflammatory modulators |
| BR112013019667B1 (pt) * | 2011-02-01 | 2019-07-02 | Bayer Intellectual Property Gmbh | Compostos derivados de heteroaril-piperidina e -piperazina, seus usos, composição, processos de produção de compostos e de composições, método para o controle de fungos fitopatogênicos prejudiciais |
| ES2661849T3 (es) | 2011-09-15 | 2018-04-04 | Bayer Intellectual Property Gmbh | Piperidinpirazoles como fungicidas |
| KR102015968B1 (ko) | 2011-12-27 | 2019-08-29 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로아릴피페리딘 및 피페라진 유도체 |
| CA2861020C (en) | 2012-02-02 | 2018-07-17 | Actelion Pharmaceuticals Ltd | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives and their use as cxcr3 receptor modulators |
| WO2013191866A1 (en) * | 2012-06-22 | 2013-12-27 | E. I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
| EP2801575A1 (en) | 2013-05-07 | 2014-11-12 | Bayer CropScience AG | Heteroaryldihydropyridine derivatives as fungicides |
| US9717243B2 (en) | 2013-06-24 | 2017-08-01 | Bayer Cropscience Aktiengesellschaft | Piperidinecarboxylic acid derivatives as fungicides |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US10259807B2 (en) | 2013-07-22 | 2019-04-16 | Idorsia Pharmaceuticals Ltd. | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
| US9924721B2 (en) | 2013-08-28 | 2018-03-27 | Bayer Cropscience Aktiengesellschaft | Malonic ester derivatives of heteroarylpiperidines and -piperazines as fungicides |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| TR201810510T4 (tr) * | 2014-03-24 | 2018-08-27 | Bayer Cropscience Ag | Fungisitler olarak fenilpiperidinkarboksamid deriveleri. |
| WO2016024350A1 (ja) | 2014-08-13 | 2016-02-18 | 株式会社エス・ディー・エス バイオテック | 縮合１１員環化合物及びそれらを含有する農園芸用殺菌剤 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| NZ734542A (en) | 2015-01-15 | 2023-02-24 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
| CN108601353B (zh) * | 2016-02-08 | 2024-04-05 | 高文作物保护公司 | 杀菌性组合物 |
| US11274076B2 (en) | 2016-02-08 | 2022-03-15 | Gowan Company, L.L.C. | Process for preparing 1, 2-benzenedimethanol compound |
| BR112019007605A2 (pt) * | 2016-10-14 | 2019-09-17 | Boehringer Ingelheim Animal Health Usa Inc | compostos pesticidas e parasiticidas de vinil isoxazolina |
| WO2019048988A1 (en) * | 2017-09-08 | 2019-03-14 | Pi Industries Ltd. | Novel fungidal heterocyclic compounds |
| MX2020002449A (es) | 2017-09-08 | 2020-11-06 | Pi Industries Ltd | Nuevos compuestos heterociclicos fungicidas. |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| EP4013750A1 (en) | 2019-08-14 | 2022-06-22 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| GEAP202516803A (en) | 2019-10-11 | 2025-10-10 | Incyte Corp | Bicyclic amines as cdk2 inhibitors |
| CN116675704A (zh) * | 2020-12-21 | 2023-09-01 | 深圳市祥根生物医药有限公司 | 一种吡咯衍生物及其制备方法和用途 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
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-
2011
- 2011-12-12 MX MX2013006936A patent/MX2013006936A/es unknown
- 2011-12-12 WO PCT/US2011/064324 patent/WO2012082580A2/en not_active Ceased
- 2011-12-12 JP JP2013544634A patent/JP2014501246A/ja active Pending
- 2011-12-12 CN CN2011800678071A patent/CN103384470A/zh active Pending
- 2011-12-12 AU AU2011344161A patent/AU2011344161A1/en not_active Abandoned
- 2011-12-12 EP EP11805311.5A patent/EP2651219A2/en not_active Withdrawn
- 2011-12-12 KR KR1020137018596A patent/KR20140017520A/ko not_active Withdrawn
- 2011-12-12 BR BR112013015166A patent/BR112013015166A2/pt not_active IP Right Cessation
- 2011-12-12 US US13/990,542 patent/US20130261154A1/en not_active Abandoned
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2013
- 2013-06-14 CL CL2013001722A patent/CL2013001722A1/es unknown