JP2014500002A5 - - Google Patents
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- JP2014500002A5 JP2014500002A5 JP2013529285A JP2013529285A JP2014500002A5 JP 2014500002 A5 JP2014500002 A5 JP 2014500002A5 JP 2013529285 A JP2013529285 A JP 2013529285A JP 2013529285 A JP2013529285 A JP 2013529285A JP 2014500002 A5 JP2014500002 A5 JP 2014500002A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tcr
- cancer
- isolated
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38493110P | 2010-09-21 | 2010-09-21 | |
| US61/384,931 | 2010-09-21 | ||
| PCT/US2011/051537 WO2012040012A1 (en) | 2010-09-21 | 2011-09-14 | Anti-ssx-2 t cell receptors and related materials and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017082965A Division JP2017158567A (ja) | 2010-09-21 | 2017-04-19 | 抗ｓｓｘ−２ ｔ細胞受容体及び関連材料並びに使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500002A JP2014500002A (ja) | 2014-01-09 |
| JP2014500002A5 true JP2014500002A5 (https=) | 2014-09-11 |
| JP6133209B2 JP6133209B2 (ja) | 2017-05-24 |
Family
ID=44720141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529285A Active JP6133209B2 (ja) | 2010-09-21 | 2011-09-14 | 抗ｓｓｘ−２ｔ細胞受容体及び関連材料並びに使用方法 |
| JP2017082965A Pending JP2017158567A (ja) | 2010-09-21 | 2017-04-19 | 抗ｓｓｘ−２ ｔ細胞受容体及び関連材料並びに使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017082965A Pending JP2017158567A (ja) | 2010-09-21 | 2017-04-19 | 抗ｓｓｘ−２ ｔ細胞受容体及び関連材料並びに使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9345748B2 (https=) |
| EP (2) | EP3533802B1 (https=) |
| JP (2) | JP6133209B2 (https=) |
| CN (1) | CN103124740B (https=) |
| AU (1) | AU2011305817B2 (https=) |
| CA (1) | CA2811788C (https=) |
| ES (2) | ES2876176T3 (https=) |
| IL (3) | IL225063A (https=) |
| PT (2) | PT3533802T (https=) |
| WO (1) | WO2012040012A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103124740B (zh) * | 2010-09-21 | 2015-09-02 | 美国卫生和人力服务部 | 抗-ssx-2t细胞受体和相关材料及使用方法 |
| BR112014010532A2 (pt) | 2011-11-03 | 2017-04-18 | Tolera Therapeutics Inc | anticorpo e métodos para inibição seletiva de respostas de célula-t |
| US20130273089A1 (en) | 2011-11-03 | 2013-10-17 | Tolera Therapeutics, Inc. | Antibody and methods for selective inhibition of t-cell responses |
| US10316289B2 (en) | 2012-09-06 | 2019-06-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing T memory stem cell populations |
| EP4282419A1 (en) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| ES2745472T3 (es) | 2013-07-15 | 2020-03-02 | The U S A As Represented By The Secretary Department Of Health And Human Services Office Of Tech Tra | Receptores de células T anti-virus del papiloma humano 16 E6 |
| WO2015113140A1 (en) * | 2014-01-29 | 2015-08-06 | University Health Network | Methods and compositions for producing a cell expressing a t cell receptor |
| US10526391B2 (en) | 2014-07-22 | 2020-01-07 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| EP3212774A4 (en) * | 2014-10-31 | 2018-04-11 | Baylor College of Medicine | Survivin specific t-cell receptor targeting tumor but not t cells |
| CA2964958A1 (en) * | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Methods and compositions for modified t cells |
| WO2017035251A1 (en) | 2015-08-25 | 2017-03-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cells modified to overexpress c-myb |
| CA2998270A1 (en) * | 2015-10-01 | 2017-04-06 | Ospedale San Raffaele S.R.L. | Tcr and uses thereof |
| WO2017070042A1 (en) | 2015-10-20 | 2017-04-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t cell populations using akt inhibitors |
| WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
| EP3439675A4 (en) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY |
| CA3021898A1 (en) * | 2016-04-26 | 2017-11-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-kk-lc-1 t cell receptors |
| WO2018057447A1 (en) | 2016-09-23 | 2018-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing an isolated population of dendritic cells and methods of treating cancer using same |
| KR20240007775A (ko) | 2016-12-08 | 2024-01-16 | 이매틱스 바이오테크놀로지스 게엠베하 | T 세포 수용체 및 이를 사용하는 면역 요법 |
| WO2018111981A1 (en) | 2016-12-13 | 2018-06-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing an isolated or purified population of thymic emigrant cells and methods of treatment using same |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| US20190359678A1 (en) | 2017-02-09 | 2019-11-28 | The Regents Of The University Of California | Chimeric t cell antigen receptors and methods of use thereof |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| KR20230166145A (ko) | 2017-03-15 | 2023-12-06 | 옥스포드 바이오메디카(유케이) 리미티드 | 방법 |
| WO2018226741A1 (en) | 2017-06-05 | 2018-12-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T-cells modified to overexpress phf19 |
| AU2018345400B2 (en) | 2017-10-05 | 2024-06-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for selectively expanding cells expressing a TCR with a murine constant region |
| WO2019069125A1 (en) | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | CHIMERIC ANTIGEN RECEPTORS |
| US20200316122A1 (en) | 2017-10-11 | 2020-10-08 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Methods of producing t cell populations using p38 mapk inhibitors |
| CR20200287A (es) * | 2017-12-04 | 2020-11-11 | Us Health | Receptores de células t restringidos a antígeno leucocitario humano (hla) clase i contra sarcoma de rata (ras) mutado |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| US12312416B2 (en) | 2018-02-06 | 2025-05-27 | Seattle Children's Hospital | Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors |
| EP3749770B9 (en) | 2018-02-09 | 2025-12-17 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Tethered interleukin-15 and interleukin-21 |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| WO2019204683A1 (en) * | 2018-04-19 | 2019-10-24 | Board Of Regents, The University Of Texas System | T cell receptors with mage-b2 specificity and uses thereof |
| CN112262212B (zh) | 2018-04-24 | 2024-07-12 | 美国卫生和人力服务部 | 使用羟基柠檬酸和/或其盐产生t细胞群体的方法 |
| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| CN110950949B (zh) * | 2018-09-26 | 2022-04-05 | 香雪生命科学技术（广东）有限公司 | 一种识别ssx2抗原的t细胞受体 |
| AU2020298326A1 (en) * | 2019-06-21 | 2022-01-27 | Children's National Medical Center | Methods and composition for a binding molecule targeting cancer cells expressing SSX2 peptide 41-49 in HLA-A*0201 context |
| WO2020263399A1 (en) | 2019-06-26 | 2020-12-30 | Massachusetts Institute Of Technology | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
| WO2021016887A1 (zh) * | 2019-07-30 | 2021-02-04 | 广东香雪精准医疗技术有限公司 | 识别ssx2抗原短肽的t细胞受体 |
| CN112409474B (zh) * | 2019-08-23 | 2023-02-28 | 香雪生命科学技术（广东）有限公司 | 一种识别ssx2抗原的高亲和力tcr |
| CN112442119B (zh) * | 2019-09-05 | 2023-02-24 | 香雪生命科学技术（广东）有限公司 | 一种识别ssx2的高亲和力t细胞受体 |
| WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
| CN115210252A (zh) | 2020-02-04 | 2022-10-18 | 西雅图儿童医院（Dba西雅图儿童研究所） | 抗二硝基苯酚的嵌合抗原受体 |
| JP2023517063A (ja) | 2020-03-10 | 2023-04-21 | マサチューセッツ インスティテュート オブ テクノロジー | 操作されたメモリー様ｎｋ細胞を作製するための方法およびその組成物 |
| US20210340524A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
| US12433954B2 (en) | 2020-05-01 | 2025-10-07 | Massachusetts Institute Of Technology | Methods of activating anti-CD19 chimeric antigen receptor (CAR) T cells using amphiphilic ligand conjugates comprising CAR-targeting protein sequence motifs |
| WO2022055946A1 (en) | 2020-09-08 | 2022-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell phenotypes associated with response to adoptive cell therapy |
| US20240018210A1 (en) | 2020-11-13 | 2024-01-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Enhanced antigen reactivity of immune cells expressing a mutant non-signaling cd3 zeta chain |
| AU2021386370A1 (en) | 2020-11-24 | 2023-06-22 | Lyell Immunopharma, Inc. | Methods for making, compositions comprising, and methods of using rejuvenated t cells |
| CN115819555A (zh) * | 2021-09-17 | 2023-03-21 | 香雪生命科学技术（广东）有限公司 | 一种识别ssx2的高亲和力tcr |
| US20250057949A1 (en) | 2021-12-31 | 2025-02-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | T cell therapy with vaccination as a combination immunotherapy against cancer |
| WO2025160480A1 (en) | 2024-01-26 | 2025-07-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Enhanced tumor reactivity of t cells lacking sit1, lax1, or trat1 |
| WO2025250587A1 (en) | 2024-05-29 | 2025-12-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Drug-regulatable, inducible cytokine expression |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| IN165717B (https=) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤 |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| WO2001058479A1 (en) | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| AU2003270311A1 (en) * | 2002-09-06 | 2004-03-29 | Mannkind Corporation | Epitope sequences |
| AU2004235395A1 (en) * | 2003-04-29 | 2004-11-11 | Wyeth | Methods for prognosis and treatment of solid tumors |
| ATE496129T1 (de) | 2003-07-22 | 2011-02-15 | Ludwig Inst Cancer Res | Von hla-klasse-ii-molekülen präsentierte ssx-2- peptide |
| CN101001868A (zh) | 2004-06-17 | 2007-07-18 | 曼康公司 | 表位类似物 |
| CA2571168A1 (en) | 2004-06-17 | 2006-01-26 | Mannkind Corporation | Mhc i-binding ssx-241-49 variants |
| NZ564359A (en) * | 2005-06-17 | 2011-09-30 | Mannkind Corp | Analogs of pepetides corresponding to class I MHC-restricted T cell epitopes |
| CA2651174A1 (en) * | 2006-05-03 | 2007-11-15 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| WO2008039694A2 (en) * | 2006-09-26 | 2008-04-03 | St. Jude Children's Research Hospital | Methods and compositions for monitoring t cell receptor diversity |
| WO2010088160A1 (en) * | 2009-01-28 | 2010-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| CN103124740B (zh) * | 2010-09-21 | 2015-09-02 | 美国卫生和人力服务部 | 抗-ssx-2t细胞受体和相关材料及使用方法 |
-
2011
- 2011-09-14 CN CN201180045492.0A patent/CN103124740B/zh active Active
- 2011-09-14 EP EP19166061.2A patent/EP3533802B1/en active Active
- 2011-09-14 EP EP11763819.7A patent/EP2619223B1/en active Active
- 2011-09-14 WO PCT/US2011/051537 patent/WO2012040012A1/en not_active Ceased
- 2011-09-14 IL IL225063A patent/IL225063A/en active IP Right Grant
- 2011-09-14 CA CA2811788A patent/CA2811788C/en active Active
- 2011-09-14 US US13/820,802 patent/US9345748B2/en active Active
- 2011-09-14 ES ES19166061T patent/ES2876176T3/es active Active
- 2011-09-14 PT PT191660612T patent/PT3533802T/pt unknown
- 2011-09-14 PT PT11763819T patent/PT2619223T/pt unknown
- 2011-09-14 ES ES11763819T patent/ES2734889T3/es active Active
- 2011-09-14 AU AU2011305817A patent/AU2011305817B2/en active Active
- 2011-09-14 JP JP2013529285A patent/JP6133209B2/ja active Active
-
2016
- 2016-04-19 US US15/132,863 patent/US10143724B2/en active Active
-
2017
- 2017-04-19 JP JP2017082965A patent/JP2017158567A/ja active Pending
- 2017-09-13 IL IL254469A patent/IL254469B/en active IP Right Grant
-
2018
- 2018-10-29 US US16/173,701 patent/US10864252B2/en active Active
-
2019
- 2019-11-28 IL IL271021A patent/IL271021B/en unknown
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