JP2014196354A5 - - Google Patents
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- JP2014196354A5 JP2014196354A5 JP2014145146A JP2014145146A JP2014196354A5 JP 2014196354 A5 JP2014196354 A5 JP 2014196354A5 JP 2014145146 A JP2014145146 A JP 2014145146A JP 2014145146 A JP2014145146 A JP 2014145146A JP 2014196354 A5 JP2014196354 A5 JP 2014196354A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- mesenchymal stem
- stem cells
- defect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 11
- 210000001258 synovial membrane Anatomy 0.000 claims 9
- 230000007547 defect Effects 0.000 claims 8
- 206010061762 Chondropathy Diseases 0.000 claims 5
- 230000005499 meniscus Effects 0.000 claims 5
- 210000000845 cartilage Anatomy 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 208000003947 Knee Osteoarthritis Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 206010031264 Osteonecrosis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 210000002449 bone cell Anatomy 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000000968 fibrocartilage Anatomy 0.000 claims 1
- 210000003035 hyaline cartilage Anatomy 0.000 claims 1
- 210000003559 hypertrophic chondrocyte Anatomy 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82313806P | 2006-08-22 | 2006-08-22 | |
| US60/823,138 | 2006-08-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525260A Division JP5656183B2 (ja) | 2006-08-22 | 2007-08-22 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014196354A JP2014196354A (ja) | 2014-10-16 |
| JP2014196354A5 true JP2014196354A5 (https=) | 2015-03-05 |
| JP5928961B2 JP5928961B2 (ja) | 2016-06-01 |
Family
ID=39106908
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525260A Active JP5656183B2 (ja) | 2006-08-22 | 2007-08-22 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
| JP2014145146A Active JP5928961B2 (ja) | 2006-08-22 | 2014-07-15 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525260A Active JP5656183B2 (ja) | 2006-08-22 | 2007-08-22 | 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20100178274A1 (https=) |
| JP (2) | JP5656183B2 (https=) |
| WO (1) | WO2008023829A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| JP5843189B2 (ja) * | 2011-03-15 | 2016-01-13 | 国立大学法人名古屋大学 | Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物 |
| WO2014110590A1 (en) * | 2013-01-14 | 2014-07-17 | Scripps Health | Tissue array printing |
| WO2015016357A1 (ja) * | 2013-08-01 | 2015-02-05 | 株式会社ツーセル | 軟骨損傷治療剤及びその製造方法 |
| EP3116557B1 (en) | 2014-03-14 | 2020-03-11 | Scripps Health | Electrospinning of cartilage and meniscus matrix polymers |
| KR101641770B1 (ko) * | 2014-06-23 | 2016-07-22 | 씨제이제일제당 (주) | O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법 |
| CN104357385A (zh) * | 2014-11-17 | 2015-02-18 | 四川大学华西医院 | 一种半月板组织来源的间充质干细胞及其制备方法和鉴定 |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| EP3463169B1 (en) | 2016-05-26 | 2023-07-19 | Scripps Health | Systems to repair tissue defects |
| JP6945242B2 (ja) * | 2017-01-13 | 2021-10-06 | 東京都公立大学法人 | 新規組織再生材料およびその製造方法 |
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| CN113454206A (zh) * | 2018-09-28 | 2021-09-28 | 希拉生物股份有限公司 | 滑膜来源间充质干细胞及其用途 |
| US12569517B2 (en) | 2019-02-07 | 2026-03-10 | Direct Biologics, Llc | Method for treating osteoarthritis with mesenchymal stem cell exosomes |
| US20220160779A1 (en) * | 2019-03-26 | 2022-05-26 | National University Corporation Tokyo Medical And Dental University | Composition for promoting cartilage tissue regeneration |
| US12213995B2 (en) | 2019-07-18 | 2025-02-04 | Direct Biologics, Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| JP6864303B1 (ja) * | 2020-07-03 | 2021-04-28 | 富士フイルム株式会社 | 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法 |
| JP6864302B1 (ja) * | 2020-07-03 | 2021-04-28 | 富士フイルム株式会社 | 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法 |
| AU2021355738B2 (en) * | 2020-10-07 | 2025-05-08 | Fujifilm Corporation | Method for producing cell formulation for joint treatment, cell formulation for joint treatment, and method for culturing mesenchymal stem cells |
| EP4292599A4 (en) * | 2021-03-12 | 2024-09-11 | FUJIFILM Corporation | PROCESS FOR PRODUCING THERAPEUTIC AGENT FOR ARTHROPATHY, AND THERAPEUTIC AGENT FOR ARTHROPATHY |
| TW202307203A (zh) | 2021-07-15 | 2023-02-16 | 日商富士軟片股份有限公司 | 特定細胞的品質管理方法及製造特定細胞之方法 |
| WO2023286305A1 (ja) | 2021-07-15 | 2023-01-19 | 富士フイルム株式会社 | 細胞の品質管理方法及び細胞を製造する方法 |
| AU2022339157A1 (en) * | 2021-08-31 | 2024-03-14 | Fujifilm Corporation | Therapeutic agent for arthropathy, and method for producing therapeutic agent for arthropathy |
| TW202407315A (zh) | 2022-06-24 | 2024-02-16 | 日商富士軟片股份有限公司 | 用以提供細胞產品的系統 |
| TW202603160A (zh) * | 2024-03-29 | 2026-01-16 | 日商富士軟片股份有限公司 | 滑膜來源間質幹細胞、其製造方法、及其利用 |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| CN119235920B (zh) * | 2024-12-06 | 2025-06-24 | 浙江大学 | 一种用于关节软骨损伤修复的mfap5阳性滑膜衬里层干细胞及其鉴定方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002247044B2 (en) * | 2001-01-30 | 2006-11-16 | Orthogene, Inc. | Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells |
| JP2003199816A (ja) * | 2002-01-10 | 2003-07-15 | Takehisa Matsuda | 軟骨組織再生用補助材、軟骨組織再生用キット及び軟骨組織再生方法 |
| WO2005001080A2 (en) * | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
-
2007
- 2007-08-22 JP JP2009525260A patent/JP5656183B2/ja active Active
- 2007-08-22 US US12/438,298 patent/US20100178274A1/en not_active Abandoned
- 2007-08-22 WO PCT/JP2007/066708 patent/WO2008023829A1/en not_active Ceased
-
2014
- 2014-07-15 JP JP2014145146A patent/JP5928961B2/ja active Active
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