JP5656183B2 - 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 - Google Patents

滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 Download PDF

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JP5656183B2
JP5656183B2 JP2009525260A JP2009525260A JP5656183B2 JP 5656183 B2 JP5656183 B2 JP 5656183B2 JP 2009525260 A JP2009525260 A JP 2009525260A JP 2009525260 A JP2009525260 A JP 2009525260A JP 5656183 B2 JP5656183 B2 JP 5656183B2
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mesenchymal stem
stem cells
cartilage
defect
cells
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JP2010501547A (ja
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一郎 関矢
一郎 関矢
宗田　大
大 宗田
森尾　友宏
友宏 森尾
清水　則夫
則夫 清水
黒岩　保幸
保幸 黒岩
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Tokyo Medical and Dental University NUC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Developmental Biology & Embryology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2009525260A 2006-08-22 2007-08-22 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用 Active JP5656183B2 (ja)

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US82313806P 2006-08-22 2006-08-22
US60/823,138 2006-08-22
PCT/JP2007/066708 WO2008023829A1 (en) 2006-08-22 2007-08-22 Application of synovium-derived mesenchymal stem cells (mscs) for cartilage or meniscus regeneration

Related Child Applications (1)

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JP2014145146A Division JP5928961B2 (ja) 2006-08-22 2014-07-15 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用

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JP2010501547A5 JP2010501547A5 (https=) 2010-10-07
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JP2014145146A Active JP5928961B2 (ja) 2006-08-22 2014-07-15 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022004879A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
WO2022004878A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
WO2022075294A1 (ja) 2020-10-07 2022-04-14 富士フイルム株式会社 関節治療用細胞製剤の製造方法、関節治療用細胞製剤および間葉系幹細胞の培養方法
WO2023286819A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 特定細胞の品質管理方法及び特定細胞を製造する方法
WO2023286305A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 細胞の品質管理方法及び細胞を製造する方法
WO2023032945A1 (ja) 2021-08-31 2023-03-09 富士フイルム株式会社 関節症治療剤、及び関節症治療剤の製造方法
WO2023249104A1 (ja) 2022-06-24 2023-12-28 富士フイルム株式会社 細胞製品を提供するためのシステム
WO2025206252A1 (ja) * 2024-03-29 2025-10-02 富士フイルム株式会社 滑膜由来間葉系幹細胞、その製造方法、およびその利用

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US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
JP5843189B2 (ja) * 2011-03-15 2016-01-13 国立大学法人名古屋大学 Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物
WO2014110590A1 (en) * 2013-01-14 2014-07-17 Scripps Health Tissue array printing
WO2015016357A1 (ja) * 2013-08-01 2015-02-05 株式会社ツーセル 軟骨損傷治療剤及びその製造方法
EP3116557B1 (en) 2014-03-14 2020-03-11 Scripps Health Electrospinning of cartilage and meniscus matrix polymers
KR101641770B1 (ko) * 2014-06-23 2016-07-22 씨제이제일제당 (주) O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법
CN104357385A (zh) * 2014-11-17 2015-02-18 四川大学华西医院 一种半月板组织来源的间充质干细胞及其制备方法和鉴定
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
EP3463169B1 (en) 2016-05-26 2023-07-19 Scripps Health Systems to repair tissue defects
JP6945242B2 (ja) * 2017-01-13 2021-10-06 東京都公立大学法人 新規組織再生材料およびその製造方法
EP3801028A4 (en) 2018-05-30 2022-04-13 Direct Biologics LLC A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use
CN113454206A (zh) * 2018-09-28 2021-09-28 希拉生物股份有限公司 滑膜来源间充质干细胞及其用途
US12569517B2 (en) 2019-02-07 2026-03-10 Direct Biologics, Llc Method for treating osteoarthritis with mesenchymal stem cell exosomes
US20220160779A1 (en) * 2019-03-26 2022-05-26 National University Corporation Tokyo Medical And Dental University Composition for promoting cartilage tissue regeneration
US12213995B2 (en) 2019-07-18 2025-02-04 Direct Biologics, Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
KR20230004709A (ko) 2020-04-22 2023-01-06 다이렉트 바이오로직스 엘엘씨 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물
EP4292599A4 (en) * 2021-03-12 2024-09-11 FUJIFILM Corporation PROCESS FOR PRODUCING THERAPEUTIC AGENT FOR ARTHROPATHY, AND THERAPEUTIC AGENT FOR ARTHROPATHY
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles
CN119235920B (zh) * 2024-12-06 2025-06-24 浙江大学 一种用于关节软骨损伤修复的mfap5阳性滑膜衬里层干细胞及其鉴定方法

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AU2002247044B2 (en) * 2001-01-30 2006-11-16 Orthogene, Inc. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
JP2003199816A (ja) * 2002-01-10 2003-07-15 Takehisa Matsuda 軟骨組織再生用補助材、軟骨組織再生用キット及び軟骨組織再生方法
WO2005001080A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system

Cited By (11)

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Publication number Priority date Publication date Assignee Title
WO2022004879A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
WO2022004878A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
KR20230025801A (ko) 2020-07-03 2023-02-23 후지필름 가부시키가이샤 활막 유래 간엽계 줄기 세포의 제조 방법 및 관절 치료용 세포 제제의 제조 방법
KR20230025800A (ko) 2020-07-03 2023-02-23 후지필름 가부시키가이샤 활막 유래 간엽계 줄기 세포의 제조 방법 및 관절 치료용 세포 제제의 제조 방법
WO2022075294A1 (ja) 2020-10-07 2022-04-14 富士フイルム株式会社 関節治療用細胞製剤の製造方法、関節治療用細胞製剤および間葉系幹細胞の培養方法
KR20230058721A (ko) 2020-10-07 2023-05-03 후지필름 가부시키가이샤 관절 치료용 세포 제제의 제조 방법, 관절 치료용 세포 제제 및 간엽계 줄기세포의 배양 방법
WO2023286819A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 特定細胞の品質管理方法及び特定細胞を製造する方法
WO2023286305A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 細胞の品質管理方法及び細胞を製造する方法
WO2023032945A1 (ja) 2021-08-31 2023-03-09 富士フイルム株式会社 関節症治療剤、及び関節症治療剤の製造方法
WO2023249104A1 (ja) 2022-06-24 2023-12-28 富士フイルム株式会社 細胞製品を提供するためのシステム
WO2025206252A1 (ja) * 2024-03-29 2025-10-02 富士フイルム株式会社 滑膜由来間葉系幹細胞、その製造方法、およびその利用

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JP5928961B2 (ja) 2016-06-01
JP2010501547A (ja) 2010-01-21
US20100178274A1 (en) 2010-07-15
WO2008023829A1 (en) 2008-02-28

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