JP2014185170A5 - - Google Patents
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- Publication number
- JP2014185170A5 JP2014185170A5 JP2014125633A JP2014125633A JP2014185170A5 JP 2014185170 A5 JP2014185170 A5 JP 2014185170A5 JP 2014125633 A JP2014125633 A JP 2014125633A JP 2014125633 A JP2014125633 A JP 2014125633A JP 2014185170 A5 JP2014185170 A5 JP 2014185170A5
- Authority
- JP
- Japan
- Prior art keywords
- sirt1
- sirtuin
- agents
- activator
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100031455 NAD-dependent protein deacetylase sirtuin-1 Human genes 0.000 claims 31
- 108010041191 Sirtuin 1 Proteins 0.000 claims 31
- 239000012190 activator Substances 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 229920005610 lignin Polymers 0.000 claims 11
- 229930182470 glycoside Natural products 0.000 claims 9
- 150000002338 glycosides Chemical class 0.000 claims 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 8
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 8
- 108010017842 Telomerase Proteins 0.000 claims 8
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 claims 8
- 239000004480 active ingredient Substances 0.000 claims 7
- 239000002246 antineoplastic agent Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000003096 antiparasitic agent Substances 0.000 claims 5
- 229940125687 antiparasitic agent Drugs 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 229920002770 condensed tannin Polymers 0.000 claims 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 4
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 4
- 229930003268 Vitamin C Natural products 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 4
- 235000013305 food Nutrition 0.000 claims 4
- 230000000091 immunopotentiator Effects 0.000 claims 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 4
- 229960001285 quercetin Drugs 0.000 claims 4
- 235000005875 quercetin Nutrition 0.000 claims 4
- 235000019154 vitamin C Nutrition 0.000 claims 4
- 239000011718 vitamin C Substances 0.000 claims 4
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical group C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 235000021283 resveratrol Nutrition 0.000 claims 3
- 229940016667 resveratrol Drugs 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241001236215 Pinus parviflora Species 0.000 claims 2
- BFPLMTPHDFFMTG-UHFFFAOYSA-N [1,3]oxazolo[5,4-b]pyridine Chemical compound C1=CN=C2OC=NC2=C1 BFPLMTPHDFFMTG-UHFFFAOYSA-N 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- IASPBORHOMBZMY-UHFFFAOYSA-N srt1720 Chemical compound C=1N=C2C=CC=CC2=NC=1C(=O)NC1=CC=CC=C1C(N=C1SC=2)=CN1C=2CN1CCNCC1 IASPBORHOMBZMY-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims 1
- 235000011613 Pinus brutia Nutrition 0.000 claims 1
- 241000018646 Pinus brutia Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- -1 immunopotentiators Substances 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 201000010901 lateral sclerosis Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014125633A JP5933633B2 (ja) | 2014-06-18 | 2014-06-18 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤及びテロメラーゼ逆転写酵素（ｔｅｒｔ）遺伝子活性化剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014125633A JP5933633B2 (ja) | 2014-06-18 | 2014-06-18 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤及びテロメラーゼ逆転写酵素（ｔｅｒｔ）遺伝子活性化剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011259573A Division JP5608629B2 (ja) | 2011-11-28 | 2011-11-28 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤及びテロメラーゼ逆転写酵素（ｔｅｒｔ）遺伝子活性化剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014185170A JP2014185170A (ja) | 2014-10-02 |
| JP2014185170A5 true JP2014185170A5 (https=) | 2015-01-29 |
| JP5933633B2 JP5933633B2 (ja) | 2016-06-15 |
Family
ID=51833061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125633A Active JP5933633B2 (ja) | 2014-06-18 | 2014-06-18 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤及びテロメラーゼ逆転写酵素（ｔｅｒｔ）遺伝子活性化剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5933633B2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822152B (zh) * | 2016-12-28 | 2019-12-13 | 哈尔滨珍宝制药有限公司 | 一种药物组合物及其应用 |
| CN110343045B (zh) * | 2019-08-13 | 2021-11-12 | 中国科学院成都生物研究所 | 芳基四氢萘型木脂素类化合物及制备和应用 |
| US20240033303A1 (en) * | 2020-12-08 | 2024-02-01 | Md Healthcare Inc. | Composition for preventing or treating neurological diseases or psychiatric diseases comprising vesicles derived from sphingomonas bacteria |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2784605B2 (ja) * | 1990-04-28 | 1998-08-06 | 靖一 田沼 | リグニン配糖体およびその用途 |
| JP2010540444A (ja) * | 2007-09-20 | 2010-12-24 | レスベラトロル パートナーズ， エルエルシー | 遺伝子産物の濃縮または活性を調節するためのレスベラトロールを含む組成物 |
-
2014
- 2014-06-18 JP JP2014125633A patent/JP5933633B2/ja active Active
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