JP2014144922A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014144922A5 JP2014144922A5 JP2013012868A JP2013012868A JP2014144922A5 JP 2014144922 A5 JP2014144922 A5 JP 2014144922A5 JP 2013012868 A JP2013012868 A JP 2013012868A JP 2013012868 A JP2013012868 A JP 2013012868A JP 2014144922 A5 JP2014144922 A5 JP 2014144922A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- alkyl group
- optionally substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 102100028704 Acetyl-CoA acetyltransferase, cytosolic Human genes 0.000 claims 2
- 101000837584 Homo sapiens Acetyl-CoA acetyltransferase, cytosolic Proteins 0.000 claims 2
- 101000642613 Homo sapiens Sterol O-acyltransferase 2 Proteins 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013012868A JP2014144922A (ja) | 2013-01-28 | 2013-01-28 | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013012868A JP2014144922A (ja) | 2013-01-28 | 2013-01-28 | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014144922A JP2014144922A (ja) | 2014-08-14 |
| JP2014144922A5 true JP2014144922A5 (https=) | 2016-06-09 |
Family
ID=51425484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013012868A Pending JP2014144922A (ja) | 2013-01-28 | 2013-01-28 | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2014144922A (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5946100B2 (ja) | 2014-06-24 | 2016-07-05 | 学校法人北里研究所 | コレステロールアシル転移酵素アイソザイム２（ａｃａｔ２）阻害活性を有する新規医薬化合物 |
| CN106032383B (zh) * | 2015-03-19 | 2019-08-13 | 中国科学院上海药物研究所 | 一类三环类似物、其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08269063A (ja) * | 1995-03-28 | 1996-10-15 | Kitasato Inst:The | ピリピロペン誘導体 |
| JPH08269065A (ja) * | 1995-04-03 | 1996-10-15 | Kitasato Inst:The | ピリピロペン誘導体 |
| US8519128B2 (en) * | 2007-12-25 | 2013-08-27 | The Kitasato Institute | Pyripyropene derivatives having an ACAT2-inhibiting activity |
| JP5554330B2 (ja) * | 2009-06-23 | 2014-07-23 | 学校法人北里研究所 | Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体 |
| CA2795064A1 (en) * | 2010-03-31 | 2011-10-06 | School Juridical Person Kitasato Institute | Pyripyropene derivative having acat2 inhibiting activity and stable to metabolizing enzymes |
-
2013
- 2013-01-28 JP JP2013012868A patent/JP2014144922A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015001571A (es) | Compuestos de anillo en puente como inhibidores del virus de la hepatitis c (hcv) y sus aplicaciones farmaceuticas. | |
| JP2016514159A5 (https=) | ||
| JP2016503793A5 (https=) | ||
| PH12016500169A1 (en) | Polymorph of syk inhibitors | |
| EA201390880A1 (ru) | Имидазопиридины в качестве противовирусных средств против респираторно-синцитиального вируса | |
| JP2015537020A5 (https=) | ||
| JP2014500861A5 (https=) | ||
| MD20180040A2 (ro) | Inhibitori ai virusului hepatic C | |
| EP4643945A3 (en) | Neuroactive steroids and methods of use thereof | |
| JP2013532687A5 (https=) | ||
| JP2014508811A5 (https=) | ||
| JP2017514910A5 (https=) | ||
| JP2011105738A5 (https=) | ||
| TN2017000075A1 (en) | Compounds and compositions as raf kinase inhibitors | |
| JP2012092103A5 (https=) | ||
| MX2013011551A (es) | Compuestos y derivados hetero - biciclicos n - sustituidos para combatir las pestes en animales. | |
| JP2016518317A5 (https=) | ||
| CN105358522A8 (en) | Ester derivatives of androgen receptor modulators and methods for their use | |
| JP2016505614A5 (https=) | ||
| AR081426A1 (es) | Derivados de pirazol inhibidores del receptor sigma | |
| JP2013532130A5 (https=) | ||
| AR085088A1 (es) | Inhibidores de histona desacetilasa y composiciones farmaceuticas que los contienen | |
| MX2016007861A (es) | Compuestos de ácido dimetilbenzoico. | |
| EP4582424A3 (en) | 1,2-naphthoquinone derivative and method for preparing same | |
| JP2012512863A5 (https=) |