JP2014129337A - Moisturizing agent and external preparation including moisturizing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a moisturizing agent with extremely high moisture retention and an external preparation including the moisturizing agent.SOLUTION: The moisturizing agent includes collagen, and a hyaluronic acid or/and a salt thereof, and trimethylglycine, and the compounding ratio (wt. ratio) of the hyaluronic acid or/and a salt thereof is 0.5-3 and that of the trimethylglycine is 0.5-6 when the collagen is 1. Or the external preparation including this moisturizing agent is disclosed. Further, it was found that the combination of a collagen, a hyaluronic acid or/and a salt thereof, and a trimethylglycine in equivalent amounts shows the highest effect.

Description

  The present invention relates to a moisturizing agent having a very high moisturizing property and an external preparation containing the moisturizing agent.

Skin preparations such as cosmetics have various necessary effects such as a whitening effect and wrinkle prevention, but moisturizing properties are required as a basic function.
In order to provide moisture retention, a moisturizer is blended in a skin external preparation such as cosmetics.
There are numerous types of moisturizers. For example, polyhydric alcohols such as maltitol, sorbitol, glycerin, propylene glycol, 1,3-butylene glycol, pyrrolidone carboxylic acid and salts thereof, lactic acid and salts thereof , Organic acids such as citric acid and salts thereof and salts thereof, hyaluronic acid and salts thereof, water-soluble proteins such as collagen, elastin, keratin and sericin, collagen hydrolysates, casein hydrolysates, silk hydrolysates, polyasparagine Peptides such as sodium acid and salts thereof, trehalose, xylobiose, maltose, sucrose, glucose, saccharides and polysaccharides such as vegetable viscous polysaccharides and their derivatives, water-soluble chitin, chitosan, pectin, chondroitin sulfate and salts thereof, etc. Glycosaminoglycans and their salts, glyc Emissions, serine, threonine, alanine, aspartic acid, tyrosine, valine, leucine, arginine, glutamine, amino acids such as proline acid, trimethylglycine, urea, and the like.
Among these, one or more types are selected and used, but blending a plurality of humectants is routinely performed.
As an example, collagen, hyaluronic acid or / and its salt, and a polyhydric alcohol combination can be mentioned.

JP, 2011-042589, A

  An object of the present invention is to obtain an unprecedented moisturizing preparation by combining humectants or limiting the ratio (weight ratio).

As a result of intensive studies by the present inventors, it has been found that a specific ratio of the combination of collagen, hyaluronic acid or / and salt thereof, and trimethylglycine can achieve the above-mentioned purpose.
As the collagen, one type or two or more types selected from the group consisting of collagen and its solubilized product, hydrolyzate, and modified product are used.
The collagen used in the present invention is water-soluble collagen.
Water-soluble extract obtained from bovine and porcine skin, bone marrow tissue, placenta, fish skin such as tuna, cod, salmon, etc., animal tissue such as fish scales, sea bass, etc. with water, ethanol or a mixed solvent thereof, sodium chloride aqueous solution Examples of atelocollagen and hydrolyzate obtained by removing collagen and telopeptide with an enzyme include collagen hydrolyzate obtained by hydrolyzing animal tissue with acid, alkali, enzyme, or a combination thereof. Examples of the modified product include succinylated products of atelocollagen, alkyl or alkenyl esters such as ethyl ester and hexadecyl ester of the hydrolyzate of collagen, and the like.
Among these, a collagen hydrolyzate and succinyl atelocollagen have high utility value, and in particular, a collagen hydrolyzate met the gist of the present invention.
One or more of these collagens are used.

As hyaluronic acid, natural hyaluronic acid derived from animals isolated from chicken crowns, umbilical cords, etc. can be used, or biohyaluronic acid produced by fermentation technology using microorganisms such as lactic acid bacteria and streptococci can be used. it can. The molecular weight is not particularly limited. It can also be blended as a salt, such as an alkali metal salt (sodium salt, lithium salt, potassium salt, etc.), an alkaline earth metal salt, a salt with an inorganic base such as an ammonium salt, a diethanolamine salt, a cyclohexylamine salt, Examples thereof include salts with organic bases such as amino acid salts.
The molecular weight is not particularly limited, and is usually selected from a range of several thousand to several million (for example, 5 million) weight average molecular weight. Also, acetylated hyaluronic acid can be used.
One or more of these hyaluronic acids or salts thereof are used.
Trimethylglycine is an organic compound having a structure in which the nitrogen of glycine is methylated to the form of quaternary ammonium. It exists in many organisms and is also contained in foods such as vegetables and mushrooms. In particular, it is contained in a large amount in beet (sugar beet) and extracted from sugar beet molasses.

By blending this collagen, hyaluronic acid or / and a salt thereof, and trimethylglycine, a result that greatly exceeds the moisturizing property of each was obtained.
The compounding ratio is such that when the collagen is 1, a synergistic effect is obtained when hyaluronic acid or / and a salt thereof is added 0.5-3 and trimethylglycine 0.5-6, As a result of studies by the semi-inventors, it was found that the effect was most strong when equal amounts of collagen, hyaluronic acid or / and salt thereof, and trimethylglycine were combined. (All weight ratios)

Besides this, there is no problem adding a moisturizer. Among them, when polyhydric alcohol is further added to these three raw materials, the moisture retention becomes high.
Examples of polyhydric alcohols include ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene. Examples include glycol, 1,3-butylene glycol, glycerin, diglycerin, and pentaerythritol.
Among these, 1,3-butylene glycol and glycerin were optimal for the purpose of moisturizing.

  In addition to the above components, surfactants, oily components, moisturizers, polymer compounds, ultraviolet absorbers, anti-inflammatory agents, antibacterial agents, antioxidants, sequestering metal ions used in various pharmaceutical and cosmetic preparations. Additives, preservatives, vitamins, pigments, fragrances, water, etc. can be blended, and the necessary moisturizer or external preparation can be obtained.

  As the surfactant, any of anionic, cationic, nonionic, natural, and synthetic surfactants can be used, but it is preferable to use a nonionic surfactant in consideration of irritation to the skin. Examples of the nonionic surfactant include glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene glycol. , Polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, alkylglycoside and the like.

  Examples of the oil component include fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils, silicone oils, and the like. Examples of the fats and oils include soybean oil, nutka oil, jojoba oil, avocado oil, almond oil, olive oil, cacao oil, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef fat, pork fat and the like, and these Hardened oil obtained by hydrogenation of natural fats and oils and synthetic triglycerides such as myristic acid glyceride and 2-ethylhexanoic acid triglyceride; waxes include, for example, carnauba wax, whale wax, beeswax, lanolin and the like; hydrocarbons For example, liquid paraffin, petrolatum, paraffin microcrystalline wax, ceresin, squalane, bristan etc .; higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, Linolenic acid, lanolinic acid, isostearic acid, etc .; Examples of the class alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, 2-hexyldecanol, etc .; examples of the esters include cetyl octanoate, triglyceride octanoate, myristyl lactate, cetyl lactate, Examples of essential oils include mint oil and jasmine. Oil, pepper brain oil, cypress oil, spruce oil, ryu oil, turpentine oil, cinnamon oil, bergamot oil, mandarin oil, ginger oil, pine , Lavender oil, bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, rose oil, sage oil, menthol, cineole, eugenol, citral, citronellal, borneol, linalool, geraniol, Camphor, thymol, spirantol, pinene, limonene, terpene compounds, etc .; examples of silicone oils include dimethylpolysiloxane. These oily components described above can be used alone or in combination of two or more. In the present invention, among these, myristic acid glyceride, 2-ethylhexanoic acid triglyceride, lanolin, liquid paraffin, petrolatum, paraffin microcrystalline wax, squalane, lauric acid, myristic acid, palmitic acid, linoleic acid, linolenic acid, isostearic acid , Cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, cetyl octanoate, triglyceride octanoate, isopropyl myristate, octyldodecyl myristate, cholesterol isostearate, POE sorbite fatty acid ester, peppermint oil, spruce oil, cinnamon oil, rose Oil, menthol, cineol, eugenol, citral, citronellal, geraniol, pinene, limonene, dimethylpolysiloxane It is preferable to use.

The following components can be further added to the preparation of the present invention, but the components are not limited thereto.
Colors: Yellow color No. 4, Blue No. 1 and Yellow No. 202 are recognized as food additives such as tar color dyes I and II dyes, chlorophyll, riboflavin, crocin, safflower, anthraquinone etc. Natural pigments.
Vitamins; vitamin A, vitamin C, vitamin D, vitamin E, etc.
Others: bactericides, preservatives, other ingredients necessary for formulation.

  The preparation of the present invention can be produced according to a conventional method by adding the optional components to the essential components as necessary, and can be in the form of cream, emulsion, lotion or the like.

EXAMPLES Next, an Example is given and this invention is demonstrated in detail.
Table 1 shows examples and comparative examples.

Confirmation Test Examples and Comparative Examples described in Table 1 were placed in 1 ml vials and allowed to stand for 1 hour under conditions of 35 ± 2 ° C. and humidity 23 ± 5%. The weight before and after was measured, and the amount of reduction was set to 1 in Comparative Example 5, and the reciprocal of the amount of reduction in each Example and Comparative Example was used as the moisture retention. (N = 5)
The results are shown in FIG.

  Although Examples 1-3 can be used also as an external preparation, it is also possible to mix this with another raw material and to make an external preparation. (Weight part)

External preparation 1
Olive oil 0.5
Polyoxyethylene (20E.O.) sorbitan monostearate 2.0
Polyoxyethylene (60E.O.) hydrogenated castor oil 2.0
Ethanol 10.0
Example 1 80.3
Methyl paraoxybenzoate 0.2

External preparation 2
Olive oil 0.5
Polyoxyethylene (20E.O.) sorbitan monostearate 2.0
Polyoxyethylene (60E.O.) hydrogenated castor oil 2.0
Ethanol 10.0
Example 3 80.3
Methyl paraoxybenzoate 0.2

External preparation 3
A
Squalane 20.0
Olive oil 2.0
Mink oil 1.0
Jojoba oil 5.0
Beeswax 5.0
Cetostearyl alcohol 2.0
Glycerol monostearate 1.0
Sorbitan monostearate 2.0
B
Example 2 51.7
Polyoxyethylene (20E.O.) sorbitan monostearate 2.0
Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
Glycerin 5.0
L-ascorbic acid-2-glucoside 2.0
Methyl paraoxybenzoate 0.1

External preparation 4
A
Squalane 20.0
Olive oil 2.0
Mink oil 1.0
Jojoba oil 5.0
Beeswax 5.0
Cetostearyl alcohol 2.0
Glycerol monostearate 1.0
Sorbitan monostearate 2.0
B
Example 1 51.7
Dipropylene glycol 2.0
Glycerin 3.0
Polyoxyethylene (20E.O.) sorbitan monostearate 2.0
Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
L-ascorbic acid-2-glucoside 2.0
Methyl paraoxybenzoate 0.1

Of course, these external preparations became very high moisturizing preparations.

The result of the confirmation test of the moisturizing power of Examples 1-3 and Comparative Examples 1-5 is shown.

Claims (4)

  A moisturizing agent containing collagen, hyaluronic acid or / and a salt thereof, and trimethylglycine, and when collagen is 1, hyaluronic acid or / and a salt thereof is 0.5 to 3, trimethylglycine is 0. A humectant having a blending ratio (weight ratio) of 5-6.   A moisturizing agent containing equal amounts (weight ratio) of collagen, hyaluronic acid or / and a salt thereof, and trimethylglycine.   The humectant according to claim 1 or 2, further comprising a polyhydric alcohol.   The external preparation which mix | blended the moisturizer of Claim 1 thru | or 3.