JP2014094916A - Drunkenness-relieving agent - Google Patents
Drunkenness-relieving agent Download PDFInfo
- Publication number
- JP2014094916A JP2014094916A JP2012247246A JP2012247246A JP2014094916A JP 2014094916 A JP2014094916 A JP 2014094916A JP 2012247246 A JP2012247246 A JP 2012247246A JP 2012247246 A JP2012247246 A JP 2012247246A JP 2014094916 A JP2014094916 A JP 2014094916A
- Authority
- JP
- Japan
- Prior art keywords
- tomato
- alcohol
- soluble component
- insoluble
- drunkenness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000015193 tomato juice Nutrition 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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Abstract
Description
本発明は酒酔い軽減剤に関し、特に、多量の飲酒による酩酊又は泥酔度合いを軽減させる酒酔い軽減剤に関する。 The present invention relates to a drunkenness alleviating agent, and more particularly to a drunky alleviating agent that reduces the degree of drought or drunkness caused by a large amount of drinking.
飲酒により体内に摂取されたアルコールは肝細胞内のミトコンドリアにより代謝され、肝毒性の強いアセトアルデヒドに分解され、次いでアセトアルデヒドは速やかに酢酸に分解される。酢酸は、肝臓から血中に放出され、末梢組織のエネルギー源としてTCA回路に入り、最終的には、二酸化炭素と水に分解される。 Alcohol taken into the body by drinking is metabolized by mitochondria in hepatocytes and decomposed into acetaldehyde having strong hepatotoxicity, and then acetaldehyde is rapidly decomposed into acetic acid. Acetic acid is released from the liver into the blood, enters the TCA circuit as a source of energy for peripheral tissues, and is eventually broken down into carbon dioxide and water.
アルコールが吸収されることによる生体への影響に対して、これまでに軽減効果が期待される食品素材・成分が多数報告されている。ヒト又は動物の生体によるアルコールの吸収を低減するための食用組成物を酒酔い軽減剤という。酒酔い軽減剤は、血中のアルコールやアセトアルデヒド濃度低下のデータをもって効果があるとするものが多数である。酒酔い軽減剤を使用して、実際に多量のアルコールを摂取した影響による酩酊又は泥酔度合いの軽減を調べた例はほとんどない。 Many food materials and ingredients that have been expected to have a mitigating effect on the effects on the living body due to the absorption of alcohol have been reported. An edible composition for reducing the absorption of alcohol by a human or animal body is called a drunk reducing agent. Many drunkenness-reducing agents are effective based on blood alcohol and acetaldehyde concentration data. There are few examples of using drunk reducing agents to examine the reduction of drought or drunkness due to the effect of actually ingesting a large amount of alcohol.
例えば、特許文献1には、肝臓の機能構造を回復させる手助けをして、血液および組織からのアルコールの排除を加速することができ、慢性アルコール酩酊および関連症候群に関連する神経心理学的障害を緩和するメタドキシン組成物が開示されている。 For example, Patent Document 1 can help restore the functional structure of the liver, accelerate the elimination of alcohol from the blood and tissues, and prevent neuropsychological disorders associated with chronic alcoholism and related syndromes. A mitigating metadoxine composition is disclosed.
非特許文献1には、マウスにエタノールを2g/kgで投与し、血中アセトアルデヒド濃度の上昇が抑制されたとあるが、血中エタノール濃度は約1.6mg/ml程度で有り、軽度〜中程度の酩酊度を呈する状態に過ぎず、また、動物の行動等も調べておらず、アルコールによる影響の軽減効果の有無については言及されていない。 Non-Patent Document 1 states that ethanol was administered to mice at 2 g / kg and the increase in blood acetaldehyde concentration was suppressed, but the blood ethanol concentration was about 1.6 mg / ml, which was mild to moderate. However, the behavior of animals is not examined, and there is no mention of the effect of reducing the effects of alcohol.
非特許文献2では、お酒に弱いタイプを対象に、アルコール投与による悪酔いに対する改善効果を調べ、胃部の不快感、吐き気が軽減されたとあるが、アルコール投与量が0.5g/kg程度、血中エタノール濃度も0.4〜0.8mg/mlの間で、軽度の酩酊を呈する程度の飲酒量での評価であり、強度酩酊以上における改善効果は検討されていない。
In
非特許文献3には、トマトジュースとアルコールを同時に摂取すると、酔いの回りが緩やかになり、飲酒後の酔い覚めも早まる可能性があること、及びその原因として、トマトの水溶性成分には、生体内でアルコール及びアセトアルデヒドを代謝する酵素の活性を高める傾向が見られ、特に、肝臓中のLDHの活性が有意に高まることが記載されている。 In Non-Patent Document 3, when tomato juice and alcohol are ingested at the same time, there is a possibility that the intoxication will be moderated and the intoxication after drinking may be accelerated, and as a cause thereof, There is a tendency to increase the activity of enzymes that metabolize alcohol and acetaldehyde in vivo, and in particular, it is described that the activity of LDH in the liver is significantly increased.
本発明は上記従来の問題を解決するものであり、その目的とするところは、多量の飲酒を行なった際の酩酊又は泥酔度合いを軽減させることができる酒酔い軽減剤を提供することにある。 The present invention solves the above-mentioned conventional problems, and an object of the present invention is to provide a drunk reducing agent capable of reducing the degree of drought or drunkness when a large amount of alcohol is consumed.
本発明は、酒酔い軽減剤の調製における、トマトの不溶性成分の使用を提供する。 The present invention provides the use of an insoluble component of tomato in the preparation of a drunk reducing agent.
ある一形態においては、前記トマトの不溶性成分が、トマト原料から水溶性成分を除去して得られる残渣である。 In one certain form, the insoluble component of the said tomato is a residue obtained by removing a water-soluble component from a tomato raw material.
ある一形態においては、前記トマトの不溶性成分が、トマト原料から水溶性成分及び脂溶性成分を除去して得られる残渣である。 In one certain form, the insoluble component of the said tomato is a residue obtained by removing a water-soluble component and a fat-soluble component from a tomato raw material.
ある一形態においては、前記トマト原料が、トマト果実、乾燥トマト粉末及びトマト果実を搾汁した後の絞り粕からなる群から選択される少なくとも一つである。 In one certain form, the tomato raw material is at least one selected from the group consisting of tomato fruit, dried tomato powder and squeezed rice cake after squeezing the tomato fruit.
ある一形態においては、前記トマト原料からの脂溶性成分の除去は、エタノール及び酢酸エチルからなる群から選択される少なくとも一種を使用して抽出することにより行われる。 In one certain form, the removal of the fat-soluble component from the said tomato raw material is performed by extracting using at least 1 type selected from the group which consists of ethanol and ethyl acetate.
また、本発明は、トマトの不溶性成分を含む酒酔い軽減剤を提供する。 The present invention also provides a drunk reducing agent comprising an insoluble component of tomato.
本発明の酒酔い軽減剤は、多量の飲酒を行なった際の酩酊又は泥酔度合いを軽減させることできる。また、本発明の酒酔い軽減剤は食用組成物として、日常的に容易にそして安全に摂取できる。 The drunkenness reducing agent of the present invention can reduce drought or drunkness when drinking a large amount of alcohol. Moreover, the drunkenness reducing agent of the present invention can be easily and safely ingested as an edible composition on a daily basis.
本発明でいうトマトは、従来から食用に用いられる品種のトマトである。トマトには、例えば、いわゆるピンク系トマト及び赤系トマトが含まれる。トマトは生食可能になった状態の果実をいう。生食可能になった状態のトマトの果実は、好ましくは完熟期の果実である。 The tomato according to the present invention is a variety of tomatoes conventionally used for food. Tomatoes include, for example, so-called pink tomatoes and red tomatoes. Tomato is a fruit that can be eaten raw. The tomato fruit in a ready-to-eat state is preferably a ripe fruit.
トマトの品種としては、例えば、「桃太郎」(商品名)、ファーストトマト、ミニトマト、プラムトマト、「絹子姫」(商品名)、シンディースイート、シンディオレンジ、ごほうび、サンロード、秀麗、パルト、マイロック、りんか409、ルネッサンス、麗夏、麗容及びろくさんまる等の生食用トマト、サンマルツァーノ、チコー3号、くりこま、ふりこま、ハイピール、カゴメ77、KGM952及びKGM993等の加工用トマト、愛知トマト、ジューンピンク及びポンテローザ等の生食加工兼用トマト等が挙げられる。 As tomato varieties, for example, “Momotaro” (product name), first tomato, mini tomato, plum tomato, “Kinkohime” (product name), Cindy sweet, Cindy orange, reward, sun road, exquisite, part, Raw tomatoes such as My Rock, Rinka 409, Renaissance, Reika, Reiko and Rokusanmaru, San Marzano, Chico No. 3, Kurikoma, Furikoma, High Peel, Kagome 77, KGM952, and KGM993 etc. Processing tomatoes, Aichi Examples include raw food processing tomatoes such as tomatoes, June pink and Ponterosa.
不溶性とは、液体に溶解しないことを意味する。液体には、水及び有機溶媒が含まれる。ここでいう有機溶媒はトマトに含まれる脂溶性成分を溶解することができる有機溶媒を意味する。有機溶媒の具体例には、アルコール系溶媒として、エタノール、プロパノール、イソプロパノール、ブタノール、イソブタノール等、エステル系溶媒として、酢酸エチル、アセト酢酸エチル、ギ酸イソアミル、ケイ皮酸メチル等、ケトン系溶媒として、アセトフェノン、イオノン、メチル‐β‐ナフチルケトン、ケトン類等、エーテル系溶媒として、1,8‐シネオール、エチルパニリン、バニリン、エーテル類、フェノールエーテル類等が挙げられる。好ましい有機溶媒はエタノール、酢酸エチルである。 Insoluble means insoluble in liquid. The liquid includes water and an organic solvent. An organic solvent here means the organic solvent which can melt | dissolve the fat-soluble component contained in tomato. Specific examples of organic solvents include alcohol solvents, ethanol, propanol, isopropanol, butanol, isobutanol, etc., ester solvents, ethyl acetate, ethyl acetoacetate, isoamyl formate, methyl cinnamate, etc., ketone solvents Examples of ether solvents such as acetophenone, ionone, methyl-β-naphthyl ketone, and ketones include 1,8-cineol, ethyl panillin, vanillin, ethers, phenol ethers, and the like. Preferred organic solvents are ethanol and ethyl acetate.
不溶性成分には非水溶性食物繊維が含まれる。食物繊維とは、食物の成分のうち、人の体内で消化酵素によって消化されない難消化性成分をいう。 Insoluble ingredients include water-insoluble dietary fiber. Dietary fiber refers to indigestible components that are not digested by digestive enzymes in the human body among the components of food.
トマトの不溶性成分は、具体的には、トマト原料から水溶性成分を除去して得られる残渣である。トマトの不溶性成分は、更に脂溶性成分を除去したものであることが好ましい。トマト原料としては、トマト果実、乾燥トマト粉末、トマトの絞り粕等が挙げられる。トマト果実は加熱した後のものであってもよい。中でも、トマト原料として、トマトの絞り粕が好ましい。トマトの絞り粕とは、ジュースなどの製造工程で副生するものであり、トマトを搾汁した後、果汁等の液体成分をろ過して取り除いた残渣である。 Specifically, the insoluble component of tomato is a residue obtained by removing the water-soluble component from the tomato raw material. It is preferable that the insoluble component of tomato is obtained by removing the fat-soluble component. Examples of tomato materials include tomato fruit, dried tomato powder, and tomato squeezed strawberries. The tomato fruit may be after heating. Among these, tomato raw material is preferably tomato pomace. Tomato squeezed rice cake is a by-product in the production process of juice and the like, and is a residue obtained by squeezing tomato and then filtering and removing liquid components such as fruit juice.
トマトの絞り粕はジュースなどの製造工程で大量に発生し、入手が容易である。そして、トマトの絞り粕は食品の製造副産物であるため、原料段階での品質検査および製造工程管理が厳しく行なわれていることから衛生品質に優れ安全である。 Tomato pomace is produced in large quantities in the manufacturing process for juice and the like, and is easy to obtain. And since tomato squeezed rice cake is a by-product of food production, quality inspection and production process management at the raw material stage are strictly carried out, so that hygiene quality is excellent and safe.
トマト原料は、必要に応じて、洗浄、破砕及び搾汁して、できるだけ液体成分を除去する。但し、液体成分を完全に除去する必要はない。その後、液体成分が除去されたトマト原料は、水溶性成分を除去する工程及び要すれば脂溶性成分を除去する工程に供される。水溶性成分を除去する工程及び脂溶性成分を除去する工程はどちらを先に行ってもよい。しかし、作業効率の観点からは、水溶性成分を除去する工程を先に行うことが好ましい。 The tomato material is washed, crushed and squeezed as necessary to remove as much liquid components as possible. However, it is not necessary to completely remove the liquid component. Thereafter, the tomato material from which the liquid component has been removed is subjected to a step of removing the water-soluble component and, if necessary, a step of removing the fat-soluble component. Either the step of removing the water-soluble component or the step of removing the fat-soluble component may be performed first. However, from the viewpoint of work efficiency, it is preferable to perform the step of removing the water-soluble component first.
トマト原料から水溶性成分を除去する工程は、例えば、トマトの絞り粕又は乾燥トマト等の液体成分ができるだけ除去されたトマト原料を水に投入して撹拌し、次いで水溶性成分を含んだ液部を固体部から分離することにより行う。液部と固体部との分離は、ろ過及び遠心分離等の通常使用される方法を用いて行う。 The step of removing the water-soluble component from the tomato raw material is, for example, putting the tomato raw material from which liquid components such as tomato pomace or dried tomato are removed as much as possible into water and stirring, and then the liquid part containing the water-soluble component By separating from the solid part. Separation of the liquid part and the solid part is performed by a commonly used method such as filtration and centrifugation.
トマト原料から脂溶性成分を取り除く工程は、例えば、トマトの絞り粕又は乾燥トマト等の液体成分ができるだけ除去されたトマト原料を上記有機溶媒に投入して撹拌し、脂溶性成分を含んだ液部を固体部から分離することにより行う。液部と固体部との分離は、ろ過及び遠心分離等の通常使用される方法を用いて行う。 The step of removing the fat-soluble component from the tomato raw material is, for example, putting the tomato raw material from which liquid components such as tomato squeezed rice cake or dried tomato are removed as much as possible into the above organic solvent and stirring, and the liquid part containing the fat-soluble component By separating from the solid part. Separation of the liquid part and the solid part is performed by a commonly used method such as filtration and centrifugation.
得られたトマトの不溶性成分は酒酔い防止剤として使用することができる。トマトは食品であり、トマトの不溶性成分は無害である。従って、トマトの不溶性成分を酒酔い防止剤としてヒトに摂取させる場合、摂取量は目的に応じて適量を決定すればよい。 The obtained insoluble component of tomato can be used as an anti-drunk agent. Tomato is a food and the insoluble components of tomato are harmless. Therefore, when the insoluble component of tomato is to be ingested by humans as an anti-drunk agent, the intake amount may be determined appropriately according to the purpose.
一例として、トマトの不溶性成分は、体重を基準にして約0.1g/kg以上の量を摂取させる。トマトの不溶性成分の摂取量が体重を基準にして0.1g/kg未満であると、多量の飲酒を行った際の酩酊又は泥酔度合を軽減させる効果は低くなる。尚、摂取量の下限例である0.1g/kgを体重60kgのヒトの摂取量に換算すると、6gとなる。 As an example, the insoluble component of tomato is ingested in an amount of about 0.1 g / kg or more based on body weight. If the intake of insoluble components in tomato is less than 0.1 g / kg based on body weight, the effect of reducing drought or drunkness when drinking a large amount of alcohol is low. Note that 0.1 g / kg, which is a lower limit example of the intake, is 6 g when converted to the intake of a human body weight of 60 kg.
本発明の酒酔い防止剤は飲酒前、飲酒中又は飲酒後に摂取して良い。本発明の酒酔い防止剤は、効果に優れ、飲酒後に摂取した場合でも酩酊又は泥酔度合の軽減効果を発揮するのが特徴である。 The anti-drunk agent of the present invention may be taken before drinking, during drinking or after drinking. The anti-drunk agent of the present invention is excellent in effect and is characterized by exhibiting the effect of reducing drought or drunkenness even when ingested after drinking.
本発明の酒酔い防止剤では、トマトの不溶性成分と共に、本発明の効果を阻害しない範囲で糖類及び賦形剤等の添加剤、又は液体成分等を併用して良い。本発明の酒酔い防止剤は食品または飲料の形態に調製してよい。食品としては、サプリメントと云われる形態が好ましく、錠剤や顆粒など形状が好ましい。飲料としては、ドリンク剤等の形態に調整するのが一般的である。アルコール飲料に混合してもよい。これら、食品または飲料は、慣用された方法により製造すればよい。例えば以下のような方法で製造することができる。 In the anti-drunk agent of the present invention, in addition to the insoluble components of tomato, additives such as sugars and excipients, or liquid components may be used in combination as long as the effects of the present invention are not impaired. The anti-drunk agent of the present invention may be prepared in the form of food or beverage. As food, a form called a supplement is preferable, and a form such as a tablet or granule is preferable. As a beverage, it is common to adjust to a form such as a drink. You may mix with alcoholic beverages. These foods or beverages may be produced by a conventional method. For example, it can be produced by the following method.
顆粒とする際は、賦形剤、甘味料などの添加剤と一緒に流動造粒機や転動造粒機などで製造することができる。錠剤とする際は、顆粒とした後、賦形剤、甘味料、滑沢剤などの添加剤を加えて混合し、ロータリー式打錠機、単発打錠機などで圧縮成型することにより、錠剤を製造することができる。 When it is made into granules, it can be produced with a fluid granulator or a tumbling granulator together with additives such as excipients and sweeteners. When making into tablets, after making into granules, additives such as excipients, sweeteners, lubricants are added and mixed, and then compressed into tablets using a rotary tableting machine, single-punch tableting machine, etc. Can be manufactured.
飲料とする際は、水に添加して攪拌し、飲料原液を調製し、容器に充填して製造することができる。なお、必要に応じて加熱殺菌など行う。また、本発明の効果を阻害しない範囲で糖類や香料等の添加剤を加えても良い。 When it is used as a beverage, it can be added to water and stirred to prepare a beverage stock solution and filled into a container for production. In addition, heat sterilization etc. are performed as needed. Moreover, you may add additives, such as saccharides and a fragrance | flavor, in the range which does not inhibit the effect of this invention.
賦形剤としては、例えば、デンプン(トウモロコシデンプン、馬鈴薯デンプン、コムギデンプン、コメデンプン等)、ラクトースコロイダルシリカ、結晶セルロース、無水ケイ酸、無水リン酸カルシウム、沈降炭酸カルシウム、ケイ酸カルシウム、軽質無水ケイ酸、含水二酸化ケイ素、二酸化ケイ素、酸化アルミニウム、炭酸マグネシウム、沈降炭酸カルシウム、結晶セルロース、合成ケイ酸アルミニウム、ケイ酸マグネシウム、メタケイ酸アルミン酸マグネシウム、デキストリン、カルメロースカルシウム等が挙げられる。これらの担体は、単独または2種以上を併用して用いても良い。前記結晶セルロースとしては、微結晶セルロースを含む。 Examples of excipients include starch (corn starch, potato starch, wheat starch, rice starch, etc.), lactose colloidal silica, crystalline cellulose, anhydrous silicic acid, anhydrous calcium phosphate, precipitated calcium carbonate, calcium silicate, light anhydrous silicic acid. Hydrous silicon dioxide, silicon dioxide, aluminum oxide, magnesium carbonate, precipitated calcium carbonate, crystalline cellulose, synthetic aluminum silicate, magnesium silicate, magnesium metasilicate aluminate, dextrin, carmellose calcium and the like. These carriers may be used alone or in combination of two or more. The crystalline cellulose includes microcrystalline cellulose.
甘味料としては、例えば、糖、糖アルコールが挙げられ、グルコース、フルクトース、ガラクトース、マンノース、ラクトース、マルトース、スクロース、白糖(精製白糖を含む。)、トレハロース、マンニトール、ソルビトール、マルチトール、アスパルテーム、エリスリトール、キシリトール等が挙げられ、これらを単独または2種以上を併用して用いても良い。 Examples of the sweetener include sugar, sugar alcohol, glucose, fructose, galactose, mannose, lactose, maltose, sucrose, sucrose (including purified sucrose), trehalose, mannitol, sorbitol, maltitol, aspartame, erythritol. Xylitol and the like, and these may be used alone or in combination of two or more.
滑沢剤としては、例えば、ステアリン酸マグネシウムやステアリン酸カルシウム、フマル酸ステアリルナトリウム、ステアリン酸、タルク、ショ糖脂肪酸エステル、グリセリン脂肪酸エステル、ポリエチレングリコール、植物油脂等が挙げられる。滑沢剤は、打錠する前に顆粒に加え混合する方法、あるいは打錠時に杵または臼に直接付着させる方法の何れの方法で添加しても良い。 Examples of the lubricant include magnesium stearate, calcium stearate, sodium stearyl fumarate, stearic acid, talc, sucrose fatty acid ester, glycerin fatty acid ester, polyethylene glycol, vegetable oil and fat. The lubricant may be added by any of the method of adding to the granule before tableting and mixing, or the method of adhering directly to the punch or die during tableting.
以下の実施例により本発明を更に具体的に説明するが、本発明はこれらに限定されない。 The following examples further illustrate the present invention, but the present invention is not limited thereto.
[酩酊、泥酔状態の評価方法]
軽度の酔いから酩酊、泥酔状態に至るまでのあらゆる酔いの状態を調べることができる自発運動量測定を用いて評価を行なった(スーパーメックス(PAT.P)、室町機械株式会社製を使用)。アルコール投与によるマウスの自発運動量の変化は、適度なアルコール量では増加し、多量になってくると量依存的に抑制されることが知られている(伊豆ら、動物心理学研究、58(1)、2008)。
[Evaluation method for drought and drunk conditions]
Evaluation was performed using spontaneous momentum measurement that can investigate all the states of sickness ranging from mild sickness to drought and drunk conditions (using Supermex (PAT.P), Muromachi Kikai Co., Ltd.). It is known that the change in spontaneous locomotor activity of mice by alcohol administration increases with an appropriate amount of alcohol and is suppressed in a dose-dependent manner when the amount increases (Izu et al., Animal Psychological Research, 58 (1). ), 2008).
ラットに対し、ヒトでいう強度酩酊期から泥酔期となる血中エタノール濃度(塚本ら、medicina、2005)に達する投与量である4g/kgのエタノールを強制胃内投与した。その30分後に被験物を水に溶解あるいは懸濁させて強制胃内投与し、その後のラットの自発運動量を経時的に調べた。被験物としては、実施例及び比較例として以下に示す素材を採用した。 Rats were forcibly intragastricly administered with 4 g / kg of ethanol, which was a dose that reached the blood ethanol concentration (Tsukamoto et al., Medicina, 2005), which is from a severe pupal period to a drunk period in humans. Thirty minutes later, the test substance was dissolved or suspended in water and administered into the forced stomach, and the subsequent locomotor activity was examined over time. As a test object, the material shown below was employ | adopted as an Example and a comparative example.
その具体的な方法としては、7週齢以上の雄性F344ラットを7時間絶食し、30%(v/v)のエタノール水溶液を8.45ml/kgで30分間の間隔をあけて2回強制胃内投与し(トータルのエタノール投与量:4g/kg)、その30分後に様々な素材を強制胃内投与し、暗期の状態で自発運動量測定システムに設置し、餌を摂取できるように給餌した後、15時間(12時間後に明期に変わり、積算自発運動量がプラトーになってくる)までの自発運動量を30分間隔で連続的に測定し、結果は積算値で表した。なお、エタノール未投与群とエタノールのみ4g/kg投与群を比較として調べた。 Specifically, male F344 rats 7 weeks of age or older were fasted for 7 hours, and a 30% (v / v) aqueous ethanol solution at 8.45 ml / kg was forcibly stomached twice at 30-minute intervals. (Total ethanol dose: 4 g / kg), 30 minutes later, various materials were forcibly administered into the stomach and placed in the spontaneous exercise amount measurement system in the dark period to feed the food. Thereafter, the spontaneous momentum up to 15 hours (changed to the light period after 12 hours and the cumulative spontaneous momentum reaches a plateau) was continuously measured at 30 minute intervals, and the result was expressed as an integrated value. In addition, the ethanol non-administration group and the ethanol-only 4 g / kg administration group were examined for comparison.
(実施例1)
生トマトをまるごと粉末化したトマト乾燥粉末(品種:ルネッサンス、石川ファーム社製)2.367gに蒸留水40mlを加えてボルテックスにて2分間激しく攪拌し、遠心処理(3000rpm、10分)し、上清の水性画分と残渣を分離した。得られたトマト残渣に蒸留水10mlを加えて懸濁液とした。16.9ml/kgの懸濁液を強制胃内投与した。本処理により得た残渣の重量は、トマト乾燥粉末中の食物繊維含有量と等しい15.7%であり、その投与量は、トマト乾燥粉末4g/kg分に相当する0.63g/kgとなった。
Example 1
Tomato dry powder (variety: Renaissance, manufactured by Ishikawa Farm Co., Ltd.) 2.367 g of whole raw tomato powder is added, 40 ml of distilled water is added, vortexed vigorously for 2 minutes, centrifuged (3000 rpm, 10 minutes), The clear aqueous fraction and residue were separated. 10 ml of distilled water was added to the obtained tomato residue to make a suspension. A suspension of 16.9 ml / kg was administered by gavage. The weight of the residue obtained by this treatment is 15.7% equal to the dietary fiber content in the dried tomato powder, and the dosage is 0.63 g / kg corresponding to 4 g / kg of tomato dried powder. It was.
(比較例1)
実施例1の操作でトマト残渣から分離した水性画分を体積が10mlになるまで減圧蒸留して濃縮した。16.9ml/kgの濃縮液を強制胃内投与した。
(Comparative Example 1)
The aqueous fraction separated from the tomato residue by the operation of Example 1 was concentrated by distillation under reduced pressure until the volume reached 10 ml. A concentrated solution of 16.9 ml / kg was administered by gavage.
(実施例2)
実施例1と同様の操作を行ってトマト残渣を得た。得られたトマト残渣を500mlのエタノール中に入れ、1時間攪拌した後、ろ過した残渣を、次は500mlの酢酸エチルに入れ、5時間攪拌した後、再度ろ過して得た残渣を一晩乾燥し、抽出処理したトマト残渣を得た。得られたトマト残渣に蒸留水10mlを加えて懸濁液とした。16.9ml/kgの懸濁液を強制胃内投与した。その投与量は、トマト乾燥粉末4g/kg分に相当する0.63g/kgとなった。
(Example 2)
The same operation as in Example 1 was performed to obtain a tomato residue. The obtained tomato residue was put in 500 ml of ethanol and stirred for 1 hour, then the filtered residue was next put in 500 ml of ethyl acetate, stirred for 5 hours and then filtered again to dry the residue overnight. And tomato residue obtained by extraction was obtained. 10 ml of distilled water was added to the obtained tomato residue to make a suspension. A suspension of 16.9 ml / kg was administered by gavage. The dosage was 0.63 g / kg corresponding to 4 g / kg of tomato dry powder.
実施例1、比較例1及び実施例2の結果を図1に示す。この結果から、トマト残渣には酩酊又は泥酔度合の軽減効果が認められ、その効果は、抽出処理したトマト残渣では増強されること、及びトマトの水性画分では殆ど認められないことが確認された。 The results of Example 1, Comparative Example 1 and Example 2 are shown in FIG. From this result, it was confirmed that the tomato residue has an effect of reducing the degree of drought or drunkness, the effect is enhanced by the extracted tomato residue, and is hardly observed in the aqueous fraction of tomato. .
(比較例2)
トマトには水溶性食物繊維としてペクチンが含まれ、不溶性食物繊維としてセルロース、ヘミセルロース、リグニン等が含まれることが知られている(Herranz J et al. Journal of Food Sciences, 46, p1927-1981)。そこで、ペクチン(カーギル社製HMペクチン)、セルロース(光洋商会社製 エンデュランス MMC VE‐050)を用い、上記試験例1と同様の方法で、アルコール投与15時間後のラットの自発運動量の積算値を調べた。
(Comparative Example 2)
It is known that tomato contains pectin as a water-soluble dietary fiber and cellulose, hemicellulose, lignin and the like as insoluble dietary fibers (Herranz J et al. Journal of Food Sciences, 46, p1927-1981). Therefore, using pectin (HM Pectin manufactured by Cargill) and cellulose (Endurance MMC VE-050 manufactured by Koyo Shosha Co., Ltd.), in the same manner as in Test Example 1 above, the integrated value of spontaneous locomotor activity of rats 15 hours after alcohol administration was calculated. Examined.
ペクチン、セルロースは、3.74%になるよう蒸留水で懸濁させた液を0.63g/kgになるよう16.9ml/kgで強制胃内投与した。 Pectin and cellulose were intragastrically administered at 16.9 ml / kg in a suspension of distilled water to 3.74% at 0.63 g / kg.
比較例2の結果を図2に示す。この結果から、食物繊維であるペクチン、セルロースには酩酊又は泥酔度合の軽減効果が認められないか、認められても弱いことが確認された。 The result of Comparative Example 2 is shown in FIG. From these results, it was confirmed that pectin and cellulose, which are dietary fibers, do not have a reduction effect on drought or drunkness, or are weak even if recognized.
(実施例3)
トマト残渣の有効量を検討するため、実施例2と同じ方法で、抽出処理したトマト残渣を製造し、投与量を0.3g/kg、0.1g/kg、0.05g/kg及び0.025g/kgとした際のラットの自発運動量を調べた。
(Example 3)
In order to examine the effective amount of tomato residue, the extraction-treated tomato residue was produced in the same manner as in Example 2, and the dosage was 0.3 g / kg, 0.1 g / kg, 0.05 g / kg, and 0. Spontaneous momentum of the rat at 025 g / kg was examined.
実施例3の結果を図3に示す。抽出処理したトマト残渣による酩酊又は泥酔度合の軽減効果は、0.1g/kg以上の投与量で発揮されることが確認された。 The results of Example 3 are shown in FIG. It was confirmed that the effect of reducing the degree of drunkenness or drunkness by the tomato residue subjected to the extraction treatment is exhibited at a dose of 0.1 g / kg or more.
アルコール4g/kg投与による血中エタノール濃度は3mg/ml付近であり、ヒトで換算するとビール大瓶5本程度の飲酒量の結果である。体重60kgのヒトの場合、抽出処理したトマト残渣を6g以上摂取しておくと酩酊又は泥酔度合の軽減効果が得られると考えられる。 The blood ethanol concentration by administration of 4 g / kg of alcohol is around 3 mg / ml, which is a result of the drinking amount of about 5 large beer bottles in terms of human. In the case of a human with a body weight of 60 kg, it is considered that if 6 g or more of the extracted tomato residue is ingested, the effect of reducing drought or drunkness can be obtained.
飲酒による多量のアルコール摂取後の酩酊及び泥酔状態を顕著に軽減させることできるため、転倒等による障害の防止が期待され、本発明の酒酔い防止剤は、食品または飲料として利用できる。 Since drought and drunk state after drinking a large amount of alcohol due to drinking can be remarkably reduced, prevention of damage due to falls is expected, and the drunk prevention agent of the present invention can be used as food or beverage.
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JP2016086715A (en) * | 2014-10-31 | 2016-05-23 | アサヒグループホールディングス株式会社 | Food and drink containing component derived from carrot |
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JP2016042826A (en) * | 2014-08-22 | 2016-04-04 | アサヒグループホールディングス株式会社 | Tomato containing food and drink |
JP2016086715A (en) * | 2014-10-31 | 2016-05-23 | アサヒグループホールディングス株式会社 | Food and drink containing component derived from carrot |
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