JP2014094916A - Drunkenness-relieving agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a drunkenness-relieving agent capable of relieving the severity of a badly or heavily drunk state in heavy alcohol use.SOLUTION: An insoluble component of a tomato is used for preparing a drunkenness-relieving agent.

Description

  The present invention relates to a drunkenness alleviating agent, and more particularly to a drunky alleviating agent that reduces the degree of drought or drunkness caused by a large amount of drinking.

  Alcohol taken into the body by drinking is metabolized by mitochondria in hepatocytes and decomposed into acetaldehyde having strong hepatotoxicity, and then acetaldehyde is rapidly decomposed into acetic acid. Acetic acid is released from the liver into the blood, enters the TCA circuit as a source of energy for peripheral tissues, and is eventually broken down into carbon dioxide and water.

Many food materials and ingredients that have been expected to have a mitigating effect on the effects on the living body due to the absorption of alcohol have been reported. An edible composition for reducing the absorption of alcohol by a human or animal body is called a drunk reducing agent. Many drunkenness-reducing agents are effective based on blood alcohol and acetaldehyde concentration data. There are few examples of using drunk reducing agents to examine the reduction of drought or drunkness due to the effect of actually ingesting a large amount of alcohol.

For example, Patent Document 1 can help restore the functional structure of the liver, accelerate the elimination of alcohol from the blood and tissues, and prevent neuropsychological disorders associated with chronic alcoholism and related syndromes. A mitigating metadoxine composition is disclosed.

Non-Patent Document 1 states that ethanol was administered to mice at 2 g / kg and the increase in blood acetaldehyde concentration was suppressed, but the blood ethanol concentration was about 1.6 mg / ml, which was mild to moderate. However, the behavior of animals is not examined, and there is no mention of the effect of reducing the effects of alcohol.

In Non-patent Document 2, the improvement effect on sickness caused by alcohol administration was investigated for the type vulnerable to alcohol, and stomach discomfort and nausea were reduced, but the alcohol dose was about 0.5 g / kg, The blood ethanol concentration is also between 0.4 and 0.8 mg / ml, and the evaluation is based on the amount of alcohol consumed that is mildly addictive.

In Non-Patent Document 3, when tomato juice and alcohol are ingested at the same time, there is a possibility that the intoxication will be moderated and the intoxication after drinking may be accelerated, and as a cause thereof, There is a tendency to increase the activity of enzymes that metabolize alcohol and acetaldehyde in vivo, and in particular, it is described that the activity of LDH in the liver is significantly increased.

Special table 2010-531872 gazette

"Effect of liver hydrolyzate on blood ethanol and metabolite concentrations in a mouse acute alcohol intoxication model", Kishimoto et al., Pharmacology and Treatment, 39 (2): p199-207, 2011 “Alcohol metabolism promotion and sickness reduction effect of“ Saijo cocoon extract ”, Koikeda et al., Medical treatment and new drug, 44: p57-65, 2007 "Human confirms that tomato reduces blood alcohol concentration after drinking" http://www.kagome.co.jp/company/news/2012/05/001371.html

  The present invention solves the above-mentioned conventional problems, and an object of the present invention is to provide a drunk reducing agent capable of reducing the degree of drought or drunkness when a large amount of alcohol is consumed.

  The present invention provides the use of an insoluble component of tomato in the preparation of a drunk reducing agent.

  In one certain form, the insoluble component of the said tomato is a residue obtained by removing a water-soluble component from a tomato raw material.

  In one certain form, the insoluble component of the said tomato is a residue obtained by removing a water-soluble component and a fat-soluble component from a tomato raw material.

  In one certain form, the tomato raw material is at least one selected from the group consisting of tomato fruit, dried tomato powder and squeezed rice cake after squeezing the tomato fruit.

  In one certain form, the removal of the fat-soluble component from the said tomato raw material is performed by extracting using at least 1 type selected from the group which consists of ethanol and ethyl acetate.

  The present invention also provides a drunk reducing agent comprising an insoluble component of tomato.

  The drunkenness reducing agent of the present invention can reduce drought or drunkness when drinking a large amount of alcohol. Moreover, the drunkenness reducing agent of the present invention can be easily and safely ingested as an edible composition on a daily basis.

It is the graph which showed the reduction effect of the tomato material with respect to the fall of the spontaneous exercise amount by alcohol administration of a rat. It is the graph which showed the reduction effect of the dietary fiber with respect to the fall of the locomotor activity amount by rat alcohol administration. It is the graph which showed the relationship between the amount of spontaneous movements and tomato material intake of the alcohol administration rat.

The tomato according to the present invention is a variety of tomatoes conventionally used for food. Tomatoes include, for example, so-called pink tomatoes and red tomatoes. Tomato is a fruit that can be eaten raw. The tomato fruit in a ready-to-eat state is preferably a ripe fruit.

As tomato varieties, for example, “Momotaro” (product name), first tomato, mini tomato, plum tomato, “Kinkohime” (product name), Cindy sweet, Cindy orange, reward, sun road, exquisite, part, Raw tomatoes such as My Rock, Rinka 409, Renaissance, Reika, Reiko and Rokusanmaru, San Marzano, Chico No. 3, Kurikoma, Furikoma, High Peel, Kagome 77, KGM952, and KGM993 etc. Processing tomatoes, Aichi Examples include raw food processing tomatoes such as tomatoes, June pink and Ponterosa.

  Insoluble means insoluble in liquid. The liquid includes water and an organic solvent. An organic solvent here means the organic solvent which can melt | dissolve the fat-soluble component contained in tomato. Specific examples of organic solvents include alcohol solvents, ethanol, propanol, isopropanol, butanol, isobutanol, etc., ester solvents, ethyl acetate, ethyl acetoacetate, isoamyl formate, methyl cinnamate, etc., ketone solvents Examples of ether solvents such as acetophenone, ionone, methyl-β-naphthyl ketone, and ketones include 1,8-cineol, ethyl panillin, vanillin, ethers, phenol ethers, and the like. Preferred organic solvents are ethanol and ethyl acetate.

  Insoluble ingredients include water-insoluble dietary fiber. Dietary fiber refers to indigestible components that are not digested by digestive enzymes in the human body among the components of food.

Specifically, the insoluble component of tomato is a residue obtained by removing the water-soluble component from the tomato raw material. It is preferable that the insoluble component of tomato is obtained by removing the fat-soluble component. Examples of tomato materials include tomato fruit, dried tomato powder, and tomato squeezed strawberries. The tomato fruit may be after heating. Among these, tomato raw material is preferably tomato pomace. Tomato squeezed rice cake is a by-product in the production process of juice and the like, and is a residue obtained by squeezing tomato and then filtering and removing liquid components such as fruit juice.

Tomato pomace is produced in large quantities in the manufacturing process for juice and the like, and is easy to obtain. And since tomato squeezed rice cake is a by-product of food production, quality inspection and production process management at the raw material stage are strictly carried out, so that hygiene quality is excellent and safe.

The tomato material is washed, crushed and squeezed as necessary to remove as much liquid components as possible. However, it is not necessary to completely remove the liquid component. Thereafter, the tomato material from which the liquid component has been removed is subjected to a step of removing the water-soluble component and, if necessary, a step of removing the fat-soluble component. Either the step of removing the water-soluble component or the step of removing the fat-soluble component may be performed first. However, from the viewpoint of work efficiency, it is preferable to perform the step of removing the water-soluble component first.

The step of removing the water-soluble component from the tomato raw material is, for example, putting the tomato raw material from which liquid components such as tomato pomace or dried tomato are removed as much as possible into water and stirring, and then the liquid part containing the water-soluble component By separating from the solid part. Separation of the liquid part and the solid part is performed by a commonly used method such as filtration and centrifugation.

The step of removing the fat-soluble component from the tomato raw material is, for example, putting the tomato raw material from which liquid components such as tomato squeezed rice cake or dried tomato are removed as much as possible into the above organic solvent and stirring, and the liquid part containing the fat-soluble component By separating from the solid part. Separation of the liquid part and the solid part is performed by a commonly used method such as filtration and centrifugation.

The obtained insoluble component of tomato can be used as an anti-drunk agent. Tomato is a food and the insoluble components of tomato are harmless. Therefore, when the insoluble component of tomato is to be ingested by humans as an anti-drunk agent, the intake amount may be determined appropriately according to the purpose.

As an example, the insoluble component of tomato is ingested in an amount of about 0.1 g / kg or more based on body weight. If the intake of insoluble components in tomato is less than 0.1 g / kg based on body weight, the effect of reducing drought or drunkness when drinking a large amount of alcohol is low. Note that 0.1 g / kg, which is a lower limit example of the intake, is 6 g when converted to the intake of a human body weight of 60 kg.

The anti-drunk agent of the present invention may be taken before drinking, during drinking or after drinking. The anti-drunk agent of the present invention is excellent in effect and is characterized by exhibiting the effect of reducing drought or drunkenness even when ingested after drinking.

  In the anti-drunk agent of the present invention, in addition to the insoluble components of tomato, additives such as sugars and excipients, or liquid components may be used in combination as long as the effects of the present invention are not impaired. The anti-drunk agent of the present invention may be prepared in the form of food or beverage. As food, a form called a supplement is preferable, and a form such as a tablet or granule is preferable. As a beverage, it is common to adjust to a form such as a drink. You may mix with alcoholic beverages. These foods or beverages may be produced by a conventional method. For example, it can be produced by the following method.

When it is made into granules, it can be produced with a fluid granulator or a tumbling granulator together with additives such as excipients and sweeteners. When making into tablets, after making into granules, additives such as excipients, sweeteners, lubricants are added and mixed, and then compressed into tablets using a rotary tableting machine, single-punch tableting machine, etc. Can be manufactured.

When it is used as a beverage, it can be added to water and stirred to prepare a beverage stock solution and filled into a container for production. In addition, heat sterilization etc. are performed as needed. Moreover, you may add additives, such as saccharides and a fragrance | flavor, in the range which does not inhibit the effect of this invention.

Examples of excipients include starch (corn starch, potato starch, wheat starch, rice starch, etc.), lactose colloidal silica, crystalline cellulose, anhydrous silicic acid, anhydrous calcium phosphate, precipitated calcium carbonate, calcium silicate, light anhydrous silicic acid. Hydrous silicon dioxide, silicon dioxide, aluminum oxide, magnesium carbonate, precipitated calcium carbonate, crystalline cellulose, synthetic aluminum silicate, magnesium silicate, magnesium metasilicate aluminate, dextrin, carmellose calcium and the like. These carriers may be used alone or in combination of two or more. The crystalline cellulose includes microcrystalline cellulose.

Examples of the sweetener include sugar, sugar alcohol, glucose, fructose, galactose, mannose, lactose, maltose, sucrose, sucrose (including purified sucrose), trehalose, mannitol, sorbitol, maltitol, aspartame, erythritol. Xylitol and the like, and these may be used alone or in combination of two or more.

Examples of the lubricant include magnesium stearate, calcium stearate, sodium stearyl fumarate, stearic acid, talc, sucrose fatty acid ester, glycerin fatty acid ester, polyethylene glycol, vegetable oil and fat. The lubricant may be added by any of the method of adding to the granule before tableting and mixing, or the method of adhering directly to the punch or die during tableting.

The following examples further illustrate the present invention, but the present invention is not limited thereto.

[Evaluation method for drought and drunk conditions]
Evaluation was performed using spontaneous momentum measurement that can investigate all the states of sickness ranging from mild sickness to drought and drunk conditions (using Supermex (PAT.P), Muromachi Kikai Co., Ltd.). It is known that the change in spontaneous locomotor activity of mice by alcohol administration increases with an appropriate amount of alcohol and is suppressed in a dose-dependent manner when the amount increases (Izu et al., Animal Psychological Research, 58 (1). ), 2008).

Rats were forcibly intragastricly administered with 4 g / kg of ethanol, which was a dose that reached the blood ethanol concentration (Tsukamoto et al., Medicina, 2005), which is from a severe pupal period to a drunk period in humans. Thirty minutes later, the test substance was dissolved or suspended in water and administered into the forced stomach, and the subsequent locomotor activity was examined over time. As a test object, the material shown below was employ | adopted as an Example and a comparative example.

Specifically, male F344 rats 7 weeks of age or older were fasted for 7 hours, and a 30% (v / v) aqueous ethanol solution at 8.45 ml / kg was forcibly stomached twice at 30-minute intervals. (Total ethanol dose: 4 g / kg), 30 minutes later, various materials were forcibly administered into the stomach and placed in the spontaneous exercise amount measurement system in the dark period to feed the food. Thereafter, the spontaneous momentum up to 15 hours (changed to the light period after 12 hours and the cumulative spontaneous momentum reaches a plateau) was continuously measured at 30 minute intervals, and the result was expressed as an integrated value. In addition, the ethanol non-administration group and the ethanol-only 4 g / kg administration group were examined for comparison.

Example 1
Tomato dry powder (variety: Renaissance, manufactured by Ishikawa Farm Co., Ltd.) 2.367 g of whole raw tomato powder is added, 40 ml of distilled water is added, vortexed vigorously for 2 minutes, centrifuged (3000 rpm, 10 minutes), The clear aqueous fraction and residue were separated. 10 ml of distilled water was added to the obtained tomato residue to make a suspension. A suspension of 16.9 ml / kg was administered by gavage. The weight of the residue obtained by this treatment is 15.7% equal to the dietary fiber content in the dried tomato powder, and the dosage is 0.63 g / kg corresponding to 4 g / kg of tomato dried powder. It was.

(Comparative Example 1)
The aqueous fraction separated from the tomato residue by the operation of Example 1 was concentrated by distillation under reduced pressure until the volume reached 10 ml. A concentrated solution of 16.9 ml / kg was administered by gavage.

(Example 2)
The same operation as in Example 1 was performed to obtain a tomato residue. The obtained tomato residue was put in 500 ml of ethanol and stirred for 1 hour, then the filtered residue was next put in 500 ml of ethyl acetate, stirred for 5 hours and then filtered again to dry the residue overnight. And tomato residue obtained by extraction was obtained. 10 ml of distilled water was added to the obtained tomato residue to make a suspension. A suspension of 16.9 ml / kg was administered by gavage. The dosage was 0.63 g / kg corresponding to 4 g / kg of tomato dry powder.

The results of Example 1, Comparative Example 1 and Example 2 are shown in FIG. From this result, it was confirmed that the tomato residue has an effect of reducing the degree of drought or drunkness, the effect is enhanced by the extracted tomato residue, and is hardly observed in the aqueous fraction of tomato. .

(Comparative Example 2)
It is known that tomato contains pectin as a water-soluble dietary fiber and cellulose, hemicellulose, lignin and the like as insoluble dietary fibers (Herranz J et al. Journal of Food Sciences, 46, p1927-1981). Therefore, using pectin (HM Pectin manufactured by Cargill) and cellulose (Endurance MMC VE-050 manufactured by Koyo Shosha Co., Ltd.), in the same manner as in Test Example 1 above, the integrated value of spontaneous locomotor activity of rats 15 hours after alcohol administration was calculated. Examined.

Pectin and cellulose were intragastrically administered at 16.9 ml / kg in a suspension of distilled water to 3.74% at 0.63 g / kg.

The result of Comparative Example 2 is shown in FIG. From these results, it was confirmed that pectin and cellulose, which are dietary fibers, do not have a reduction effect on drought or drunkness, or are weak even if recognized.

(Example 3)
In order to examine the effective amount of tomato residue, the extraction-treated tomato residue was produced in the same manner as in Example 2, and the dosage was 0.3 g / kg, 0.1 g / kg, 0.05 g / kg, and 0. Spontaneous momentum of the rat at 025 g / kg was examined.

The results of Example 3 are shown in FIG. It was confirmed that the effect of reducing the degree of drunkenness or drunkness by the tomato residue subjected to the extraction treatment is exhibited at a dose of 0.1 g / kg or more.

The blood ethanol concentration by administration of 4 g / kg of alcohol is around 3 mg / ml, which is a result of the drinking amount of about 5 large beer bottles in terms of human. In the case of a human with a body weight of 60 kg, it is considered that if 6 g or more of the extracted tomato residue is ingested, the effect of reducing drought or drunkness can be obtained.

  Since drought and drunk state after drinking a large amount of alcohol due to drinking can be remarkably reduced, prevention of damage due to falls is expected, and the drunk prevention agent of the present invention can be used as food or beverage.

Claims (6)

  Use of insoluble components of tomatoes in the preparation of hangover agents.   The use according to claim 1, wherein the insoluble component of the tomato is a residue obtained by removing the water-soluble component from the tomato raw material.   The use according to claim 1, wherein the insoluble component of the tomato is a residue obtained by removing a water-soluble component and a fat-soluble component from the tomato raw material.   The use according to any one of claims 1 to 3, wherein the tomato material is at least one selected from the group consisting of tomato fruit, dried tomato powder and tomato pomace.   The use according to claim 3 or 4, wherein the removal of the fat-soluble component from the tomato raw material is performed by extraction using at least one organic solvent selected from the group consisting of ethanol and ethyl acetate.   Drunkenness reducing agent containing insoluble components of tomato.

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